Amino acid dipepetide frequency for Betaproteobacteria bacterium SCN2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.648AlaAla: 15.648 ± 0.226	1.291AlaCys: 1.291 ± 0.044	6.286AlaAsp: 6.286 ± 0.096	7.919AlaGlu: 7.919 ± 0.129	3.778AlaPhe: 3.778 ± 0.076	10.431AlaGly: 10.431 ± 0.137	2.653AlaHis: 2.653 ± 0.058	5.464AlaIle: 5.464 ± 0.088	3.968AlaLys: 3.968 ± 0.09	13.149AlaLeu: 13.149 ± 0.165	3.346AlaMet: 3.346 ± 0.065	2.882AlaAsn: 2.882 ± 0.075	4.695AlaPro: 4.695 ± 0.091	4.549AlaGln: 4.549 ± 0.09	8.995AlaArg: 8.995 ± 0.122	5.873AlaSer: 5.873 ± 0.089	4.742AlaThr: 4.742 ± 0.098	8.011AlaVal: 8.011 ± 0.105	1.865AlaTrp: 1.865 ± 0.054	2.649AlaTyr: 2.649 ± 0.058	0.001AlaXaa: 0.001 ± 0.001
Cys	0.985CysAla: 0.985 ± 0.035	0.138CysCys: 0.138 ± 0.015	0.482CysAsp: 0.482 ± 0.024	0.52CysGlu: 0.52 ± 0.026	0.311CysPhe: 0.311 ± 0.02	0.995CysGly: 0.995 ± 0.044	0.34CysHis: 0.34 ± 0.023	0.401CysIle: 0.401 ± 0.024	0.326CysLys: 0.326 ± 0.02	0.884CysLeu: 0.884 ± 0.034	0.232CysMet: 0.232 ± 0.017	0.252CysAsn: 0.252 ± 0.019	0.593CysPro: 0.593 ± 0.031	0.282CysGln: 0.282 ± 0.018	0.69CysArg: 0.69 ± 0.03	0.521CysSer: 0.521 ± 0.028	0.413CysThr: 0.413 ± 0.026	0.631CysVal: 0.631 ± 0.028	0.1CysTrp: 0.1 ± 0.012	0.231CysTyr: 0.231 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.429AspAla: 6.429 ± 0.086	0.465AspCys: 0.465 ± 0.024	2.705AspAsp: 2.705 ± 0.071	3.69AspGlu: 3.69 ± 0.066	2.312AspPhe: 2.312 ± 0.052	4.335AspGly: 4.335 ± 0.092	1.084AspHis: 1.084 ± 0.036	3.023AspIle: 3.023 ± 0.065	2.244AspLys: 2.244 ± 0.062	5.424AspLeu: 5.424 ± 0.086	1.447AspMet: 1.447 ± 0.039	1.384AspAsn: 1.384 ± 0.041	2.756AspPro: 2.756 ± 0.064	1.46AspGln: 1.46 ± 0.036	3.397AspArg: 3.397 ± 0.075	2.574AspSer: 2.574 ± 0.057	2.494AspThr: 2.494 ± 0.067	3.625AspVal: 3.625 ± 0.067	1.032AspTrp: 1.032 ± 0.038	1.656AspTyr: 1.656 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.876GluAla: 7.876 ± 0.12	0.417GluCys: 0.417 ± 0.023	2.86GluAsp: 2.86 ± 0.063	3.567GluGlu: 3.567 ± 0.079	2.174GluPhe: 2.174 ± 0.054	3.973GluGly: 3.973 ± 0.075	1.521GluHis: 1.521 ± 0.043	3.638GluIle: 3.638 ± 0.07	2.976GluLys: 2.976 ± 0.063	6.749GluLeu: 6.749 ± 0.094	1.636GluMet: 1.636 ± 0.045	1.848GluAsn: 1.848 ± 0.055	2.603GluPro: 2.603 ± 0.061	2.648GluGln: 2.648 ± 0.055	4.657GluArg: 4.657 ± 0.084	3.193GluSer: 3.193 ± 0.068	3.216GluThr: 3.216 ± 0.061	4.365GluVal: 4.365 ± 0.085	0.842GluTrp: 0.842 ± 0.036	1.483GluTyr: 