Amino acid dipepetide frequency for Spirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.76AlaAla: 14.76 ± 0.216	0.735AlaCys: 0.735 ± 0.028	6.038AlaAsp: 6.038 ± 0.087	7.12AlaGlu: 7.12 ± 0.099	3.025AlaPhe: 3.025 ± 0.061	9.712AlaGly: 9.712 ± 0.15	1.77AlaHis: 1.77 ± 0.043	5.053AlaIle: 5.053 ± 0.082	2.019AlaLys: 2.019 ± 0.061	8.801AlaLeu: 8.801 ± 0.112	2.318AlaMet: 2.318 ± 0.062	2.129AlaAsn: 2.129 ± 0.052	3.558AlaPro: 3.558 ± 0.069	3.117AlaGln: 3.117 ± 0.063	6.44AlaArg: 6.44 ± 0.101	4.497AlaSer: 4.497 ± 0.075	3.95AlaThr: 3.95 ± 0.068	8.52AlaVal: 8.52 ± 0.09	1.115AlaTrp: 1.115 ± 0.037	2.393AlaTyr: 2.393 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.708CysAla: 0.708 ± 0.031	0.12CysCys: 0.12 ± 0.012	0.412CysAsp: 0.412 ± 0.024	0.379CysGlu: 0.379 ± 0.022	0.297CysPhe: 0.297 ± 0.018	0.707CysGly: 0.707 ± 0.032	0.161CysHis: 0.161 ± 0.013	0.545CysIle: 0.545 ± 0.027	0.183CysLys: 0.183 ± 0.014	0.687CysLeu: 0.687 ± 0.027	0.178CysMet: 0.178 ± 0.014	0.218CysAsn: 0.218 ± 0.018	0.427CysPro: 0.427 ± 0.023	0.215CysGln: 0.215 ± 0.015	0.686CysArg: 0.686 ± 0.026	0.695CysSer: 0.695 ± 0.027	0.47CysThr: 0.47 ± 0.026	0.479CysVal: 0.479 ± 0.02	0.099CysTrp: 0.099 ± 0.01	0.195CysTyr: 0.195 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.42AspAla: 5.42 ± 0.077	0.437AspCys: 0.437 ± 0.022	3.334AspAsp: 3.334 ± 0.08	3.758AspGlu: 3.758 ± 0.072	2.512AspPhe: 2.512 ± 0.061	4.627AspGly: 4.627 ± 0.12	1.222AspHis: 1.222 ± 0.036	3.738AspIle: 3.738 ± 0.068	1.33AspLys: 1.33 ± 0.051	5.471AspLeu: 5.471 ± 0.072	1.322AspMet: 1.322 ± 0.038	1.65AspAsn: 1.65 ± 0.048	3.583AspPro: 3.583 ± 0.07	2.205AspGln: 2.205 ± 0.047	3.999AspArg: 3.999 ± 0.072	3.706AspSer: 3.706 ± 0.058	3.443AspThr: 3.443 ± 0.067	3.29AspVal: 3.29 ± 0.061	0.937AspTrp: 0.937 ± 0.031	1.965AspTyr: 1.965 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.492GluAla: 5.492 ± 0.089	0.325GluCys: 0.325 ± 0.02	3.468GluAsp: 3.468 ± 0.083	3.805GluGlu: 3.805 ± 0.093	2.59GluPhe: 2.59 ± 0.051	3.672GluGly: 3.672 ± 0.067	1.694GluHis: 1.694 ± 0.044	4.522GluIle: 4.522 ± 0.07	2.039GluLys: 2.039 ± 0.065	8.128GluLeu: 8.128 ± 0.12	1.559GluMet: 1.559 ± 0.043	2.073GluAsn: 2.073 ± 0.059	2.856GluPro: 2.856 ± 0.077	3.876GluGln: 3.876 ± 0.079	4.652GluArg: 4.652 ± 0.093	3.501GluSer: 3.501 ± 0.057	3.255GluThr: 3.255 ± 0.062	4.36GluVal: 4.36 ± 0.071	0.704GluTrp: 0.704 ± 0.027	2.253GluTyr: 2.253 