Amino acid dipepetide frequency for Klebsiella pneumoniae subsp. ozaenae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.964AlaAla: 11.964 ± 0.141	1.252AlaCys: 1.252 ± 0.034	5.421AlaAsp: 5.421 ± 0.068	5.97AlaGlu: 5.97 ± 0.078	3.682AlaPhe: 3.682 ± 0.048	8.789AlaGly: 8.789 ± 0.088	2.016AlaHis: 2.016 ± 0.036	5.925AlaIle: 5.925 ± 0.071	3.609AlaLys: 3.609 ± 0.054	12.563AlaLeu: 12.563 ± 0.103	3.208AlaMet: 3.208 ± 0.046	2.888AlaAsn: 2.888 ± 0.045	4.127AlaPro: 4.127 ± 0.068	4.635AlaGln: 4.635 ± 0.065	6.421AlaArg: 6.421 ± 0.074	5.773AlaSer: 5.773 ± 0.074	4.859AlaThr: 4.859 ± 0.065	7.357AlaVal: 7.357 ± 0.077	1.844AlaTrp: 1.844 ± 0.042	1.926AlaTyr: 1.926 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.164CysAla: 1.164 ± 0.029	0.222CysCys: 0.222 ± 0.012	0.573CysAsp: 0.573 ± 0.02	0.571CysGlu: 0.571 ± 0.02	0.463CysPhe: 0.463 ± 0.019	1.116CysGly: 1.116 ± 0.028	0.326CysHis: 0.326 ± 0.016	0.54CysIle: 0.54 ± 0.02	0.318CysLys: 0.318 ± 0.016	1.082CysLeu: 1.082 ± 0.025	0.313CysMet: 0.313 ± 0.015	0.302CysAsn: 0.302 ± 0.015	0.584CysPro: 0.584 ± 0.027	0.459CysGln: 0.459 ± 0.017	0.952CysArg: 0.952 ± 0.031	0.743CysSer: 0.743 ± 0.027	0.477CysThr: 0.477 ± 0.019	0.772CysVal: 0.772 ± 0.025	0.254CysTrp: 0.254 ± 0.012	0.334CysTyr: 0.334 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.318AspAla: 5.318 ± 0.064	0.514AspCys: 0.514 ± 0.017	2.933AspAsp: 2.933 ± 0.049	3.363AspGlu: 3.363 ± 0.054	1.996AspPhe: 1.996 ± 0.035	3.836AspGly: 3.836 ± 0.055	1.028AspHis: 1.028 ± 0.029	3.16AspIle: 3.16 ± 0.055	2.315AspLys: 2.315 ± 0.04	4.67AspLeu: 4.67 ± 0.058	1.282AspMet: 1.282 ± 0.028	2.058AspAsn: 2.058 ± 0.041	2.416AspPro: 2.416 ± 0.039	1.577AspGln: 1.577 ± 0.035	2.98AspArg: 2.98 ± 0.048	2.735AspSer: 2.735 ± 0.065	2.325AspThr: 2.325 ± 0.042	3.513AspVal: 3.513 ± 0.055	0.829AspTrp: 0.829 ± 0.023	1.76AspTyr: 1.76 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.56GluAla: 5.56 ± 0.072	0.456GluCys: 0.456 ± 0.019	2.166GluAsp: 2.166 ± 0.042	3.179GluGlu: 3.179 ± 0.052	1.672GluPhe: 1.672 ± 0.036	3.499GluGly: 3.499 ± 0.057	1.323GluHis: 1.323 ± 0.03	2.985GluIle: 2.985 ± 0.047	2.914GluLys: 2.914 ± 0.052	5.566GluLeu: 5.566 ± 0.072	1.76GluMet: 1.76 ± 0.035	2.036GluAsn: 2.036 ± 0.039	2.054GluPro: 2.054 ± 0.044	3.193GluGln: 3.193 ± 0.052	3.809GluArg: 3.809 ± 0.057	2.899GluSer: 2.899 ± 0.043	2.778GluThr: 2.778 ± 0.048	3.65GluVal: 3.65 ± 0.052	0.791GluTrp: 0.791 ± 0.024	1.344GluTyr: 1.344 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.877PheAla: 3.877 ± 0.053	0.573PheCys: 0.573 ± 0.021	2.179PheAsp: 2.179 ± 0.04	1.543PheGlu: 1.543 ± 0.032	1.669PhePhe: 1.669 ± 0.04	3.065PheGly: 3.065 ± 0.045	0.807PheHis: 0.807 ± 0.021	2.4PheIle: 2.4 ± 0.043	1.12PheLys: 1.12 ± 0.028	3.228PheLeu: 3.228 ± 0.055	0.962PheMet: 0.962 ± 0.028	1.58PheAsn: 1.58 ± 0.03	1.594PhePro: 1.594 ± 0.032	1.127PheGln: 1.127 ± 0.028	1.995PheArg: 1.995 ± 0.037	3.016PheSer: 3.016 ± 0.053	2.396PheThr: 2.396 ± 0.048	2.495PheVal: 2.495 ± 0.042	0.649PheTrp: 0.649 ± 0.024	1.187PheTyr: 1.187 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.841GlyAla: 6.841 ± 0.074	1.097GlyCys: 1.097 ± 0.032	3.898GlyAsp: 3.898 ± 0.051	4.715GlyGlu: 4.715 ± 0.059	3.167GlyPhe: 3.167 ± 0.049	6.073GlyGly: 6.073 ± 0.081	1.713GlyHis: 1.713 ± 0.034	4.856GlyIle: 4.856 ± 0.064	3.801GlyLys: 3.801 ± 0.053	7.841GlyLeu: 7.841 ± 0.095	2.557GlyMet: 2.557 ± 0.044	2.546GlyAsn: 2.546 ± 0.041	2.3GlyPro: 2.3 ± 0.034	3.054GlyGln: 3.054 ± 0.049	4.461GlyArg: 4.461 ± 0.064	4.214GlySer: 4.214 ± 0.052	3.526GlyThr: 3.526 ± 0.05	5.797GlyVal: 5.797 ± 0.068	1.392GlyTrp: 1.392 ± 0.031	2.61GlyTyr: 2.61 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.991HisAla: 1.991 ± 0.032	0.329HisCys: 0.329 ± 0.016	1.215HisAsp: 1.215 ± 0.027	1.027HisGlu: 1.027 ± 0.026	1.038HisPhe: 1.038 ± 0.023	1.843HisGly: 1.843 ± 0.038	0.867HisHis: 0.867 ± 0.028	1.265HisIle: 1.265 ± 0.031	0.708HisLys: 0.708 ± 0.023	2.386HisLeu: 2.386 ± 0.042	0.537HisMet: 0.537 ± 0.018	0.783HisAsn: 0.783 ± 0.023	1.452HisPro: 1.452 ± 0.028	1.253HisGln: 1.253 ± 0.033	1.536HisArg: 1.536 ± 0.036	1.254HisSer: 1.254 ± 0.031	1.033HisThr: 1.033 ± 0.03	1.311HisVal: 1.311 ± 0.031	0.402HisTrp: 0.402 ± 0.017	0.929HisTyr: 0.929 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.545IleAla: 6.545 ± 0.066	0.711IleCys: 0.711 ± 0.022	3.315IleAsp: 3.315 ± 0.05	2.948IleGlu: 2.948 ± 0.054	2.003IlePhe: 2.003 ± 0.043	4.461IleGly: 4.461 ± 0.062	1.159IleHis: 1.159 ± 0.028	3.151IleIle: 3.151 ± 0.053	2.089IleLys: 2.089 ± 0.042	4.744IleLeu: 4.744 ± 0.066	1.203IleMet: 1.203 ± 0.03	2.317IleAsn: 2.317 ± 0.04	2.718IlePro: 2.718 ± 0.048	1.656IleGln: 1.656 ± 0.033	2.929IleArg: 2.929 ± 0.047	3.55IleSer: 3.55 ± 0.048	3.169IleThr: 3.169 ± 0.048	3.862IleVal: 3.862 ± 0.05	0.675IleTrp: 0.675 ± 0.019	1.406IleTyr: 1.406 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.103LysAla: 4.103 ± 0.055	0.262LysCys: 0.262 ± 0.014	1.727LysAsp: 1.727 ± 0.036	2.118LysGlu: 2.118 ± 0.045	1.0LysPhe: 1.0 ± 0.028	2.73LysGly: 2.73 ± 0.04	0.787LysHis: 0.787 ± 0.021	2.14LysIle: 2.14 ± 0.039	1.982LysLys: 1.982 ± 0.043	3.812LysLeu: 3.812 ± 0.056	1.157LysMet: 1.157 ± 0.029	1.492LysAsn: 1.492 ± 0.038	1.989LysPro: 1.989 ± 0.038	1.772LysGln: 1.772 ± 0.043	2.573LysArg: 2.573 ± 0.041	2.21LysSer: 2.21 ± 0.035	2.384LysThr: 2.384 ± 0.041	2.755LysVal: 2.755 ± 0.041	0.412LysTrp: 0.412 ± 0.018	1.064LysTyr: 1.064 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.486LeuAla: 12.486 ± 0.116	1.359LeuCys: 1.359 ± 0.032	5.236LeuAsp: 5.236 ± 0.058	5.256LeuGlu: 5.256 ± 0.063	4.266LeuPhe: 4.266 ± 0.066	7.381LeuGly: 7.381 ± 0.083	2.273LeuHis: 2.273 ± 0.04	5.554LeuIle: 5.554 ± 0.066	4.199LeuLys: 4.199 ± 0.06	12.297LeuLeu: 12.297 ± 0.12	2.95LeuMet: 2.95 ± 0.048	3.918LeuAsn: 3.918 ± 0.048	6.039LeuPro: 6.039 ± 0.073	4.481LeuGln: 4.481 ± 0.062	6.734LeuArg: 6.734 ± 0.066	7.286LeuSer: 7.286 ± 0.084	6.302LeuThr: 6.302 ± 0.064	6.93LeuVal: 6.93 ± 0.07	1.543LeuTrp: 1.543 ± 0.033	2.585LeuTyr: 2.585 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.164MetAla: 3.164 ± 0.048	0.232MetCys: 0.232 ± 0.013	1.156MetAsp: 1.156 ± 0.026	1.203MetGlu: 1.203 ± 0.026	0.878MetPhe: 0.878 ± 0.022	1.888MetGly: 1.888 ± 0.04	0.544MetHis: 0.544 ± 0.018	1.461MetIle: 1.461 ± 0.032	1.379MetLys: 1.379 ± 0.03	3.211MetLeu: 3.211 ± 0.053	0.921MetMet: 0.921 ± 0.029	1.101MetAsn: 1.101 ± 0.029	1.485MetPro: 1.485 ± 0.028	1.203MetGln: 1.203 ± 0.025	1.678MetArg: 1.678 ± 0.03	1.881MetSer: 1.881 ± 0.038	1.865MetThr: 1.865 ± 0.034	2.053MetVal: 2.053 ± 0.039	0.286MetTrp: 0.286 ± 0.016	0.515MetTyr: 0.515 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.244AsnAla: 3.244 ± 0.051	0.322AsnCys: 0.322 ± 0.014	1.87AsnAsp: 1.87 ± 0.034	1.661AsnGlu: 1.661 ± 0.036	1.161AsnPhe: 1.161 ± 0.029	2.807AsnGly: 2.807 ± 0.044	0.805AsnHis: 0.805 ± 0.024	2.041AsnIle: 2.041 ± 0.035	1.358AsnLys: 1.358 ± 0.036	3.256AsnLeu: 3.256 ± 0.046	0.873AsnMet: 0.873 ± 0.023	1.318AsnAsn: 1.318 ± 0.033	2.024AsnPro: 2.024 ± 0.039	1.379AsnGln: 1.379 ± 0.026	2.016AsnArg: 2.016 ± 0.031	1.777AsnSer: 1.777 ± 0.039	1.732AsnThr: 1.732 ± 0.032	2.356AsnVal: 2.356 ± 0.04	0.511AsnTrp: 0.511 ± 0.018	1.044AsnTyr: 1.044 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.488ProAla: 5.488 ± 0.078	0.475ProCys: 0.475 ± 0.017	2.777ProAsp: 2.777 ± 0.043	3.215ProGlu: 3.215 ± 0.045	1.883ProPhe: 1.883 ± 0.041	4.011ProGly: 4.011 ± 0.064	1.126ProHis: 1.126 ± 0.025	1.761ProIle: 1.761 ± 0.036	1.346ProLys: 1.346 ± 0.033	5.503ProLeu: 5.503 ± 0.074	1.164ProMet: 1.164 ± 0.027	1.174ProAsn: 1.174 ± 0.029	2.075ProPro: 2.075 ± 0.046	2.574ProGln: 2.574 ± 0.048	2.593ProArg: 2.593 ± 0.046	2.291ProSer: 2.291 ± 0.042	2.17ProThr: 2.17 ± 0.038	3.965ProVal: 3.965 ± 0.053	0.864ProTrp: 0.864 ± 0.023	1.178ProTyr: 1.178 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.998GlnAla: 4.998 ± 0.068	0.376GlnCys: 0.376 ± 0.016	1.709GlnAsp: 1.709 ± 0.032	2.069GlnGlu: 2.069 ± 0.042	1.424GlnPhe: 1.424 ± 0.034	3.152GlnGly: 3.152 ± 0.046	1.32GlnHis: 1.32 ± 0.03	2.119GlnIle: 2.119 ± 0.042	1.68GlnLys: 1.68 ± 0.033	5.025GlnLeu: 5.025 ± 0.071	1.223GlnMet: 1.223 ± 0.03	1.251GlnAsn: 1.251 ± 0.029	2.457GlnPro: 2.457 ± 0.045	3.454GlnGln: 3.454 ± 0.064	3.671GlnArg: 3.671 ± 0.049	2.23GlnSer: 2.23 ± 0.042	2.164GlnThr: 2.164 ± 0.038	2.936GlnVal: 2.936 ± 0.045	0.701GlnTrp: 0.701 ± 0.022	1.161GlnTyr: 1.161 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.303ArgAla: 5.303 ± 0.057	0.854ArgCys: 0.854 ± 0.028	3.215ArgAsp: 3.215 ± 0.053	3.957ArgGlu: 3.957 ± 0.054	2.762ArgPhe: 2.762 ± 0.047	3.917ArgGly: 3.917 ± 0.061	1.982ArgHis: 1.982 ± 0.035	3.348ArgIle: 3.348 ± 0.049	2.37ArgLys: 2.37 ± 0.049	7.239ArgLeu: 7.239 ± 0.074	1.949ArgMet: 1.949 ± 0.038	1.929ArgAsn: 1.929 ± 0.035	2.868ArgPro: 2.868 ± 0.05	3.765ArgGln: 3.765 ± 0.063	5.028ArgArg: 5.028 ± 0.08	3.206ArgSer: 3.206 ± 0.048	2.652ArgThr: 2.652 ± 0.049	3.926ArgVal: 3.926 ± 0.048	1.233ArgTrp: 1.233 ± 0.029	2.347ArgTyr: 2.347 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.112SerAla: 6.112 ± 0.071	0.635SerCys: 0.635 ± 0.024	3.067SerAsp: 3.067 ± 0.071	3.003SerGlu: 3.003 ± 0.047	2.189SerPhe: 2.189 ± 0.039	5.37SerGly: 5.37 ± 0.065	1.444SerHis: 1.444 ± 0.03	2.774SerIle: 2.774 ± 0.041	1.826SerLys: 1.826 ± 0.034	6.738SerLeu: 6.738 ± 0.073	1.522SerMet: 1.522 ± 0.038	1.658SerAsn: 1.658 ± 0.036	2.864SerPro: 2.864 ± 0.039	2.462SerGln: 2.462 ± 0.038	3.844SerArg: 3.844 ± 0.05	3.404SerSer: 3.404 ± 0.054	2.824SerThr: 2.824 ± 0.046	4.042SerVal: 4.042 ± 0.056	1.06SerTrp: 1.06 ± 0.028	1.51SerTyr: 1.51 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.183ThrAla: 5.183 ± 0.066	0.534ThrCys: 0.534 ± 0.022	2.389ThrAsp: 2.389 ± 0.044	2.367ThrGlu: 2.367 ± 0.043	1.929ThrPhe: 1.929 ± 0.037	4.428ThrGly: 4.428 ± 0.058	1.129ThrHis: 1.129 ± 0.025	2.741ThrIle: 2.741 ± 0.042	1.309ThrLys: 1.309 ± 0.033	7.341ThrLeu: 7.341 ± 0.08	1.152ThrMet: 1.152 ± 0.028	1.327ThrAsn: 1.327 ± 0.034	3.253ThrPro: 3.253 ± 0.049	1.895ThrGln: 1.895 ± 0.04	3.234ThrArg: 3.234 ± 0.047	2.781ThrSer: 2.781 ± 0.047	2.773ThrThr: 2.773 ± 0.048	3.779ThrVal: 3.779 ± 0.053	0.834ThrTrp: 0.834 ± 0.026	1.066ThrTyr: 1.066 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	7.339ValAla: 7.339 ± 0.073	0.801ValCys: 0.801 ± 0.026	3.619ValAsp: 3.619 ± 0.057	3.778ValGlu: 3.778 ± 0.048	2.506ValPhe: 2.506 ± 0.041	4.901ValGly: 4.901 ± 0.063	1.257ValHis: 1.257 ± 0.031	4.37ValIle: 4.37 ± 0.059	2.826ValLys: 2.826 ± 0.045	7.094ValLeu: 7.094 ± 0.077	2.27ValMet: 2.27 ± 0.038	2.579ValAsn: 2.579 ± 0.045	3.083ValPro: 3.083 ± 0.043	2.373ValGln: 2.373 ± 0.044	3.867ValArg: 3.867 ± 0.051	4.529ValSer: 4.529 ± 0.062	4.059ValThr: 4.059 ± 0.049	5.545ValVal: 5.545 ± 0.064	1.055ValTrp: 1.055 ± 0.026	1.753ValTyr: 1.753 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.064TrpAla: 1.064 ± 0.024	0.2TrpCys: 0.2 ± 0.011	0.642TrpAsp: 0.642 ± 0.024	0.582TrpGlu: 0.582 ± 0.019	0.728TrpPhe: 0.728 ± 0.026	1.0TrpGly: 1.0 ± 0.028	0.491TrpHis: 0.491 ± 0.02	0.727TrpIle: 0.727 ± 0.022	0.503TrpLys: 0.503 ± 0.017	2.49TrpLeu: 2.49 ± 0.038	0.5TrpMet: 0.5 ± 0.019	0.473TrpAsn: 0.473 ± 0.02	0.825TrpPro: 0.825 ± 0.025	1.251TrpGln: 1.251 ± 0.031	1.441TrpArg: 1.441 ± 0.036	0.9TrpSer: 0.9 ± 0.024	0.604TrpThr: 0.604 ± 0.021	0.944TrpVal: 0.944 ± 0.026	0.273TrpTrp: 0.273 ± 0.014	0.406TrpTyr: 0.406 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.483TyrAla: 2.483 ± 0.046	0.361TyrCys: 0.361 ± 0.015	1.499TyrAsp: 1.499 ± 0.031	1.112TyrGlu: 1.112 ± 0.027	1.047TyrPhe: 1.047 ± 0.029	2.192TyrGly: 2.192 ± 0.04	0.763TyrHis: 0.763 ± 0.023	1.292TyrIle: 1.292 ± 0.027	0.814TyrLys: 0.814 ± 0.026	2.992TyrLeu: 2.992 ± 0.051	0.598TyrMet: 0.598 ± 0.021	0.825TyrAsn: 0.825 ± 0.026	1.427TyrPro: 1.427 ± 0.03	1.556TyrGln: 1.556 ± 0.034	2.09TyrArg: 2.09 ± 0.037	1.67TyrSer: 1.67 ± 0.036	1.353TyrThr: 1.353 ± 0.032	1.614TyrVal: 1.614 ± 0.033	0.436TyrTrp: 0.436 ± 0.018	0.899TyrTyr: 0.899 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6726 proteins (1452714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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