Amino acid dipepetide frequency for Shigella phage Sf11 SMD-2017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.928AlaAla: 7.928 ± 1.444
0.5AlaCys: 0.5 ± 0.206
4.643AlaAsp: 4.643 ± 0.581
6.642AlaGlu: 6.642 ± 0.91
2.357AlaPhe: 2.357 ± 0.478
7.857AlaGly: 7.857 ± 0.819
0.714AlaHis: 0.714 ± 0.236
5.642AlaIle: 5.642 ± 0.526
5.071AlaLys: 5.071 ± 0.802
6.428AlaLeu: 6.428 ± 0.837
3.5AlaMet: 3.5 ± 0.518
4.357AlaAsn: 4.357 ± 0.637
2.357AlaPro: 2.357 ± 0.407
3.143AlaGln: 3.143 ± 0.695
4.214AlaArg: 4.214 ± 0.661
5.642AlaSer: 5.642 ± 0.755
5.428AlaThr: 5.428 ± 0.832
5.714AlaVal: 5.714 ± 0.666
1.0AlaTrp: 1.0 ± 0.247
2.357AlaTyr: 2.357 ± 0.443
0.0AlaXaa: 0.0 ± 0.0
Cys
1.143CysAla: 1.143 ± 0.286
0.357CysCys: 0.357 ± 0.157
1.0CysAsp: 1.0 ± 0.335
1.071CysGlu: 1.071 ± 0.378
0.429CysPhe: 0.429 ± 0.159
1.428CysGly: 1.428 ± 0.417
0.571CysHis: 0.571 ± 0.207
0.5CysIle: 0.5 ± 0.166
1.214CysLys: 1.214 ± 0.265
0.857CysLeu: 0.857 ± 0.25
0.286CysMet: 0.286 ± 0.134
0.5CysAsn: 0.5 ± 0.177
0.357CysPro: 0.357 ± 0.177
0.357CysGln: 0.357 ± 0.134
0.5CysArg: 0.5 ± 0.171
0.5CysSer: 0.5 ± 0.187
0.929CysThr: 0.929 ± 0.255
0.786CysVal: 0.786 ± 0.22
0.214CysTrp: 0.214 ± 0.12
0.429CysTyr: 0.429 ± 0.205
0.0CysXaa: 0.0 ± 0.0
Asp
5.214AspAla: 5.214 ± 0.723
0.571AspCys: 0.571 ± 0.175
4.785AspAsp: 4.785 ± 0.65
4.643AspGlu: 4.643 ± 0.71
2.643AspPhe: 2.643 ± 0.353
6.642AspGly: 6.642 ± 0.889
0.857AspHis: 0.857 ± 0.258
4.357AspIle: 4.357 ± 0.509
3.928AspLys: 3.928 ± 0.59
2.928AspLeu: 2.928 ± 0.359
1.643AspMet: 1.643 ± 0.346
2.286AspAsn: 2.286 ± 0.42
1.786AspPro: 1.786 ± 0.371
1.286AspGln: 1.286 ± 0.359
2.0AspArg: 2.0 ± 0.325
2.928AspSer: 2.928 ± 0.461
2.643AspThr: 2.643 ± 0.424
5.357AspVal: 5.357 ± 0.618
0.857AspTrp: 0.857 ± 0.246
3.071AspTyr: 3.071 ± 0.417
0.0AspXaa: 0.0 ± 0.0
Glu
5.142GluAla: 5.142 ± 0.753
1.643GluCys: 1.643 ± 0.364
4.143GluAsp: 4.143 ± 0.525
5.285GluGlu: 5.285 ± 0.726
2.571GluPhe: 2.571 ± 0.4
3.0GluGly: 3.0 ± 0.457
0.786GluHis: 0.786 ± 0.275
5.142GluIle: 5.142 ± 0.521
4.428GluLys: 4.428 ± 0.555
5.357GluLeu: 5.357 ± 0.522
2.857GluMet: 2.857 ± 0.416
3.285GluAsn: 3.285 ± 0.547
2.0GluPro: 2.0 ± 0.414
3.5GluGln: 3.5 ± 0.714
3.5GluArg: 3.5 ± 0.583
3.357GluSer: 3.357 ± 0.414
2.786GluThr: 2.786 ± 0.473
4.214GluVal: 4.214 ± 0.523
1.214GluTrp: 1.214 ± 0.31