1.483 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.136PheAla: 4.136 ± 0.082	0.382PheCys: 0.382 ± 0.024	2.482PheAsp: 2.482 ± 0.059	2.313PheGlu: 2.313 ± 0.048	1.496PhePhe: 1.496 ± 0.051	3.127PheGly: 3.127 ± 0.074	0.835PheHis: 0.835 ± 0.032	1.779PheIle: 1.779 ± 0.051	1.3PheLys: 1.3 ± 0.044	3.53PheLeu: 3.53 ± 0.081	0.903PheMet: 0.903 ± 0.034	1.171PheAsn: 1.171 ± 0.036	1.578PhePro: 1.578 ± 0.043	1.02PheGln: 1.02 ± 0.034	2.156PheArg: 2.156 ± 0.052	2.302PheSer: 2.302 ± 0.052	1.734PheThr: 1.734 ± 0.046	2.66PheVal: 2.66 ± 0.06	0.531PheTrp: 0.531 ± 0.027	1.002PheTyr: 1.002 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	7.503GlyAla: 7.503 ± 0.103	0.924GlyCys: 0.924 ± 0.033	3.875GlyAsp: 3.875 ± 0.085	5.234GlyGlu: 5.234 ± 0.076	3.367GlyPhe: 3.367 ± 0.07	6.591GlyGly: 6.591 ± 0.14	2.028GlyHis: 2.028 ± 0.053	4.429GlyIle: 4.429 ± 0.085	3.976GlyLys: 3.976 ± 0.081	8.719GlyLeu: 8.719 ± 0.117	2.587GlyMet: 2.587 ± 0.066	2.304GlyAsn: 2.304 ± 0.076	2.637GlyPro: 2.637 ± 0.054	2.969GlyGln: 2.969 ± 0.066	5.351GlyArg: 5.351 ± 0.105	4.118GlySer: 4.118 ± 0.073	3.606GlyThr: 3.606 ± 0.081	6.023GlyVal: 6.023 ± 0.101	1.336GlyTrp: 1.336 ± 0.041	2.378GlyTyr: 2.378 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.974HisAla: 2.974 ± 0.066	0.309HisCys: 0.309 ± 0.022	1.243HisAsp: 1.243 ± 0.038	1.364HisGlu: 1.364 ± 0.043	0.99HisPhe: 0.99 ± 0.033	2.128HisGly: 2.128 ± 0.053	0.713HisHis: 0.713 ± 0.03	1.091HisIle: 1.091 ± 0.034	0.827HisLys: 0.827 ± 0.031	2.371HisLeu: 2.371 ± 0.061	0.537HisMet: 0.537 ± 0.025	0.605HisAsn: 0.605 ± 0.026	1.527HisPro: 1.527 ± 0.048	0.709HisGln: 0.709 ± 0.026	1.486HisArg: 1.486 ± 0.046	1.047HisSer: 1.047 ± 0.04	1.039HisThr: 1.039 ± 0.037	1.635HisVal: 1.635 ± 0.047	0.372HisTrp: 0.372 ± 0.021	0.819HisTyr: 0.819 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.019IleAla: 6.019 ± 0.093	0.456IleCys: 0.456 ± 0.024	3.226IleAsp: 3.226 ± 0.065	3.67IleGlu: 3.67 ± 0.074	1.548IlePhe: 1.548 ± 0.046	4.182IleGly: 4.182 ± 0.087	1.06IleHis: 1.06 ± 0.037	2.075IleIle: 2.075 ± 0.056	1.877IleLys: 1.877 ± 0.05	4.484IleLeu: 4.484 ± 0.079	0.943IleMet: 0.943 ± 0.038	1.552IleAsn: 1.552 ± 0.048	2.44IlePro: 2.44 ± 0.063	1.542IleGln: 1.542 ± 0.047	3.397IleArg: 3.397 ± 0.072	2.736IleSer: 2.736 ± 0.062	2.374IleThr: 2.374 ± 0.057	3.553IleVal: 3.553 ± 0.071	0.528IleTrp: 0.528 ± 0.027	1.167IleTyr: 1.167 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.309LysAla: 4.309 ± 0.087	0.267LysCys: 0.267 ± 0.023	2.032LysAsp: 2.032 ± 0.053	2.084LysGlu: 2.084 ± 0.059	1.175LysPhe: 1.175 ± 0.042	2.866LysGly: 2.866 ± 0.063	0.867LysHis: 0.867 ± 0.038	1.893LysIle: 1.893 ± 0.046	1.946LysLys: 1.946 ± 0.072	4.566LysLeu: 4.566 ± 0.091	1.074LysMet: 1.074 ± 0.04	1.24LysAsn: 1.24 ± 0.042	2.414LysPro: 2.414 ± 0.064	1.611LysGln: 1.611 ± 0.042	2.722LysArg: 2.722 ± 0.061	2.117LysSer: 2.117 ± 0.054	2.254LysThr: 2.254 ± 0.052	2.731LysVal: 2.731 ± 0.067	0.473LysTrp: 0.473 ± 0.024	0.91LysTyr: 0.91 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	15.134LeuAla: 15.134 ± 0.17	0.874LeuCys: 0.874 ± 0.035	6.45LeuAsp: 6.45 ± 0.095	6.117LeuGlu: 6.117 ± 0.098	3.861LeuPhe: 3.861 ± 0.083	8.393LeuGly: 8.393 ± 0.099	2.479LeuHis: 2.479 ± 0.057	4.848LeuIle: 4.848 ± 0.08	4.745LeuLys: 4.745 ± 0.081	11.586LeuLeu: 11.586 ± 0.194	2.659LeuMet: 2.659 ± 0.061	3.108LeuAsn: 3.108 ± 0.063	6.345LeuPro: 6.345 ± 0.103	3.712LeuGln: 3.712 ± 0.069	6.998LeuArg: 6.998 ± 0.121	6.458LeuSer: 6.458 ± 0.099	5.25LeuThr: 5.25 ± 0.08	7.271LeuVal: 7.271 ± 0.109	1.322LeuTrp: 1.322 ± 0.044	2.405LeuTyr: 2.405 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.011MetAla: 3.011 ± 0.063	0.155MetCys: 0.155 ± 0.014	1.282MetAsp: 1.282 ± 0.047	1.364MetGlu: 1.364 ± 0.045	0.733MetPhe: 0.733 ± 0.031	1.945MetGly: 1.945 ± 0.058	0.61MetHis: 0.61 ± 0.026	1.109MetIle: 1.109 ± 0.041	1.337MetLys: 1.337 ± 0.041	2.868MetLeu: 2.868 ± 0.06	0.615MetMet: 0.615 ± 0.032	0.954MetAsn: 0.954 ± 0.035	1.517MetPro: 1.517 ± 0.045	1.273MetGln: 1.273 ± 0.034	1.828MetArg: 1.828 ± 0.046	1.625MetSer: 1.625 ± 0.045	1.347MetThr: 1.347 ± 0.041	1.625MetVal: 1.625 ± 0.045	0.238MetTrp: 0.238 ± 0.021	0.422MetTyr: 0.422 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.088AsnAla: 3.088 ± 0.066	0.32AsnCys: 0.32 ± 0.02	1.382AsnAsp: 1.382 ± 0.063	1.607AsnGlu: 1.607 ± 0.043	1.062AsnPhe: 1.062 ± 0.034	2.249AsnGly: 2.249 ± 0.06	0.609AsnHis: 0.609 ± 0.027	1.517AsnIle: 1.517 ± 0.048	1.024AsnLys: 1.024 ± 0.038	3.165AsnLeu: 3.165 ± 0.063	0.666AsnMet: 0.666 ± 0.028	0.769AsnAsn: 0.769 ± 0.034	1.952AsnPro: 1.952 ± 0.051	1.032AsnGln: 1.032 ± 0.035	2.024AsnArg: 2.024 ± 0.048	1.211AsnSer: 1.211 ± 0.044	1.338AsnThr: 1.338 ± 0.047	1.89AsnVal: 1.89 ± 0.053	0.451AsnTrp: 0.451 ± 0.024	0.779AsnTyr: 0.779 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	6.321ProAla: 6.321 ± 0.118	0.389ProCys: 0.389 ± 0.025	3.194ProAsp: 3.194 ± 0.063	3.83ProGlu: 3.83 ± 0.066	1.749ProPhe: 1.749 ± 0.048	4.361ProGly: 4.361 ± 0.08	1.151ProHis: 1.151 ± 0.039	1.941ProIle: 1.941 ± 0.053	1.485ProLys: 1.485 ± 0.048	5.06ProLeu: 5.06 ± 0.094	1.217ProMet: 1.217 ± 0.04	1.275ProAsn: 1.275 ± 0.041	2.406ProPro: 2.406 ± 0.081	1.931ProGln: 1.931 ± 0.049	2.887ProArg: 2.887 ± 0.062	2.324ProSer: 2.324 ± 0.067	1.929ProThr: 1.929 ± 0.048	4.13ProVal: 4.13 ± 0.075	0.67ProTrp: 0.67 ± 0.032	1.24ProTyr: 1.24 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	5.094GlnAla: 5.094 ± 0.097	0.287GlnCys: 0.287 ± 0.019	1.71GlnAsp: 1.71 ± 0.049	2.097GlnGlu: 2.097 ± 0.049	1.25GlnPhe: 1.25 ± 0.039	2.746GlnGly: 2.746 ± 0.053	0.886GlnHis: 0.886 ± 0.035	1.761GlnIle: 1.761 ± 0.049	1.545GlnLys: 1.545 ± 0.048	3.839GlnLeu: 3.839 ± 0.064	1.006GlnMet: 1.006 ± 0.035	1.013GlnAsn: 1.013 ± 0.032	2.047GlnPro: 2.047 ± 0.053	1.624GlnGln: 1.624 ± 0.046	2.52GlnArg: 2.52 ± 0.057	2.03GlnSer: 2.03 ± 0.048	1.751GlnThr: 1.751 ± 0.049	2.667GlnVal: 2.667 ± 0.057	0.466GlnTrp: 0.466 ± 0.027	0.873GlnTyr: 0.873 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.933ArgAla: 6.933 ± 0.103	0.557ArgCys: 0.557 ± 0.03	3.632ArgAsp: 3.632 ± 0.075	4.896ArgGlu: 4.896 ± 0.075	2.843ArgPhe: 2.843 ± 0.061	4.295ArgGly: 4.295 ± 0.071	2.019ArgHis: 2.019 ± 0.052	3.952ArgIle: 3.952 ± 0.066	2.656ArgLys: 2.656 ± 0.057	8.509ArgLeu: 8.509 ± 0.135	1.95ArgMet: 1.95 ± 0.045	2.09ArgAsn: 2.09 ± 0.054	3.093ArgPro: 3.093 ± 0.068	3.191ArgGln: 3.191 ± 0.062	4.929ArgArg: 4.929 ± 0.105	3.021ArgSer: 3.021 ± 0.072	2.824ArgThr: 2.824 ± 0.061	4.613ArgVal: 4.613 ± 0.079	0.972ArgTrp: 0.972 ± 0.035	2.032ArgTyr: 2.032 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.648SerAla: 5.648 ± 0.094	0.536SerCys: 0.536 ± 0.029	2.53SerAsp: 2.53 ± 0.067	2.853SerGlu: 2.853 ± 0.063	1.998SerPhe: 1.998 ± 0.043	5.113SerGly: 5.113 ± 0.09	1.302SerHis: 1.302 ± 0.041	2.631SerIle: 2.631 ± 0.054	1.798SerLys: 1.798 ± 0.049	5.908SerLeu: 5.908 ± 0.093	1.384SerMet: 1.384 ± 0.035	1.402SerAsn: 1.402 ± 0.048	2.634SerPro: 2.634 ± 0.06	1.894SerGln: 1.894 ± 0.053	3.959SerArg: 3.959 ± 0.069	2.688SerSer: 2.688 ± 0.059	2.357SerThr: 2.357 ± 0.059	3.571SerVal: 3.571 ± 0.066	0.736SerTrp: 0.736 ± 0.033	1.207SerTyr: 1.207 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.064ThrAla: 5.064 ± 0.084	0.428ThrCys: 0.428 ± 0.024	2.327ThrAsp: 2.327 ± 0.054	2.466ThrGlu: 2.466 ± 0.058	1.516ThrPhe: 1.516 ± 0.049	4.406ThrGly: 4.406 ± 0.091	1.127ThrHis: 1.127 ± 0.041	1.991ThrIle: 1.991 ± 0.054	1.131ThrLys: 1.131 ± 0.037	6.192ThrLeu: 6.192 ± 0.092	0.855ThrMet: 0.855 ± 0.031	1.029ThrAsn: 1.029 ± 0.039	2.956ThrPro: 2.956 ± 0.062	1.635ThrGln: 1.635 ± 0.04	3.258ThrArg: 3.258 ± 0.068	2.252ThrSer: 2.252 ± 0.053	2.168ThrThr: 2.168 ± 0.057	3.692ThrVal: 3.692 ± 0.084	0.604ThrTrp: 0.604 ± 0.031	1.114ThrTyr: 1.114 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.985ValAla: 7.985 ± 0.111	0.709ValCys: 0.709 ± 0.032	3.854ValAsp: 3.854 ± 0.072	4.639ValGlu: 4.639 ± 0.081	2.667ValPhe: 2.667 ± 0.058	4.837ValGly: 4.837 ± 0.074	1.493ValHis: 1.493 ± 0.046	3.669ValIle: 3.669 ± 0.078	2.925ValLys: 2.925 ± 0.069	7.921ValLeu: 7.921 ± 0.113	1.911ValMet: 1.911 ± 0.055	2.163ValAsn: 2.163 ± 0.053	3.345ValPro: 3.345 ± 0.057	2.278ValGln: 2.278 ± 0.058	4.693ValArg: 4.693 ± 0.079	4.144ValSer: 4.144 ± 0.068	3.588ValThr: 3.588 ± 0.084	5.46ValVal: 5.46 ± 0.097	0.969ValTrp: 0.969 ± 0.036	1.643ValTyr: 1.643 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.279TrpAla: 1.279 ± 0.039	0.154TrpCys: 0.154 ± 0.015	0.6TrpAsp: 0.6 ± 0.029	0.69TrpGlu: 0.69 ± 0.029	0.559TrpPhe: 0.559 ± 0.03	0.884TrpGly: 0.884 ± 0.038	0.42TrpHis: 0.42 ± 0.024	0.667TrpIle: 0.667 ± 0.028	0.613TrpLys: 0.613 ± 0.026	2.228TrpLeu: 2.228 ± 0.067	0.396TrpMet: 0.396 ± 0.023	0.427TrpAsn: 0.427 ± 0.024	0.624TrpPro: 0.624 ± 0.027	0.833TrpGln: 0.833 ± 0.032	1.068TrpArg: 1.068 ± 0.032	0.61TrpSer: 0.61 ± 0.029	0.544TrpThr: 0.544 ± 0.025	1.027TrpVal: 1.027 ± 0.036	0.256TrpTrp: 0.256 ± 0.02	0.277TrpTyr: 0.277 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.76TyrAla: 2.76 ± 0.059	0.268TyrCys: 0.268 ± 0.018	1.384TyrAsp: 1.384 ± 0.043	1.321TyrGlu: 1.321 ± 0.038	1.046TyrPhe: 1.046 ± 0.039	2.099TyrGly: 2.099 ± 0.059	0.589TyrHis: 0.589 ± 0.026	0.953TyrIle: 0.953 ± 0.038	0.851TyrLys: 0.851 ± 0.034	2.869TyrLeu: 2.869 ± 0.07	0.492TyrMet: 0.492 ± 0.022	0.667TyrAsn: 0.667 ± 0.029	1.33TyrPro: 1.33 ± 0.041	1.02TyrGln: 1.02 ± 0.038	1.989TyrArg: 1.989 ± 0.048	1.304TyrSer: 1.304 ± 0.043	1.242TyrThr: 1.242 ± 0.041	1.713TyrVal: 1.713 ± 0.045	0.392TyrTrp: 0.392 ± 0.021	0.726TyrTyr: 0.726 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 2629 proteins (806251 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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