Amino acid dipepetide frequency for Leptospirillum ferrooxidans (strain C2-3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.029AlaAla: 5.029 ± 0.103	0.646AlaCys: 0.646 ± 0.035	3.069AlaAsp: 3.069 ± 0.06	3.785AlaGlu: 3.785 ± 0.068	3.317AlaPhe: 3.317 ± 0.071	6.07AlaGly: 6.07 ± 0.099	1.57AlaHis: 1.57 ± 0.042	5.385AlaIle: 5.385 ± 0.082	3.27AlaLys: 3.27 ± 0.075	8.735AlaLeu: 8.735 ± 0.112	2.214AlaMet: 2.214 ± 0.049	2.118AlaAsn: 2.118 ± 0.068	3.229AlaPro: 3.229 ± 0.075	2.366AlaGln: 2.366 ± 0.063	4.648AlaArg: 4.648 ± 0.083	5.086AlaSer: 5.086 ± 0.092	3.442AlaThr: 3.442 ± 0.066	4.694AlaVal: 4.694 ± 0.089	0.738AlaTrp: 0.738 ± 0.03	1.807AlaTyr: 1.807 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.532CysAla: 0.532 ± 0.028	0.086CysCys: 0.086 ± 0.013	0.388CysAsp: 0.388 ± 0.023	0.435CysGlu: 0.435 ± 0.023	0.368CysPhe: 0.368 ± 0.022	0.782CysGly: 0.782 ± 0.039	0.37CysHis: 0.37 ± 0.025	0.335CysIle: 0.335 ± 0.024	0.224CysLys: 0.224 ± 0.017	0.967CysLeu: 0.967 ± 0.035	0.136CysMet: 0.136 ± 0.013	0.217CysAsn: 0.217 ± 0.018	0.544CysPro: 0.544 ± 0.034	0.392CysGln: 0.392 ± 0.022	0.518CysArg: 0.518 ± 0.028	0.549CysSer: 0.549 ± 0.032	0.316CysThr: 0.316 ± 0.023	0.473CysVal: 0.473 ± 0.026	0.074CysTrp: 0.074 ± 0.011	0.202CysTyr: 0.202 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.163AspAla: 3.163 ± 0.069	0.416AspCys: 0.416 ± 0.025	2.033AspAsp: 2.033 ± 0.056	2.868AspGlu: 2.868 ± 0.062	2.373AspPhe: 2.373 ± 0.054	3.936AspGly: 3.936 ± 0.076	1.527AspHis: 1.527 ± 0.041	3.028AspIle: 3.028 ± 0.059	1.772AspLys: 1.772 ± 0.052	6.546AspLeu: 6.546 ± 0.111	1.096AspMet: 1.096 ± 0.035	1.26AspAsn: 1.26 ± 0.043	3.873AspPro: 3.873 ± 0.076	1.924AspGln: 1.924 ± 0.051	4.041AspArg: 4.041 ± 0.086	3.205AspSer: 3.205 ± 0.059	2.066AspThr: 2.066 ± 0.053	3.041AspVal: 3.041 ± 0.065	0.753AspTrp: 0.753 ± 0.028	1.318AspTyr: 1.318 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.137GluAla: 5.137 ± 0.088	0.442GluCys: 0.442 ± 0.027	3.004GluAsp: 3.004 ± 0.068	4.856GluGlu: 4.856 ± 0.09	2.133GluPhe: 2.133 ± 0.063	5.02GluGly: 5.02 ± 0.079	1.299GluHis: 1.299 ± 0.041	5.06GluIle: 5.06 ± 0.096	4.953GluLys: 4.953 ± 0.097	5.266GluLeu: 5.266 ± 0.086	1.979GluMet: 1.979 ± 0.05	2.495GluAsn: 2.495 ± 0.061	2.094GluPro: 2.094 ± 0.052	1.784GluGln: 1.784 ± 0.049	4.226GluArg: 4.226 ± 0.08	4.623GluSer: 4.623 ± 0.092	3.696GluThr: 3.696 ± 0.075	3.92GluVal: 3.92 ± 0.077	0.801GluTrp: 0.801 ± 0.031	1.328GluTyr: 1.328 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.606PheAla: 2.606 ± 0.072	0.463PheCys: 0.463 ± 0.025	2.289PheAsp: 2.289 ± 0.058	2.316PheGlu: 2.316 ± 0.062	2.596PhePhe: 2.596 ± 0.061	3.383PheGly: 3.383 ± 0.081	1.255PheHis: 1.255 ± 0.039	2.216PheIle: 2.216 ± 0.067	1.464PheLys: 1.464 ± 0.047	6.088PheLeu: 6.088 ± 0.124	1.083PheMet: 1.083 ± 0.038	1.17PheAsn: 1.17 ± 0.044	2.579PhePro: 2.579 ± 0.064	1.538PheGln: 1.538 ± 0.046	2.695PheArg: 2.695 ± 0.06	4.356PheSer: 4.356 ± 0.092	1.755PheThr: 1.755 ± 0.048	2.723PheVal: 2.723 ± 0.059	0.719PheTrp: 0.719 ± 0.031	1.29PheTyr: 1.29 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.766GlyAla: 5.766 ± 0.095	0.816GlyCys: 0.816 ± 0.037	3.87GlyAsp: 3.87 ± 0.071	5.2GlyGlu: 5.2 ± 0.097	3.749GlyPhe: 3.749 ± 0.077	6.418GlyGly: 6.418 ± 0.125	1.927GlyHis: 1.927 ± 0.044	6.025GlyIle: 6.025 ± 0.105	4.797GlyLys: 4.797 ± 0.085	7.671GlyLeu: 7.671 ± 0.115	2.436GlyMet: 2.436 ± 0.063	2.669GlyAsn: 2.669 ± 0.06	2.851GlyPro: 2.851 ± 0.071	2.658GlyGln: 2.658 ± 0.06	4.599GlyArg: 4.599 ± 0.082	5.557GlySer: 5.557 ± 0.082	4.343GlyThr: 4.343 ± 0.082	5.949GlyVal: 5.949 ± 0.11	1.08GlyTrp: 1.08 ± 0.036	2.361GlyTyr: 2.361 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.446HisAla: 1.446 ± 0.049	0.195HisCys: 0.195 ± 0.014	0.988HisAsp: 0.988 ± 0.035	1.316HisGlu: 1.316 ± 0.048	1.26HisPhe: 1.26 ± 0.045	1.623HisGly: 1.623 ± 0.052	0.793HisHis: 0.793 ± 0.035	1.236HisIle: 1.236 ± 0.037	0.799HisLys: 0.799 ± 0.03	2.87HisLeu: 2.87 ± 0.065	0.535HisMet: 0.535 ± 0.025	0.556HisAsn: 0.556 ± 0.028	1.911HisPro: 1.911 ± 0.055	0.936HisGln: 0.936 ± 0.031	1.569HisArg: 1.569 ± 0.045	1.559HisSer: 1.559 ± 0.048	0.858HisThr: 0.858 ± 0.033	1.515HisVal: 1.515 ± 0.045	0.302HisTrp: 0.302 ± 0.02	0.688HisTyr: 0.688 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	4.914IleAla: 4.914 ± 0.087	0.513IleCys: 0.513 ± 0.027	3.601IleAsp: 3.601 ± 0.072	3.866IleGlu: 3.866 ± 0.085	2.725IlePhe: 2.725 ± 0.057	4.883IleGly: 4.883 ± 0.081	1.806IleHis: 1.806 ± 0.046	3.116IleIle: 3.116 ± 0.077	2.273IleLys: 2.273 ± 0.063	8.501IleLeu: 8.501 ± 0.108	1.264IleMet: 1.264 ± 0.04	1.856IleAsn: 1.856 ± 0.051	4.107IlePro: 4.107 ± 0.077	2.085IleGln: 2.085 ± 0.048	4.982IleArg: 4.982 ± 0.088	5.215IleSer: 5.215 ± 0.087	3.012IleThr: 3.012 ± 0.066	4.184IleVal: 4.184 ± 0.073	0.628IleTrp: 0.628 ± 0.028	1.344IleTyr: 1.344 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.827LysAla: 3.827 ± 0.069	0.215LysCys: 0.215 ± 0.017	2.902LysAsp: 2.902 ± 0.061	4.1LysGlu: 4.1 ± 0.091	1.097LysPhe: 1.097 ± 0.046	4.073LysGly: 4.073 ± 0.069	0.839LysHis: 0.839 ± 0.033	3.653LysIle: 3.653 ± 0.077	4.262LysLys: 4.262 ± 0.097	3.476LysLeu: 3.476 ± 0.068	1.518LysMet: 1.518 ± 0.05	2.424LysAsn: 2.424 ± 0.065	1.993LysPro: 1.993 ± 0.056	1.137LysGln: 1.137 ± 0.041	2.837LysArg: 2.837 ± 0.066	3.577LysSer: 3.577 ± 0.083	3.337LysThr: 3.337 ± 0.074	3.307LysVal: 3.307 ± 0.065	0.564LysTrp: 0.564 ± 0.027	0.893LysTyr: 0.893 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	8.337LeuAla: 8.337 ± 0.115	0.801LeuCys: 0.801 ± 0.031	5.63LeuAsp: 5.63 ± 0.096	6.837LeuGlu: 6.837 ± 0.104	5.421LeuPhe: 5.421 ± 0.102	8.09LeuGly: 8.09 ± 0.11	2.2LeuHis: 2.2 ± 0.061	5.806LeuIle: 5.806 ± 0.097	5.716LeuLys: 5.716 ± 0.085	12.359LeuLeu: 12.359 ± 0.165	2.509LeuMet: 2.509 ± 0.062	2.949LeuAsn: 2.949 ± 0.07	6.235LeuPro: 6.235 ± 0.087	2.557LeuGln: 2.557 ± 0.054	5.498LeuArg: 5.498 ± 0.107	11.469LeuSer: 11.469 ± 0.135	5.311LeuThr: 5.311 ± 0.09	7.098LeuVal: 7.098 ± 0.099	1.355LeuTrp: 1.355 ± 0.046	2.596LeuTyr: 2.596 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.809MetAla: 2.809 ± 0.066	0.123MetCys: 0.123 ± 0.013	1.625MetAsp: 1.625 ± 0.045	2.017MetGlu: 2.017 ± 0.047	0.768MetPhe: 0.768 ± 0.031	2.631MetGly: 2.631 ± 0.061	0.341MetHis: 0.341 ± 0.023	2.043MetIle: 2.043 ± 0.051	1.67MetLys: 1.67 ± 0.047	1.9MetLeu: 1.9 ± 0.049	0.789MetMet: 0.789 ± 0.033	1.088MetAsn: 1.088 ± 0.041	1.029MetPro: 1.029 ± 0.039	0.51MetGln: 0.51 ± 0.03	1.219MetArg: 1.219 ± 0.039	1.893MetSer: 1.893 ± 0.052	1.773MetThr: 1.773 ± 0.05	1.975MetVal: 1.975 ± 0.05	0.174MetTrp: 0.174 ± 0.015	0.311MetTyr: 0.311 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.404AsnAla: 2.404 ± 0.057	0.232AsnCys: 0.232 ± 0.015	1.475AsnAsp: 1.475 ± 0.048	1.611AsnGlu: 1.611 ± 0.044	1.064AsnPhe: 1.064 ± 0.04	2.668AsnGly: 2.668 ± 0.066	0.886AsnHis: 0.886 ± 0.037	2.074AsnIle: 2.074 ± 0.055	1.143AsnLys: 1.143 ± 0.042	3.55AsnLeu: 3.55 ± 0.07	0.804AsnMet: 0.804 ± 0.028	1.026AsnAsn: 1.026 ± 0.047	2.655AsnPro: 2.655 ± 0.069	1.22AsnGln: 1.22 ± 0.052	2.238AsnArg: 2.238 ± 0.058	1.908AsnSer: 1.908 ± 0.063	1.567AsnThr: 1.567 ± 0.052	1.872AsnVal: 1.872 ± 0.054	0.385AsnTrp: 0.385 ± 0.025	0.784AsnTyr: 0.784 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.331ProAla: 3.331 ± 0.068	0.349ProCys: 0.349 ± 0.026	3.613ProAsp: 3.613 ± 0.073	4.495ProGlu: 4.495 ± 0.087	2.664ProPhe: 2.664 ± 0.062	4.576ProGly: 4.576 ± 0.099	1.057ProHis: 1.057 ± 0.037	3.008ProIle: 3.008 ± 0.06	2.309ProLys: 2.309 ± 0.057	5.218ProLeu: 5.218 ± 0.096	1.406ProMet: 1.406 ± 0.04	1.477ProAsn: 1.477 ± 0.049	2.809ProPro: 2.809 ± 0.074	1.62ProGln: 1.62 ± 0.045	2.13ProArg: 2.13 ± 0.052	4.247ProSer: 4.247 ± 0.081	2.19ProThr: 2.19 ± 0.061	4.603ProVal: 4.603 ± 0.087	0.661ProTrp: 0.661 ± 0.026	1.308ProTyr: 1.308 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.581GlnAla: 2.581 ± 0.075	0.199GlnCys: 0.199 ± 0.017	1.573GlnAsp: 1.573 ± 0.047	2.331GlnGlu: 2.331 ± 0.05	1.102GlnPhe: 1.102 ± 0.038	2.42GlnGly: 2.42 ± 0.053	0.477GlnHis: 0.477 ± 0.028	2.215GlnIle: 2.215 ± 0.059	2.552GlnLys: 2.552 ± 0.066	2.203GlnLeu: 2.203 ± 0.057	1.023GlnMet: 1.023 ± 0.036	1.334GlnAsn: 1.334 ± 0.047	1.052GlnPro: 1.052 ± 0.039	0.785GlnGln: 0.785 ± 0.035	1.554GlnArg: 1.554 ± 0.049	2.476GlnSer: 2.476 ± 0.056	1.977GlnThr: 1.977 ± 0.053	2.056GlnVal: 2.056 ± 0.052	0.403GlnTrp: 0.403 ± 0.023	0.735GlnTyr: 0.735 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.687ArgAla: 3.687 ± 0.077	0.384ArgCys: 0.384 ± 0.03	2.957ArgAsp: 2.957 ± 0.07	4.922ArgGlu: 4.922 ± 0.106	2.941ArgPhe: 2.941 ± 0.065	3.71ArgGly: 3.71 ± 0.076	1.343ArgHis: 1.343 ± 0.044	4.877ArgIle: 4.877 ± 0.097	3.795ArgLys: 3.795 ± 0.076	6.377ArgLeu: 6.377 ± 0.089	2.013ArgMet: 2.013 ± 0.057	2.047ArgAsn: 2.047 ± 0.065	2.537ArgPro: 2.537 ± 0.058	2.103ArgGln: 2.103 ± 0.054	3.313ArgArg: 3.313 ± 0.07	4.355ArgSer: 4.355 ± 0.092	2.98ArgThr: 2.98 ± 0.063	4.025ArgVal: 4.025 ± 0.072	0.846ArgTrp: 0.846 ± 0.035	1.756ArgTyr: 1.756 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.827SerAla: 4.827 ± 0.088	0.72SerCys: 0.72 ± 0.032	3.824SerAsp: 3.824 ± 0.071	4.697SerGlu: 4.697 ± 0.094	3.875SerPhe: 3.875 ± 0.096	7.855SerGly: 7.855 ± 0.095	1.701SerHis: 1.701 ± 0.041	4.67SerIle: 4.67 ± 0.082	2.878SerLys: 2.878 ± 0.067	9.13SerLeu: 9.13 ± 0.135	2.001SerMet: 2.001 ± 0.05	2.098SerAsn: 2.098 ± 0.063	4.716SerPro: 4.716 ± 0.083	2.619SerGln: 2.619 ± 0.063	5.203SerArg: 5.203 ± 0.099	5.74SerSer: 5.74 ± 0.104	3.049SerThr: 3.049 ± 0.065	5.104SerVal: 5.104 ± 0.082	1.001SerTrp: 1.001 ± 0.038	1.893SerTyr: 1.893 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.362ThrAla: 3.362 ± 0.08	0.391ThrCys: 0.391 ± 0.024	2.328ThrAsp: 2.328 ± 0.054	2.505ThrGlu: 2.505 ± 0.062	2.181ThrPhe: 2.181 ± 0.058	4.753ThrGly: 4.753 ± 0.083	1.162ThrHis: 1.162 ± 0.042	3.539ThrIle: 3.539 ± 0.067	1.954ThrLys: 1.954 ± 0.059	5.988ThrLeu: 5.988 ± 0.093	1.19ThrMet: 1.19 ± 0.036	1.476ThrAsn: 1.476 ± 0.052	3.373ThrPro: 3.373 ± 0.072	1.464ThrGln: 1.464 ± 0.044	2.674ThrArg: 2.674 ± 0.059	3.276ThrSer: 3.276 ± 0.067	2.56ThrThr: 2.56 ± 0.07	3.704ThrVal: 3.704 ± 0.069	0.514ThrTrp: 0.514 ± 0.028	1.114ThrTyr: 1.114 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.864ValAla: 4.864 ± 0.096	0.614ValCys: 0.614 ± 0.029	3.344ValAsp: 3.344 ± 0.071	3.718ValGlu: 3.718 ± 0.069	3.155ValPhe: 3.155 ± 0.065	5.0ValGly: 5.0 ± 0.092	1.516ValHis: 1.516 ± 0.045	4.359ValIle: 4.359 ± 0.085	2.67ValLys: 2.67 ± 0.06	7.876ValLeu: 7.876 ± 0.11	1.835ValMet: 1.835 ± 0.044	2.055ValAsn: 2.055 ± 0.059	3.415ValPro: 3.415 ± 0.072	1.812ValGln: 1.812 ± 0.045	4.467ValArg: 4.467 ± 0.089	5.887ValSer: 5.887 ± 0.098	3.663ValThr: 3.663 ± 0.068	5.104ValVal: 5.104 ± 0.108	0.718ValTrp: 0.718 ± 0.03	1.558ValTyr: 1.558 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.92TrpAla: 0.92 ± 0.035	0.101TrpCys: 0.101 ± 0.012	0.549TrpAsp: 0.549 ± 0.026	0.869TrpGlu: 0.869 ± 0.038	0.555TrpPhe: 0.555 ± 0.027	0.971TrpGly: 0.971 ± 0.04	0.257TrpHis: 0.257 ± 0.018	1.01TrpIle: 1.01 ± 0.042	0.7TrpLys: 0.7 ± 0.035	1.157TrpLeu: 1.157 ± 0.035	0.357TrpMet: 0.357 ± 0.023	0.533TrpAsn: 0.533 ± 0.028	0.517TrpPro: 0.517 ± 0.028	0.342TrpGln: 0.342 ± 0.024	0.552TrpArg: 0.552 ± 0.025	0.865TrpSer: 0.865 ± 0.036	0.595TrpThr: 0.595 ± 0.031	0.908TrpVal: 0.908 ± 0.037	0.135TrpTrp: 0.135 ± 0.013	0.296TrpTyr: 0.296 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.676TyrAla: 1.676 ± 0.053	0.202TyrCys: 0.202 ± 0.017	1.177TyrAsp: 1.177 ± 0.041	1.375TyrGlu: 1.375 ± 0.036	1.239TyrPhe: 1.239 ± 0.047	1.88TyrGly: 1.88 ± 0.053	0.628TyrHis: 0.628 ± 0.032	1.217TyrIle: 1.217 ± 0.044	0.832TyrLys: 0.832 ± 0.035	2.896TyrLeu: 2.896 ± 0.074	0.498TyrMet: 0.498 ± 0.026	0.715TyrAsn: 0.715 ± 0.035	1.554TyrPro: 1.554 ± 0.048	1.196TyrGln: 1.196 ± 0.043	2.004TyrArg: 2.004 ± 0.061	1.756TyrSer: 1.756 ± 0.053	1.021TyrThr: 1.021 ± 0.042	1.376TyrVal: 1.376 ± 0.042	0.339TyrTrp: 0.339 ± 0.02	0.712TyrTyr: 0.712 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2413 proteins (742622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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