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.561PheAla: 3.561 ± 0.061	0.394PheCys: 0.394 ± 0.02	2.325PheAsp: 2.325 ± 0.048	2.133PheGlu: 2.133 ± 0.048	1.847PhePhe: 1.847 ± 0.056	3.28PheGly: 3.28 ± 0.06	0.875PheHis: 0.875 ± 0.027	1.985PheIle: 1.985 ± 0.058	0.757PheLys: 0.757 ± 0.028	3.939PheLeu: 3.939 ± 0.07	0.765PheMet: 0.765 ± 0.028	1.039PheAsn: 1.039 ± 0.037	2.081PhePro: 2.081 ± 0.045	1.444PheGln: 1.444 ± 0.041	2.719PheArg: 2.719 ± 0.052	3.151PheSer: 3.151 ± 0.052	2.328PheThr: 2.328 ± 0.049	2.353PheVal: 2.353 ± 0.055	0.543PheTrp: 0.543 ± 0.025	1.102PheTyr: 1.102 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.336GlyAla: 6.336 ± 0.108	0.863GlyCys: 0.863 ± 0.029	4.244GlyAsp: 4.244 ± 0.065	4.586GlyGlu: 4.586 ± 0.076	3.705GlyPhe: 3.705 ± 0.065	5.836GlyGly: 5.836 ± 0.117	1.476GlyHis: 1.476 ± 0.038	5.846GlyIle: 5.846 ± 0.07	2.576GlyLys: 2.576 ± 0.067	7.843GlyLeu: 7.843 ± 0.106	2.321GlyMet: 2.321 ± 0.053	2.353GlyAsn: 2.353 ± 0.064	2.306GlyPro: 2.306 ± 0.053	2.797GlyGln: 2.797 ± 0.05	5.192GlyArg: 5.192 ± 0.096	5.77GlySer: 5.77 ± 0.096	4.285GlyThr: 4.285 ± 0.075	5.605GlyVal: 5.605 ± 0.097	1.147GlyTrp: 1.147 ± 0.034	2.791GlyTyr: 2.791 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.073HisAla: 2.073 ± 0.051	0.218HisCys: 0.218 ± 0.015	1.347HisAsp: 1.347 ± 0.038	1.327HisGlu: 1.327 ± 0.038	0.78HisPhe: 0.78 ± 0.03	1.887HisGly: 1.887 ± 0.048	0.763HisHis: 0.763 ± 0.035	1.319HisIle: 1.319 ± 0.038	0.523HisLys: 0.523 ± 0.026	2.153HisLeu: 2.153 ± 0.054	0.456HisMet: 0.456 ± 0.02	0.77HisAsn: 0.77 ± 0.026	1.506HisPro: 1.506 ± 0.047	0.945HisGln: 0.945 ± 0.031	1.899HisArg: 1.899 ± 0.041	1.436HisSer: 1.436 ± 0.036	1.43HisThr: 1.43 ± 0.041	1.219HisVal: 1.219 ± 0.033	0.312HisTrp: 0.312 ± 0.018	0.714HisTyr: 0.714 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.028IleAla: 6.028 ± 0.099	0.5IleCys: 0.5 ± 0.021	3.858IleAsp: 3.858 ± 0.064	4.152IleGlu: 4.152 ± 0.071	1.843IlePhe: 1.843 ± 0.05	4.825IleGly: 4.825 ± 0.094	1.34IleHis: 1.34 ± 0.037	3.372IleIle: 3.372 ± 0.076	1.545IleLys: 1.545 ± 0.052	5.814IleLeu: 5.814 ± 0.083	1.194IleMet: 1.194 ± 0.039	1.756IleAsn: 1.756 ± 0.054	3.27IlePro: 3.27 ± 0.06	2.394IleGln: 2.394 ± 0.053	4.287IleArg: 4.287 ± 0.07	3.784IleSer: 3.784 ± 0.071	3.683IleThr: 3.683 ± 0.065	3.581IleVal: 3.581 ± 0.069	0.578IleTrp: 0.578 ± 0.024	1.505IleTyr: 1.505 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	2.159LysAla: 2.159 ± 0.06	0.143LysCys: 0.143 ± 0.012	1.4LysAsp: 1.4 ± 0.048	1.635LysGlu: 1.635 ± 0.062	0.716LysPhe: 0.716 ± 0.031	1.734LysGly: 1.734 ± 0.057	0.617LysHis: 0.617 ± 0.027	1.71LysIle: 1.71 ± 0.058	1.507LysLys: 1.507 ± 0.065	2.738LysLeu: 2.738 ± 0.063	0.601LysMet: 0.601 ± 0.025	1.002LysAsn: 1.002 ± 0.039	1.368LysPro: 1.368 ± 0.044	1.349LysGln: 1.349 ± 0.041	1.883LysArg: 1.883 ± 0.056	1.472LysSer: 1.472 ± 0.046	1.63LysThr: 1.63 ± 0.044	1.727LysVal: 1.727 ± 0.052	0.227LysTrp: 0.227 ± 0.015	0.765LysTyr: 0.765 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	9.961LeuAla: 9.961 ± 0.127	0.816LeuCys: 0.816 ± 0.034	5.927LeuAsp: 5.927 ± 0.075	6.9LeuGlu: 6.9 ± 0.105	4.07LeuPhe: 4.07 ± 0.085	7.3LeuGly: 7.3 ± 0.096	2.805LeuHis: 2.805 ± 0.061	5.226LeuIle: 5.226 ± 0.087	2.767LeuLys: 2.767 ± 0.076	12.166LeuLeu: 12.166 ± 0.178	2.226LeuMet: 2.226 ± 0.053	2.891LeuAsn: 2.891 ± 0.049	5.96LeuPro: 5.96 ± 0.089	6.738LeuGln: 6.738 ± 0.104	7.363LeuArg: 7.363 ± 0.11	6.535LeuSer: 6.535 ± 0.08	4.929LeuThr: 4.929 ± 0.073	6.863LeuVal: 6.863 ± 0.097	0.977LeuTrp: 0.977 ± 0.029	3.088LeuTyr: 3.088 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.072MetAla: 2.072 ± 0.053	0.117MetCys: 0.117 ± 0.009	1.275MetAsp: 1.275 ± 0.038	1.398MetGlu: 1.398 ± 0.039	0.81MetPhe: 0.81 ± 0.031	1.449MetGly: 1.449 ± 0.039	0.557MetHis: 0.557 ± 0.022	1.443MetIle: 1.443 ± 0.042	0.922MetLys: 0.922 ± 0.033	2.496MetLeu: 2.496 ± 0.053	0.543MetMet: 0.543 ± 0.024	0.897MetAsn: 0.897 ± 0.031	1.13MetPro: 1.13 ± 0.035	1.401MetGln: 1.401 ± 0.044	1.626MetArg: 1.626 ± 0.044	1.416MetSer: 1.416 ± 0.041	1.181MetThr: 1.181 ± 0.034	1.695MetVal: 1.695 ± 0.041	0.154MetTrp: 0.154 ± 0.013	0.62MetTyr: 0.62 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.317AsnAla: 2.317 ± 0.051	0.239AsnCys: 0.239 ± 0.016	1.43AsnAsp: 1.43 ± 0.046	1.52AsnGlu: 1.52 ± 0.042	1.005AsnPhe: 1.005 ± 0.038	2.122AsnGly: 2.122 ± 0.051	0.688AsnHis: 0.688 ± 0.028	1.819AsnIle: 1.819 ± 0.053	0.778AsnLys: 0.778 ± 0.035	3.209AsnLeu: 3.209 ± 0.058	0.697AsnMet: 0.697 ± 0.028	0.915AsnAsn: 0.915 ± 0.039	2.103AsnPro: 2.103 ± 0.05	1.271AsnGln: 1.271 ± 0.035	2.256AsnArg: 2.256 ± 0.049	1.676AsnSer: 1.676 ± 0.049	1.677AsnThr: 1.677 ± 0.046	1.573AsnVal: 1.573 ± 0.04	0.387AsnTrp: 0.387 ± 0.023	0.878AsnTyr: 0.878 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.465ProAla: 5.465 ± 0.093	0.275ProCys: 