Amino acid dipepetide frequency for human papillomavirus 163

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.076AlaAla: 3.076 ± 0.993
0.439AlaCys: 0.439 ± 0.503
3.076AlaAsp: 3.076 ± 0.741
4.394AlaGlu: 4.394 ± 1.618
2.197AlaPhe: 2.197 ± 0.676
3.515AlaGly: 3.515 ± 1.141
1.318AlaHis: 1.318 ± 0.759
3.954AlaIle: 3.954 ± 0.802
2.636AlaLys: 2.636 ± 0.85
4.394AlaLeu: 4.394 ± 1.15
1.757AlaMet: 1.757 ± 0.956
0.879AlaAsn: 0.879 ± 0.451
2.636AlaPro: 2.636 ± 1.048
3.515AlaGln: 3.515 ± 1.53
2.636AlaArg: 2.636 ± 0.961
3.954AlaSer: 3.954 ± 0.759
4.394AlaThr: 4.394 ± 1.689
3.515AlaVal: 3.515 ± 1.19
1.318AlaTrp: 1.318 ± 0.421
2.636AlaTyr: 2.636 ± 0.931
0.0AlaXaa: 0.0 ± 0.0
Cys
1.318CysAla: 1.318 ± 0.913
1.318CysCys: 1.318 ± 1.404
2.197CysAsp: 2.197 ± 0.895
1.318CysGlu: 1.318 ± 0.686
2.636CysPhe: 2.636 ± 1.172
0.0CysGly: 0.0 ± 0.0
0.879CysHis: 0.879 ± 0.943
2.197CysIle: 2.197 ± 0.579
0.879CysLys: 0.879 ± 1.006
1.757CysLeu: 1.757 ± 2.011
0.0CysMet: 0.0 ± 0.0
0.439CysAsn: 0.439 ± 0.337
1.757CysPro: 1.757 ± 0.886
0.439CysGln: 0.439 ± 0.503
1.318CysArg: 1.318 ± 0.913
1.318CysSer: 1.318 ± 0.778
1.318CysThr: 1.318 ± 1.011
1.757CysVal: 1.757 ± 1.06
1.318CysTrp: 1.318 ± 0.421
0.439CysTyr: 0.439 ± 0.503
0.0CysXaa: 0.0 ± 0.0
Asp
5.272AspAla: 5.272 ± 0.997
2.636AspCys: 2.636 ± 1.031
3.076AspAsp: 3.076 ± 0.882
1.757AspGlu: 1.757 ± 1.343
3.954AspPhe: 3.954 ± 2.058
3.515AspGly: 3.515 ± 1.324
0.439AspHis: 0.439 ± 0.407
3.954AspIle: 3.954 ± 1.068
3.515AspLys: 3.515 ± 1.171
6.591AspLeu: 6.591 ± 2.766
1.318AspMet: 1.318 ± 0.421
3.515AspAsn: 3.515 ± 1.379
3.954AspPro: 3.954 ± 1.279
1.757AspGln: 1.757 ± 0.888
2.197AspArg: 2.197 ± 0.536
5.272AspSer: 5.272 ± 1.558
3.954AspThr: 3.954 ± 0.706
5.272AspVal: 5.272 ± 2.801
0.439AspTrp: 0.439 ± 0.337
0.439AspTyr: 0.439 ± 0.407
0.0AspXaa: 0.0 ± 0.0
Glu
1.757GluAla: 1.757 ± 0.77
2.197GluCys: 2.197 ± 1.148
5.272GluAsp: 5.272 ± 1.135
7.03GluGlu: 7.03 ± 3.908
2.636GluPhe: 2.636 ± 0.833
5.272GluGly: 5.272 ± 0.794
1.318GluHis: 1.318 ± 0.764
1.757GluIle: 1.757 ± 0.77
1.757GluLys: 1.757 ± 1.137
4.394GluLeu: 4.394 ± 1.825
1.757GluMet: 1.757 ± 0.628
2.197GluAsn: 2.197 ± 0.473
2.636GluPro: 2.636 ± 0.826
2.197GluGln: 2.197 ± 1.287
0.879GluArg: 0.879 ± 0.451
4.833GluSer: 4.833 ± 1.554
5.272GluThr: 5.272 ± 1.408
4.833GluVal: 4.833 ± 0.973
0.439GluTrp: 0.439 ± 0.388
1.757GluTyr: 1.757 ± 0.813
0.0GluXaa: 0.0 ± 0.0
Phe
1.757PheAla: 1.757 ± 1.367
1.318PheCys: 1.318 ± 0.564
3.954PheAsp: 3.954 ± 1.47
3.954PheGlu: 3.954 ± 1.183
2.197PhePhe: 2.197 ± 0.882
2.636PheGly: 2.636 ± 1.063
1.318PheHis: 1.318 ± 0.686
3.515PheIle: 3.515 ± 1.339
0.879PheLys: 0.879 ± 0.451
4.394PheLeu: 4.394 ± 1.281
0.439PheMet: 0.439 ± 0.347
1.757PheAsn: 1.757 ± 0.672
1.318PhePro: 1.318 ± 0.421
2.197PheGln: 2.197 ± 0.716
2.636PheArg: 2.636 ± 0.768
2.636PheSer: 2.636 ± 0.509
3.515PheThr: 3.515 ± 0.659
4.394PheVal: 4.394 ± 1.161
1.318PheTrp: 1.318 ± 0.421
1.757PheTyr: 1.757 ± 0.696
0.0PheXaa: 0.0 ± 0.0
Gly
2.197GlyAla: 2.197 ± 0.735
0.439GlyCys: 0.439 ± 0.388
4.833GlyAsp: 4.833 ± 1.445
4.833GlyGlu: 4.833 ± 1.616
2.636GlyPhe: 2.636 ± 0.606
3.515GlyGly: 3.515 ± 1.77
1.757GlyHis: 1.757 ± 0.673
2.197GlyIle: 2.197 ± 1.203
3.515GlyLys: 3.515 ± 1.786
6.591GlyLeu: 6.591 ± 2.449
0.0GlyMet: 0.0 ± 0.0
3.515GlyAsn: 3.515 ± 0.699
2.197GlyPro: 2.197 ± 0.473
2.636GlyGln: 2.636 ± 1.35
5.712GlyArg: 5.712 ± 1.856
3.076GlySer: 3.076 ± 1.14
6.151GlyThr: 6.151 ± 2.172
3.515GlyVal: 3.515 ± 1.141
0.0GlyTrp: 0.0 ± 0.0
1.318GlyTyr: 1.318 ± 0.781
0.0GlyXaa: 0.0 ± 0.0
His
0.439HisAla: 0.439 ± 0.388
1.318HisCys: 1.318 ± 0.555
0.879HisAsp: 0.879 ± 0.385
0.439HisGlu: 0.439 ± 0.337
0.879HisPhe: 0.879 ± 0.771
0.439HisGly: 0.439 ± 0.407
0.0HisHis: 0.0 ± 0.0
1.757HisIle: 1.757 ± 0.713
1.318HisLys: 1.318 ± 0.685
2.636HisLeu: 2.636 ± 1.165
0.0HisMet: 0.0 ± 0.0
0.879HisAsn: 0.879 ± 0.454
2.197HisPro: 2.197 ± 0.782
0.439HisGln: 0.439 ± 0.388
0.879HisArg: 0.879 ± 0.489
1.318HisSer: 1.318 ± 0.901
0.879HisThr: 0.879 ± 0.771
3.076HisVal: 3.076 ± 1.374
0.439HisTrp: 0.439 ± 0.388
0.879HisTyr: 0.879 ± 0.454
0.0HisXaa: 0.0 ± 0.0
Ile
4.833IleAla: 4.833 ± 1.202
0.439IleCys: 0.439 ± 0.388
3.515IleAsp: 3.515 ± 1.484
5.272IleGlu: 5.272 ± 2.259
1.757IlePhe: 1.757 ± 0.735
3.515IleGly: 3.515 ± 1.497
0.439IleHis: 0.439 ± 0.337
1.757IleIle: 1.757 ± 0.712
0.439IleLys: 0.439 ± 0.388
5.272IleLeu: 5.272 ± 0.629
0.439IleMet: 0.439 ± 0.337
3.076IleAsn: 3.076 ± 1.068
3.515IlePro: 3.515 ± 1.762
3.076IleGln: 3.076 ± 0.593
2.636IleArg: 2.636 ± 0.681
4.394IleSer: 4.394 ± 1.275
1.757IleThr: 1.757 ± 0.699
4.833IleVal: 4.833 ± 1.546
0.879IleTrp: 0.879 ± 0.562