2.143GluTyr: 2.143 ± 0.423
0.0GluXaa: 0.0 ± 0.0
Phe
2.571PheAla: 2.571 ± 0.425
0.714PheCys: 0.714 ± 0.229
2.143PheAsp: 2.143 ± 0.404
2.786PheGlu: 2.786 ± 0.416
1.0PhePhe: 1.0 ± 0.3
2.857PheGly: 2.857 ± 0.413
0.429PheHis: 0.429 ± 0.158
2.571PheIle: 2.571 ± 0.443
1.714PheLys: 1.714 ± 0.336
1.5PheLeu: 1.5 ± 0.362
1.0PheMet: 1.0 ± 0.269
2.786PheAsn: 2.786 ± 0.389
1.214PhePro: 1.214 ± 0.312
1.071PheGln: 1.071 ± 0.263
1.928PheArg: 1.928 ± 0.423
2.428PheSer: 2.428 ± 0.355
2.0PheThr: 2.0 ± 0.401
2.286PheVal: 2.286 ± 0.386
0.857PheTrp: 0.857 ± 0.313
1.0PheTyr: 1.0 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
5.571GlyAla: 5.571 ± 0.832
1.143GlyCys: 1.143 ± 0.289
4.357GlyAsp: 4.357 ± 0.491
4.571GlyGlu: 4.571 ± 0.597
2.643GlyPhe: 2.643 ± 0.422
6.071GlyGly: 6.071 ± 0.858
0.857GlyHis: 0.857 ± 0.18
4.928GlyIle: 4.928 ± 0.57
5.5GlyLys: 5.5 ± 0.648
3.571GlyLeu: 3.571 ± 0.5
2.143GlyMet: 2.143 ± 0.355
2.928GlyAsn: 2.928 ± 0.369
0.929GlyPro: 0.929 ± 0.319
2.143GlyGln: 2.143 ± 0.429
4.071GlyArg: 4.071 ± 0.499
5.357GlySer: 5.357 ± 0.775
4.143GlyThr: 4.143 ± 0.634
5.285GlyVal: 5.285 ± 0.662
1.286GlyTrp: 1.286 ± 0.272
4.0GlyTyr: 4.0 ± 0.485
0.0GlyXaa: 0.0 ± 0.0
His
1.571HisAla: 1.571 ± 0.323
0.214HisCys: 0.214 ± 0.129
1.214HisAsp: 1.214 ± 0.251
0.786HisGlu: 0.786 ± 0.239
0.857HisPhe: 0.857 ± 0.261
1.286HisGly: 1.286 ± 0.306
0.286HisHis: 0.286 ± 0.14
0.571HisIle: 0.571 ± 0.235
0.786HisLys: 0.786 ± 0.274
1.214HisLeu: 1.214 ± 0.249
0.571HisMet: 0.571 ± 0.199
0.929HisAsn: 0.929 ± 0.232
1.0HisPro: 1.0 ± 0.241
0.5HisGln: 0.5 ± 0.182
0.857HisArg: 0.857 ± 0.235
0.929HisSer: 0.929 ± 0.249
0.357HisThr: 0.357 ± 0.181
1.214HisVal: 1.214 ± 0.377
0.143HisTrp: 0.143 ± 0.093
0.714HisTyr: 0.714 ± 0.247
0.0HisXaa: 0.0 ± 0.0
Ile
5.5IleAla: 5.5 ± 0.571
1.071IleCys: 1.071 ± 0.318
5.428IleAsp: 5.428 ± 0.395
4.5IleGlu: 4.5 ± 0.578
1.928IlePhe: 1.928 ± 0.317
4.428IleGly: 4.428 ± 0.564
1.428IleHis: 1.428 ± 0.308
5.357IleIle: 5.357 ± 0.735
5.357IleLys: 5.357 ± 0.762
4.357IleLeu: 4.357 ± 0.509
2.357IleMet: 2.357 ± 0.53
3.571IleAsn: 3.571 ± 0.414
2.071IlePro: 2.071 ± 0.367
2.071IleGln: 2.071 ± 0.289
3.571IleArg: 3.571 ± 0.495
4.071IleSer: 4.071 ± 0.532
4.571IleThr: 4.571 ± 0.67
4.571IleVal: 4.571 ± 0.598
0.357IleTrp: 0.357 ± 0.138
1.786IleTyr: 1.786 ± 0.456
