Amino acid dipepetide frequency for Loktanella phage pCB2051-A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.94AlaAla: 10.94 ± 2.037
0.393AlaCys: 0.393 ± 0.19
6.396AlaAsp: 6.396 ± 0.565
7.013AlaGlu: 7.013 ± 0.998
3.366AlaPhe: 3.366 ± 0.434
7.518AlaGly: 7.518 ± 0.857
1.066AlaHis: 1.066 ± 0.227
6.115AlaIle: 6.115 ± 0.813
4.825AlaLys: 4.825 ± 0.627
7.742AlaLeu: 7.742 ± 1.057
2.974AlaMet: 2.974 ± 0.441
2.637AlaAsn: 2.637 ± 0.396
3.647AlaPro: 3.647 ± 0.413
3.198AlaGln: 3.198 ± 0.458
4.657AlaArg: 4.657 ± 0.652
5.386AlaSer: 5.386 ± 0.469
5.667AlaThr: 5.667 ± 0.503
5.274AlaVal: 5.274 ± 0.593
0.673AlaTrp: 0.673 ± 0.176
2.805AlaTyr: 2.805 ± 0.402
0.0AlaXaa: 0.0 ± 0.0
Cys
0.898CysAla: 0.898 ± 0.24
0.056CysCys: 0.056 ± 0.058
0.785CysAsp: 0.785 ± 0.184
0.785CysGlu: 0.785 ± 0.222
0.449CysPhe: 0.449 ± 0.157
1.178CysGly: 1.178 ± 0.29
0.393CysHis: 0.393 ± 0.149
0.281CysIle: 0.281 ± 0.122
0.281CysLys: 0.281 ± 0.122
0.393CysLeu: 0.393 ± 0.143
0.281CysMet: 0.281 ± 0.137
0.224CysAsn: 0.224 ± 0.118
0.842CysPro: 0.842 ± 0.195
0.281CysGln: 0.281 ± 0.151
0.729CysArg: 0.729 ± 0.186
0.224CysSer: 0.224 ± 0.1
0.393CysThr: 0.393 ± 0.144
0.449CysVal: 0.449 ± 0.16
0.168CysTrp: 0.168 ± 0.108
0.112CysTyr: 0.112 ± 0.085
0.0CysXaa: 0.0 ± 0.0
Asp
7.013AspAla: 7.013 ± 0.782
0.785AspCys: 0.785 ± 0.196
6.845AspAsp: 6.845 ± 1.31
6.284AspGlu: 6.284 ± 1.209
3.478AspPhe: 3.478 ± 0.393
5.049AspGly: 5.049 ± 0.476
1.515AspHis: 1.515 ± 0.302
4.432AspIle: 4.432 ± 0.395
2.861AspLys: 2.861 ± 0.397
5.891AspLeu: 5.891 ± 0.539
2.525AspMet: 2.525 ± 0.41
1.964AspAsn: 1.964 ± 0.289
2.974AspPro: 2.974 ± 0.302
2.132AspGln: 2.132 ± 0.307
3.478AspArg: 3.478 ± 0.477
2.469AspSer: 2.469 ± 0.319
3.591AspThr: 3.591 ± 0.519
4.657AspVal: 4.657 ± 0.685
1.459AspTrp: 1.459 ± 0.302
2.132AspTyr: 2.132 ± 0.439
0.0AspXaa: 0.0 ± 0.0
Glu
8.191GluAla: 8.191 ± 0.736
0.281GluCys: 0.281 ± 0.112
5.498GluAsp: 5.498 ± 0.601
5.162GluGlu: 5.162 ± 1.021
2.861GluPhe: 2.861 ± 0.394
5.049GluGly: 5.049 ± 0.509
0.954GluHis: 0.954 ± 0.286
3.983GluIle: 3.983 ± 0.715
3.815GluLys: 3.815 ± 0.461
4.993GluLeu: 4.993 ± 0.591
2.02GluMet: 2.02 ± 0.281
2.3GluAsn: 2.3 ± 0.382
2.244GluPro: 2.244 ± 0.547
1.851GluGln: 1.851 ± 0.326
5.105GluArg: 5.105 ± 0.533
2.749GluSer: 2.749 ± 0.46
3.591GluThr: 3.591 ± 0.441
4.937GluVal: 4.937 ± 0.615