2.197IleTyr: 2.197 ± 1.203
0.0IleXaa: 0.0 ± 0.0
Lys
1.318LysAla: 1.318 ± 0.686
2.636LysCys: 2.636 ± 1.172
2.197LysAsp: 2.197 ± 0.895
2.636LysGlu: 2.636 ± 0.77
1.318LysPhe: 1.318 ± 0.421
3.076LysGly: 3.076 ± 1.011
2.636LysHis: 2.636 ± 1.323
4.394LysIle: 4.394 ± 1.431
2.197LysLys: 2.197 ± 0.492
3.515LysLeu: 3.515 ± 1.578
2.197LysMet: 2.197 ± 0.87
1.318LysAsn: 1.318 ± 0.404
0.879LysPro: 0.879 ± 0.454
3.076LysGln: 3.076 ± 1.079
4.833LysArg: 4.833 ± 1.038
5.712LysSer: 5.712 ± 2.075
2.636LysThr: 2.636 ± 0.997
1.318LysVal: 1.318 ± 0.653
0.439LysTrp: 0.439 ± 0.388
2.636LysTyr: 2.636 ± 1.373
0.0LysXaa: 0.0 ± 0.0
Leu
3.515LeuAla: 3.515 ± 0.961
2.197LeuCys: 2.197 ± 1.233
4.394LeuAsp: 4.394 ± 1.029
4.833LeuGlu: 4.833 ± 1.425
4.394LeuPhe: 4.394 ± 0.763
6.151LeuGly: 6.151 ± 2.161
1.757LeuHis: 1.757 ± 0.628
3.954LeuIle: 3.954 ± 1.139
7.469LeuLys: 7.469 ± 3.163
4.394LeuLeu: 4.394 ± 0.606
0.879LeuMet: 0.879 ± 0.744
1.757LeuAsn: 1.757 ± 0.759
5.712LeuPro: 5.712 ± 0.725
6.151LeuGln: 6.151 ± 2.225
2.197LeuArg: 2.197 ± 0.809
8.348LeuSer: 8.348 ± 1.394
5.712LeuThr: 5.712 ± 1.213
7.03LeuVal: 7.03 ± 1.49
0.439LeuTrp: 0.439 ± 0.407
4.394LeuTyr: 4.394 ± 0.963
0.0LeuXaa: 0.0 ± 0.0
Met
1.318MetAla: 1.318 ± 0.421
0.439MetCys: 0.439 ± 0.388
0.0MetAsp: 0.0 ± 0.0
1.757MetGlu: 1.757 ± 0.565
0.439MetPhe: 0.439 ± 0.386
1.318MetGly: 1.318 ± 0.763
0.439MetHis: 0.439 ± 0.407
1.318MetIle: 1.318 ± 0.555
1.318MetLys: 1.318 ± 0.686
0.879MetLeu: 0.879 ± 0.674
0.0MetMet: 0.0 ± 0.0
0.879MetAsn: 0.879 ± 0.464
0.439MetPro: 0.439 ± 0.503
0.879MetGln: 0.879 ± 0.385
1.318MetArg: 1.318 ± 0.727
0.439MetSer: 0.439 ± 0.386
0.879MetThr: 0.879 ± 0.674
0.879MetVal: 0.879 ± 0.451
0.0MetTrp: 0.0 ± 0.0
0.879MetTyr: 0.879 ± 0.451
0.0MetXaa: 0.0 ± 0.0
Asn
5.712AsnAla: 5.712 ± 1.356
0.879AsnCys: 0.879 ± 0.385
2.197AsnAsp: 2.197 ± 0.765
0.879AsnGlu: 0.879 ± 0.451
1.757AsnPhe: 1.757 ± 0.986
2.636AsnGly: 2.636 ± 1.239
0.0AsnHis: 0.0 ± 0.0
2.197AsnIle: 2.197 ± 1.033
1.757AsnLys: 1.757 ± 0.673
2.197AsnLeu: 2.197 ± 0.583
0.439AsnMet: 0.439 ± 0.337
2.197AsnAsn: 2.197 ± 1.014
3.515AsnPro: 3.515 ± 1.476
1.757AsnGln: 1.757 ± 0.67
2.636AsnArg: 2.636 ± 1.028
2.197AsnSer: 2.197 ± 0.833
4.394AsnThr: 4.394 ± 1.194
3.076AsnVal: 3.076 ± 1.272
1.318AsnTrp: 1.318 ± 0.791
1.757AsnTyr: 1.757 ± 0.735