0.0IleXaa: 0.0 ± 0.0
Lys
5.071LysAla: 5.071 ± 0.595
0.929LysCys: 0.929 ± 0.229
3.071LysAsp: 3.071 ± 0.458
3.571LysGlu: 3.571 ± 0.572
1.928LysPhe: 1.928 ± 0.402
4.071LysGly: 4.071 ± 0.633
1.643LysHis: 1.643 ± 0.382
3.214LysIle: 3.214 ± 0.447
3.785LysLys: 3.785 ± 0.684
5.5LysLeu: 5.5 ± 0.695
2.928LysMet: 2.928 ± 0.475
3.0LysAsn: 3.0 ± 0.461
2.357LysPro: 2.357 ± 0.472
2.786LysGln: 2.786 ± 0.479
3.285LysArg: 3.285 ± 0.454
4.143LysSer: 4.143 ± 0.573
3.785LysThr: 3.785 ± 0.518
3.928LysVal: 3.928 ± 0.576
1.357LysTrp: 1.357 ± 0.278
2.357LysTyr: 2.357 ± 0.328
0.0LysXaa: 0.0 ± 0.0
Leu
6.142LeuAla: 6.142 ± 0.782
1.143LeuCys: 1.143 ± 0.306
3.714LeuAsp: 3.714 ± 0.477
4.071LeuGlu: 4.071 ± 0.526
2.357LeuPhe: 2.357 ± 0.359
4.357LeuGly: 4.357 ± 0.41
0.929LeuHis: 0.929 ± 0.252
4.571LeuIle: 4.571 ± 0.614
4.785LeuLys: 4.785 ± 0.645
4.214LeuLeu: 4.214 ± 0.641
1.214LeuMet: 1.214 ± 0.316
3.714LeuAsn: 3.714 ± 0.654
2.857LeuPro: 2.857 ± 0.409
2.786LeuGln: 2.786 ± 0.442
4.857LeuArg: 4.857 ± 0.635
4.5LeuSer: 4.5 ± 0.533
4.714LeuThr: 4.714 ± 0.55
4.714LeuVal: 4.714 ± 0.709
1.357LeuTrp: 1.357 ± 0.271
3.0LeuTyr: 3.0 ± 0.537
0.0LeuXaa: 0.0 ± 0.0
Met
3.857MetAla: 3.857 ± 0.61
0.214MetCys: 0.214 ± 0.118
1.714MetAsp: 1.714 ± 0.407
1.928MetGlu: 1.928 ± 0.368
1.428MetPhe: 1.428 ± 0.318
1.071MetGly: 1.071 ± 0.31
0.571MetHis: 0.571 ± 0.255
2.714MetIle: 2.714 ± 0.457
2.428MetLys: 2.428 ± 0.46
2.286MetLeu: 2.286 ± 0.356
1.5MetMet: 1.5 ± 0.354
1.286MetAsn: 1.286 ± 0.352
1.857MetPro: 1.857 ± 0.379
1.286MetGln: 1.286 ± 0.339
1.357MetArg: 1.357 ± 0.291
1.786MetSer: 1.786 ± 0.371
2.0MetThr: 2.0 ± 0.375
1.5MetVal: 1.5 ± 0.336
0.5MetTrp: 0.5 ± 0.169
0.786MetTyr: 0.786 ± 0.245
0.0MetXaa: 0.0 ± 0.0
Asn
4.785AsnAla: 4.785 ± 0.922
0.643AsnCys: 0.643 ± 0.204
3.071AsnAsp: 3.071 ± 0.546
2.428AsnGlu: 2.428 ± 0.355
1.0AsnPhe: 1.0 ± 0.27
4.285AsnGly: 4.285 ± 0.643
0.929AsnHis: 0.929 ± 0.334
2.857AsnIle: 2.857 ± 0.382
2.857AsnLys: 2.857 ± 0.523
4.143AsnLeu: 4.143 ± 0.63
1.214AsnMet: 1.214 ± 0.306
3.0AsnAsn: 3.0 ± 0.61
2.071AsnPro: 2.071 ± 0.394
1.428AsnGln: 1.428 ± 0.263
3.285AsnArg: 3.285 ± 0.41
2.714AsnSer: 2.714 ± 0.457
2.428AsnThr: 2.428 ± 0.554
3.5AsnVal: 3.5 ± 0.618
0.643AsnTrp: 0.643 ± 0.191
2.214AsnTyr: 2.214 ± 0.411
0.0AsnXaa: 0.0 ± 0.0
Pro
3.357ProAla: 3.357 ± 0.572
0.214ProCys: 0.214 ± 0.114
2.571ProAsp: 2.571 ± 0.381
3.071ProGlu: 3.071 ± 0.436
0.929ProPhe: 0.929 ± 0.255
1.928ProGly: 1.928 ± 0.38
0.5ProHis: 0.5 ± 0.199
1.714ProIle: 1.714 ± 0.337
1.643ProLys: 1.643 ± 0.364
2.714ProLeu: 2.714 ± 0.42
0.714ProMet: 0.714 ± 0.23
1.571ProAsn: 1.571 ± 0.307
1.286ProPro: 1.286 ± 0.266
1.286ProGln: 1.286 ± 0.44
1.071ProArg: 1.071 ± 0.258
2.071ProSer: 2.071 ± 0.413
1.928ProThr: 1.928 ± 0.427
3.857ProVal: 3.857 ± 0.535
0.5ProTrp: 0.5 ± 0.187
1.5ProTyr: 1.5 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
3.214GlnAla: 3.214 ± 0.85
0.357GlnCys: 0.357 ± 0.18
0.857GlnAsp: 0.857 ± 0.284
2.571GlnGlu: 2.571 ± 0.363
1.357GlnPhe: 1.357 ± 0.414
1.143GlnGly: 1.143 ± 0.361
0.857GlnHis: 0.857 ± 0.25
3.0GlnIle: 3.0 ± 0.455
2.357GlnLys: 2.357 ± 0.437
3.5GlnLeu: 3.5 ± 0.535
1.643GlnMet: 1.643 ± 0.338
1.5GlnAsn: 1.5 ± 0.311
1.071GlnPro: 1.071 ± 0.279
2.143GlnGln: 2.143 ± 0.508
2.071GlnArg: 2.071 ± 0.419
2.786GlnSer: 2.786 ± 0.434
2.214GlnThr: 2.214 ± 0.507
2.0GlnVal: 2.0 ± 0.299
0.643GlnTrp: 0.643 ± 0.178
1.143GlnTyr: 1.143 ± 0.34
0.0GlnXaa: 0.0 ± 0.0
Arg
4.071ArgAla: 4.071 ± 0.436
1.071ArgCys: 1.071 ± 0.262
3.071ArgAsp: 3.071 ± 0.565
3.357ArgGlu: 3.357 ± 0.567
1.857ArgPhe: 1.857 ± 0.361
2.5ArgGly: 2.5 ± 0.508
0.857ArgHis: 0.857 ± 0.241
4.143ArgIle: 4.143 ± 0.53
3.428ArgLys: 3.428 ± 0.614
3.928ArgLeu: 3.928 ± 0.556
1.214ArgMet: 1.214 ± 0.282
3.5ArgAsn: 3.5 ± 0.498
1.571ArgPro: 1.571 ± 0.311
2.286ArgGln: 2.286 ± 0.537
3.0ArgArg: 3.0 ± 0.631
2.357ArgSer: 2.357 ± 0.402
1.928ArgThr: 1.928 ± 0.394
3.714ArgVal: 3.714 ± 0.582
0.786ArgTrp: 0.786 ± 0.282
2.5ArgTyr: 2.5 ± 0.444
0.0ArgXaa: 0.0 ± 0.0
Ser
6.071SerAla: 6.071 ± 0.84
0.643SerCys: 0.643 ± 0.24
4.214SerAsp: 4.214 ± 0.532
3.714SerGlu: 3.714 ± 0.496
2.571SerPhe: 2.571 ± 0.538
5.714SerGly: 5.714 ± 0.607
0.786SerHis: 0.786 ± 0.243
4.357SerIle: 4.357 ± 0.598
3.857SerLys: 3.857 ± 0.471
5.071SerLeu: 5.071 ± 0.656
2.214SerMet: 2.214 ± 0.381
1.928SerAsn: 1.928 ± 0.342
2.214SerPro: 2.214 ± 0.341
2.643SerGln: 2.643 ± 0.425
2.571SerArg: 2.571 ± 0.468
5.214SerSer: 5.214 ± 0.769
3.357SerThr: 3.357 ± 0.57
4.928SerVal: 4.928 ± 0.682
1.071SerTrp: 1.071 ± 0.268
2.714SerTyr: 2.714 ± 0.507
0.0SerXaa: 0.0 ± 0.0
Thr
4.071ThrAla: 4.071 ± 0.536
0.571ThrCys: 0.571 ± 0.159
3.071ThrAsp: 3.071 ± 0.494
3.857ThrGlu: 3.857 ± 0.56
2.071ThrPhe: 2.071 ± 0.457
5.642ThrGly: 5.642 ± 0.655
0.786ThrHis: 0.786 ± 0.241
3.428ThrIle: 3.428 ± 0.486
2.786ThrLys: 2.786 ± 0.437
3.643ThrLeu: 3.643 ± 0.582
1.357ThrMet: 1.357 ± 0.296
2.286ThrAsn: 2.286 ± 0.45
3.357ThrPro: 3.357 ± 0.511
2.071ThrGln: 2.071 ± 0.379
2.5ThrArg: 2.5 ± 0.454
4.857ThrSer: 4.857 ± 0.708
3.714ThrThr: 3.714 ± 0.649
3.571ThrVal: 3.571 ± 0.615
0.786ThrTrp: 0.786 ± 0.277
1.786ThrTyr: 1.786 ± 0.407
0.0ThrXaa: 0.0 ± 0.0
Val
5.857ValAla: 5.857 ± 0.844
0.714ValCys: 0.714 ± 0.226
3.857ValAsp: 3.857 ± 0.773
3.857ValGlu: 3.857 ± 0.568
2.714ValPhe: 2.714 ± 0.611
4.214ValGly: 4.214 ± 0.606
1.0ValHis: 1.0 ± 0.226
5.428ValIle: 5.428 ± 0.669
3.928ValLys: 3.928 ± 0.673
4.357ValLeu: 4.357 ± 0.591
2.786ValMet: 2.786 ± 0.461
4.643ValAsn: 4.643 ± 0.545
2.286ValPro: 2.286 ± 0.451
2.071ValGln: 2.071 ± 0.361
3.285ValArg: 3.285 ± 0.504
6.428ValSer: 6.428 ± 0.692
4.571ValThr: 4.571 ± 0.831
5.0ValVal: 5.0 ± 0.743
1.286ValTrp: 1.286 ± 0.337
2.643ValTyr: 2.643 ± 0.384
0.0ValXaa: 0.0 ± 0.0
Trp
1.143TrpAla: 1.143 ± 0.247
0.214TrpCys: 0.214 ± 0.143
0.786TrpAsp: 0.786 ± 0.183
0.786TrpGlu: 0.786 ± 0.253
0.714TrpPhe: 0.714 ± 0.209
0.643TrpGly: 0.643 ± 0.177
0.5TrpHis: 0.5 ± 0.186
1.357TrpIle: 1.357 ± 0.369
0.929TrpLys: 0.929 ± 0.27
1.428TrpLeu: 1.428 ± 0.288
0.214TrpMet: 0.214 ± 0.12
0.857TrpAsn: 0.857 ± 0.256
0.643TrpPro: 0.643 ± 0.161
0.5TrpGln: 0.5 ± 0.181
1.071TrpArg: 1.071 ± 0.299
0.929TrpSer: 0.929 ± 0.246
1.0TrpThr: 1.0 ± 0.242
1.571TrpVal: 1.571 ± 0.297
0.357TrpTrp: 0.357 ± 0.168
0.571TrpTyr: 0.571 ± 0.197
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.214TyrAla: 3.214 ± 0.393
0.5TyrCys: 0.5 ± 0.179
2.714TyrAsp: 2.714 ± 0.402
2.857TyrGlu: 2.857 ± 0.404
1.5TyrPhe: 1.5 ± 0.36
2.357TyrGly: 2.357 ± 0.404
0.714TyrHis: 0.714 ± 0.226
2.5TyrIle: 2.5 ± 0.41
1.928TyrLys: 1.928 ± 0.417
3.0TyrLeu: 3.0 ± 0.469
0.643TyrMet: 0.643 ± 0.254
1.571TyrAsn: 1.571 ± 0.302
1.143TyrPro: 1.143 ± 0.293
1.143TyrGln: 1.143 ± 0.293
2.143TyrArg: 2.143 ± 0.376
2.857TyrSer: 2.857 ± 0.458
1.714TyrThr: 1.714 ± 0.388
3.214TyrVal: 3.214 ± 0.442
1.0TyrTrp: 1.0 ± 0.229
1.428TyrTyr: 1.428 ± 0.289
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (14002 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski