Amino acid dipepetide frequency for Actinomyces denticolens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.492AlaAla: 22.492 ± 0.284	1.135AlaCys: 1.135 ± 0.039	8.56AlaAsp: 8.56 ± 0.116	8.522AlaGlu: 8.522 ± 0.142	3.141AlaPhe: 3.141 ± 0.058	14.17AlaGly: 14.17 ± 0.18	2.615AlaHis: 2.615 ± 0.064	5.663AlaIle: 5.663 ± 0.096	2.365AlaLys: 2.365 ± 0.066	16.175AlaLeu: 16.175 ± 0.214	3.106AlaMet: 3.106 ± 0.062	1.986AlaAsn: 1.986 ± 0.058	9.611AlaPro: 9.611 ± 0.167	4.1AlaGln: 4.1 ± 0.081	11.488AlaArg: 11.488 ± 0.155	8.531AlaSer: 8.531 ± 0.132	7.653AlaThr: 7.653 ± 0.089	11.45AlaVal: 11.45 ± 0.141	2.291AlaTrp: 2.291 ± 0.068	2.302AlaTyr: 2.302 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.045	0.077CysCys: 0.077 ± 0.011	0.425CysAsp: 0.425 ± 0.023	0.409CysGlu: 0.409 ± 0.024	0.206CysPhe: 0.206 ± 0.016	0.771CysGly: 0.771 ± 0.032	0.189CysHis: 0.189 ± 0.017	0.201CysIle: 0.201 ± 0.018	0.092CysLys: 0.092 ± 0.012	0.794CysLeu: 0.794 ± 0.029	0.103CysMet: 0.103 ± 0.01	0.101CysAsn: 0.101 ± 0.009	0.472CysPro: 0.472 ± 0.028	0.213CysGln: 0.213 ± 0.017	0.484CysArg: 0.484 ± 0.022	0.448CysSer: 0.448 ± 0.022	0.417CysThr: 0.417 ± 0.027	0.532CysVal: 0.532 ± 0.025	0.112CysTrp: 0.112 ± 0.013	0.158CysTyr: 0.158 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.794AspAla: 8.794 ± 0.12	0.421AspCys: 0.421 ± 0.024	4.075AspAsp: 4.075 ± 0.094	3.939AspGlu: 3.939 ± 0.086	1.394AspPhe: 1.394 ± 0.043	6.397AspGly: 6.397 ± 0.094	1.271AspHis: 1.271 ± 0.037	2.103AspIle: 2.103 ± 0.053	0.981AspLys: 0.981 ± 0.038	6.101AspLeu: 6.101 ± 0.096	0.91AspMet: 0.91 ± 0.034	0.859AspAsn: 0.859 ± 0.038	4.379AspPro: 4.379 ± 0.09	1.336AspGln: 1.336 ± 0.039	3.893AspArg: 3.893 ± 0.066	3.244AspSer: 3.244 ± 0.063	2.488AspThr: 2.488 ± 0.063	4.442AspVal: 4.442 ± 0.078	0.95AspTrp: 0.95 ± 0.036	1.33AspTyr: 1.33 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.756GluAla: 8.756 ± 0.132	0.349GluCys: 0.349 ± 0.023	3.224GluAsp: 3.224 ± 0.066	3.672GluGlu: 3.672 ± 0.066	1.046GluPhe: 1.046 ± 0.032	4.62GluGly: 4.62 ± 0.075	1.378GluHis: 1.378 ± 0.039	2.664GluIle: 2.664 ± 0.067	1.043GluLys: 1.043 ± 0.045	5.672GluLeu: 5.672 ± 0.094	1.084GluMet: 1.084 ± 0.04	0.961GluAsn: 0.961 ± 0.033	3.312GluPro: 3.312 ± 0.068	1.855GluGln: 1.855 ± 0.053	5.531GluArg: 5.531 ± 0.099	2.77GluSer: 2.77 ± 0.058	2.504GluThr: 2.504 ± 0.054	4.189GluVal: 4.189 ± 0.082	0.59GluTrp: 0.59 ± 0.028	0.942GluTyr: 0.942 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	2.853PheAla: 2.853 ± 0.071	0.205PheCys: 0.205 ± 0.017	1.65PheAsp: 1.65 ± 0.05	1.21PheGlu: 1.21 ± 0.048	0.777PhePhe: 0.777 ± 0.034	2.19PheGly: 2.19 ± 0.062	0.472PheHis: 0.472 ± 0.026	1.03PheIle: 1.03 ± 0.041	0.51PheLys: 0.51 ± 0.024	2.344PheLeu: 2.344 ± 0.064	0.445PheMet: 0.445 ± 0.022	0.573PheAsn: 0.573 ± 0.03	1.133PhePro: 1.133 ± 0.037	0.562PheGln: 0.562 ± 0.027	1.264PheArg: 1.264 ± 0.042	1.586PheSer: 1.586 ± 0.051	1.681PheThr: 1.681 ± 0.044	1.72PheVal: 1.72 ± 0.05	0.338PheTrp: 0.338 ± 0.024	0.543PheTyr: 0.543 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	14.716GlyAla: 14.716 ± 0.186	0.707GlyCys: 0.707 ± 0.03	4.828GlyAsp: 4.828 ± 0.083	5.1GlyGlu: 5.1 ± 0.082	2.353GlyPhe: 2.353 ± 0.058	8.815GlyGly: 8.815 ± 0.161	1.91GlyHis: 1.91 ± 0.05	4.435GlyIle: 4.435 ± 0.078	1.975GlyLys: 1.975 ± 0.052	9.483GlyLeu: 9.483 ± 0.137	2.204GlyMet: 2.204 ± 0.053	1.514GlyAsn: 1.514 ± 0.044	5.152GlyPro: 5.152 ± 0.107	2.621GlyGln: 2.621 ± 0.064	7.65GlyArg: 7.65 ± 0.133	5.951GlySer: 5.951 ± 0.098	5.724GlyThr: 5.724 ± 0.089	7.012GlyVal: 7.012 ± 0.1	1.626GlyTrp: 1.626 ± 0.062	2.052GlyTyr: 2.052 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.377HisAla: 2.377 ± 0.064	0.196HisCys: 0.196 ± 0.016	1.255HisAsp: 1.255 ± 0.04	1.157HisGlu: 1.157 ± 0.037	0.391HisPhe: 0.391 ± 0.02	2.016HisGly: 2.016 ± 0.048	0.547HisHis: 0.547 ± 0.03	0.612HisIle: 0.612 ± 0.028	0.251HisLys: 0.251 ± 0.015	2.106HisLeu: 2.106 ± 0.051	0.362HisMet: 0.362 ± 0.024	0.398HisAsn: 0.398 ± 0.024	1.481HisPro: 1.481 ± 0.042	0.53HisGln: 0.53 ± 0.025	1.77HisArg: 1.77 ± 0.053	1.03HisSer: 1.03 ± 0.04	0.83HisThr: 0.83 ± 0.036	1.459HisVal: 1.459 ± 0.044	0.338HisTrp: 0.338 ± 0.02	0.434HisTyr: 0.434 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.353IleAla: 6.353 ± 0.096	0.332IleCys: 0.332 ± 0.022	3.229IleAsp: 3.229 ± 0.068	2.659IleGlu: 2.659 ± 0.06	0.828IlePhe: 0.828 ± 0.038	4.283IleGly: 4.283 ± 0.085	0.861IleHis: 0.861 ± 0.034	2.196IleIle: 2.196 ± 0.063	0.832IleLys: 0.832 ± 0.038	4.079IleLeu: 4.079 ± 0.076	0.799IleMet: 0.799 ± 0.032	0.969IleAsn: 0.969 ± 0.034	2.483IlePro: 2.483 ± 0.063	0.901IleGln: 0.901 ± 0.035	2.441IleArg: 2.441 ± 0.05	2.361IleSer: 2.361 ± 0.055	2.889IleThr: 2.889 ± 0.072	3.851IleVal: 3.851 ± 0.078	0.397IleTrp: 0.397 ± 0.024	0.634IleTyr: 0.634 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.387LysAla: 2.387 ± 0.07	0.088LysCys: 0.088 ± 0.011	1.265LysAsp: 1.265 ± 0.041	1.089LysGlu: 1.089 ± 0.045	0.289LysPhe: 0.289 ± 0.021	1.661LysGly: 1.661 ± 0.051	0.362LysHis: 0.362 ± 0.023	0.748LysIle: 0.748 ± 0.029	0.666LysLys: 0.666 ± 0.039	1.175LysLeu: 1.175 ± 0.048	0.353LysMet: 0.353 ± 0.026	0.471LysAsn: 0.471 ± 0.024	0.958LysPro: 0.958 ± 0.042	0.486LysGln: 0.486 ± 0.02	1.548LysArg: 1.548 ± 0.05	0.967LysSer: 0.967 ± 0.037	1.092LysThr: 1.092 ± 0.04	1.329LysVal: 1.329 ± 0.045	0.174LysTrp: 0.174 ± 0.015	0.392LysTyr: 0.392 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	16.059LeuAla: 16.059 ± 0.195	0.665LeuCys: 0.665 ± 0.029	6.444LeuAsp: 6.444 ± 0.103	4.88LeuGlu: 4.88 ± 0.087	2.02LeuPhe: 2.02 ± 0.06	9.583LeuGly: 9.583 ± 0.131	1.748LeuHis: 1.748 ± 0.047	4.382LeuIle: 4.382 ± 0.092	1.574LeuLys: 1.574 ± 0.05	10.257LeuLeu: 10.257 ± 0.157	1.969LeuMet: 1.969 ± 0.05	1.55LeuAsn: 1.55 ± 0.052	5.963LeuPro: 5.963 ± 0.097	1.777LeuGln: 1.777 ± 0.055	7.832LeuArg: 7.832 ± 0.127	5.574LeuSer: 5.574 ± 0.095	6.728LeuThr: 6.728 ± 0.094	8.191LeuVal: 8.191 ± 0.119	1.172LeuTrp: 1.172 ± 0.038	1.485LeuTyr: 1.485 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.667MetAla: 2.667 ± 0.059	0.137MetCys: 0.137 ± 0.012	1.013MetAsp: 1.013 ± 0.036	0.944MetGlu: 0.944 ± 0.032	0.387MetPhe: 0.387 ± 0.022	1.783MetGly: 1.783 ± 0.058	0.298MetHis: 0.298 ± 0.024	0.94MetIle: 0.94 ± 0.039	0.325MetLys: 0.325 ± 0.02	1.839MetLeu: 1.839 ± 0.052	0.375MetMet: 0.375 ± 0.022	0.407MetAsn: 0.407 ± 0.022	1.347MetPro: 1.347 ± 0.048	0.352MetGln: 0.352 ± 0.022	1.764MetArg: 1.764 ± 0.048	1.866MetSer: 1.866 ± 0.047	1.829MetThr: 1.829 ± 0.046	1.426MetVal: 1.426 ± 0.043	0.228MetTrp: 0.228 ± 0.017	0.287MetTyr: 0.287 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.12AsnAla: 2.12 ± 0.056	0.128AsnCys: 0.128 ± 0.013	1.014AsnAsp: 1.014 ± 0.035	0.859AsnGlu: 0.859 ± 0.033	0.403AsnPhe: 0.403 ± 0.027	1.683AsnGly: 1.683 ± 0.054	0.386AsnHis: 0.386 ± 0.025	0.767AsnIle: 0.767 ± 0.032	0.374AsnLys: 0.374 ± 0.024	1.593AsnLeu: 1.593 ± 0.046	0.287AsnMet: 0.287 ± 0.021	0.456AsnAsn: 0.456 ± 0.024	1.385AsnPro: 1.385 ± 0.049	0.511AsnGln: 0.511 ± 0.026	1.247AsnArg: 1.247 ± 0.045	0.841AsnSer: 0.841 ± 0.033	0.948AsnThr: 0.948 ± 0.037	1.16AsnVal: 1.16 ± 0.042	0.283AsnTrp: 0.283 ± 0.019	0.411AsnTyr: 0.411 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	9.525ProAla: 9.525 ± 0.139	0.291ProCys: 0.291 ± 0.018	3.907ProAsp: 3.907 ± 0.078	4.283ProGlu: 4.283 ± 0.092	1.312ProPhe: 1.312 ± 0.04	6.955ProGly: 6.955 ± 0.11	1.099ProHis: 1.099 ± 0.036	2.157ProIle: 2.157 ± 0.05	0.894ProLys: 0.894 ± 0.04	4.999ProLeu: 4.999 ± 0.086	1.172ProMet: 1.172 ± 0.039	0.825ProAsn: 0.825 ± 0.034	2.846ProPro: 2.846 ± 0.074	1.564ProGln: 1.564 ± 0.054	3.985ProArg: 3.985 ± 0.079	4.322ProSer: 4.322 ± 0.104	3.732ProThr: 3.732 ± 0.076	4.937ProVal: 4.937 ± 0.077	0.938ProTrp: 0.938 ± 0.04	1.003ProTyr: 1.003 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.972GlnAla: 3.972 ± 0.089	0.166GlnCys: 0.166 ± 0.013	1.354GlnAsp: 1.354 ± 0.045	1.377GlnGlu: 1.377 ± 0.045	0.538GlnPhe: 0.538 ± 0.026	2.355GlnGly: 2.355 ± 0.051	0.452GlnHis: 0.452 ± 0.023	1.177GlnIle: 1.177 ± 0.038	0.38GlnLys: 0.38 ± 0.024	2.087GlnLeu: 2.087 ± 0.051	0.575GlnMet: 0.575 ± 0.027	0.414GlnAsn: 0.414 ± 0.022	1.289GlnPro: 1.289 ± 0.05	0.807GlnGln: 0.807 ± 0.039	2.224GlnArg: 2.224 ± 0.056	1.329GlnSer: 1.329 ± 0.041	1.152GlnThr: 1.152 ± 0.036	2.3GlnVal: 2.3 ± 0.056	0.486GlnTrp: 0.486 ± 0.025	0.531GlnTyr: 0.531 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	11.579ArgAla: 11.579 ± 0.174	0.516ArgCys: 0.516 ± 0.024	3.887ArgAsp: 3.887 ± 0.073	4.345ArgGlu: 4.345 ± 0.083	1.933ArgPhe: 1.933 ± 0.053	6.014ArgGly: 6.014 ± 0.103	1.659ArgHis: 1.659 ± 0.054	3.631ArgIle: 3.631 ± 0.076	1.255ArgLys: 1.255 ± 0.042	8.174ArgLeu: 8.174 ± 0.119	1.763ArgMet: 1.763 ± 0.044	1.084ArgAsn: 1.084 ± 0.041	4.686ArgPro: 4.686 ± 0.091	1.86ArgGln: 1.86 ± 0.051	7.919ArgArg: 7.919 ± 0.149	4.596ArgSer: 4.596 ± 0.074	4.042ArgThr: 4.042 ± 0.074	5.712ArgVal: 5.712 ± 0.083	1.203ArgTrp: 1.203 ± 0.041	1.482ArgTyr: 1.482 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	8.821SerAla: 8.821 ± 0.148	0.414SerCys: 0.414 ± 0.023	2.915SerAsp: 2.915 ± 0.074	2.695SerGlu: 2.695 ± 0.053	1.71SerPhe: 1.71 ± 0.045	6.339SerGly: 6.339 ± 0.101	1.139SerHis: 1.139 ± 0.039	2.381SerIle: 2.381 ± 0.058	1.058SerLys: 1.058 ± 0.041	5.902SerLeu: 5.902 ± 0.089	1.293SerMet: 1.293 ± 0.04	0.997SerAsn: 0.997 ± 0.035	4.016SerPro: 4.016 ± 0.097	1.705SerGln: 1.705 ± 0.04	4.258SerArg: 4.258 ± 0.071	4.169SerSer: 4.169 ± 0.098	3.936SerThr: 3.936 ± 0.075	4.08SerVal: 4.08 ± 0.074	0.997SerTrp: 0.997 ± 0.041	1.094SerTyr: 1.094 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	8.701ThrAla: 8.701 ± 0.129	0.519ThrCys: 0.519 ± 0.029	3.251ThrAsp: 3.251 ± 0.065	2.583ThrGlu: 2.583 ± 0.062	1.318ThrPhe: 1.318 ± 0.047	6.529ThrGly: 6.529 ± 0.093	1.081ThrHis: 1.081 ± 0.041	2.934ThrIle: 2.934 ± 0.065	0.959ThrLys: 0.959 ± 0.036	5.027ThrLeu: 5.027 ± 0.09	1.137ThrMet: 1.137 ± 0.038	1.102ThrAsn: 1.102 ± 0.04	3.849ThrPro: 3.849 ± 0.071	1.246ThrGln: 1.246 ± 0.044	3.806ThrArg: 3.806 ± 0.065	3.517ThrSer: 3.517 ± 0.072	4.183ThrThr: 4.183 ± 0.091	4.791ThrVal: 4.791 ± 0.092	1.005ThrTrp: 1.005 ± 0.04	1.164ThrTyr: 1.164 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	10.041ValAla: 10.041 ± 0.126	0.657ValCys: 0.657 ± 0.031	4.968ValAsp: 4.968 ± 0.101	4.58ValGlu: 4.58 ± 0.089	2.012ValPhe: 2.012 ± 0.051	6.79ValGly: 6.79 ± 0.109	1.411ValHis: 1.411 ± 0.049	4.016ValIle: 4.016 ± 0.084	1.362ValLys: 1.362 ± 0.043	8.604ValLeu: 8.604 ± 0.123	1.583ValMet: 1.583 ± 0.043	1.426ValAsn: 1.426 ± 0.043	4.67ValPro: 4.67 ± 0.082	1.537ValGln: 1.537 ± 0.049	5.457ValArg: 5.457 ± 0.083	4.655ValSer: 4.655 ± 0.078	4.954ValThr: 4.954 ± 0.087	7.777ValVal: 7.777 ± 0.107	0.931ValTrp: 0.931 ± 0.037	1.322ValTyr: 1.322 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.85TrpAla: 1.85 ± 0.064	0.137TrpCys: 0.137 ± 0.013	0.868TrpAsp: 0.868 ± 0.034	0.785TrpGlu: 0.785 ± 0.032	0.446TrpPhe: 0.446 ± 0.026	1.134TrpGly: 1.134 ± 0.039	0.3TrpHis: 0.3 ± 0.021	0.678TrpIle: 0.678 ± 0.031	0.255TrpLys: 0.255 ± 0.016	1.495TrpLeu: 1.495 ± 0.05	0.353TrpMet: 0.353 ± 0.023	0.358TrpAsn: 0.358 ± 0.025	0.709TrpPro: 0.709 ± 0.032	0.455TrpGln: 0.455 ± 0.024	1.29TrpArg: 1.29 ± 0.046	0.958TrpSer: 0.958 ± 0.035	0.91TrpThr: 0.91 ± 0.035	1.003TrpVal: 1.003 ± 0.036	0.348TrpTrp: 0.348 ± 0.023	0.379TrpTyr: 0.379 ± 0.034	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.213TyrAla: 2.213 ± 0.057	0.145TyrCys: 0.145 ± 0.014	1.173TyrAsp: 1.173 ± 0.042	1.072TyrGlu: 1.072 ± 0.039	0.581TyrPhe: 0.581 ± 0.027	1.743TyrGly: 1.743 ± 0.045	0.363TyrHis: 0.363 ± 0.021	0.662TyrIle: 0.662 ± 0.03	0.348TyrLys: 0.348 ± 0.021	1.947TyrLeu: 1.947 ± 0.05	0.341TyrMet: 0.341 ± 0.02	0.406TyrAsn: 0.406 ± 0.023	1.004TyrPro: 1.004 ± 0.042	0.547TyrGln: 0.547 ± 0.028	1.49TyrArg: 1.49 ± 0.046	1.205TyrSer: 1.205 ± 0.038	1.009TyrThr: 1.009 ± 0.034	1.393TyrVal: 1.393 ± 0.045	0.303TyrTrp: 0.303 ± 0.02	0.554TyrTyr: 0.554 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2279 proteins (815642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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