0.0AsnXaa: 0.0 ± 0.0
Pro
3.076ProAla: 3.076 ± 1.904
0.439ProCys: 0.439 ± 0.388
3.076ProAsp: 3.076 ± 1.227
4.833ProGlu: 4.833 ± 1.076
1.318ProPhe: 1.318 ± 0.686
0.879ProGly: 0.879 ± 0.489
0.879ProHis: 0.879 ± 0.464
4.394ProIle: 4.394 ± 1.491
3.515ProLys: 3.515 ± 0.633
6.591ProLeu: 6.591 ± 2.019
1.318ProMet: 1.318 ± 0.778
2.636ProAsn: 2.636 ± 0.85
7.03ProPro: 7.03 ± 1.926
2.636ProGln: 2.636 ± 0.832
1.318ProArg: 1.318 ± 1.157
5.712ProSer: 5.712 ± 1.484
2.636ProThr: 2.636 ± 0.826
1.757ProVal: 1.757 ± 0.227
0.439ProTrp: 0.439 ± 0.407
1.757ProTyr: 1.757 ± 1.12
0.0ProXaa: 0.0 ± 0.0
Gln
3.076GlnAla: 3.076 ± 0.917
2.197GlnCys: 2.197 ± 1.557
3.954GlnAsp: 3.954 ± 1.692
2.636GlnGlu: 2.636 ± 1.255
2.197GlnPhe: 2.197 ± 1.187
1.757GlnGly: 1.757 ± 0.227
0.879GlnHis: 0.879 ± 0.451
1.318GlnIle: 1.318 ± 0.778
0.879GlnLys: 0.879 ± 0.451
6.591GlnLeu: 6.591 ± 1.416
0.439GlnMet: 0.439 ± 0.337
2.636GlnAsn: 2.636 ± 0.639
3.076GlnPro: 3.076 ± 0.482
3.515GlnGln: 3.515 ± 1.023
1.757GlnArg: 1.757 ± 0.673
2.197GlnSer: 2.197 ± 0.847
1.757GlnThr: 1.757 ± 0.67
2.197GlnVal: 2.197 ± 0.735
0.879GlnTrp: 0.879 ± 0.674
0.879GlnTyr: 0.879 ± 0.451
0.0GlnXaa: 0.0 ± 0.0
Arg
3.076ArgAla: 3.076 ± 1.118
1.318ArgCys: 1.318 ± 0.564
2.197ArgAsp: 2.197 ± 1.032
1.757ArgGlu: 1.757 ± 0.699
4.394ArgPhe: 4.394 ± 1.217
4.833ArgGly: 4.833 ± 1.991
2.197ArgHis: 2.197 ± 0.723
1.318ArgIle: 1.318 ± 0.999
3.954ArgLys: 3.954 ± 0.752
5.712ArgLeu: 5.712 ± 1.003
0.879ArgMet: 0.879 ± 0.705
3.076ArgAsn: 3.076 ± 1.591
3.076ArgPro: 3.076 ± 0.845
1.318ArgGln: 1.318 ± 0.77
7.03ArgArg: 7.03 ± 2.331
2.197ArgSer: 2.197 ± 0.765
1.757ArgThr: 1.757 ± 0.694
3.515ArgVal: 3.515 ± 1.951
1.318ArgTrp: 1.318 ± 0.555
1.318ArgTyr: 1.318 ± 0.813
0.0ArgXaa: 0.0 ± 0.0
Ser
3.076SerAla: 3.076 ± 1.055
1.757SerCys: 1.757 ± 1.563
3.515SerAsp: 3.515 ± 0.659
3.954SerGlu: 3.954 ± 0.942
3.954SerPhe: 3.954 ± 1.332
3.954SerGly: 3.954 ± 0.872
2.197SerHis: 2.197 ± 0.847
2.197SerIle: 2.197 ± 0.492
2.197SerLys: 2.197 ± 1.297
6.591SerLeu: 6.591 ± 1.786
0.439SerMet: 0.439 ± 0.337
3.076SerAsn: 3.076 ± 1.102
3.076SerPro: 3.076 ± 1.456
3.076SerGln: 3.076 ± 1.011
3.954SerArg: 3.954 ± 1.211
9.666SerSer: 9.666 ± 1.826
7.469SerThr: 7.469 ± 2.972
5.712SerVal: 5.712 ± 1.171
0.439SerTrp: 0.439 ± 0.337
3.954SerTyr: 3.954 ± 1.778
0.0SerXaa: 0.0 ± 0.0
Thr
2.197ThrAla: 2.197 ± 1.367
0.879ThrCys: 0.879 ± 0.736
5.712ThrAsp: 5.712 ± 0.966
3.954ThrGlu: 3.954 ± 0.614
0.879ThrPhe: 0.879 ± 0.725
5.712ThrGly: 5.712 ± 1.8
0.879ThrHis: 0.879 ± 0.444
3.515ThrIle: 3.515 ± 1.744
2.636ThrLys: 2.636 ± 1.84
5.272ThrLeu: 5.272 ± 1.088
1.757ThrMet: 1.757 ± 0.628
2.636ThrAsn: 2.636 ± 0.509
5.272ThrPro: 5.272 ± 2.634
1.757ThrGln: 1.757 ± 0.735
4.394ThrArg: 4.394 ± 2.036
4.833ThrSer: 4.833 ± 1.375
6.591ThrThr: 6.591 ± 1.454
6.591ThrVal: 6.591 ± 1.372
0.439ThrTrp: 0.439 ± 0.407
2.197ThrTyr: 2.197 ± 0.765
0.0ThrXaa: 0.0 ± 0.0
Val
5.712ValAla: 5.712 ± 1.715
0.879ValCys: 0.879 ± 0.674
6.591ValAsp: 6.591 ± 1.131
3.515ValGlu: 3.515 ± 0.903
3.954ValPhe: 3.954 ± 1.085
3.954ValGly: 3.954 ± 1.26
1.318ValHis: 1.318 ± 0.813
5.712ValIle: 5.712 ± 2.104
4.394ValLys: 4.394 ± 1.22
3.515ValLeu: 3.515 ± 1.269
0.879ValMet: 0.879 ± 0.444
3.076ValAsn: 3.076 ± 0.703
3.076ValPro: 3.076 ± 0.827
2.636ValGln: 2.636 ± 0.753
5.272ValArg: 5.272 ± 1.009
3.954ValSer: 3.954 ± 0.79
3.954ValThr: 3.954 ± 1.467
3.515ValVal: 3.515 ± 1.762
0.879ValTrp: 0.879 ± 0.454
2.197ValTyr: 2.197 ± 0.763
0.0ValXaa: 0.0 ± 0.0
Trp
0.439TrpAla: 0.439 ± 0.337
0.0TrpCys: 0.0 ± 0.0
0.879TrpAsp: 0.879 ± 0.454
0.0TrpGlu: 0.0 ± 0.0
0.879TrpPhe: 0.879 ± 0.451
1.318TrpGly: 1.318 ± 0.421
0.439TrpHis: 0.439 ± 0.407
0.879TrpIle: 0.879 ± 0.674
2.197TrpLys: 2.197 ± 0.682
2.197TrpLeu: 2.197 ± 0.735
0.0TrpMet: 0.0 ± 0.0
0.439TrpAsn: 0.439 ± 0.407
0.439TrpPro: 0.439 ± 0.388
0.439TrpGln: 0.439 ± 0.388
0.879TrpArg: 0.879 ± 0.663
0.439TrpSer: 0.439 ± 0.337
1.318TrpThr: 1.318 ± 0.77
0.439TrpVal: 0.439 ± 0.407
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.076TyrAla: 3.076 ± 0.476
0.879TyrCys: 0.879 ± 1.006
1.318TyrAsp: 1.318 ± 0.693
0.439TyrGlu: 0.439 ± 0.386
3.515TyrPhe: 3.515 ± 1.345
2.636TyrGly: 2.636 ± 0.544
0.0TyrHis: 0.0 ± 0.0
1.757TyrIle: 1.757 ± 0.888
3.515TyrLys: 3.515 ± 1.53
2.636TyrLeu: 2.636 ± 1.144
0.439TyrMet: 0.439 ± 0.326
3.515TyrAsn: 3.515 ± 0.691
0.439TyrPro: 0.439 ± 0.386
1.318TyrGln: 1.318 ± 0.421
1.757TyrArg: 1.757 ± 0.745
1.757TyrSer: 1.757 ± 0.561
1.757TyrThr: 1.757 ± 0.713
1.757TyrVal: 1.757 ± 0.565
0.879TyrTrp: 0.879 ± 0.454
0.879TyrTyr: 0.879 ± 0.489
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski