Amino acid dipepetide frequency for Pelolinea submarina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.509AlaAla: 9.509 ± 0.136	1.029AlaCys: 1.029 ± 0.038	5.138AlaAsp: 5.138 ± 0.125	5.716AlaGlu: 5.716 ± 0.092	3.596AlaPhe: 3.596 ± 0.069	6.975AlaGly: 6.975 ± 0.153	1.6AlaHis: 1.6 ± 0.039	5.884AlaIle: 5.884 ± 0.084	3.444AlaLys: 3.444 ± 0.067	9.692AlaLeu: 9.692 ± 0.138	2.301AlaMet: 2.301 ± 0.06	3.024AlaAsn: 3.024 ± 0.076	2.893AlaPro: 2.893 ± 0.07	3.58AlaGln: 3.58 ± 0.074	4.039AlaArg: 4.039 ± 0.085	4.639AlaSer: 4.639 ± 0.072	3.699AlaThr: 3.699 ± 0.077	6.521AlaVal: 6.521 ± 0.093	1.065AlaTrp: 1.065 ± 0.038	2.868AlaTyr: 2.868 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.809CysAla: 0.809 ± 0.033	0.105CysCys: 0.105 ± 0.011	0.551CysAsp: 0.551 ± 0.024	0.538CysGlu: 0.538 ± 0.024	0.34CysPhe: 0.34 ± 0.02	1.069CysGly: 1.069 ± 0.038	0.218CysHis: 0.218 ± 0.018	0.542CysIle: 0.542 ± 0.021	0.348CysLys: 0.348 ± 0.022	0.935CysLeu: 0.935 ± 0.031	0.221CysMet: 0.221 ± 0.016	0.315CysAsn: 0.315 ± 0.021	0.573CysPro: 0.573 ± 0.028	0.371CysGln: 0.371 ± 0.017	0.511CysArg: 0.511 ± 0.022	0.598CysSer: 0.598 ± 0.026	0.484CysThr: 0.484 ± 0.023	0.636CysVal: 0.636 ± 0.026	0.111CysTrp: 0.111 ± 0.01	0.277CysTyr: 0.277 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.517AspAla: 4.517 ± 0.081	0.57AspCys: 0.57 ± 0.026	2.897AspAsp: 2.897 ± 0.123	4.072AspGlu: 4.072 ± 0.065	2.686AspPhe: 2.686 ± 0.047	4.253AspGly: 4.253 ± 0.158	1.02AspHis: 1.02 ± 0.032	3.873AspIle: 3.873 ± 0.094	2.454AspLys: 2.454 ± 0.059	6.094AspLeu: 6.094 ± 0.089	1.483AspMet: 1.483 ± 0.044	2.108AspAsn: 2.108 ± 0.067	2.756AspPro: 2.756 ± 0.058	2.191AspGln: 2.191 ± 0.044	2.365AspArg: 2.365 ± 0.054	3.139AspSer: 3.139 ± 0.103	2.781AspThr: 2.781 ± 0.156	3.731AspVal: 3.731 ± 0.076	0.988AspTrp: 0.988 ± 0.034	2.263AspTyr: 2.263 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.44GluAla: 5.44 ± 0.092	0.47GluCys: 0.47 ± 0.025	3.449GluAsp: 3.449 ± 0.072	4.856GluGlu: 4.856 ± 0.097	2.3GluPhe: 2.3 ± 0.054	3.873GluGly: 3.873 ± 0.063	1.101GluHis: 1.101 ± 0.039	5.154GluIle: 5.154 ± 0.082	4.591GluLys: 4.591 ± 0.102	5.989GluLeu: 5.989 ± 0.106	1.999GluMet: 1.999 ± 0.053	3.33GluAsn: 3.33 ± 0.053	2.279GluPro: 2.279 ± 0.052	2.518GluGln: 2.518 ± 0.061	3.184GluArg: 3.184 ± 0.071	3.377GluSer: 3.377 ± 0.061	3.339GluThr: 3.339 ± 0.056	4.257GluVal: 4.257 ± 0.083	0.807GluTrp: 0.807 ± 0.034	1.823GluTyr: 1.823 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.128PheAla: 3.128 ± 0.066	0.453PheCys: 0.453 ± 0.024	2.317PheAsp: 2.317 ± 0.047	2.391PheGlu: 2.391 ± 0.053	1.984PhePhe: 1.984 ± 0.063	3.29PheGly: 3.29 ± 0.066	0.758PheHis: 0.758 ± 0.028	3.121PheIle: 3.121 ± 0.066	1.774PheLys: 1.774 ± 0.047	4.367PheLeu: 4.367 ± 0.099	0.996PheMet: 0.996 ± 0.036	1.908PheAsn: 1.908 ± 0.04	1.796PhePro: 1.796 ± 0.045	1.357PheGln: 1.357 ± 0.039	1.735PheArg: 1.735 ± 0.046	3.428PheSer: 3.428 ± 0.067	2.506PheThr: 2.506 ± 0.072	2.592PheVal: 2.592 ± 0.049	0.652PheTrp: 0.652 ± 0.032	1.519PheTyr: 1.519 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.644GlyAla: 5.644 ± 0.163	0.814GlyCys: 0.814 ± 0.033	3.666GlyAsp: 3.666 ± 0.138	4.331GlyGlu: 4.331 ± 0.069	3.357GlyPhe: 3.357 ± 0.066	5.642GlyGly: 5.642 ± 0.248	1.265GlyHis: 1.265 ± 0.033	5.617GlyIle: 5.617 ± 0.084	4.177GlyLys: 4.177 ± 0.073	7.825GlyLeu: 7.825 ± 0.11	2.324GlyMet: 2.324 ± 0.057	2.923GlyAsn: 2.923 ± 0.114	2.064GlyPro: 2.064 ± 0.051	2.814GlyGln: 2.814 ± 0.061	3.295GlyArg: 3.295 ± 0.059	5.004GlySer: 5.004 ± 0.213	4.107GlyThr: 4.107 ± 0.15	5.178GlyVal: 5.178 ± 0.101	1.216GlyTrp: 1.216 ± 0.037	2.698GlyTyr: 2.698 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.524HisAla: 1.524 ± 0.036	0.207HisCys: 0.207 ± 0.014	0.888HisAsp: 0.888 ± 0.028	1.006HisGlu: 1.006 ± 0.036	0.939HisPhe: 0.939 ± 0.033	1.326HisGly: 1.326 ± 0.04	0.462HisHis: 0.462 ± 0.024	1.282HisIle: 1.282 ± 0.038	0.746HisLys: 0.746 ± 0.029	1.918HisLeu: 1.918 ± 0.047	0.44HisMet: 0.44 ± 0.021	0.78HisAsn: 0.78 ± 0.028	1.177HisPro: 1.177 ± 0.038	0.708HisGln: 0.708 ± 0.025	0.777HisArg: 0.777 ± 0.028	1.066HisSer: 1.066 ± 0.031	0.942HisThr: 0.942 ± 0.036	1.06HisVal: 1.06 ± 0.034	0.287HisTrp: 0.287 ± 0.017	0.622HisTyr: 0.622 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.031IleAla: 6.031 ± 0.077	0.748IleCys: 0.748 ± 0.027	3.87IleAsp: 3.87 ± 0.078	4.272IleGlu: 4.272 ± 0.08	3.098IlePhe: 3.098 ± 0.071	5.215IleGly: 5.215 ± 0.09	1.373IleHis: 1.373 ± 0.039	4.633IleIle: 4.633 ± 0.084	3.013IleLys: 3.013 ± 0.065	7.318IleLeu: 7.318 ± 0.105	1.458IleMet: 1.458 ± 0.041	3.039IleAsn: 3.039 ± 0.073	3.619IlePro: 3.619 ± 0.081	2.77IleGln: 2.77 ± 0.052	3.229IleArg: 3.229 ± 0.071	5.086IleSer: 5.086 ± 0.095	4.055IleThr: 4.055 ± 0.075	4.29IleVal: 4.29 ± 0.075	0.837IleTrp: 0.837 ± 0.031	2.312IleTyr: 2.312 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.054LysAla: 4.054 ± 0.074	0.321LysCys: 0.321 ± 0.018	2.703LysAsp: 2.703 ± 0.058	3.408LysGlu: 3.408 ± 0.087	1.574LysPhe: 1.574 ± 0.046	3.156LysGly: 3.156 ± 0.064	0.781LysHis: 0.781 ± 0.031	3.435LysIle: 3.435 ± 0.072	3.168LysLys: 3.168 ± 0.078	4.277LysLeu: 4.277 ± 0.075	1.436LysMet: 1.436 ± 0.046	2.315LysAsn: 2.315 ± 0.056	2.172LysPro: 2.172 ± 0.054	1.763LysGln: 1.763 ± 0.049	2.365LysArg: 2.365 ± 0.063	2.777LysSer: 2.777 ± 0.057	2.762LysThr: 2.762 ± 0.064	3.29LysVal: 3.29 ± 0.062	0.536LysTrp: 0.536 ± 0.025	1.484LysTyr: 1.484 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.824LeuAla: 9.824 ± 0.126	0.926LeuCys: 0.926 ± 0.028	6.05LeuAsp: 6.05 ± 0.095	6.516LeuGlu: 6.516 ± 0.106	4.141LeuPhe: 4.141 ± 0.091	7.278LeuGly: 7.278 ± 0.1	1.699LeuHis: 1.699 ± 0.045	7.102LeuIle: 7.102 ± 0.111	4.985LeuLys: 4.985 ± 0.105	10.86LeuLeu: 10.86 ± 0.177	2.5LeuMet: 2.5 ± 0.059	4.285LeuAsn: 4.285 ± 0.078	5.341LeuPro: 5.341 ± 0.095	3.576LeuGln: 3.576 ± 0.073	4.873LeuArg: 4.873 ± 0.096	7.074LeuSer: 7.074 ± 0.09	5.845LeuThr: 5.845 ± 0.094	7.242LeuVal: 7.242 ± 0.113	1.193LeuTrp: 1.193 ± 0.046	2.879LeuTyr: 2.879 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	2.374MetAla: 2.374 ± 0.05	0.134MetCys: 0.134 ± 0.012	1.692MetAsp: 1.692 ± 0.043	1.644MetGlu: 1.644 ± 0.044	0.718MetPhe: 0.718 ± 0.029	1.973MetGly: 1.973 ± 0.05	0.456MetHis: 0.456 ± 0.019	1.606MetIle: 1.606 ± 0.046	1.488MetLys: 1.488 ± 0.044	2.761MetLeu: 2.761 ± 0.065	0.601MetMet: 0.601 ± 0.028	1.184MetAsn: 1.184 ± 0.036	1.224MetPro: 1.224 ± 0.036	1.08MetGln: 1.08 ± 0.032	1.435MetArg: 1.435 ± 0.039	1.383MetSer: 1.383 ± 0.034	1.364MetThr: 1.364 ± 0.038	1.922MetVal: 1.922 ± 0.047	0.187MetTrp: 0.187 ± 0.014	0.491MetTyr: 0.491 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.197AsnAla: 3.197 ± 0.073	0.405AsnCys: 0.405 ± 0.018	2.199AsnAsp: 2.199 ± 0.1	2.291AsnGlu: 2.291 ± 0.051	1.654AsnPhe: 1.654 ± 0.048	3.291AsnGly: 3.291 ± 0.113	0.787AsnHis: 0.787 ± 0.028	2.921AsnIle: 2.921 ± 0.068	1.738AsnLys: 1.738 ± 0.049	4.456AsnLeu: 4.456 ± 0.074	0.937AsnMet: 0.937 ± 0.032	1.867AsnAsn: 1.867 ± 0.065	2.433AsnPro: 2.433 ± 0.053	1.815AsnGln: 1.815 ± 0.043	1.985AsnArg: 1.985 ± 0.042	2.385AsnSer: 2.385 ± 0.058	2.191AsnThr: 2.191 ± 0.056	2.466AsnVal: 2.466 ± 0.057	0.671AsnTrp: 0.671 ± 0.026	1.428AsnTyr: 1.428 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	4.135ProAla: 4.135 ± 0.084	0.306ProCys: 0.306 ± 0.021	3.152ProAsp: 3.152 ± 0.058	3.663ProGlu: 3.663 ± 0.073	1.938ProPhe: 1.938 ± 0.06	3.13ProGly: 3.13 ± 0.054	0.796ProHis: 0.796 ± 0.029	2.665ProIle: 2.665 ± 0.054	1.682ProLys: 1.682 ± 0.042	4.315ProLeu: 4.315 ± 0.084	0.983ProMet: 0.983 ± 0.033	1.668ProAsn: 1.668 ± 0.043	1.466ProPro: 1.466 ± 0.038	1.994ProGln: 1.994 ± 0.05	1.69ProArg: 1.69 ± 0.04	2.473ProSer: 2.473 ± 0.051	2.483ProThr: 2.483 ± 0.07	3.487ProVal: 3.487 ± 0.07	0.529ProTrp: 0.529 ± 0.023	1.545ProTyr: 1.545 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	4.12GlnAla: 4.12 ± 0.075	0.286GlnCys: 0.286 ± 0.019	1.969GlnAsp: 1.969 ± 0.051	2.456GlnGlu: 2.456 ± 0.064	1.397GlnPhe: 1.397 ± 0.031	2.435GlnGly: 2.435 ± 0.053	0.694GlnHis: 0.694 ± 0.028	2.776GlnIle: 2.776 ± 0.06	2.104GlnLys: 2.104 ± 0.057	3.351GlnLeu: 3.351 ± 0.073	1.006GlnMet: 1.006 ± 0.028	1.586GlnAsn: 1.586 ± 0.042	2.098GlnPro: 2.098 ± 0.052	1.574GlnGln: 1.574 ± 0.045	2.012GlnArg: 2.012 ± 0.057	2.379GlnSer: 2.379 ± 0.045	2.203GlnThr: 2.203 ± 0.053	2.865GlnVal: 2.865 ± 0.065	0.423GlnTrp: 0.423 ± 0.021	1.23GlnTyr: 1.23 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.67ArgAla: 3.67 ± 0.076	0.416ArgCys: 0.416 ± 0.024	2.471ArgAsp: 2.471 ± 0.048	3.397ArgGlu: 3.397 ± 0.074	2.017ArgPhe: 2.017 ± 0.053	2.901ArgGly: 2.901 ± 0.062	0.825ArgHis: 0.825 ± 0.03	3.344ArgIle: 3.344 ± 0.057	2.666ArgLys: 2.666 ± 0.059	4.969ArgLeu: 4.969 ± 0.095	1.45ArgMet: 1.45 ± 0.039	1.84ArgAsn: 1.84 ± 0.048	1.674ArgPro: 1.674 ± 0.046	2.058ArgGln: 2.058 ± 0.059	2.528ArgArg: 2.528 ± 0.065	2.545ArgSer: 2.545 ± 0.06	2.26ArgThr: 2.26 ± 0.053	3.256ArgVal: 3.256 ± 0.059	0.727ArgTrp: 0.727 ± 0.028	1.686ArgTyr: 1.686 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.41SerAla: 5.41 ± 0.124	0.559SerCys: 0.559 ± 0.026	3.515SerAsp: 3.515 ± 0.09	3.555SerGlu: 3.555 ± 0.072	2.642SerPhe: 2.642 ± 0.056	5.937SerGly: 5.937 ± 0.245	1.114SerHis: 1.114 ± 0.036	4.33SerIle: 4.33 ± 0.088	2.527SerLys: 2.527 ± 0.053	6.621SerLeu: 6.621 ± 0.084	1.594SerMet: 1.594 ± 0.042	2.341SerAsn: 2.341 ± 0.062	2.575SerPro: 2.575 ± 0.046	2.39SerGln: 2.39 ± 0.057	2.757SerArg: 2.757 ± 0.062	4.027SerSer: 4.027 ± 0.102	3.283SerThr: 3.283 ± 0.086	4.056SerVal: 4.056 ± 0.083	0.739SerTrp: 0.739 ± 0.026	1.86SerTyr: 1.86 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.946ThrAla: 4.946 ± 0.097	0.545ThrCys: 0.545 ± 0.029	2.89ThrAsp: 2.89 ± 0.096	2.879ThrGlu: 2.879 ± 0.061	2.296ThrPhe: 2.296 ± 0.076	4.262ThrGly: 4.262 ± 0.105	1.06ThrHis: 1.06 ± 0.032	3.974ThrIle: 3.974 ± 0.111	1.815ThrLys: 1.815 ± 0.047	5.756ThrLeu: 5.756 ± 0.118	1.055ThrMet: 1.055 ± 0.036	2.002ThrAsn: 2.002 ± 0.057	2.969ThrPro: 2.969 ± 0.081	1.953ThrGln: 1.953 ± 0.043	2.408ThrArg: 2.408 ± 0.054	3.268ThrSer: 3.268 ± 0.087	2.877ThrThr: 2.877 ± 0.078	3.903ThrVal: 3.903 ± 0.134	0.691ThrTrp: 0.691 ± 0.024	1.859ThrTyr: 1.859 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	5.349ValAla: 5.349 ± 0.073	0.762ValCys: 0.762 ± 0.03	4.247ValAsp: 4.247 ± 0.092	4.531ValGlu: 4.531 ± 0.075	3.1ValPhe: 3.1 ± 0.065	4.613ValGly: 4.613 ± 0.09	1.181ValHis: 1.181 ± 0.034	5.22ValIle: 5.22 ± 0.075	3.071ValLys: 3.071 ± 0.068	7.378ValLeu: 7.378 ± 0.096	1.83ValMet: 1.83 ± 0.049	2.797ValAsn: 2.797 ± 0.074	2.881ValPro: 2.881 ± 0.067	2.212ValGln: 2.212 ± 0.052	3.131ValArg: 3.131 ± 0.063	4.329ValSer: 4.329 ± 0.088	3.853ValThr: 3.853 ± 0.117	5.111ValVal: 5.111 ± 0.085	0.822ValTrp: 0.822 ± 0.027	2.186ValTyr: 2.186 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.982TrpAla: 0.982 ± 0.035	0.112TrpCys: 0.112 ± 0.009	0.728TrpAsp: 0.728 ± 0.026	0.808TrpGlu: 0.808 ± 0.034	0.529TrpPhe: 0.529 ± 0.024	0.92TrpGly: 0.92 ± 0.037	0.244TrpHis: 0.244 ± 0.017	0.838TrpIle: 0.838 ± 0.035	0.671TrpLys: 0.671 ± 0.023	1.633TrpLeu: 1.633 ± 0.049	0.4TrpMet: 0.4 ± 0.02	0.579TrpAsn: 0.579 ± 0.025	0.488TrpPro: 0.488 ± 0.021	0.714TrpGln: 0.714 ± 0.028	0.68TrpArg: 0.68 ± 0.028	0.731TrpSer: 0.731 ± 0.041	0.593TrpThr: 0.593 ± 0.023	0.925TrpVal: 0.925 ± 0.032	0.23TrpTrp: 0.23 ± 0.016	0.427TrpTyr: 0.427 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.549TyrAla: 2.549 ± 0.05	0.384TyrCys: 0.384 ± 0.019	1.848TyrAsp: 1.848 ± 0.045	1.805TyrGlu: 1.805 ± 0.042	1.769TyrPhe: 1.769 ± 0.047	2.42TyrGly: 2.42 ± 0.061	0.722TyrHis: 0.722 ± 0.028	1.949TyrIle: 1.949 ± 0.046	1.316TyrLys: 1.316 ± 0.04	3.677TyrLeu: 3.677 ± 0.073	0.701TyrMet: 0.701 ± 0.024	1.224TyrAsn: 1.224 ± 0.039	1.62TyrPro: 1.62 ± 0.047	1.528TyrGln: 1.528 ± 0.041	1.701TyrArg: 1.701 ± 0.046	2.125TyrSer: 2.125 ± 0.063	1.779TyrThr: 1.779 ± 0.059	1.819TyrVal: 1.819 ± 0.041	0.52TyrTrp: 0.52 ± 0.027	1.304TyrTyr: 1.304 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3066 proteins (1049187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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