1.01GluTrp: 1.01 ± 0.261
2.076GluTyr: 2.076 ± 0.329
0.0GluXaa: 0.0 ± 0.0
Phe
3.142PheAla: 3.142 ± 0.366
0.393PheCys: 0.393 ± 0.133
2.581PheAsp: 2.581 ± 0.372
2.356PheGlu: 2.356 ± 0.328
1.066PhePhe: 1.066 ± 0.298
3.759PheGly: 3.759 ± 0.456
0.729PheHis: 0.729 ± 0.228
1.851PheIle: 1.851 ± 0.342
2.02PheLys: 2.02 ± 0.349
2.861PheLeu: 2.861 ± 0.417
1.459PheMet: 1.459 ± 0.281
1.908PheAsn: 1.908 ± 0.389
1.403PhePro: 1.403 ± 0.346
1.29PheGln: 1.29 ± 0.276
2.076PheArg: 2.076 ± 0.312
2.637PheSer: 2.637 ± 0.29
2.188PheThr: 2.188 ± 0.376
2.637PheVal: 2.637 ± 0.35
0.729PheTrp: 0.729 ± 0.175
1.29PheTyr: 1.29 ± 0.288
0.0PheXaa: 0.0 ± 0.0
Gly
6.115GlyAla: 6.115 ± 0.727
1.29GlyCys: 1.29 ± 0.314
5.947GlyAsp: 5.947 ± 0.608
4.881GlyGlu: 4.881 ± 0.546
2.525GlyPhe: 2.525 ± 0.404
6.62GlyGly: 6.62 ± 0.808
1.515GlyHis: 1.515 ± 0.325
3.591GlyIle: 3.591 ± 0.454
4.432GlyLys: 4.432 ± 0.39
6.396GlyLeu: 6.396 ± 0.697
3.254GlyMet: 3.254 ± 0.49
2.805GlyAsn: 2.805 ± 0.368
3.03GlyPro: 3.03 ± 0.46
2.637GlyGln: 2.637 ± 0.408
6.115GlyArg: 6.115 ± 1.525
4.713GlySer: 4.713 ± 0.59
4.825GlyThr: 4.825 ± 0.682
5.442GlyVal: 5.442 ± 0.597
1.627GlyTrp: 1.627 ± 0.339
2.244GlyTyr: 2.244 ± 0.351
0.0GlyXaa: 0.0 ± 0.0
His
0.898HisAla: 0.898 ± 0.211
0.112HisCys: 0.112 ± 0.072
1.234HisAsp: 1.234 ± 0.297
1.403HisGlu: 1.403 ± 0.31
0.729HisPhe: 0.729 ± 0.19
1.571HisGly: 1.571 ± 0.286
0.673HisHis: 0.673 ± 0.236
0.898HisIle: 0.898 ± 0.258
0.673HisLys: 0.673 ± 0.228
1.515HisLeu: 1.515 ± 0.381
0.785HisMet: 0.785 ± 0.224
0.898HisAsn: 0.898 ± 0.245
1.01HisPro: 1.01 ± 0.322
0.785HisGln: 0.785 ± 0.207
1.795HisArg: 1.795 ± 0.408
0.729HisSer: 0.729 ± 0.208
1.122HisThr: 1.122 ± 0.272
1.01HisVal: 1.01 ± 0.266
0.168HisTrp: 0.168 ± 0.1
0.337HisTyr: 0.337 ± 0.16
0.0HisXaa: 0.0 ± 0.0
Ile
4.488IleAla: 4.488 ± 0.558
0.673IleCys: 0.673 ± 0.187
4.152IleAsp: 4.152 ± 0.419
4.657IleGlu: 4.657 ± 0.456
1.851IlePhe: 1.851 ± 0.303
4.039IleGly: 4.039 ± 0.431
1.122IleHis: 1.122 ± 0.26
2.805IleIle: 2.805 ± 0.534
3.591IleLys: 3.591 ± 0.461
2.861IleLeu: 2.861 ± 0.437
1.964IleMet: 1.964 ± 0.276
2.356IleAsn: 2.356 ± 0.358
3.254IlePro: 3.254 ± 0.45
2.076IleGln: 2.076 ± 0.392
2.861IleArg: 2.861 ± 0.354
3.254IleSer: 3.254 ± 0.335
3.647IleThr: 3.647 ± 0.548
3.31IleVal: 3.31 ± 0.402
0.729IleTrp: 0.729 ± 0.199
1.515IleTyr: 1.515 ± 0.362
0.0IleXaa: 0.0 ± 0.0
Lys
6.789LysAla: 6.789 ± 0.952
0.337LysCys: 0.337 ± 0.135
3.086LysAsp: 3.086 ± 0.364
3.03LysGlu: 3.03 ± 0.45
2.02LysPhe: 2.02 ± 0.298
4.601LysGly: 4.601 ± 0.464
1.346LysHis: 1.346 ± 0.289
3.366LysIle: 3.366 ± 0.451
3.086LysLys: 3.086 ± 0.467
4.264LysLeu: 4.264 ± 0.498
2.3LysMet: 2.3 ± 0.398
1.964LysAsn: 1.964 ± 0.377
3.535LysPro: 3.535 ± 0.477
1.851LysGln: 1.851 ± 0.293
2.525LysArg: 2.525 ± 0.325
3.198LysSer: 3.198 ± 0.498
3.647LysThr: 3.647 ± 0.433
3.591LysVal: 3.591 ± 0.462
0.729LysTrp: 0.729 ± 0.198
1.571LysTyr: 1.571 ± 0.391
0.0LysXaa: 0.0 ± 0.0
Leu
7.181LeuAla: 7.181 ± 0.818
0.281LeuCys: 0.281 ± 0.124
4.713LeuAsp: 4.713 ± 0.436
5.162LeuGlu: 5.162 ± 0.571
2.132LeuPhe: 2.132 ± 0.293
5.667LeuGly: 5.667 ± 0.558
1.683LeuHis: 1.683 ± 0.39
3.983LeuIle: 3.983 ± 0.43
5.33LeuLys: 5.33 ± 0.573
4.152LeuLeu: 4.152 ± 0.444
2.805LeuMet: 2.805 ± 0.439
2.805LeuAsn: 2.805 ± 0.474
3.422LeuPro: 3.422 ± 0.493
2.244LeuGln: 2.244 ± 0.304
3.871LeuArg: 3.871 ± 0.469
5.274LeuSer: 5.274 ± 0.593
5.386LeuThr: 5.386 ± 0.607
4.208LeuVal: 4.208 ± 0.538
0.842LeuTrp: 0.842 ± 0.199
1.627LeuTyr: 1.627 ± 0.262
0.0LeuXaa: 0.0 ± 0.0
Met
3.422MetAla: 3.422 ± 0.407
0.337MetCys: 0.337 ± 0.119
1.964MetAsp: 1.964 ± 0.363
2.076MetGlu: 2.076 ± 0.314
1.515MetPhe: 1.515 ± 0.362
2.805MetGly: 2.805 ± 0.326
0.337MetHis: 0.337 ± 0.142
2.02MetIle: 2.02 ± 0.303
2.3MetLys: 2.3 ± 0.353
2.861MetLeu: 2.861 ± 0.312
1.739MetMet: 1.739 ± 0.326
1.459MetAsn: 1.459 ± 0.322
1.403MetPro: 1.403 ± 0.264
0.954MetGln: 0.954 ± 0.26
2.469MetArg: 2.469 ± 0.321
2.525MetSer: 2.525 ± 0.375
3.03MetThr: 3.03 ± 0.487
2.3MetVal: 2.3 ± 0.389
0.337MetTrp: 0.337 ± 0.142
0.617MetTyr: 0.617 ± 0.165
0.0MetXaa: 0.0 ± 0.0
Asn
3.03AsnAla: 3.03 ± 0.412
0.505AsnCys: 0.505 ± 0.158
1.908AsnAsp: 1.908 ± 0.317
1.908AsnGlu: 1.908 ± 0.327
1.795AsnPhe: 1.795 ± 0.319
3.591AsnGly: 3.591 ± 0.693
0.842AsnHis: 0.842 ± 0.194
1.908AsnIle: 1.908 ± 0.39
2.244AsnLys: 2.244 ± 0.304
2.581AsnLeu: 2.581 ± 0.365
1.346AsnMet: 1.346 ± 0.27
1.627AsnAsn: 1.627 ± 0.27
2.132AsnPro: 2.132 ± 0.341
0.898AsnGln: 0.898 ± 0.22
2.581AsnArg: 2.581 ± 0.435
1.795AsnSer: 1.795 ± 0.289
2.581AsnThr: 2.581 ± 0.402
2.412AsnVal: 2.412 ± 0.386
1.122AsnTrp: 1.122 ± 0.327
1.515AsnTyr: 1.515 ± 0.319
0.0AsnXaa: 0.0 ± 0.0
Pro
4.32ProAla: 4.32 ± 0.569
0.281ProCys: 0.281 ± 0.133
3.535ProAsp: 3.535 ± 0.51
3.535ProGlu: 3.535 ± 0.645
2.132ProPhe: 2.132 ± 0.327
3.31ProGly: 3.31 ± 0.434
0.617ProHis: 0.617 ± 0.2
1.571ProIle: 1.571 ± 0.333
2.525ProLys: 2.525 ± 0.502
3.086ProLeu: 3.086 ± 0.553
1.795ProMet: 1.795 ± 0.286
2.469ProAsn: 2.469 ± 0.463
1.403ProPro: 1.403 ± 0.314
1.403ProGln: 1.403 ± 0.275
2.525ProArg: 2.525 ± 0.485
2.637ProSer: 2.637 ± 0.483
2.861ProThr: 2.861 ± 0.387
3.086ProVal: 3.086 ± 0.42
0.617ProTrp: 0.617 ± 0.202
1.627ProTyr: 1.627 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
2.581GlnAla: 2.581 ± 0.526
0.561GlnCys: 0.561 ± 0.171
2.244GlnAsp: 2.244 ± 0.271
1.346GlnGlu: 1.346 ± 0.273
1.627GlnPhe: 1.627 ± 0.304
2.132GlnGly: 2.132 ± 0.305
0.561GlnHis: 0.561 ± 0.178
2.356GlnIle: 2.356 ± 0.355
1.964GlnLys: 1.964 ± 0.386
2.02GlnLeu: 2.02 ± 0.408
1.346GlnMet: 1.346 ± 0.258
1.234GlnAsn: 1.234 ± 0.241
1.01GlnPro: 1.01 ± 0.25
1.403GlnGln: 1.403 ± 0.279
2.356GlnArg: 2.356 ± 0.358
2.076GlnSer: 2.076 ± 0.302
1.403GlnThr: 1.403 ± 0.286
2.076GlnVal: 2.076 ± 0.331
0.617GlnTrp: 0.617 ± 0.195
0.785GlnTyr: 0.785 ± 0.236
0.0GlnXaa: 0.0 ± 0.0
Arg
3.086ArgAla: 3.086 ± 0.566
0.505ArgCys: 0.505 ± 0.149
5.105ArgAsp: 5.105 ± 0.973
3.535ArgGlu: 3.535 ± 0.432
2.132ArgPhe: 2.132 ± 0.318
5.442ArgGly: 5.442 ± 1.772
1.403ArgHis: 1.403 ± 0.27
4.096ArgIle: 4.096 ± 0.575
3.478ArgLys: 3.478 ± 0.353
4.488ArgLeu: 4.488 ± 0.544
2.637ArgMet: 2.637 ± 0.469
2.356ArgAsn: 2.356 ± 0.314
2.749ArgPro: 2.749 ± 0.361
1.851ArgGln: 1.851 ± 0.324
3.815ArgArg: 3.815 ± 0.52
3.086ArgSer: 3.086 ± 0.426
3.647ArgThr: 3.647 ± 0.525
3.591ArgVal: 3.591 ± 0.426
1.066ArgTrp: 1.066 ± 0.256
1.908ArgTyr: 1.908 ± 0.369
0.0ArgXaa: 0.0 ± 0.0
Ser
5.779SerAla: 5.779 ± 0.657
0.785SerCys: 0.785 ± 0.185
3.815SerAsp: 3.815 ± 0.487
3.422SerGlu: 3.422 ± 0.514
2.356SerPhe: 2.356 ± 0.355
4.601SerGly: 4.601 ± 0.441
0.954SerHis: 0.954 ± 0.252
3.198SerIle: 3.198 ± 0.359
4.152SerLys: 4.152 ± 0.442
4.264SerLeu: 4.264 ± 0.491
1.683SerMet: 1.683 ± 0.308
1.683SerAsn: 1.683 ± 0.373
2.3SerPro: 2.3 ± 0.38
1.178SerGln: 1.178 ± 0.346
3.478SerArg: 3.478 ± 0.484
3.086SerSer: 3.086 ± 0.451
3.815SerThr: 3.815 ± 0.515
2.749SerVal: 2.749 ± 0.471
0.842SerTrp: 0.842 ± 0.202
1.627SerTyr: 1.627 ± 0.306
0.0SerXaa: 0.0 ± 0.0
Thr
6.115ThrAla: 6.115 ± 0.945
0.224ThrCys: 0.224 ± 0.105
3.983ThrAsp: 3.983 ± 0.498
3.254ThrGlu: 3.254 ± 0.457
2.02ThrPhe: 2.02 ± 0.334
4.937ThrGly: 4.937 ± 0.513
1.122ThrHis: 1.122 ± 0.297
3.703ThrIle: 3.703 ± 0.442
3.759ThrLys: 3.759 ± 0.543
4.825ThrLeu: 4.825 ± 0.685
2.02ThrMet: 2.02 ± 0.356
1.908ThrAsn: 1.908 ± 0.307
3.871ThrPro: 3.871 ± 0.524
1.683ThrGln: 1.683 ± 0.314
2.917ThrArg: 2.917 ± 0.413
3.759ThrSer: 3.759 ± 0.594
3.815ThrThr: 3.815 ± 0.71
4.488ThrVal: 4.488 ± 0.683
1.01ThrTrp: 1.01 ± 0.278
2.412ThrTyr: 2.412 ± 0.432
0.0ThrXaa: 0.0 ± 0.0
Val
5.33ValAla: 5.33 ± 0.522
0.393ValCys: 0.393 ± 0.143
4.039ValAsp: 4.039 ± 0.408
5.218ValGlu: 5.218 ± 0.427
2.525ValPhe: 2.525 ± 0.382
4.488ValGly: 4.488 ± 0.534
0.842ValHis: 0.842 ± 0.227
3.254ValIle: 3.254 ± 0.403
3.815ValLys: 3.815 ± 0.407
3.983ValLeu: 3.983 ± 0.484
2.244ValMet: 2.244 ± 0.327
3.422ValAsn: 3.422 ± 0.409
2.917ValPro: 2.917 ± 0.447
2.076ValGln: 2.076 ± 0.367
3.703ValArg: 3.703 ± 0.409
3.198ValSer: 3.198 ± 0.357
4.152ValThr: 4.152 ± 0.433
3.535ValVal: 3.535 ± 0.536
1.066ValTrp: 1.066 ± 0.216
2.244ValTyr: 2.244 ± 0.444
0.0ValXaa: 0.0 ± 0.0
Trp
1.066TrpAla: 1.066 ± 0.216
0.393TrpCys: 0.393 ± 0.241
1.346TrpAsp: 1.346 ± 0.338
1.122TrpGlu: 1.122 ± 0.203
0.561TrpPhe: 0.561 ± 0.232
1.178TrpGly: 1.178 ± 0.403
0.112TrpHis: 0.112 ± 0.071
0.449TrpIle: 0.449 ± 0.168
0.673TrpLys: 0.673 ± 0.178
1.346TrpLeu: 1.346 ± 0.249
0.673TrpMet: 0.673 ± 0.216
0.673TrpAsn: 0.673 ± 0.266
0.842TrpPro: 0.842 ± 0.21
0.673TrpGln: 0.673 ± 0.203
1.066TrpArg: 1.066 ± 0.253
0.842TrpSer: 0.842 ± 0.17
1.01TrpThr: 1.01 ± 0.224
0.954TrpVal: 0.954 ± 0.261
0.337TrpTrp: 0.337 ± 0.137
0.281TrpTyr: 0.281 ± 0.131
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.908TyrAla: 1.908 ± 0.307
0.617TyrCys: 0.617 ± 0.179
2.356TyrAsp: 2.356 ± 0.406
2.525TyrGlu: 2.525 ± 0.362
1.234TyrPhe: 1.234 ± 0.289
2.469TyrGly: 2.469 ± 0.352
0.561TyrHis: 0.561 ± 0.162
1.403TyrIle: 1.403 ± 0.267
1.01TyrLys: 1.01 ± 0.299
2.244TyrLeu: 2.244 ± 0.357
0.561TyrMet: 0.561 ± 0.2
1.627TyrAsn: 1.627 ± 0.243
1.346TyrPro: 1.346 ± 0.314
1.234TyrGln: 1.234 ± 0.185
1.851TyrArg: 1.851 ± 0.362
2.132TyrSer: 2.132 ± 0.382
1.459TyrThr: 1.459 ± 0.289
1.739TyrVal: 1.739 ± 0.378
0.449TyrTrp: 0.449 ± 0.149
0.617TyrTyr: 0.617 ± 0.297
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (17825 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski