Amino acid dipepetide frequency for Streptococcus satellite phage Javan743

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.128AlaAla: 1.128 ± 0.519
0.451AlaCys: 0.451 ± 0.417
3.384AlaAsp: 3.384 ± 0.58
5.414AlaGlu: 5.414 ± 1.45
2.707AlaPhe: 2.707 ± 1.041
2.481AlaGly: 2.481 ± 0.816
0.226AlaHis: 0.226 ± 0.217
4.06AlaIle: 4.06 ± 0.885
4.737AlaLys: 4.737 ± 0.797
5.414AlaLeu: 5.414 ± 1.068
1.353AlaMet: 1.353 ± 0.85
2.707AlaAsn: 2.707 ± 0.889
0.451AlaPro: 0.451 ± 0.318
1.805AlaGln: 1.805 ± 0.535
4.06AlaArg: 4.06 ± 0.966
1.128AlaSer: 1.128 ± 0.466
3.384AlaThr: 3.384 ± 0.807
4.06AlaVal: 4.06 ± 0.803
0.677AlaTrp: 0.677 ± 0.389
1.128AlaTyr: 1.128 ± 0.703
0.0AlaXaa: 0.0 ± 0.0
Cys
0.451CysAla: 0.451 ± 0.292
0.0CysCys: 0.0 ± 0.0
0.677CysAsp: 0.677 ± 0.347
0.226CysGlu: 0.226 ± 0.208
0.0CysPhe: 0.0 ± 0.0
0.677CysGly: 0.677 ± 0.543
0.451CysHis: 0.451 ± 0.277
0.451CysIle: 0.451 ± 0.392
0.226CysLys: 0.226 ± 0.294
0.902CysLeu: 0.902 ± 0.398
0.226CysMet: 0.226 ± 0.271
0.226CysAsn: 0.226 ± 0.196
0.451CysPro: 0.451 ± 0.304
0.451CysGln: 0.451 ± 0.35
0.451CysArg: 0.451 ± 0.394
0.0CysSer: 0.0 ± 0.0
0.226CysThr: 0.226 ± 0.237
0.451CysVal: 0.451 ± 0.305
0.0CysTrp: 0.0 ± 0.0
0.451CysTyr: 0.451 ± 0.305
0.0CysXaa: 0.0 ± 0.0
Asp
0.677AspAla: 0.677 ± 0.471
0.677AspCys: 0.677 ± 0.522
4.06AspAsp: 4.06 ± 0.951
6.767AspGlu: 6.767 ± 1.456
4.512AspPhe: 4.512 ± 1.022
3.835AspGly: 3.835 ± 1.028
0.0AspHis: 0.0 ± 0.0
6.767AspIle: 6.767 ± 1.091
5.865AspLys: 5.865 ± 1.231
6.091AspLeu: 6.091 ± 1.502
1.805AspMet: 1.805 ± 0.541
2.707AspAsn: 2.707 ± 0.75
1.353AspPro: 1.353 ± 0.466
1.579AspGln: 1.579 ± 0.597
2.707AspArg: 2.707 ± 1.01
3.158AspSer: 3.158 ± 0.782
2.481AspThr: 2.481 ± 0.738
2.707AspVal: 2.707 ± 0.662
0.226AspTrp: 0.226 ± 0.231
2.933AspTyr: 2.933 ± 0.959
0.0AspXaa: 0.0 ± 0.0
Glu
5.188GluAla: 5.188 ± 1.024
0.677GluCys: 0.677 ± 0.36
3.158GluAsp: 3.158 ± 0.92
6.091GluGlu: 6.091 ± 1.229
3.609GluPhe: 3.609 ± 0.899
3.384GluGly: 3.384 ± 0.905
1.579GluHis: 1.579 ± 0.54
8.572GluIle: 8.572 ± 1.105
5.64GluLys: 5.64 ± 1.127
11.505GluLeu: 11.505 ± 1.769
2.256GluMet: 2.256 ± 0.898
4.963GluAsn: 4.963 ± 1.127
2.707GluPro: 2.707 ± 1.026
3.835GluGln: 3.835 ± 1.01
6.091GluArg: 6.091 ± 1.082
4.737GluSer: 4.737 ± 1.261
4.06GluThr: 4.06 ± 0.785
5.188GluVal: 5.188 ± 1.371
0.451GluTrp: 0.451 ± 0.247
3.158GluTyr: 3.158 ± 0.693
0.0GluXaa: 0.0 ± 0.0
Phe
1.353PheAla: 1.353 ± 0.569
0.0PheCys: 0.0 ± 0.0
4.06PheAsp: 4.06 ± 0.676
2.707PheGlu: 2.707 ± 0.917
1.353PhePhe: 1.353 ± 0.576
3.158PheGly: 3.158 ± 0.819
0.451PheHis: 0.451 ± 0.286
3.158PheIle: 3.158 ± 0.926
3.384PheLys: 3.384 ± 0.754
4.286PheLeu: 4.286 ± 1.167
0.677PheMet: 0.677 ± 0.397
3.158PheAsn: 3.158 ± 0.728
0.226PhePro: 0.226 ± 0.256
2.03PheGln: 2.03 ± 0.718
2.707PheArg: 2.707 ± 0.741
3.609PheSer: 3.609 ± 0.728
2.03PheThr: 2.03 ± 0.624
2.256PheVal: 2.256 ± 0.746
0.451PheTrp: 0.451 ± 0.336
3.158PheTyr: 3.158 ± 0.727
0.0PheXaa: 0.0 ± 0.0
Gly
1.128GlyAla: 1.128 ± 0.576
0.226GlyCys: 0.226 ± 0.199
3.158GlyAsp: 3.158 ± 0.871
3.384GlyGlu: 3.384 ± 0.898
2.03GlyPhe: 2.03 ± 0.604
2.707GlyGly: 2.707 ± 1.067
0.677GlyHis: 0.677 ± 0.334
3.158GlyIle: 3.158 ± 0.756
4.512GlyLys: 4.512 ± 0.916
5.188GlyLeu: 5.188 ± 0.979
1.353GlyMet: 1.353 ± 0.589
1.805GlyAsn: 1.805 ± 0.469
0.226GlyPro: 0.226 ± 0.199
2.481GlyGln: 2.481 ± 0.595
3.158GlyArg: 3.158 ± 0.907
2.256GlySer: 2.256 ± 0.573
4.737GlyThr: 4.737 ± 0.949
4.286GlyVal: 4.286 ± 1.029
0.902GlyTrp: 0.902 ± 0.596
3.158GlyTyr: 3.158 ± 1.063
0.0GlyXaa: 0.0 ± 0.0
His
0.902HisAla: 0.902 ± 0.6
0.0HisCys: 0.0 ± 0.0
1.128HisAsp: 1.128 ± 0.45
0.902HisGlu: 0.902 ± 0.495
0.677HisPhe: 0.677 ± 0.334
1.128HisGly: 1.128 ± 0.517
0.451HisHis: 0.451 ± 0.301
0.902HisIle: 0.902 ± 0.481
1.128HisLys: 1.128 ± 0.61
1.353HisLeu: 1.353 ± 0.568
0.226HisMet: 0.226 ± 0.255
1.353HisAsn: 1.353 ± 0.687
0.677HisPro: 0.677 ± 0.363
0.677HisGln: 0.677 ± 0.441
0.677HisArg: 0.677 ± 0.413
0.677HisSer: 0.677 ± 0.313
0.677HisThr: 0.677 ± 0.465
0.226HisVal: 0.226 ± 0.196
0.226HisTrp: 0.226 ± 0.231
1.128HisTyr: 1.128 ± 0.434
0.0HisXaa: 0.0 ± 0.0
Ile
5.414IleAla: 5.414 ± 1.081
0.902IleCys: 0.902 ± 0.429
7.219IleAsp: 7.219 ± 1.797
6.542IleGlu: 6.542 ± 1.369
2.707IlePhe: 2.707 ± 0.872
3.384IleGly: 3.384 ± 1.017
1.579IleHis: 1.579 ± 0.624
3.609IleIle: 3.609 ± 0.758
6.091IleLys: 6.091 ± 1.129
4.286IleLeu: 4.286 ± 0.972
0.451IleMet: 0.451 ± 0.32
2.707IleAsn: 2.707 ± 0.92
2.707IlePro: 2.707 ± 0.831
2.707IleGln: 2.707 ± 0.743
3.384IleArg: 3.384 ± 0.854
6.542IleSer: 6.542 ± 1.241
3.835IleThr: 3.835 ± 0.722
2.933IleVal: 2.933 ± 0.759
0.451IleTrp: 0.451 ± 0.392
2.256IleTyr: 2.256 ± 0.872
0.0IleXaa: 0.0 ± 0.0
Lys
7.444LysAla: 7.444 ± 1.514
0.226LysCys: 0.226 ± 0.208
2.256LysAsp: 2.256 ± 0.862
10.602LysGlu: 10.602 ± 1.159
3.835LysPhe: 3.835 ± 0.904
3.609LysGly: 3.609 ± 1.046
3.384LysHis: 3.384 ± 0.773
4.512LysIle: 4.512 ± 1.122
7.219LysLys: 7.219 ± 0.962
8.346LysLeu: 8.346 ± 1.013
1.805LysMet: 1.805 ± 0.726
4.286LysAsn: 4.286 ± 0.901
3.158LysPro: 3.158 ± 1.081
4.06LysGln: 4.06 ± 0.809
6.542LysArg: 6.542 ± 1.513
4.286LysSer: 4.286 ± 0.797
6.091LysThr: 6.091 ± 1.351
3.835LysVal: 3.835 ± 0.662
1.128LysTrp: 1.128 ± 0.47
2.707LysTyr: 2.707 ± 0.927
0.0LysXaa: 0.0 ± 0.0
Leu
6.316LeuAla: 6.316 ± 1.25
1.128LeuCys: 1.128 ± 0.501
9.249LeuAsp: 9.249 ± 1.741
10.602LeuGlu: 10.602 ± 1.977
3.158LeuPhe: 3.158 ± 0.712
4.512LeuGly: 4.512 ± 1.027
1.353LeuHis: 1.353 ± 0.434
5.188LeuIle: 5.188 ± 1.493
9.474LeuLys: 9.474 ± 1.16
7.895LeuLeu: 7.895 ± 1.345
2.933LeuMet: 2.933 ± 0.774
6.767LeuAsn: 6.767 ± 1.348
2.481LeuPro: 2.481 ± 0.774
3.835LeuGln: 3.835 ± 0.812
4.286LeuArg: 4.286 ± 1.165
5.865LeuSer: 5.865 ± 1.092
6.542LeuThr: 6.542 ± 1.27
3.384LeuVal: 3.384 ± 0.824
0.451LeuTrp: 0.451 ± 0.3
4.286LeuTyr: 4.286 ± 0.659
0.0LeuXaa: 0.0 ± 0.0
Met
2.256MetAla: 2.256 ± 0.674
0.0MetCys: 0.0 ± 0.0
1.128MetAsp: 1.128 ± 0.499
3.158MetGlu: 3.158 ± 0.853
0.902MetPhe: 0.902 ± 0.384
2.481MetGly: 2.481 ± 0.683
0.0MetHis: 0.0 ± 0.0
1.353MetIle: 1.353 ± 0.646
2.256MetLys: 2.256 ± 0.893
2.03MetLeu: 2.03 ± 0.677
1.128MetMet: 1.128 ± 0.505
2.481MetAsn: 2.481 ± 0.782
0.902MetPro: 0.902 ± 0.316
0.677MetGln: 0.677 ± 0.341
1.353MetArg: 1.353 ± 0.506
1.128MetSer: 1.128 ± 0.492
3.158MetThr: 3.158 ± 0.946
1.128MetVal: 1.128 ± 0.526
0.226MetTrp: 0.226 ± 0.196
0.226MetTyr: 0.226 ± 0.243
0.0MetXaa: 0.0 ± 0.0
Asn
2.256AsnAla: 2.256 ± 0.711
0.0AsnCys: 0.0 ± 0.0
4.286AsnAsp: 4.286 ± 1.095
3.384AsnGlu: 3.384 ± 0.767
2.481AsnPhe: 2.481 ± 0.857
4.06AsnGly: 4.06 ± 0.882
0.677AsnHis: 0.677 ± 0.398
2.707AsnIle: 2.707 ± 0.958
7.219AsnLys: 7.219 ± 1.237
5.414AsnLeu: 5.414 ± 1.074
2.256AsnMet: 2.256 ± 0.78
3.158AsnAsn: 3.158 ± 0.838
1.805AsnPro: 1.805 ± 0.521
2.256AsnGln: 2.256 ± 0.897
1.579AsnArg: 1.579 ± 0.554
2.707AsnSer: 2.707 ± 0.772
3.158AsnThr: 3.158 ± 1.063
2.03AsnVal: 2.03 ± 0.75
0.226AsnTrp: 0.226 ± 0.199
2.256AsnTyr: 2.256 ± 0.808
0.0AsnXaa: 0.0 ± 0.0
Pro
1.128ProAla: 1.128 ± 0.584
0.226ProCys: 0.226 ± 0.196
1.805ProAsp: 1.805 ± 0.558
2.707ProGlu: 2.707 ± 0.801
1.579ProPhe: 1.579 ± 0.736
0.677ProGly: 0.677 ± 0.54
0.0ProHis: 0.0 ± 0.0
1.579ProIle: 1.579 ± 0.519
2.03ProLys: 2.03 ± 0.601
1.805ProLeu: 1.805 ± 0.684
1.128ProMet: 1.128 ± 0.481
1.579ProAsn: 1.579 ± 0.631
1.128ProPro: 1.128 ± 0.585
0.902ProGln: 0.902 ± 0.52
3.384ProArg: 3.384 ± 0.813
0.902ProSer: 0.902 ± 0.458
1.128ProThr: 1.128 ± 0.413
1.353ProVal: 1.353 ± 0.716
0.0ProTrp: 0.0 ± 0.0
1.128ProTyr: 1.128 ± 0.449
0.0ProXaa: 0.0 ± 0.0
Gln
2.707GlnAla: 2.707 ± 0.619
0.0GlnCys: 0.0 ± 0.0
1.579GlnAsp: 1.579 ± 0.529
3.835GlnGlu: 3.835 ± 0.68
1.128GlnPhe: 1.128 ± 0.499
2.256GlnGly: 2.256 ± 0.85
0.226GlnHis: 0.226 ± 0.243
2.03GlnIle: 2.03 ± 0.788
4.286GlnLys: 4.286 ± 0.762
4.06GlnLeu: 4.06 ± 1.001
0.451GlnMet: 0.451 ± 0.316
1.805GlnAsn: 1.805 ± 0.879
0.677GlnPro: 0.677 ± 0.332
2.256GlnGln: 2.256 ± 0.784
2.933GlnArg: 2.933 ± 0.711
2.707GlnSer: 2.707 ± 0.496
2.481GlnThr: 2.481 ± 0.89
2.707GlnVal: 2.707 ± 0.721
1.128GlnTrp: 1.128 ± 0.37
1.353GlnTyr: 1.353 ± 0.509
0.0GlnXaa: 0.0 ± 0.0
Arg
2.933ArgAla: 2.933 ± 0.69
0.451ArgCys: 0.451 ± 0.333
2.481ArgAsp: 2.481 ± 0.762
5.188ArgGlu: 5.188 ± 1.306
3.609ArgPhe: 3.609 ± 0.761
3.609ArgGly: 3.609 ± 1.052
0.677ArgHis: 0.677 ± 0.321
3.835ArgIle: 3.835 ± 0.815
4.963ArgLys: 4.963 ± 1.075
6.993ArgLeu: 6.993 ± 1.343
2.03ArgMet: 2.03 ± 0.624
3.384ArgAsn: 3.384 ± 0.722
0.902ArgPro: 0.902 ± 0.428
1.805ArgGln: 1.805 ± 0.514
2.256ArgArg: 2.256 ± 0.798
2.707ArgSer: 2.707 ± 0.933
2.707ArgThr: 2.707 ± 0.65
3.384ArgVal: 3.384 ± 0.857
0.451ArgTrp: 0.451 ± 0.285
3.384ArgTyr: 3.384 ± 1.049
0.0ArgXaa: 0.0 ± 0.0
Ser
2.256SerAla: 2.256 ± 0.66
0.451SerCys: 0.451 ± 0.394
2.707SerAsp: 2.707 ± 0.665
4.06SerGlu: 4.06 ± 1.141
3.835SerPhe: 3.835 ± 0.993
2.933SerGly: 2.933 ± 0.643
0.226SerHis: 0.226 ± 0.199
4.737SerIle: 4.737 ± 1.018
4.286SerLys: 4.286 ± 0.984
6.091SerLeu: 6.091 ± 1.166
2.256SerMet: 2.256 ± 0.721
4.286SerAsn: 4.286 ± 1.244
0.902SerPro: 0.902 ± 0.42
2.481SerGln: 2.481 ± 0.775
3.609SerArg: 3.609 ± 1.108
2.933SerSer: 2.933 ± 0.864
2.481SerThr: 2.481 ± 0.692
2.256SerVal: 2.256 ± 0.793
0.226SerTrp: 0.226 ± 0.22
3.158SerTyr: 3.158 ± 0.732
0.0SerXaa: 0.0 ± 0.0
Thr
1.805ThrAla: 1.805 ± 0.631
0.677ThrCys: 0.677 ± 0.451
3.835ThrAsp: 3.835 ± 1.276
3.158ThrGlu: 3.158 ± 0.826
2.481ThrPhe: 2.481 ± 0.696
1.128ThrGly: 1.128 ± 0.631
2.03ThrHis: 2.03 ± 0.502
4.737ThrIle: 4.737 ± 1.169
5.64ThrLys: 5.64 ± 1.457
6.542ThrLeu: 6.542 ± 1.336
2.256ThrMet: 2.256 ± 0.682
0.677ThrAsn: 0.677 ± 0.468
2.03ThrPro: 2.03 ± 0.589
2.03ThrGln: 2.03 ± 0.671
2.933ThrArg: 2.933 ± 0.62
3.835ThrSer: 3.835 ± 1.051
5.188ThrThr: 5.188 ± 1.593
3.835ThrVal: 3.835 ± 1.061
0.451ThrTrp: 0.451 ± 0.293
3.835ThrTyr: 3.835 ± 1.222
0.0ThrXaa: 0.0 ± 0.0
Val
3.384ValAla: 3.384 ± 0.991
0.226ValCys: 0.226 ± 0.196
2.03ValAsp: 2.03 ± 0.6
4.737ValGlu: 4.737 ± 0.908
1.353ValPhe: 1.353 ± 0.665
2.481ValGly: 2.481 ± 0.899
0.0ValHis: 0.0 ± 0.0
4.06ValIle: 4.06 ± 0.791
4.963ValLys: 4.963 ± 1.118
5.865ValLeu: 5.865 ± 1.066
1.353ValMet: 1.353 ± 0.585
2.933ValAsn: 2.933 ± 0.706
1.805ValPro: 1.805 ± 0.561
1.805ValGln: 1.805 ± 0.652
1.579ValArg: 1.579 ± 0.68
2.933ValSer: 2.933 ± 0.884
2.707ValThr: 2.707 ± 0.609
2.933ValVal: 2.933 ± 0.875
0.677ValTrp: 0.677 ± 0.373
3.158ValTyr: 3.158 ± 0.844
0.0ValXaa: 0.0 ± 0.0
Trp
0.451TrpAla: 0.451 ± 0.295
0.0TrpCys: 0.0 ± 0.0
0.451TrpAsp: 0.451 ± 0.335
1.353TrpGlu: 1.353 ± 0.516
0.451TrpPhe: 0.451 ± 0.3
0.677TrpGly: 0.677 ± 0.373
0.226TrpHis: 0.226 ± 0.196
0.226TrpIle: 0.226 ± 0.255
0.226TrpLys: 0.226 ± 0.213
0.902TrpLeu: 0.902 ± 0.346
0.0TrpMet: 0.0 ± 0.0
0.451TrpAsn: 0.451 ± 0.325
0.0TrpPro: 0.0 ± 0.0
0.677TrpGln: 0.677 ± 0.391
0.451TrpArg: 0.451 ± 0.247
0.677TrpSer: 0.677 ± 0.327
0.451TrpThr: 0.451 ± 0.304
0.677TrpVal: 0.677 ± 0.451
0.0TrpTrp: 0.0 ± 0.0
0.451TrpTyr: 0.451 ± 0.247
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.579TyrAla: 1.579 ± 0.705
0.677TyrCys: 0.677 ± 0.302
2.256TyrAsp: 2.256 ± 0.576
2.03TyrGlu: 2.03 ± 0.735
1.805TyrPhe: 1.805 ± 0.8
1.579TyrGly: 1.579 ± 0.55
0.902TyrHis: 0.902 ± 0.381
4.06TyrIle: 4.06 ± 1.228
5.188TyrLys: 5.188 ± 1.504
4.737TyrLeu: 4.737 ± 1.194
1.805TyrMet: 1.805 ± 0.732
2.481TyrAsn: 2.481 ± 0.6
1.579TyrPro: 1.579 ± 0.652
2.256TyrGln: 2.256 ± 0.781
3.609TyrArg: 3.609 ± 0.677
3.384TyrSer: 3.384 ± 0.923
1.579TyrThr: 1.579 ± 0.817
1.353TyrVal: 1.353 ± 0.453
0.451TyrTrp: 0.451 ± 0.349
1.128TyrTyr: 1.128 ± 0.643
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 29 proteins (4434 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski