Amino acid dipepetide frequency for Mycobacterium phage ByChance

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.437AlaAla: 15.437 ± 1.838
0.867AlaCys: 0.867 ± 0.239
7.805AlaAsp: 7.805 ± 0.642
6.765AlaGlu: 6.765 ± 0.727
2.891AlaPhe: 2.891 ± 0.424
10.58AlaGly: 10.58 ± 1.239
1.85AlaHis: 1.85 ± 0.326
4.163AlaIle: 4.163 ± 0.53
4.51AlaLys: 4.51 ± 0.494
8.846AlaLeu: 8.846 ± 0.766
2.024AlaMet: 2.024 ± 0.322
2.891AlaAsn: 2.891 ± 0.362
5.03AlaPro: 5.03 ± 0.535
3.585AlaGln: 3.585 ± 0.526
7.632AlaArg: 7.632 ± 0.767
5.724AlaSer: 5.724 ± 0.612
6.475AlaThr: 6.475 ± 0.546
6.186AlaVal: 6.186 ± 0.653
2.139AlaTrp: 2.139 ± 0.385
2.313AlaTyr: 2.313 ± 0.329
0.0AlaXaa: 0.0 ± 0.0
Cys
1.099CysAla: 1.099 ± 0.272
0.0CysCys: 0.0 ± 0.0
1.099CysAsp: 1.099 ± 0.32
0.809CysGlu: 0.809 ± 0.201
0.231CysPhe: 0.231 ± 0.111
1.156CysGly: 1.156 ± 0.309
0.405CysHis: 0.405 ± 0.14
0.116CysIle: 0.116 ± 0.075
0.52CysLys: 0.52 ± 0.18
0.867CysLeu: 0.867 ± 0.254
0.058CysMet: 0.058 ± 0.05
0.405CysAsn: 0.405 ± 0.144
1.099CysPro: 1.099 ± 0.292
0.173CysGln: 0.173 ± 0.089
0.694CysArg: 0.694 ± 0.206
0.925CysSer: 0.925 ± 0.309
0.405CysThr: 0.405 ± 0.185
0.752CysVal: 0.752 ± 0.19
0.463CysTrp: 0.463 ± 0.152
0.289CysTyr: 0.289 ± 0.127
0.0CysXaa: 0.0 ± 0.0
Asp
6.765AspAla: 6.765 ± 0.673
0.463AspCys: 0.463 ± 0.151
4.857AspAsp: 4.857 ± 0.623
3.064AspGlu: 3.064 ± 0.414
1.85AspPhe: 1.85 ± 0.304
7.169AspGly: 7.169 ± 0.604
1.099AspHis: 1.099 ± 0.228
2.717AspIle: 2.717 ± 0.381
2.024AspLys: 2.024 ± 0.336
5.435AspLeu: 5.435 ± 0.491
1.445AspMet: 1.445 ± 0.323
1.908AspAsn: 1.908 ± 0.401
5.435AspPro: 5.435 ± 0.572
2.255AspGln: 2.255 ± 0.325
4.336AspArg: 4.336 ± 0.567
3.642AspSer: 3.642 ± 0.512
4.221AspThr: 4.221 ± 0.516
4.51AspVal: 4.51 ± 0.519
1.503AspTrp: 1.503 ± 0.292
1.85AspTyr: 1.85 ± 0.349
0.0AspXaa: 0.0 ± 0.0
Glu
5.435GluAla: 5.435 ± 0.569
0.925GluCys: 0.925 ± 0.266
3.18GluAsp: 3.18 ± 0.372
3.353GluGlu: 3.353 ± 0.557
1.735GluPhe: 1.735 ± 0.301
3.469GluGly: 3.469 ± 0.4
1.619GluHis: 1.619 ± 0.384
1.908GluIle: 1.908 ± 0.315
2.081GluLys: 2.081 ± 0.363
5.84GluLeu: 5.84 ± 0.741
1.85GluMet: 1.85 ± 0.31
1.792GluAsn: 1.792 ± 0.319
2.602GluPro: 2.602 ± 0.432
3.18GluGln: 3.18 ± 0.376
4.51GluArg: 4.51 ± 0.611
3.18GluSer: 3.18 ± 0.539
3.932GluThr: 3.932 ± 0.562
4.047GluVal: 4.047 ± 0.528
1.677GluTrp: 1.677 ± 0.302
1.735GluTyr: 1.735 ± 0.337
0.0GluXaa: 0.0 ± 0.0
Phe
2.602PheAla: 2.602 ± 0.365
0.173PheCys: 0.173 ± 0.1
2.486PheAsp: 2.486 ± 0.426
1.966PheGlu: 1.966 ± 0.287
0.867PhePhe: 0.867 ± 0.254
2.833PheGly: 2.833 ± 0.56
0.52PheHis: 0.52 ± 0.185
1.503PheIle: 1.503 ± 0.406
0.578PheLys: 0.578 ± 0.14
1.619PheLeu: 1.619 ± 0.272
0.636PheMet: 0.636 ± 0.2
1.33PheAsn: 1.33 ± 0.368
1.677PhePro: 1.677 ± 0.281
0.983PheGln: 0.983 ± 0.352
1.85PheArg: 1.85 ± 0.259
1.503PheSer: 1.503 ± 0.307
2.197PheThr: 2.197 ± 0.344
2.486PheVal: 2.486 ± 0.322
0.463PheTrp: 0.463 ± 0.16
1.041PheTyr: 1.041 ± 0.294
0.0PheXaa: 0.0 ± 0.0
Gly
9.309GlyAla: 9.309 ± 1.185
0.925GlyCys: 0.925 ± 0.245
5.493GlyAsp: 5.493 ± 0.567
4.163GlyGlu: 4.163 ± 0.486
2.66GlyPhe: 2.66 ± 0.361
10.407GlyGly: 10.407 ± 2.244
1.85GlyHis: 1.85 ± 0.293
3.874GlyIle: 3.874 ± 0.531
2.602GlyLys: 2.602 ± 0.387
5.724GlyLeu: 5.724 ± 0.719
2.486GlyMet: 2.486 ± 0.456
3.064GlyAsn: 3.064 ± 0.356
4.163GlyPro: 4.163 ± 0.621
2.313GlyGln: 2.313 ± 0.581
5.319GlyArg: 5.319 ± 0.618
6.649GlySer: 6.649 ± 0.991
6.649GlyThr: 6.649 ± 0.709
5.55GlyVal: 5.55 ± 0.658
2.139GlyTrp: 2.139 ± 0.385
2.139GlyTyr: 2.139 ± 0.401
0.0GlyXaa: 0.0 ± 0.0
His
2.081HisAla: 2.081 ± 0.382
0.347HisCys: 0.347 ± 0.157
1.503HisAsp: 1.503 ± 0.269
1.156HisGlu: 1.156 ± 0.26
0.347HisPhe: 0.347 ± 0.119
1.33HisGly: 1.33 ± 0.375
0.867HisHis: 0.867 ± 0.222
1.33HisIle: 1.33 ± 0.334
0.983HisLys: 0.983 ± 0.237
1.33HisLeu: 1.33 ± 0.296
0.867HisMet: 0.867 ± 0.188
0.752HisAsn: 0.752 ± 0.199
1.677HisPro: 1.677 ± 0.348
0.809HisGln: 0.809 ± 0.24
2.139HisArg: 2.139 ± 0.423
0.636HisSer: 0.636 ± 0.172
1.272HisThr: 1.272 ± 0.319
1.156HisVal: 1.156 ± 0.264
0.231HisTrp: 0.231 ± 0.103
0.578HisTyr: 0.578 ± 0.162
0.0HisXaa: 0.0 ± 0.0
Ile
5.493IleAla: 5.493 ± 0.563
0.983IleCys: 0.983 ± 0.283
3.527IleAsp: 3.527 ± 0.453
3.7IleGlu: 3.7 ± 0.404
0.694IlePhe: 0.694 ± 0.23
3.527IleGly: 3.527 ± 0.421
1.272IleHis: 1.272 ± 0.274
1.272IleIle: 1.272 ± 0.228
0.983IleLys: 0.983 ± 0.253
2.139IleLeu: 2.139 ± 0.4
0.52IleMet: 0.52 ± 0.158
1.445IleAsn: 1.445 ± 0.298
3.296IlePro: 3.296 ± 0.397
1.272IleGln: 1.272 ± 0.304
2.486IleArg: 2.486 ± 0.42
2.197IleSer: 2.197 ± 0.422
4.047IleThr: 4.047 ± 0.467
2.891IleVal: 2.891 ± 0.357
0.925IleTrp: 0.925 ± 0.256
0.752IleTyr: 0.752 ± 0.181
0.0IleXaa: 0.0 ± 0.0
Lys
4.221LysAla: 4.221 ± 0.566
0.636LysCys: 0.636 ± 0.165
2.197LysAsp: 2.197 ± 0.336
1.445LysGlu: 1.445 ± 0.266
1.561LysPhe: 1.561 ± 0.281
2.313LysGly: 2.313 ± 0.397
0.752LysHis: 0.752 ± 0.265
0.983LysIle: 0.983 ± 0.24
1.561LysLys: 1.561 ± 0.346
2.602LysLeu: 2.602 ± 0.502
0.867LysMet: 0.867 ± 0.187
1.099LysAsn: 1.099 ± 0.252
2.428LysPro: 2.428 ± 0.437
1.445LysGln: 1.445 ± 0.31
1.966LysArg: 1.966 ± 0.384
2.255LysSer: 2.255 ± 0.3
1.85LysThr: 1.85 ± 0.365
2.891LysVal: 2.891 ± 0.397
0.809LysTrp: 0.809 ± 0.215
0.752LysTyr: 0.752 ± 0.204
0.0LysXaa: 0.0 ± 0.0
Leu
8.037LeuAla: 8.037 ± 0.815
0.983LeuCys: 0.983 ± 0.252
4.683LeuAsp: 4.683 ± 0.513
4.278LeuGlu: 4.278 ± 0.601
2.486LeuPhe: 2.486 ± 0.316
5.261LeuGly: 5.261 ± 0.589
0.809LeuHis: 0.809 ± 0.259
3.469LeuIle: 3.469 ± 0.46
2.255LeuLys: 2.255 ± 0.362
5.261LeuLeu: 5.261 ± 0.541
1.677LeuMet: 1.677 ± 0.277
3.122LeuAsn: 3.122 ± 0.477
4.452LeuPro: 4.452 ± 0.522
2.66LeuGln: 2.66 ± 0.429
4.683LeuArg: 4.683 ± 0.617
5.088LeuSer: 5.088 ± 0.52
5.204LeuThr: 5.204 ± 0.497
5.493LeuVal: 5.493 ± 0.609
1.156LeuTrp: 1.156 ± 0.303
1.908LeuTyr: 1.908 ± 0.366
0.0LeuXaa: 0.0 ± 0.0
Met
2.486MetAla: 2.486 ± 0.377
0.058MetCys: 0.058 ± 0.054
1.33MetAsp: 1.33 ± 0.317
0.983MetGlu: 0.983 ± 0.218
0.694MetPhe: 0.694 ± 0.268
1.503MetGly: 1.503 ± 0.241
0.173MetHis: 0.173 ± 0.109
0.867MetIle: 0.867 ± 0.231
0.809MetLys: 0.809 ± 0.242
1.85MetLeu: 1.85 ± 0.306
0.52MetMet: 0.52 ± 0.208
0.809MetAsn: 0.809 ± 0.227
1.33MetPro: 1.33 ± 0.256
0.578MetGln: 0.578 ± 0.14
1.792MetArg: 1.792 ± 0.292
2.66MetSer: 2.66 ± 0.353
2.66MetThr: 2.66 ± 0.355
1.445MetVal: 1.445 ± 0.38
0.347MetTrp: 0.347 ± 0.158
0.405MetTyr: 0.405 ± 0.13
0.0MetXaa: 0.0 ± 0.0
Asn
3.642AsnAla: 3.642 ± 0.486
0.231AsnCys: 0.231 ± 0.11
1.85AsnAsp: 1.85 ± 0.301
1.677AsnGlu: 1.677 ± 0.378
0.809AsnPhe: 0.809 ± 0.248
3.758AsnGly: 3.758 ± 0.543
0.925AsnHis: 0.925 ± 0.245
1.619AsnIle: 1.619 ± 0.5
1.156AsnLys: 1.156 ± 0.267
2.37AsnLeu: 2.37 ± 0.384
0.752AsnMet: 0.752 ± 0.192
2.024AsnAsn: 2.024 ± 0.331
2.544AsnPro: 2.544 ± 0.363
1.33AsnGln: 1.33 ± 0.312
1.908AsnArg: 1.908 ± 0.297
1.503AsnSer: 1.503 ± 0.242
2.081AsnThr: 2.081 ± 0.312
2.313AsnVal: 2.313 ± 0.347
0.867AsnTrp: 0.867 ± 0.182
1.041AsnTyr: 1.041 ± 0.233
0.0AsnXaa: 0.0 ± 0.0
Pro
4.914ProAla: 4.914 ± 0.618
0.694ProCys: 0.694 ± 0.194
4.336ProAsp: 4.336 ± 0.536
3.642ProGlu: 3.642 ± 0.482
1.735ProPhe: 1.735 ± 0.379
6.591ProGly: 6.591 ± 0.635
1.85ProHis: 1.85 ± 0.344
1.85ProIle: 1.85 ± 0.323
2.255ProLys: 2.255 ± 0.348
4.625ProLeu: 4.625 ± 0.525
1.272ProMet: 1.272 ± 0.309
2.486ProAsn: 2.486 ± 0.427
3.411ProPro: 3.411 ± 0.566
2.66ProGln: 2.66 ± 0.394
3.238ProArg: 3.238 ± 0.551
3.989ProSer: 3.989 ± 0.509
4.105ProThr: 4.105 ± 0.534
4.568ProVal: 4.568 ± 0.442
1.041ProTrp: 1.041 ± 0.214
1.156ProTyr: 1.156 ± 0.295
0.0ProXaa: 0.0 ± 0.0
Gln
4.914GlnAla: 4.914 ± 0.546
0.52GlnCys: 0.52 ± 0.227
1.33GlnAsp: 1.33 ± 0.232
1.561GlnGlu: 1.561 ± 0.256
1.214GlnPhe: 1.214 ± 0.252
2.428GlnGly: 2.428 ± 0.404
1.041GlnHis: 1.041 ± 0.251
2.255GlnIle: 2.255 ± 0.379
1.214GlnLys: 1.214 ± 0.25
3.122GlnLeu: 3.122 ± 0.387
0.752GlnMet: 0.752 ± 0.207
0.983GlnAsn: 0.983 ± 0.292
2.37GlnPro: 2.37 ± 0.451
1.156GlnGln: 1.156 ± 0.249
2.313GlnArg: 2.313 ± 0.378
1.85GlnSer: 1.85 ± 0.293
1.792GlnThr: 1.792 ± 0.268
2.544GlnVal: 2.544 ± 0.347
0.867GlnTrp: 0.867 ± 0.187
0.752GlnTyr: 0.752 ± 0.208
0.0GlnXaa: 0.0 ± 0.0
Arg
6.707ArgAla: 6.707 ± 0.805
1.099ArgCys: 1.099 ± 0.32
4.568ArgAsp: 4.568 ± 0.525
4.221ArgGlu: 4.221 ± 0.577
2.081ArgPhe: 2.081 ± 0.384
3.932ArgGly: 3.932 ± 0.476
1.214ArgHis: 1.214 ± 0.312
3.758ArgIle: 3.758 ± 0.552
2.602ArgLys: 2.602 ± 0.427
5.319ArgLeu: 5.319 ± 0.55
1.966ArgMet: 1.966 ± 0.369
2.486ArgAsn: 2.486 ± 0.424
4.105ArgPro: 4.105 ± 0.487
1.792ArgGln: 1.792 ± 0.338
5.724ArgArg: 5.724 ± 0.69
3.469ArgSer: 3.469 ± 0.414
3.18ArgThr: 3.18 ± 0.492
4.683ArgVal: 4.683 ± 0.601
1.85ArgTrp: 1.85 ± 0.358
2.139ArgTyr: 2.139 ± 0.368
0.0ArgXaa: 0.0 ± 0.0
Ser
6.186SerAla: 6.186 ± 0.761
0.463SerCys: 0.463 ± 0.177
4.221SerAsp: 4.221 ± 0.539
3.585SerGlu: 3.585 ± 0.619
1.966SerPhe: 1.966 ± 0.307
6.533SerGly: 6.533 ± 0.994
1.272SerHis: 1.272 ± 0.267
3.122SerIle: 3.122 ± 0.472
2.197SerLys: 2.197 ± 0.382
3.296SerLeu: 3.296 ± 0.417
1.503SerMet: 1.503 ± 0.317
2.197SerAsn: 2.197 ± 0.373
3.7SerPro: 3.7 ± 0.366
1.85SerGln: 1.85 ± 0.316
3.527SerArg: 3.527 ± 0.521
3.7SerSer: 3.7 ± 0.711
3.585SerThr: 3.585 ± 0.496
4.914SerVal: 4.914 ± 0.736
1.214SerTrp: 1.214 ± 0.236
1.33SerTyr: 1.33 ± 0.238
0.0SerXaa: 0.0 ± 0.0
Thr
6.418ThrAla: 6.418 ± 0.607
0.694ThrCys: 0.694 ± 0.246
4.278ThrAsp: 4.278 ± 0.62
3.932ThrGlu: 3.932 ± 0.436
1.792ThrPhe: 1.792 ± 0.347
6.36ThrGly: 6.36 ± 0.572
1.619ThrHis: 1.619 ± 0.289
3.585ThrIle: 3.585 ± 0.472
2.255ThrLys: 2.255 ± 0.354
4.047ThrLeu: 4.047 ± 0.455
1.561ThrMet: 1.561 ± 0.297
2.024ThrAsn: 2.024 ± 0.382
4.394ThrPro: 4.394 ± 0.459
2.37ThrGln: 2.37 ± 0.331
4.221ThrArg: 4.221 ± 0.503
4.163ThrSer: 4.163 ± 0.422
4.568ThrThr: 4.568 ± 0.566
5.955ThrVal: 5.955 ± 0.692
1.156ThrTrp: 1.156 ± 0.256
1.677ThrTyr: 1.677 ± 0.368
0.0ThrXaa: 0.0 ± 0.0
Val
7.169ValAla: 7.169 ± 0.736
0.867ValCys: 0.867 ± 0.22
4.972ValAsp: 4.972 ± 0.576
5.03ValGlu: 5.03 ± 0.545
2.197ValPhe: 2.197 ± 0.399
5.204ValGly: 5.204 ± 0.67
1.388ValHis: 1.388 ± 0.326
2.891ValIle: 2.891 ± 0.479
2.486ValLys: 2.486 ± 0.372
5.261ValLeu: 5.261 ± 0.66
1.388ValMet: 1.388 ± 0.241
2.197ValAsn: 2.197 ± 0.376
4.047ValPro: 4.047 ± 0.409
2.717ValGln: 2.717 ± 0.355
4.336ValArg: 4.336 ± 0.582
4.914ValSer: 4.914 ± 0.693
5.493ValThr: 5.493 ± 0.597
6.591ValVal: 6.591 ± 0.874
2.081ValTrp: 2.081 ± 0.436
1.503ValTyr: 1.503 ± 0.266
0.0ValXaa: 0.0 ± 0.0
Trp
2.255TrpAla: 2.255 ± 0.425
0.463TrpCys: 0.463 ± 0.153
1.099TrpAsp: 1.099 ± 0.26
0.925TrpGlu: 0.925 ± 0.325
0.752TrpPhe: 0.752 ± 0.169
1.099TrpGly: 1.099 ± 0.224
0.578TrpHis: 0.578 ± 0.194
1.041TrpIle: 1.041 ± 0.226
0.983TrpLys: 0.983 ± 0.18
2.024TrpLeu: 2.024 ± 0.434
0.809TrpMet: 0.809 ± 0.214
0.636TrpAsn: 0.636 ± 0.226
0.983TrpPro: 0.983 ± 0.286
0.925TrpGln: 0.925 ± 0.285
2.428TrpArg: 2.428 ± 0.445
1.156TrpSer: 1.156 ± 0.256
1.677TrpThr: 1.677 ± 0.303
1.33TrpVal: 1.33 ± 0.333
0.809TrpTrp: 0.809 ± 0.204
0.405TrpTyr: 0.405 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.544TyrAla: 2.544 ± 0.448
0.173TyrCys: 0.173 ± 0.105
1.735TyrAsp: 1.735 ± 0.396
1.792TyrGlu: 1.792 ± 0.284
0.752TyrPhe: 0.752 ± 0.223
2.024TyrGly: 2.024 ± 0.34
0.289TyrHis: 0.289 ± 0.136
1.099TyrIle: 1.099 ± 0.196
0.578TyrLys: 0.578 ± 0.196
1.388TyrLeu: 1.388 ± 0.233
0.289TyrMet: 0.289 ± 0.117
0.752TyrAsn: 0.752 ± 0.204
1.677TyrPro: 1.677 ± 0.293
0.925TyrGln: 0.925 ± 0.247
1.792TyrArg: 1.792 ± 0.317
1.156TyrSer: 1.156 ± 0.253
1.735TyrThr: 1.735 ± 0.289
2.428TyrVal: 2.428 ± 0.386
0.636TyrTrp: 0.636 ± 0.197
0.636TyrTyr: 0.636 ± 0.201
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (17297 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski