Amino acid dipepetide frequency for Mesorhizobium denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.511AlaAla: 15.511 ± 0.144
0.949AlaCys: 0.949 ± 0.029
6.647AlaAsp: 6.647 ± 0.076
7.434AlaGlu: 7.434 ± 0.088
4.473AlaPhe: 4.473 ± 0.066
9.776AlaGly: 9.776 ± 0.098
2.112AlaHis: 2.112 ± 0.043
6.94AlaIle: 6.94 ± 0.078
4.792AlaLys: 4.792 ± 0.08
12.434AlaLeu: 12.434 ± 0.116
3.469AlaMet: 3.469 ± 0.057
3.318AlaAsn: 3.318 ± 0.059
4.919AlaPro: 4.919 ± 0.068
3.807AlaGln: 3.807 ± 0.054
7.698AlaArg: 7.698 ± 0.089
6.397AlaSer: 6.397 ± 0.066
5.839AlaThr: 5.839 ± 0.119
8.281AlaVal: 8.281 ± 0.092
1.338AlaTrp: 1.338 ± 0.037
2.681AlaTyr: 2.681 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.928CysAla: 0.928 ± 0.028
0.12CysCys: 0.12 ± 0.01
0.499CysAsp: 0.499 ± 0.019
0.421CysGlu: 0.421 ± 0.017
0.345CysPhe: 0.345 ± 0.018
0.877CysGly: 0.877 ± 0.029
0.22CysHis: 0.22 ± 0.014
0.411CysIle: 0.411 ± 0.018
0.221CysLys: 0.221 ± 0.013
0.732CysLeu: 0.732 ± 0.024
0.151CysMet: 0.151 ± 0.01
0.223CysAsn: 0.223 ± 0.015
0.39CysPro: 0.39 ± 0.019
0.207CysGln: 0.207 ± 0.012
0.579CysArg: 0.579 ± 0.02
0.47CysSer: 0.47 ± 0.02
0.43CysThr: 0.43 ± 0.02
0.615CysVal: 0.615 ± 0.022
0.109CysTrp: 0.109 ± 0.009
0.229CysTyr: 0.229 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.643AspAla: 6.643 ± 0.081
0.523AspCys: 0.523 ± 0.021
3.049AspAsp: 3.049 ± 0.057
3.679AspGlu: 3.679 ± 0.061
2.27AspPhe: 2.27 ± 0.038
5.183AspGly: 5.183 ± 0.077
1.249AspHis: 1.249 ± 0.029
3.239AspIle: 3.239 ± 0.055
2.027AspLys: 2.027 ± 0.038
5.538AspLeu: 5.538 ± 0.077
1.396AspMet: 1.396 ± 0.036
1.428AspAsn: 1.428 ± 0.039
3.267AspPro: 3.267 ± 0.057
1.75AspGln: 1.75 ± 0.036
4.115AspArg: 4.115 ± 0.069
2.333AspSer: 2.333 ± 0.043
2.687AspThr: 2.687 ± 0.064
4.03AspVal: 4.03 ± 0.058
0.915AspTrp: 0.915 ± 0.029
1.489AspTyr: 1.489 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.32GluAla: 7.32 ± 0.096
0.37GluCys: 0.37 ± 0.019
2.756GluAsp: 2.756 ± 0.048
3.246GluGlu: 3.246 ± 0.059
1.955GluPhe: 1.955 ± 0.041
4.109GluGly: 4.109 ± 0.057
1.23GluHis: 1.23 ± 0.028
3.926GluIle: 3.926 ± 0.062
2.871GluLys: 2.871 ± 0.059
5.507GluLeu: 5.507 ± 0.067
1.684GluMet: 1.684 ± 0.036
1.888GluAsn: 1.888 ± 0.041
2.863GluPro: 2.863 ± 0.055
2.29GluGln: 2.29 ± 0.044
4.912GluArg: 4.912 ± 0.07
2.663GluSer: 2.663 ± 0.054
3.476GluThr: 3.476 ± 0.049
3.747GluVal: 3.747 ± 0.056
0.729GluTrp: 0.729 ± 0.022
1.138GluTyr: 1.138 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.655PheAla: 4.655 ± 0.062
0.403PheCys: 0.403 ± 0.017
2.765PheAsp: 2.765 ± 0.043
2.321PheGlu: 2.321 ± 0.048
1.562PhePhe: 1.562 ± 0.044
3.831PheGly: 3.831 ± 0.063
0.76PheHis: 0.76 ± 0.025
1.88PheIle: 1.88 ± 0.04
1.186PheLys: 1.186 ± 0.032
3.403PheLeu: 3.403 ± 0.068
0.839PheMet: 0.839 ± 0.026
1.174PheAsn: 1.174 ± 0.036
1.633PhePro: 1.633 ± 0.034
1.107PheGln: 1.107 ± 0.025
2.254PheArg: 2.254 ± 0.041
2.396PheSer: 2.396 ± 0.042
1.988PheThr: 1.988 ± 0.04
2.987PheVal: 2.987 ± 0.05
0.582PheTrp: 0.582 ± 0.021
0.989PheTyr: 0.989 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
8.767GlyAla: 8.767 ± 0.139
0.803GlyCys: 0.803 ± 0.028
4.298GlyAsp: 4.298 ± 0.073
4.875GlyGlu: 4.875 ± 0.063
3.588GlyPhe: 3.588 ± 0.053
7.061GlyGly: 7.061 ± 0.111
1.797GlyHis: 1.797 ± 0.042
4.889GlyIle: 4.889 ± 0.071
4.017GlyLys: 4.017 ± 0.058
8.189GlyLeu: 8.189 ± 0.086
2.351GlyMet: 2.351 ± 0.044
2.455GlyAsn: 2.455 ± 0.052
3.085GlyPro: 3.085 ± 0.053
2.756GlyGln: 2.756 ± 0.05
5.505GlyArg: 5.505 ± 0.083
4.819GlySer: 4.819 ± 0.077
4.603GlyThr: 4.603 ± 0.091
6.125GlyVal: 6.125 ± 0.077
1.286GlyTrp: 1.286 ± 0.038
2.346GlyTyr: 2.346 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.076HisAla: 2.076 ± 0.042
0.237HisCys: 0.237 ± 0.015
1.203HisAsp: 1.203 ± 0.034
1.108HisGlu: 1.108 ± 0.03
0.862HisPhe: 0.862 ± 0.023
1.859HisGly: 1.859 ± 0.038
0.518HisHis: 0.518 ± 0.025
1.082HisIle: 1.082 ± 0.028
0.583HisLys: 0.583 ± 0.021
1.923HisLeu: 1.923 ± 0.043
0.523HisMet: 0.523 ± 0.018
0.511HisAsn: 0.511 ± 0.017
1.291HisPro: 1.291 ± 0.034
0.58HisGln: 0.58 ± 0.023
1.317HisArg: 1.317 ± 0.031
1.067HisSer: 1.067 ± 0.028
0.825HisThr: 0.825 ± 0.024
1.422HisVal: 1.422 ± 0.032
0.339HisTrp: 0.339 ± 0.017
0.552HisTyr: 0.552 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.789IleAla: 7.789 ± 0.086
0.567IleCys: 0.567 ± 0.023
3.885IleAsp: 3.885 ± 0.057
3.844IleGlu: 3.844 ± 0.048
2.036IlePhe: 2.036 ± 0.045
5.166IleGly: 5.166 ± 0.071
0.926IleHis: 0.926 ± 0.028
2.85IleIle: 2.85 ± 0.05
1.801IleLys: 1.801 ± 0.039
4.717IleLeu: 4.717 ± 0.062
1.197IleMet: 1.197 ± 0.031
1.623IleAsn: 1.623 ± 0.038
2.392IlePro: 2.392 ± 0.042
1.309IleGln: 1.309 ± 0.032
3.38IleArg: 3.38 ± 0.056
3.419IleSer: 3.419 ± 0.059
2.898IleThr: 2.898 ± 0.061
4.737IleVal: 4.737 ± 0.065
0.664IleTrp: 0.664 ± 0.025
1.334IleTyr: 1.334 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.745LysAla: 4.745 ± 0.07
0.185LysCys: 0.185 ± 0.012
2.086LysAsp: 2.086 ± 0.044
1.955LysGlu: 1.955 ± 0.043
1.111LysPhe: 1.111 ± 0.029
2.991LysGly: 2.991 ± 0.049
0.724LysHis: 0.724 ± 0.022
2.139LysIle: 2.139 ± 0.042
1.712LysLys: 1.712 ± 0.049
4.081LysLeu: 4.081 ± 0.061
0.996LysMet: 0.996 ± 0.033
1.159LysAsn: 1.159 ± 0.031
2.493LysPro: 2.493 ± 0.054
1.317LysGln: 1.317 ± 0.035
2.785LysArg: 2.785 ± 0.051
2.381LysSer: 2.381 ± 0.045
2.178LysThr: 2.178 ± 0.044
2.874LysVal: 2.874 ± 0.051
0.438LysTrp: 0.438 ± 0.021
0.741LysTyr: 0.741 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
12.47LeuAla: 12.47 ± 0.109
0.794LeuCys: 0.794 ± 0.025
5.658LeuAsp: 5.658 ± 0.066
5.205LeuGlu: 5.205 ± 0.068
3.609LeuPhe: 3.609 ± 0.055
7.933LeuGly: 7.933 ± 0.08
1.781LeuHis: 1.781 ± 0.036
5.341LeuIle: 5.341 ± 0.08
4.047LeuLys: 4.047 ± 0.055
8.957LeuLeu: 8.957 ± 0.1
2.32LeuMet: 2.32 ± 0.042
2.846LeuAsn: 2.846 ± 0.052
5.216LeuPro: 5.216 ± 0.064
2.689LeuGln: 2.689 ± 0.043
6.23LeuArg: 6.23 ± 0.075
6.609LeuSer: 6.609 ± 0.073
5.341LeuThr: 5.341 ± 0.069
7.095LeuVal: 7.095 ± 0.082
1.079LeuTrp: 1.079 ± 0.033
2.065LeuTyr: 2.065 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
3.073MetAla: 3.073 ± 0.051
0.17MetCys: 0.17 ± 0.01
1.168MetAsp: 1.168 ± 0.032
1.221MetGlu: 1.221 ± 0.034
0.812MetPhe: 0.812 ± 0.027
1.839MetGly: 1.839 ± 0.04
0.461MetHis: 0.461 ± 0.018
1.454MetIle: 1.454 ± 0.035
1.148MetLys: 1.148 ± 0.028
2.597MetLeu: 2.597 ± 0.045
0.706MetMet: 0.706 ± 0.022
0.915MetAsn: 0.915 ± 0.026
1.479MetPro: 1.479 ± 0.037
0.9MetGln: 0.9 ± 0.025
1.944MetArg: 1.944 ± 0.043
1.791MetSer: 1.791 ± 0.039
1.731MetThr: 1.731 ± 0.037
1.81MetVal: 1.81 ± 0.038
0.214MetTrp: 0.214 ± 0.014
0.342MetTyr: 0.342 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.523AsnAla: 3.523 ± 0.056
0.271AsnCys: 0.271 ± 0.013
1.639AsnAsp: 1.639 ± 0.047
1.581AsnGlu: 1.581 ± 0.037
1.089AsnPhe: 1.089 ± 0.031
2.762AsnGly: 2.762 ± 0.064
0.56AsnHis: 0.56 ± 0.019
1.603AsnIle: 1.603 ± 0.037
0.907AsnLys: 0.907 ± 0.03
2.757AsnLeu: 2.757 ± 0.046
0.736AsnMet: 0.736 ± 0.026
0.804AsnAsn: 0.804 ± 0.023
1.929AsnPro: 1.929 ± 0.043
0.846AsnGln: 0.846 ± 0.024
1.934AsnArg: 1.934 ± 0.04
1.431AsnSer: 1.431 ± 0.036
1.369AsnThr: 1.369 ± 0.042
2.283AsnVal: 2.283 ± 0.042
0.479AsnTrp: 0.479 ± 0.02
0.797AsnTyr: 0.797 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
5.751ProAla: 5.751 ± 0.074
0.301ProCys: 0.301 ± 0.015
3.456ProAsp: 3.456 ± 0.053
3.551ProGlu: 3.551 ± 0.06
1.981ProPhe: 1.981 ± 0.043
4.037ProGly: 4.037 ± 0.066
1.062ProHis: 1.062 ± 0.028
2.491ProIle: 2.491 ± 0.048
1.916ProLys: 1.916 ± 0.042
4.419ProLeu: 4.419 ± 0.054
1.108ProMet: 1.108 ± 0.033
1.575ProAsn: 1.575 ± 0.036
2.112ProPro: 2.112 ± 0.055
1.62ProGln: 1.62 ± 0.042
2.618ProArg: 2.618 ± 0.048
2.689ProSer: 2.689 ± 0.045
2.485ProThr: 2.485 ± 0.047
4.13ProVal: 4.13 ± 0.062
0.666ProTrp: 0.666 ± 0.024
1.229ProTyr: 1.229 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.72GlnAla: 3.72 ± 0.06
0.196GlnCys: 0.196 ± 0.012
1.453GlnAsp: 1.453 ± 0.028
1.577GlnGlu: 1.577 ± 0.042
1.156GlnPhe: 1.156 ± 0.035
2.243GlnGly: 2.243 ± 0.048
0.629GlnHis: 0.629 ± 0.023
1.961GlnIle: 1.961 ± 0.037
1.29GlnLys: 1.29 ± 0.032
2.854GlnLeu: 2.854 ± 0.052
0.974GlnMet: 0.974 ± 0.028
0.956GlnAsn: 0.956 ± 0.028
1.846GlnPro: 1.846 ± 0.045
1.301GlnGln: 1.301 ± 0.036
2.423GlnArg: 2.423 ± 0.046
1.881GlnSer: 1.881 ± 0.039
1.806GlnThr: 1.806 ± 0.033
2.077GlnVal: 2.077 ± 0.04
0.4GlnTrp: 0.4 ± 0.016
0.631GlnTyr: 0.631 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
7.256ArgAla: 7.256 ± 0.093
0.452ArgCys: 0.452 ± 0.02
3.886ArgAsp: 3.886 ± 0.055
4.179ArgGlu: 4.179 ± 0.079
2.853ArgPhe: 2.853 ± 0.049
4.477ArgGly: 4.477 ± 0.068
1.549ArgHis: 1.549 ± 0.033
4.054ArgIle: 4.054 ± 0.054
2.824ArgLys: 2.824 ± 0.052
7.101ArgLeu: 7.101 ± 0.074
1.837ArgMet: 1.837 ± 0.035
2.064ArgAsn: 2.064 ± 0.044
3.099ArgPro: 3.099 ± 0.057
2.372ArgGln: 2.372 ± 0.043
5.007ArgArg: 5.007 ± 0.084
3.698ArgSer: 3.698 ± 0.056
3.333ArgThr: 3.333 ± 0.052
4.438ArgVal: 4.438 ± 0.06
0.89ArgTrp: 0.89 ± 0.028
1.677ArgTyr: 1.677 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.439SerAla: 6.439 ± 0.071
0.424SerCys: 0.424 ± 0.019
3.212SerAsp: 3.212 ± 0.04
3.164SerGlu: 3.164 ± 0.052
2.468SerPhe: 2.468 ± 0.05
5.744SerGly: 5.744 ± 0.072
1.096SerHis: 1.096 ± 0.031
3.198SerIle: 3.198 ± 0.051
1.983SerLys: 1.983 ± 0.04
5.457SerLeu: 5.457 ± 0.069
1.536SerMet: 1.536 ± 0.035
1.611SerAsn: 1.611 ± 0.042
2.625SerPro: 2.625 ± 0.046
1.711SerGln: 1.711 ± 0.037
3.673SerArg: 3.673 ± 0.064
3.161SerSer: 3.161 ± 0.056
2.902SerThr: 2.902 ± 0.054
4.24SerVal: 4.24 ± 0.064
0.778SerTrp: 0.778 ± 0.023
1.428SerTyr: 1.428 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.842ThrAla: 5.842 ± 0.086
0.411ThrCys: 0.411 ± 0.018
2.907ThrAsp: 2.907 ± 0.049
2.73ThrGlu: 2.73 ± 0.051
2.135ThrPhe: 2.135 ± 0.048
5.195ThrGly: 5.195 ± 0.178
1.027ThrHis: 1.027 ± 0.031
3.299ThrIle: 3.299 ± 0.066
1.716ThrLys: 1.716 ± 0.039
5.424ThrLeu: 5.424 ± 0.066
1.302ThrMet: 1.302 ± 0.035
1.53ThrAsn: 1.53 ± 0.037
3.115ThrPro: 3.115 ± 0.049
1.391ThrGln: 1.391 ± 0.037
3.079ThrArg: 3.079 ± 0.044
2.898ThrSer: 2.898 ± 0.053
2.803ThrThr: 2.803 ± 0.055
4.344ThrVal: 4.344 ± 0.086
0.599ThrTrp: 0.599 ± 0.023
1.236ThrTyr: 1.236 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
8.635ValAla: 8.635 ± 0.1
0.631ValCys: 0.631 ± 0.022
4.07ValAsp: 4.07 ± 0.067
4.681ValGlu: 4.681 ± 0.068
2.862ValPhe: 2.862 ± 0.05
5.574ValGly: 5.574 ± 0.076
1.395ValHis: 1.395 ± 0.033
4.044ValIle: 4.044 ± 0.064
2.719ValLys: 2.719 ± 0.048
7.3ValLeu: 7.3 ± 0.073
1.812ValMet: 1.812 ± 0.041
2.075ValAsn: 2.075 ± 0.048
3.68ValPro: 3.68 ± 0.055
2.119ValGln: 2.119 ± 0.037
4.785ValArg: 4.785 ± 0.068
4.595ValSer: 4.595 ± 0.06
4.408ValThr: 4.408 ± 0.074
5.817ValVal: 5.817 ± 0.075
0.894ValTrp: 0.894 ± 0.028
1.491ValTyr: 1.491 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.179TrpAla: 1.179 ± 0.032
0.121TrpCys: 0.121 ± 0.01
0.625TrpAsp: 0.625 ± 0.029
0.563TrpGlu: 0.563 ± 0.021
0.547TrpPhe: 0.547 ± 0.021
0.819TrpGly: 0.819 ± 0.026
0.302TrpHis: 0.302 ± 0.015
0.672TrpIle: 0.672 ± 0.025
0.57TrpLys: 0.57 ± 0.021
1.607TrpLeu: 1.607 ± 0.042
0.348TrpMet: 0.348 ± 0.018
0.492TrpAsn: 0.492 ± 0.02
0.665TrpPro: 0.665 ± 0.025
0.568TrpGln: 0.568 ± 0.026
1.073TrpArg: 1.073 ± 0.029
0.802TrpSer: 0.802 ± 0.028
0.721TrpThr: 0.721 ± 0.025
0.772TrpVal: 0.772 ± 0.028
0.216TrpTrp: 0.216 ± 0.014
0.315TrpTyr: 0.315 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.491TyrAla: 2.491 ± 0.049
0.249TyrCys: 0.249 ± 0.012
1.549TyrAsp: 1.549 ± 0.034
1.342TyrGlu: 1.342 ± 0.035
0.999TyrPhe: 0.999 ± 0.03
2.14TyrGly: 2.14 ± 0.044
0.484TyrHis: 0.484 ± 0.02
1.058TyrIle: 1.058 ± 0.025
0.759TyrLys: 0.759 ± 0.026
2.286TyrLeu: 2.286 ± 0.043
0.49TyrMet: 0.49 ± 0.019
0.651TyrAsn: 0.651 ± 0.019
1.098TyrPro: 1.098 ± 0.034
0.738TyrGln: 0.738 ± 0.024
1.739TyrArg: 1.739 ± 0.041
1.351TyrSer: 1.351 ± 0.033
1.16TyrThr: 1.16 ± 0.033
1.765TyrVal: 1.765 ± 0.036
0.362TyrTrp: 0.362 ± 0.019
0.607TyrTyr: 0.607 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4119 proteins (1302846 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski