Amino acid dipepetide frequency for Streptococcus phage Javan618

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.604AlaAla: 3.604 ± 0.699
0.503AlaCys: 0.503 ± 0.185
4.275AlaAsp: 4.275 ± 0.555
4.275AlaGlu: 4.275 ± 0.706
2.179AlaPhe: 2.179 ± 0.358
5.113AlaGly: 5.113 ± 0.796
0.587AlaHis: 0.587 ± 0.183
5.029AlaIle: 5.029 ± 0.87
5.448AlaLys: 5.448 ± 0.581
6.203AlaLeu: 6.203 ± 0.87
2.096AlaMet: 2.096 ± 0.353
3.185AlaAsn: 3.185 ± 0.457
1.509AlaPro: 1.509 ± 0.359
2.347AlaGln: 2.347 ± 0.46
3.269AlaArg: 3.269 ± 0.444
4.443AlaSer: 4.443 ± 0.656
4.359AlaThr: 4.359 ± 0.743
4.694AlaVal: 4.694 ± 0.695
0.671AlaTrp: 0.671 ± 0.187
3.604AlaTyr: 3.604 ± 0.423
0.0AlaXaa: 0.0 ± 0.0
Cys
0.671CysAla: 0.671 ± 0.24
0.251CysCys: 0.251 ± 0.129
0.335CysAsp: 0.335 ± 0.153
0.503CysGlu: 0.503 ± 0.178
0.251CysPhe: 0.251 ± 0.149
0.671CysGly: 0.671 ± 0.267
0.084CysHis: 0.084 ± 0.086
0.503CysIle: 0.503 ± 0.214
0.419CysLys: 0.419 ± 0.183
0.754CysLeu: 0.754 ± 0.29
0.084CysMet: 0.084 ± 0.073
0.251CysAsn: 0.251 ± 0.175
0.503CysPro: 0.503 ± 0.178
1.006CysGln: 1.006 ± 0.305
0.671CysArg: 0.671 ± 0.168
0.587CysSer: 0.587 ± 0.265
0.168CysThr: 0.168 ± 0.114
0.503CysVal: 0.503 ± 0.215
0.0CysTrp: 0.0 ± 0.0
0.754CysTyr: 0.754 ± 0.266
0.0CysXaa: 0.0 ± 0.0
Asp
3.604AspAla: 3.604 ± 0.531
0.587AspCys: 0.587 ± 0.208
3.018AspAsp: 3.018 ± 0.773
5.784AspGlu: 5.784 ± 0.595
3.437AspPhe: 3.437 ± 0.432
4.862AspGly: 4.862 ± 0.772
0.922AspHis: 0.922 ± 0.372
4.359AspIle: 4.359 ± 0.671
4.191AspLys: 4.191 ± 0.565
6.203AspLeu: 6.203 ± 0.866
1.844AspMet: 1.844 ± 0.373
2.515AspAsn: 2.515 ± 0.44
1.593AspPro: 1.593 ± 0.501
1.928AspGln: 1.928 ± 0.46
2.347AspArg: 2.347 ± 0.613
3.94AspSer: 3.94 ± 0.616
2.598AspThr: 2.598 ± 0.43
3.269AspVal: 3.269 ± 0.555
0.922AspTrp: 0.922 ± 0.253
2.682AspTyr: 2.682 ± 0.485
0.0AspXaa: 0.0 ± 0.0
Glu
4.778GluAla: 4.778 ± 0.56
0.587GluCys: 0.587 ± 0.245
4.694GluAsp: 4.694 ± 0.726
5.868GluGlu: 5.868 ± 1.142
2.347GluPhe: 2.347 ± 0.436
4.61GluGly: 4.61 ± 0.551
1.676GluHis: 1.676 ± 0.365
4.359GluIle: 4.359 ± 0.623
6.538GluLys: 6.538 ± 0.798
8.131GluLeu: 8.131 ± 0.83
2.263GluMet: 2.263 ± 0.588
4.023GluAsn: 4.023 ± 0.694
1.593GluPro: 1.593 ± 0.466
3.185GluGln: 3.185 ± 0.551
2.515GluArg: 2.515 ± 0.407
3.437GluSer: 3.437 ± 0.442
4.191GluThr: 4.191 ± 0.587
4.275GluVal: 4.275 ± 0.575
0.922GluTrp: 0.922 ± 0.345
1.509GluTyr: 1.509 ± 0.328
0.0GluXaa: 0.0 ± 0.0
Phe
2.347PheAla: 2.347 ± 0.525
0.754PheCys: 0.754 ± 0.332
3.018PheAsp: 3.018 ± 0.531
3.101PheGlu: 3.101 ± 0.527
1.844PhePhe: 1.844 ± 0.401
2.85PheGly: 2.85 ± 0.511
1.09PheHis: 1.09 ± 0.315
2.431PheIle: 2.431 ± 0.516
3.269PheLys: 3.269 ± 0.63
3.353PheLeu: 3.353 ± 0.717
0.754PheMet: 0.754 ± 0.294
2.179PheAsn: 2.179 ± 0.318
0.587PhePro: 0.587 ± 0.238
1.341PheGln: 1.341 ± 0.328
1.257PheArg: 1.257 ± 0.295
2.85PheSer: 2.85 ± 0.518
1.76PheThr: 1.76 ± 0.341
1.76PheVal: 1.76 ± 0.369
0.587PheTrp: 0.587 ± 0.196
1.844PheTyr: 1.844 ± 0.389
0.0PheXaa: 0.0 ± 0.0
Gly
3.688GlyAla: 3.688 ± 0.518
0.503GlyCys: 0.503 ± 0.194
3.772GlyAsp: 3.772 ± 0.564
3.437GlyGlu: 3.437 ± 0.592
2.263GlyPhe: 2.263 ± 0.358
4.778GlyGly: 4.778 ± 0.88
1.928GlyHis: 1.928 ± 0.457
5.448GlyIle: 5.448 ± 0.674
4.946GlyLys: 4.946 ± 0.604
6.622GlyLeu: 6.622 ± 0.839
1.844GlyMet: 1.844 ± 0.372
3.688GlyAsn: 3.688 ± 0.604
1.006GlyPro: 1.006 ± 0.284
2.934GlyGln: 2.934 ± 0.698
4.107GlyArg: 4.107 ± 0.422
5.029GlySer: 5.029 ± 0.897
4.359GlyThr: 4.359 ± 0.701
4.694GlyVal: 4.694 ± 0.655
0.754GlyTrp: 0.754 ± 0.207
3.269GlyTyr: 3.269 ± 0.531
0.0GlyXaa: 0.0 ± 0.0
His
1.09HisAla: 1.09 ± 0.268
0.168HisCys: 0.168 ± 0.096
1.425HisAsp: 1.425 ± 0.302
0.838HisGlu: 0.838 ± 0.313
1.257HisPhe: 1.257 ± 0.282
1.341HisGly: 1.341 ± 0.279
0.754HisHis: 0.754 ± 0.259
1.509HisIle: 1.509 ± 0.325
1.174HisLys: 1.174 ± 0.293
2.263HisLeu: 2.263 ± 0.306
0.419HisMet: 0.419 ± 0.192
1.425HisAsn: 1.425 ± 0.299
1.257HisPro: 1.257 ± 0.401
0.503HisGln: 0.503 ± 0.221
1.174HisArg: 1.174 ± 0.379
1.09HisSer: 1.09 ± 0.316
1.006HisThr: 1.006 ± 0.383
0.922HisVal: 0.922 ± 0.301
0.168HisTrp: 0.168 ± 0.14
0.587HisTyr: 0.587 ± 0.29
0.0HisXaa: 0.0 ± 0.0
Ile
4.443IleAla: 4.443 ± 0.461
0.587IleCys: 0.587 ± 0.199
5.7IleAsp: 5.7 ± 0.548
3.437IleGlu: 3.437 ± 0.567
1.593IlePhe: 1.593 ± 0.425
4.191IleGly: 4.191 ± 0.624
1.006IleHis: 1.006 ± 0.31
3.269IleIle: 3.269 ± 0.545
4.694IleLys: 4.694 ± 0.724
5.365IleLeu: 5.365 ± 0.638
0.671IleMet: 0.671 ± 0.232
2.934IleAsn: 2.934 ± 0.472
2.431IlePro: 2.431 ± 0.407
2.934IleGln: 2.934 ± 0.411
2.347IleArg: 2.347 ± 0.4
5.616IleSer: 5.616 ± 1.247
4.191IleThr: 4.191 ± 0.721
3.604IleVal: 3.604 ± 0.678
1.174IleTrp: 1.174 ± 0.418
2.766IleTyr: 2.766 ± 0.576
0.0IleXaa: 0.0 ± 0.0
Lys
6.957LysAla: 6.957 ± 0.71
0.503LysCys: 0.503 ± 0.191
3.94LysAsp: 3.94 ± 0.593
5.029LysGlu: 5.029 ± 0.647
2.85LysPhe: 2.85 ± 0.559
4.359LysGly: 4.359 ± 0.621
2.096LysHis: 2.096 ± 0.463
4.61LysIle: 4.61 ± 0.731
5.029LysLys: 5.029 ± 0.708
5.7LysLeu: 5.7 ± 0.707
1.76LysMet: 1.76 ± 0.452
3.018LysAsn: 3.018 ± 0.464
2.012LysPro: 2.012 ± 0.405
3.772LysGln: 3.772 ± 0.707
3.94LysArg: 3.94 ± 0.601
4.359LysSer: 4.359 ± 0.561
4.694LysThr: 4.694 ± 0.74
4.61LysVal: 4.61 ± 0.605
1.09LysTrp: 1.09 ± 0.305
2.096LysTyr: 2.096 ± 0.517
0.0LysXaa: 0.0 ± 0.0
Leu
6.203LeuAla: 6.203 ± 0.905
0.503LeuCys: 0.503 ± 0.178
5.616LeuAsp: 5.616 ± 0.571
8.047LeuGlu: 8.047 ± 0.897
2.515LeuPhe: 2.515 ± 0.489
5.365LeuGly: 5.365 ± 0.683
1.257LeuHis: 1.257 ± 0.358
4.191LeuIle: 4.191 ± 0.449
6.873LeuLys: 6.873 ± 0.618
8.047LeuLeu: 8.047 ± 0.762
2.263LeuMet: 2.263 ± 0.301
4.946LeuAsn: 4.946 ± 0.647
3.185LeuPro: 3.185 ± 0.697
3.688LeuGln: 3.688 ± 0.607
3.521LeuArg: 3.521 ± 0.613
7.376LeuSer: 7.376 ± 0.644
6.37LeuThr: 6.37 ± 0.992
6.37LeuVal: 6.37 ± 0.648
0.754LeuTrp: 0.754 ± 0.167
4.694LeuTyr: 4.694 ± 0.809
0.0LeuXaa: 0.0 ± 0.0
Met
2.179MetAla: 2.179 ± 0.483
0.168MetCys: 0.168 ± 0.094
1.257MetAsp: 1.257 ± 0.309
1.425MetGlu: 1.425 ± 0.421
0.838MetPhe: 0.838 ± 0.272
2.347MetGly: 2.347 ± 0.485
0.168MetHis: 0.168 ± 0.121
1.593MetIle: 1.593 ± 0.376
1.76MetLys: 1.76 ± 0.406
1.257MetLeu: 1.257 ± 0.359
0.922MetMet: 0.922 ± 0.288
0.922MetAsn: 0.922 ± 0.301
0.503MetPro: 0.503 ± 0.188
0.838MetGln: 0.838 ± 0.328
1.006MetArg: 1.006 ± 0.274
1.928MetSer: 1.928 ± 0.372
2.096MetThr: 2.096 ± 0.422
1.425MetVal: 1.425 ± 0.365
0.084MetTrp: 0.084 ± 0.088
0.587MetTyr: 0.587 ± 0.235
0.0MetXaa: 0.0 ± 0.0
Asn
3.521AsnAla: 3.521 ± 0.615
0.251AsnCys: 0.251 ± 0.118
2.515AsnAsp: 2.515 ± 0.482
3.269AsnGlu: 3.269 ± 0.432
2.096AsnPhe: 2.096 ± 0.493
5.784AsnGly: 5.784 ± 0.648
1.257AsnHis: 1.257 ± 0.293
1.76AsnIle: 1.76 ± 0.392
2.598AsnLys: 2.598 ± 0.423
3.437AsnLeu: 3.437 ± 0.502
1.174AsnMet: 1.174 ± 0.297
1.844AsnAsn: 1.844 ± 0.571
2.179AsnPro: 2.179 ± 0.383
2.179AsnGln: 2.179 ± 0.412
2.598AsnArg: 2.598 ± 0.506
2.934AsnSer: 2.934 ± 0.507
2.682AsnThr: 2.682 ± 0.655
3.018AsnVal: 3.018 ± 0.551
1.257AsnTrp: 1.257 ± 0.331
0.838AsnTyr: 0.838 ± 0.28
0.0AsnXaa: 0.0 ± 0.0
Pro
1.09ProAla: 1.09 ± 0.342
0.251ProCys: 0.251 ± 0.13
2.012ProAsp: 2.012 ± 0.541
1.76ProGlu: 1.76 ± 0.461
0.838ProPhe: 0.838 ± 0.298
1.425ProGly: 1.425 ± 0.321
0.922ProHis: 0.922 ± 0.27
2.263ProIle: 2.263 ± 0.419
2.179ProLys: 2.179 ± 0.544
2.682ProLeu: 2.682 ± 0.402
0.419ProMet: 0.419 ± 0.15
1.593ProAsn: 1.593 ± 0.324
0.838ProPro: 0.838 ± 0.304
0.922ProGln: 0.922 ± 0.256
1.76ProArg: 1.76 ± 0.378
2.682ProSer: 2.682 ± 0.532
2.263ProThr: 2.263 ± 0.527
2.012ProVal: 2.012 ± 0.41
0.419ProTrp: 0.419 ± 0.187
1.174ProTyr: 1.174 ± 0.345
0.0ProXaa: 0.0 ± 0.0
Gln
3.94GlnAla: 3.94 ± 0.654
0.503GlnCys: 0.503 ± 0.217
2.012GlnAsp: 2.012 ± 0.365
3.101GlnGlu: 3.101 ± 0.542
1.676GlnPhe: 1.676 ± 0.388
1.928GlnGly: 1.928 ± 0.458
0.671GlnHis: 0.671 ± 0.223
2.431GlnIle: 2.431 ± 0.435
2.682GlnLys: 2.682 ± 0.482
4.275GlnLeu: 4.275 ± 0.552
1.09GlnMet: 1.09 ± 0.36
2.347GlnAsn: 2.347 ± 0.503
1.09GlnPro: 1.09 ± 0.377
1.76GlnGln: 1.76 ± 0.329
1.257GlnArg: 1.257 ± 0.297
3.018GlnSer: 3.018 ± 0.473
2.096GlnThr: 2.096 ± 0.377
3.521GlnVal: 3.521 ± 0.548
0.754GlnTrp: 0.754 ± 0.31
1.174GlnTyr: 1.174 ± 0.296
0.0GlnXaa: 0.0 ± 0.0
Arg
2.431ArgAla: 2.431 ± 0.531
0.587ArgCys: 0.587 ± 0.26
2.347ArgAsp: 2.347 ± 0.382
3.269ArgGlu: 3.269 ± 0.409
1.928ArgPhe: 1.928 ± 0.393
2.263ArgGly: 2.263 ± 0.402
0.838ArgHis: 0.838 ± 0.305
2.598ArgIle: 2.598 ± 0.357
3.604ArgLys: 3.604 ± 0.701
4.275ArgLeu: 4.275 ± 0.684
0.587ArgMet: 0.587 ± 0.182
1.928ArgAsn: 1.928 ± 0.345
1.509ArgPro: 1.509 ± 0.371
2.934ArgGln: 2.934 ± 0.513
1.928ArgArg: 1.928 ± 0.474
2.85ArgSer: 2.85 ± 0.356
2.347ArgThr: 2.347 ± 0.506
3.604ArgVal: 3.604 ± 0.578
0.754ArgTrp: 0.754 ± 0.212
1.341ArgTyr: 1.341 ± 0.369
0.0ArgXaa: 0.0 ± 0.0
Ser
5.197SerAla: 5.197 ± 0.834
0.335SerCys: 0.335 ± 0.187
4.191SerAsp: 4.191 ± 0.728
5.448SerGlu: 5.448 ± 0.987
2.682SerPhe: 2.682 ± 0.582
5.281SerGly: 5.281 ± 0.832
1.928SerHis: 1.928 ± 0.402
4.191SerIle: 4.191 ± 0.597
4.778SerLys: 4.778 ± 0.524
5.784SerLeu: 5.784 ± 0.642
1.425SerMet: 1.425 ± 0.351
3.018SerAsn: 3.018 ± 0.673
2.096SerPro: 2.096 ± 0.368
2.179SerGln: 2.179 ± 0.342
3.101SerArg: 3.101 ± 0.54
5.532SerSer: 5.532 ± 1.157
4.946SerThr: 4.946 ± 0.979
4.443SerVal: 4.443 ± 0.688
1.257SerTrp: 1.257 ± 0.209
2.598SerTyr: 2.598 ± 0.397
0.0SerXaa: 0.0 ± 0.0
Thr
4.526ThrAla: 4.526 ± 0.655
0.335ThrCys: 0.335 ± 0.194
2.682ThrAsp: 2.682 ± 0.526
3.94ThrGlu: 3.94 ± 0.637
3.353ThrPhe: 3.353 ± 0.729
4.61ThrGly: 4.61 ± 0.644
1.09ThrHis: 1.09 ± 0.295
4.946ThrIle: 4.946 ± 1.309
4.023ThrLys: 4.023 ± 0.552
6.119ThrLeu: 6.119 ± 0.758
1.09ThrMet: 1.09 ± 0.265
2.431ThrAsn: 2.431 ± 0.444
2.263ThrPro: 2.263 ± 0.623
1.676ThrGln: 1.676 ± 0.416
2.096ThrArg: 2.096 ± 0.323
4.694ThrSer: 4.694 ± 0.807
4.778ThrThr: 4.778 ± 0.676
5.616ThrVal: 5.616 ± 0.865
1.257ThrTrp: 1.257 ± 0.409
2.096ThrTyr: 2.096 ± 0.452
0.0ThrXaa: 0.0 ± 0.0
Val
3.772ValAla: 3.772 ± 0.693
0.587ValCys: 0.587 ± 0.22
4.023ValAsp: 4.023 ± 0.605
4.946ValGlu: 4.946 ± 0.693
2.598ValPhe: 2.598 ± 0.433
4.107ValGly: 4.107 ± 0.592
1.006ValHis: 1.006 ± 0.219
5.029ValIle: 5.029 ± 0.8
4.862ValLys: 4.862 ± 0.81
6.454ValLeu: 6.454 ± 0.698
1.341ValMet: 1.341 ± 0.372
2.515ValAsn: 2.515 ± 0.462
2.012ValPro: 2.012 ± 0.39
2.179ValGln: 2.179 ± 0.367
2.515ValArg: 2.515 ± 0.491
4.526ValSer: 4.526 ± 0.868
5.365ValThr: 5.365 ± 0.937
3.353ValVal: 3.353 ± 0.567
1.09ValTrp: 1.09 ± 0.287
2.431ValTyr: 2.431 ± 0.505
0.0ValXaa: 0.0 ± 0.0
Trp
0.754TrpAla: 0.754 ± 0.234
0.251TrpCys: 0.251 ± 0.133
0.503TrpAsp: 0.503 ± 0.248
1.09TrpGlu: 1.09 ± 0.378
0.838TrpPhe: 0.838 ± 0.286
0.587TrpGly: 0.587 ± 0.195
0.251TrpHis: 0.251 ± 0.131
0.671TrpIle: 0.671 ± 0.265
0.671TrpLys: 0.671 ± 0.335
1.257TrpLeu: 1.257 ± 0.218
0.671TrpMet: 0.671 ± 0.166
1.09TrpAsn: 1.09 ± 0.26
0.168TrpPro: 0.168 ± 0.119
1.257TrpGln: 1.257 ± 0.262
0.838TrpArg: 0.838 ± 0.289
1.09TrpSer: 1.09 ± 0.364
1.174TrpThr: 1.174 ± 0.4
0.754TrpVal: 0.754 ± 0.262
0.251TrpTrp: 0.251 ± 0.13
0.168TrpTyr: 0.168 ± 0.112
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.598TyrAla: 2.598 ± 0.484
0.754TyrCys: 0.754 ± 0.262
3.353TyrAsp: 3.353 ± 0.729
2.934TyrGlu: 2.934 ± 0.433
1.593TyrPhe: 1.593 ± 0.349
2.598TyrGly: 2.598 ± 0.498
0.838TyrHis: 0.838 ± 0.273
1.76TyrIle: 1.76 ± 0.422
2.682TyrLys: 2.682 ± 0.58
3.604TyrLeu: 3.604 ± 0.699
0.503TyrMet: 0.503 ± 0.2
1.341TyrAsn: 1.341 ± 0.331
1.174TyrPro: 1.174 ± 0.268
1.76TyrGln: 1.76 ± 0.374
1.676TyrArg: 1.676 ± 0.287
2.431TyrSer: 2.431 ± 0.471
2.179TyrThr: 2.179 ± 0.448
2.263TyrVal: 2.263 ± 0.346
0.168TyrTrp: 0.168 ± 0.126
1.425TyrTyr: 1.425 ± 0.36
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 38 proteins (11931 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski