Amino acid dipepetide frequency for Rhodobacterales bacterium HTCC2255

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.992AlaAla: 7.992 ± 0.165	0.947AlaCys: 0.947 ± 0.037	4.416AlaAsp: 4.416 ± 0.086	4.838AlaGlu: 4.838 ± 0.101	3.518AlaPhe: 3.518 ± 0.08	6.628AlaGly: 6.628 ± 0.109	1.594AlaHis: 1.594 ± 0.055	6.449AlaIle: 6.449 ± 0.104	5.075AlaLys: 5.075 ± 0.083	8.806AlaLeu: 8.806 ± 0.122	2.762AlaMet: 2.762 ± 0.076	3.572AlaAsn: 3.572 ± 0.069	2.988AlaPro: 2.988 ± 0.086	2.829AlaGln: 2.829 ± 0.062	3.935AlaArg: 3.935 ± 0.087	5.37AlaSer: 5.37 ± 0.09	4.198AlaThr: 4.198 ± 0.061	5.304AlaVal: 5.304 ± 0.098	0.903AlaTrp: 0.903 ± 0.039	2.374AlaTyr: 2.374 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.896CysAla: 0.896 ± 0.032	0.136CysCys: 0.136 ± 0.014	0.656CysAsp: 0.656 ± 0.032	0.598CysGlu: 0.598 ± 0.035	0.495CysPhe: 0.495 ± 0.03	0.965CysGly: 0.965 ± 0.032	0.288CysHis: 0.288 ± 0.02	0.782CysIle: 0.782 ± 0.033	0.495CysLys: 0.495 ± 0.026	0.933CysLeu: 0.933 ± 0.035	0.246CysMet: 0.246 ± 0.018	0.436CysAsn: 0.436 ± 0.026	0.49CysPro: 0.49 ± 0.029	0.288CysGln: 0.288 ± 0.021	0.424CysArg: 0.424 ± 0.027	0.703CysSer: 0.703 ± 0.034	0.456CysThr: 0.456 ± 0.029	0.65CysVal: 0.65 ± 0.032	0.133CysTrp: 0.133 ± 0.014	0.27CysTyr: 0.27 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.93AspAla: 4.93 ± 0.093	0.552AspCys: 0.552 ± 0.027	2.89AspAsp: 2.89 ± 0.087	3.695AspGlu: 3.695 ± 0.082	2.581AspPhe: 2.581 ± 0.06	4.342AspGly: 4.342 ± 0.077	1.266AspHis: 1.266 ± 0.05	4.666AspIle: 4.666 ± 0.079	2.977AspLys: 2.977 ± 0.061	5.698AspLeu: 5.698 ± 0.091	1.681AspMet: 1.681 ± 0.051	2.286AspAsn: 2.286 ± 0.054	2.464AspPro: 2.464 ± 0.058	1.922AspGln: 1.922 ± 0.058	2.706AspArg: 2.706 ± 0.062	2.462AspSer: 2.462 ± 0.059	2.846AspThr: 2.846 ± 0.06	3.802AspVal: 3.802 ± 0.082	0.977AspTrp: 0.977 ± 0.04	1.672AspTyr: 1.672 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.355GluAla: 5.355 ± 0.099	0.535GluCys: 0.535 ± 0.027	2.977GluAsp: 2.977 ± 0.064	3.468GluGlu: 3.468 ± 0.082	2.331GluPhe: 2.331 ± 0.054	3.586GluGly: 3.586 ± 0.076	1.212GluHis: 1.212 ± 0.04	5.2GluIle: 5.2 ± 0.096	4.043GluLys: 4.043 ± 0.083	5.93GluLeu: 5.93 ± 0.109	1.882GluMet: 1.882 ± 0.053	3.485GluAsn: 3.485 ± 0.08	2.074GluPro: 2.074 ± 0.115	1.826GluGln: 1.826 ± 0.065	2.934GluArg: 2.934 ± 0.068	2.75GluSer: 2.75 ± 0.06	3.45GluThr: 3.45 ± 0.071	3.726GluVal: 3.726 ± 0.079	0.765GluTrp: 0.765 ± 0.039	1.613GluTyr: 1.613 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.516PheAla: 3.516 ± 0.08	0.619PheCys: 0.619 ± 0.031	2.929PheAsp: 2.929 ± 0.069	2.716PheGlu: 2.716 ± 0.068	1.987PhePhe: 1.987 ± 0.07	3.824PheGly: 3.824 ± 0.084	0.768PheHis: 0.768 ± 0.034	3.335PheIle: 3.335 ± 0.077	2.217PheLys: 2.217 ± 0.066	3.954PheLeu: 3.954 ± 0.089	1.099PheMet: 1.099 ± 0.04	2.108PheAsn: 2.108 ± 0.05	1.652PhePro: 1.652 ± 0.046	1.192PheGln: 1.192 ± 0.042	1.601PheArg: 1.601 ± 0.05	3.248PheSer: 3.248 ± 0.066	2.179PheThr: 2.179 ± 0.056	2.615PheVal: 2.615 ± 0.064	0.605PheTrp: 0.605 ± 0.033	1.219PheTyr: 1.219 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.469GlyAla: 6.469 ± 0.106	0.889GlyCys: 0.889 ± 0.036	3.742GlyAsp: 3.742 ± 0.076	4.02GlyGlu: 4.02 ± 0.078	3.674GlyPhe: 3.674 ± 0.076	5.881GlyGly: 5.881 ± 0.112	1.58GlyHis: 1.58 ± 0.055	5.771GlyIle: 5.771 ± 0.103	4.56GlyLys: 4.56 ± 0.076	7.538GlyLeu: 7.538 ± 0.126	2.28GlyMet: 2.28 ± 0.063	2.941GlyAsn: 2.941 ± 0.073	2.513GlyPro: 2.513 ± 0.069	2.517GlyGln: 2.517 ± 0.063	3.444GlyArg: 3.444 ± 0.073	4.784GlySer: 4.784 ± 0.079	3.721GlyThr: 3.721 ± 0.09	5.335GlyVal: 5.335 ± 0.087	1.157GlyTrp: 1.157 ± 0.048	2.416GlyTyr: 2.416 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.651HisAla: 1.651 ± 0.052	0.236HisCys: 0.236 ± 0.018	1.116HisAsp: 1.116 ± 0.054	1.077HisGlu: 1.077 ± 0.045	0.856HisPhe: 0.856 ± 0.038	1.577HisGly: 1.577 ± 0.05	0.515HisHis: 0.515 ± 0.036	1.439HisIle: 1.439 ± 0.045	1.033HisLys: 1.033 ± 0.043	1.86HisLeu: 1.86 ± 0.047	0.544HisMet: 0.544 ± 0.03	0.87HisAsn: 0.87 ± 0.034	1.146HisPro: 1.146 ± 0.048	0.677HisGln: 0.677 ± 0.032	0.894HisArg: 0.894 ± 0.038	1.229HisSer: 1.229 ± 0.044	0.93HisThr: 0.93 ± 0.036	1.144HisVal: 1.144 ± 0.042	0.297HisTrp: 0.297 ± 0.021	0.591HisTyr: 0.591 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.913IleAla: 6.913 ± 0.119	0.882IleCys: 0.882 ± 0.036	4.846IleAsp: 4.846 ± 0.089	5.001IleGlu: 5.001 ± 0.081	3.413IlePhe: 3.413 ± 0.075	6.033IleGly: 6.033 ± 0.098	1.307IleHis: 1.307 ± 0.042	6.212IleIle: 6.212 ± 0.115	4.632IleLys: 4.632 ± 0.098	7.501IleLeu: 7.501 ± 0.123	1.911IleMet: 1.911 ± 0.058	4.04IleAsn: 4.04 ± 0.083	3.238IlePro: 3.238 ± 0.074	2.08IleGln: 2.08 ± 0.057	3.122IleArg: 3.122 ± 0.069	6.081IleSer: 6.081 ± 0.103	4.073IleThr: 4.073 ± 0.081	4.746IleVal: 4.746 ± 0.082	0.975IleTrp: 0.975 ± 0.038	1.922IleTyr: 1.922 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.473LysAla: 4.473 ± 0.08	0.446LysCys: 0.446 ± 0.024	3.386LysAsp: 3.386 ± 0.068	3.433LysGlu: 3.433 ± 0.078	2.29LysPhe: 2.29 ± 0.062	3.64LysGly: 3.64 ± 0.073	1.165LysHis: 1.165 ± 0.04	5.214LysIle: 5.214 ± 0.101	4.25LysLys: 4.25 ± 0.089	5.562LysLeu: 5.562 ± 0.093	1.909LysMet: 1.909 ± 0.056	3.733LysAsn: 3.733 ± 0.091	2.361LysPro: 2.361 ± 0.059	1.706LysGln: 1.706 ± 0.051	2.936LysArg: 2.936 ± 0.069	4.348LysSer: 4.348 ± 0.08	3.245LysThr: 3.245 ± 0.069	3.486LysVal: 3.486 ± 0.076	0.642LysTrp: 0.642 ± 0.03	1.723LysTyr: 1.723 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	8.415LeuAla: 8.415 ± 0.126	0.981LeuCys: 0.981 ± 0.042	5.708LeuAsp: 5.708 ± 0.105	5.741LeuGlu: 5.741 ± 0.094	4.027LeuPhe: 4.027 ± 0.092	7.159LeuGly: 7.159 ± 0.117	1.701LeuHis: 1.701 ± 0.042	7.603LeuIle: 7.603 ± 0.131	5.901LeuLys: 5.901 ± 0.102	8.367LeuLeu: 8.367 ± 0.137	2.717LeuMet: 2.717 ± 0.067	4.961LeuAsn: 4.961 ± 0.091	4.418LeuPro: 4.418 ± 0.083	2.63LeuGln: 2.63 ± 0.066	4.646LeuArg: 4.646 ± 0.09	7.656LeuSer: 7.656 ± 0.12	5.105LeuThr: 5.105 ± 0.079	5.461LeuVal: 5.461 ± 0.103	1.028LeuTrp: 1.028 ± 0.045	2.19LeuTyr: 2.19 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.798MetAla: 2.798 ± 0.068	0.254MetCys: 0.254 ± 0.018	1.418MetAsp: 1.418 ± 0.051	1.41MetGlu: 1.41 ± 0.044	0.978MetPhe: 0.978 ± 0.035	2.295MetGly: 2.295 ± 0.062	0.535MetHis: 0.535 ± 0.032	2.092MetIle: 2.092 ± 0.057	1.659MetLys: 1.659 ± 0.057	2.625MetLeu: 2.625 ± 0.064	0.818MetMet: 0.818 ± 0.034	1.403MetAsn: 1.403 ± 0.046	1.351MetPro: 1.351 ± 0.046	0.994MetGln: 0.994 ± 0.036	1.506MetArg: 1.506 ± 0.048	2.127MetSer: 2.127 ± 0.054	1.799MetThr: 1.799 ± 0.053	1.797MetVal: 1.797 ± 0.055	0.243MetTrp: 0.243 ± 0.017	0.524MetTyr: 0.524 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.823AsnAla: 3.823 ± 0.072	0.501AsnCys: 0.501 ± 0.027	2.762AsnAsp: 2.762 ± 0.063	2.736AsnGlu: 2.736 ± 0.065	2.185AsnPhe: 2.185 ± 0.058	3.538AsnGly: 3.538 ± 0.079	0.95AsnHis: 0.95 ± 0.035	4.246AsnIle: 4.246 ± 0.082	2.971AsnLys: 2.971 ± 0.073	4.723AsnLeu: 4.723 ± 0.089	1.229AsnMet: 1.229 ± 0.039	2.554AsnAsn: 2.554 ± 0.076	2.359AsnPro: 2.359 ± 0.055	1.566AsnGln: 1.566 ± 0.051	2.029AsnArg: 2.029 ± 0.062	3.181AsnSer: 3.181 ± 0.065	2.436AsnThr: 2.436 ± 0.069	2.877AsnVal: 2.877 ± 0.072	0.747AsnTrp: 0.747 ± 0.036	1.376AsnTyr: 1.376 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.734ProAla: 2.734 ± 0.058	0.332ProCys: 0.332 ± 0.025	2.511ProAsp: 2.511 ± 0.063	3.053ProGlu: 3.053 ± 0.11	1.933ProPhe: 1.933 ± 0.051	2.669ProGly: 2.669 ± 0.067	0.872ProHis: 0.872 ± 0.04	3.306ProIle: 3.306 ± 0.068	2.643ProLys: 2.643 ± 0.067	3.78ProLeu: 3.78 ± 0.067	1.114ProMet: 1.114 ± 0.041	2.303ProAsn: 2.303 ± 0.052	1.323ProPro: 1.323 ± 0.046	1.161ProGln: 1.161 ± 0.035	1.573ProArg: 1.573 ± 0.05	2.775ProSer: 2.775 ± 0.068	2.199ProThr: 2.199 ± 0.054	2.822ProVal: 2.822 ± 0.057	0.494ProTrp: 0.494 ± 0.03	1.089ProTyr: 1.089 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.636GlnAla: 2.636 ± 0.067	0.238GlnCys: 0.238 ± 0.019	1.5GlnAsp: 1.5 ± 0.048	1.669GlnGlu: 1.669 ± 0.047	1.227GlnPhe: 1.227 ± 0.043	2.034GlnGly: 2.034 ± 0.053	0.542GlnHis: 0.542 ± 0.031	2.588GlnIle: 2.588 ± 0.061	2.043GlnLys: 2.043 ± 0.054	2.809GlnLeu: 2.809 ± 0.075	1.033GlnMet: 1.033 ± 0.039	1.678GlnAsn: 1.678 ± 0.049	1.096GlnPro: 1.096 ± 0.042	0.9GlnGln: 0.9 ± 0.041	1.615GlnArg: 1.615 ± 0.052	2.273GlnSer: 2.273 ± 0.054	1.615GlnThr: 1.615 ± 0.053	1.905GlnVal: 1.905 ± 0.059	0.416GlnTrp: 0.416 ± 0.023	0.802GlnTyr: 0.802 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.748ArgAla: 3.748 ± 0.08	0.43ArgCys: 0.43 ± 0.022	2.629ArgAsp: 2.629 ± 0.058	2.711ArgGlu: 2.711 ± 0.07	1.925ArgPhe: 1.925 ± 0.047	3.028ArgGly: 3.028 ± 0.076	0.926ArgHis: 0.926 ± 0.035	3.516ArgIle: 3.516 ± 0.073	2.781ArgLys: 2.781 ± 0.067	4.744ArgLeu: 4.744 ± 0.091	1.319ArgMet: 1.319 ± 0.044	2.135ArgAsn: 2.135 ± 0.058	1.84ArgPro: 1.84 ± 0.054	1.532ArgGln: 1.532 ± 0.05	2.439ArgArg: 2.439 ± 0.07	2.85ArgSer: 2.85 ± 0.062	2.163ArgThr: 2.163 ± 0.057	3.055ArgVal: 3.055 ± 0.067	0.558ArgTrp: 0.558 ± 0.029	1.278ArgTyr: 1.278 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.376SerAla: 5.376 ± 0.094	0.643SerCys: 0.643 ± 0.035	4.012SerAsp: 4.012 ± 0.08	4.182SerGlu: 4.182 ± 0.081	3.063SerPhe: 3.063 ± 0.072	5.864SerGly: 5.864 ± 0.092	1.329SerHis: 1.329 ± 0.038	5.034SerIle: 5.034 ± 0.071	4.301SerLys: 4.301 ± 0.087	6.242SerLeu: 6.242 ± 0.104	1.868SerMet: 1.868 ± 0.049	3.347SerAsn: 3.347 ± 0.067	2.586SerPro: 2.586 ± 0.058	2.172SerGln: 2.172 ± 0.051	2.798SerArg: 2.798 ± 0.071	4.385SerSer: 4.385 ± 0.091	3.201SerThr: 3.201 ± 0.073	4.27SerVal: 4.27 ± 0.074	0.822SerTrp: 0.822 ± 0.037	1.749SerTyr: 1.749 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.276ThrAla: 4.276 ± 0.084	0.511ThrCys: 0.511 ± 0.027	2.73ThrAsp: 2.73 ± 0.064	2.701ThrGlu: 2.701 ± 0.066	2.246ThrPhe: 2.246 ± 0.068	4.291ThrGly: 4.291 ± 0.088	1.1ThrHis: 1.1 ± 0.038	3.934ThrIle: 3.934 ± 0.076	2.873ThrLys: 2.873 ± 0.063	5.356ThrLeu: 5.356 ± 0.094	1.276ThrMet: 1.276 ± 0.047	2.381ThrAsn: 2.381 ± 0.059	2.653ThrPro: 2.653 ± 0.068	1.546ThrGln: 1.546 ± 0.045	2.24ThrArg: 2.24 ± 0.054	3.528ThrSer: 3.528 ± 0.065	2.706ThrThr: 2.706 ± 0.066	3.349ThrVal: 3.349 ± 0.067	0.632ThrTrp: 0.632 ± 0.032	1.385ThrTyr: 1.385 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	5.333ValAla: 5.333 ± 0.104	0.74ValCys: 0.74 ± 0.031	3.705ValAsp: 3.705 ± 0.076	3.856ValGlu: 3.856 ± 0.079	2.72ValPhe: 2.72 ± 0.069	4.775ValGly: 4.775 ± 0.102	1.15ValHis: 1.15 ± 0.04	5.001ValIle: 5.001 ± 0.084	3.357ValLys: 3.357 ± 0.073	5.957ValLeu: 5.957 ± 0.101	1.871ValMet: 1.871 ± 0.052	2.701ValAsn: 2.701 ± 0.066	2.449ValPro: 2.449 ± 0.068	1.807ValGln: 1.807 ± 0.05	2.772ValArg: 2.772 ± 0.061	4.763ValSer: 4.763 ± 0.083	3.428ValThr: 3.428 ± 0.075	4.449ValVal: 4.449 ± 0.1	0.727ValTrp: 0.727 ± 0.035	1.604ValTyr: 1.604 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.989TrpAla: 0.989 ± 0.039	0.149TrpCys: 0.149 ± 0.013	0.696TrpAsp: 0.696 ± 0.034	0.667TrpGlu: 0.667 ± 0.03	0.618TrpPhe: 0.618 ± 0.03	0.873TrpGly: 0.873 ± 0.038	0.294TrpHis: 0.294 ± 0.02	0.822TrpIle: 0.822 ± 0.033	0.677TrpLys: 0.677 ± 0.032	1.408TrpLeu: 1.408 ± 0.049	0.406TrpMet: 0.406 ± 0.024	0.606TrpAsn: 0.606 ± 0.031	0.575TrpPro: 0.575 ± 0.027	0.446TrpGln: 0.446 ± 0.024	0.748TrpArg: 0.748 ± 0.033	0.838TrpSer: 0.838 ± 0.035	0.653TrpThr: 0.653 ± 0.032	0.782TrpVal: 0.782 ± 0.041	0.187TrpTrp: 0.187 ± 0.016	0.295TrpTyr: 0.295 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.173TyrAla: 2.173 ± 0.057	0.319TyrCys: 0.319 ± 0.022	1.786TyrAsp: 1.786 ± 0.055	1.569TyrGlu: 1.569 ± 0.047	1.317TyrPhe: 1.317 ± 0.042	2.226TyrGly: 2.226 ± 0.056	0.588TyrHis: 0.588 ± 0.034	1.718TyrIle: 1.718 ± 0.058	1.459TyrLys: 1.459 ± 0.046	2.625TyrLeu: 2.625 ± 0.068	0.659TyrMet: 0.659 ± 0.032	1.248TyrAsn: 1.248 ± 0.047	1.112TyrPro: 1.112 ± 0.04	0.83TyrGln: 0.83 ± 0.035	1.244TyrArg: 1.244 ± 0.038	1.895TyrSer: 1.895 ± 0.055	1.312TyrThr: 1.312 ± 0.045	1.59TyrVal: 1.59 ± 0.047	0.423TyrTrp: 0.423 ± 0.026	0.745TyrTyr: 0.745 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2236 proteins (704440 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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