0.275 ± 0.018	4.008ProAsp: 4.008 ± 0.08	4.496ProGlu: 4.496 ± 0.084	1.756ProPhe: 1.756 ± 0.045	4.797ProGly: 4.797 ± 0.078	1.121ProHis: 1.121 ± 0.037	2.062ProIle: 2.062 ± 0.045	0.963ProLys: 0.963 ± 0.035	4.48ProLeu: 4.48 ± 0.078	0.934ProMet: 0.934 ± 0.031	1.151ProAsn: 1.151 ± 0.034	2.198ProPro: 2.198 ± 0.066	2.095ProGln: 2.095 ± 0.055	2.755ProArg: 2.755 ± 0.071	2.307ProSer: 2.307 ± 0.047	1.903ProThr: 1.903 ± 0.049	4.158ProVal: 4.158 ± 0.077	0.585ProTrp: 0.585 ± 0.026	1.359ProTyr: 1.359 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.357GlnAla: 4.357 ± 0.079	0.217GlnCys: 0.217 ± 0.016	2.591GlnAsp: 2.591 ± 0.054	3.25GlnGlu: 3.25 ± 0.061	1.381GlnPhe: 1.381 ± 0.037	2.856GlnGly: 2.856 ± 0.05	1.329GlnHis: 1.329 ± 0.041	2.416GlnIle: 2.416 ± 0.047	1.186GlnLys: 1.186 ± 0.042	5.56GlnLeu: 5.56 ± 0.091	0.891GlnMet: 0.891 ± 0.027	1.248GlnAsn: 1.248 ± 0.036	2.217GlnPro: 2.217 ± 0.054	3.333GlnGln: 3.333 ± 0.074	3.654GlnArg: 3.654 ± 0.077	2.214GlnSer: 2.214 ± 0.053	2.036GlnThr: 2.036 ± 0.038	2.955GlnVal: 2.955 ± 0.061	0.425GlnTrp: 0.425 ± 0.021	1.219GlnTyr: 1.219 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	5.071ArgAla: 5.071 ± 0.083	0.569ArgCys: 0.569 ± 0.026	3.988ArgAsp: 3.988 ± 0.07	5.239ArgGlu: 5.239 ± 0.089	3.206ArgPhe: 3.206 ± 0.057	4.394ArgGly: 4.394 ± 0.071	1.655ArgHis: 1.655 ± 0.042	5.215ArgIle: 5.215 ± 0.075	2.231ArgLys: 2.231 ± 0.06	7.769ArgLeu: 7.769 ± 0.112	1.965ArgMet: 1.965 ± 0.045	2.313ArgAsn: 2.313 ± 0.054	2.784ArgPro: 2.784 ± 0.059	3.184ArgGln: 3.184 ± 0.069	5.694ArgArg: 5.694 ± 0.092	4.673ArgSer: 4.673 ± 0.072	3.746ArgThr: 3.746 ± 0.074	4.765ArgVal: 4.765 ± 0.083	0.946ArgTrp: 0.946 ± 0.033	2.559ArgTyr: 2.559 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.559SerAla: 5.559 ± 0.074	0.564SerCys: 0.564 ± 0.027	3.176SerAsp: 3.176 ± 0.059	3.379SerGlu: 3.379 ± 0.063	2.573SerPhe: 2.573 ± 0.053	5.888SerGly: 5.888 ± 0.089	1.251SerHis: 1.251 ± 0.034	3.553SerIle: 3.553 ± 0.06	1.289SerLys: 1.289 ± 0.042	6.674SerLeu: 6.674 ± 0.095	1.55SerMet: 1.55 ± 0.043	1.488SerAsn: 1.488 ± 0.045	3.156SerPro: 3.156 ± 0.06	2.11SerGln: 2.11 ± 0.044	4.637SerArg: 4.637 ± 0.072	3.941SerSer: 3.941 ± 0.074	2.933SerThr: 2.933 ± 0.058	4.138SerVal: 4.138 ± 0.069	0.809SerTrp: 0.809 ± 0.033	1.868SerTyr: 1.868 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.32ThrAla: 6.32 ± 0.089	0.323ThrCys: 0.323 ± 0.018	3.033ThrAsp: 3.033 ± 0.06	3.162ThrGlu: 3.162 ± 0.058	1.539ThrPhe: 1.539 ± 0.044	5.042ThrGly: 5.042 ± 0.075	1.069ThrHis: 1.069 ± 0.031	3.14ThrIle: 3.14 ± 0.061	1.119ThrLys: 1.119 ± 0.038	4.856ThrLeu: 4.856 ± 0.085	1.161ThrMet: 1.161 ± 0.033	1.316ThrAsn: 1.316 ± 0.041	2.857ThrPro: 2.857 ± 0.057	1.46ThrGln: 1.46 ± 0.04	3.513ThrArg: 3.513 ± 0.061	2.816ThrSer: 2.816 ± 0.052	2.895ThrThr: 2.895 ± 0.057	4.195ThrVal: 4.195 ± 0.067	0.603ThrTrp: 0.603 ± 0.027	1.242ThrTyr: 1.242 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.028ValAla: 6.028 ± 0.095	0.638ValCys: 0.638 ± 0.027	3.661ValAsp: 3.661 ± 0.071	4.261ValGlu: 4.261 ± 0.071	3.178ValPhe: 3.178 ± 0.06	4.653ValGly: 4.653 ± 0.074	1.535ValHis: 1.535 ± 0.042	3.947ValIle: 3.947 ± 0.07	1.627ValLys: 1.627 ± 0.041	7.994ValLeu: 7.994 ± 0.114	1.581ValMet: 1.581 ± 0.043	1.906ValAsn: 1.906 ± 0.049	3.497ValPro: 3.497 ± 0.063	3.246ValGln: 3.246 ± 0.065	4.974ValArg: 4.974 ± 0.078	4.354ValSer: 4.354 ± 0.069	3.657ValThr: 3.657 ± 0.071	5.438ValVal: 5.438 ± 0.095	0.809ValTrp: 0.809 ± 0.029	2.212ValTyr: 2.212 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.8TrpAla: 0.8 ± 0.031	0.101TrpCys: 0.101 ± 0.009	0.734TrpAsp: 0.734 ± 0.034	0.735TrpGlu: 0.735 ± 0.028	0.536TrpPhe: 0.536 ± 0.025	0.912TrpGly: 0.912 ± 0.033	0.294TrpHis: 0.294 ± 0.018	0.759TrpIle: 0.759 ± 0.03	0.364TrpLys: 0.364 ± 0.019	1.312TrpLeu: 1.312 ± 0.04	0.336TrpMet: 0.336 ± 0.018	0.491TrpAsn: 0.491 ± 0.024	0.436TrpPro: 0.436 ± 0.023	0.708TrpGln: 0.708 ± 0.028	0.82TrpArg: 0.82 ± 0.029	0.711TrpSer: 0.711 ± 0.03	0.481TrpThr: 0.481 ± 0.024	0.791TrpVal: 0.791 ± 0.03	0.164TrpTrp: 0.164 ± 0.012	0.441TrpTyr: 0.441 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.056	0.266TyrCys: 0.266 ± 0.016	1.698TyrAsp: 1.698 ± 0.046	1.59TyrGlu: 1.59 ± 0.04	1.251TyrPhe: 1.251 ± 0.038	2.189TyrGly: 2.189 ± 0.052	0.854TyrHis: 0.854 ± 0.027	1.641TyrIle: 1.641 ± 0.045	0.657TyrLys: 0.657 ± 0.028	3.418TyrLeu: 3.418 ± 0.063	0.603TyrMet: 0.603 ± 0.026	0.957TyrAsn: 0.957 ± 0.037	1.575TyrPro: 1.575 ± 0.041	1.446TyrGln: 1.446 ± 0.042	2.919TyrArg: 2.919 ± 0.056	1.881TyrSer: 1.881 ± 0.047	1.747TyrThr: 1.747 ± 0.039	1.489TyrVal: 1.489 ± 0.039	0.403TyrTrp: 0.403 ± 0.019	1.1TyrTyr: 1.1 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2766 proteins (1014669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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