Amino acid dipepetide frequency for Silicimonas algicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.739AlaAla: 16.739 ± 0.167	1.073AlaCys: 1.073 ± 0.032	7.042AlaAsp: 7.042 ± 0.08	8.282AlaGlu: 8.282 ± 0.094	4.668AlaPhe: 4.668 ± 0.065	10.672AlaGly: 10.672 ± 0.088	2.229AlaHis: 2.229 ± 0.04	5.971AlaIle: 5.971 ± 0.074	3.197AlaLys: 3.197 ± 0.06	13.924AlaLeu: 13.924 ± 0.141	3.71AlaMet: 3.71 ± 0.044	2.466AlaAsn: 2.466 ± 0.049	5.568AlaPro: 5.568 ± 0.089	3.512AlaGln: 3.512 ± 0.054	9.402AlaArg: 9.402 ± 0.114	6.184AlaSer: 6.184 ± 0.072	6.239AlaThr: 6.239 ± 0.078	8.958AlaVal: 8.958 ± 0.099	1.645AlaTrp: 1.645 ± 0.037	2.381AlaTyr: 2.381 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.03CysAla: 1.03 ± 0.032	0.107CysCys: 0.107 ± 0.009	0.58CysAsp: 0.58 ± 0.021	0.456CysGlu: 0.456 ± 0.021	0.31CysPhe: 0.31 ± 0.016	0.935CysGly: 0.935 ± 0.024	0.262CysHis: 0.262 ± 0.016	0.395CysIle: 0.395 ± 0.02	0.154CysLys: 0.154 ± 0.013	0.905CysLeu: 0.905 ± 0.029	0.181CysMet: 0.181 ± 0.011	0.185CysAsn: 0.185 ± 0.014	0.507CysPro: 0.507 ± 0.022	0.201CysGln: 0.201 ± 0.011	0.622CysArg: 0.622 ± 0.021	0.402CysSer: 0.402 ± 0.019	0.403CysThr: 0.403 ± 0.017	0.602CysVal: 0.602 ± 0.023	0.123CysTrp: 0.123 ± 0.009	0.197CysTyr: 0.197 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.856AspAla: 7.856 ± 0.097	0.516AspCys: 0.516 ± 0.017	3.765AspAsp: 3.765 ± 0.072	3.957AspGlu: 3.957 ± 0.063	2.356AspPhe: 2.356 ± 0.046	5.92AspGly: 5.92 ± 0.083	1.3AspHis: 1.3 ± 0.037	2.95AspIle: 2.95 ± 0.045	1.361AspLys: 1.361 ± 0.035	6.561AspLeu: 6.561 ± 0.076	1.579AspMet: 1.579 ± 0.042	1.077AspAsn: 1.077 ± 0.03	3.778AspPro: 3.778 ± 0.054	1.563AspGln: 1.563 ± 0.033	5.062AspArg: 5.062 ± 0.069	2.032AspSer: 2.032 ± 0.043	2.981AspThr: 2.981 ± 0.051	4.589AspVal: 4.589 ± 0.056	1.228AspTrp: 1.228 ± 0.031	1.459AspTyr: 1.459 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.927GluAla: 8.927 ± 0.105	0.37GluCys: 0.37 ± 0.017	3.547GluAsp: 3.547 ± 0.052	3.612GluGlu: 3.612 ± 0.076	1.75GluPhe: 1.75 ± 0.036	5.395GluGly: 5.395 ± 0.066	1.083GluHis: 1.083 ± 0.027	3.422GluIle: 3.422 ± 0.053	1.923GluLys: 1.923 ± 0.045	4.892GluLeu: 4.892 ± 0.063	1.773GluMet: 1.773 ± 0.038	1.459GluAsn: 1.459 ± 0.042	2.686GluPro: 2.686 ± 0.054	1.636GluGln: 1.636 ± 0.043	4.844GluArg: 4.844 ± 0.07	2.326GluSer: 2.326 ± 0.042	4.34GluThr: 4.34 ± 0.064	4.666GluVal: 4.666 ± 0.063	0.785GluTrp: 0.785 ± 0.023	1.028GluTyr: 1.028 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.532PheAla: 4.532 ± 0.058	0.412PheCys: 0.412 ± 0.019	2.775PheAsp: 2.775 ± 0.052	2.257PheGlu: 2.257 ± 0.039	1.417PhePhe: 1.417 ± 0.038	3.742PheGly: 3.742 ± 0.059	0.787PheHis: 0.787 ± 0.026	1.513PheIle: 1.513 ± 0.04	0.766PheLys: 0.766 ± 0.028	3.732PheLeu: 3.732 ± 0.06	0.768PheMet: 0.768 ± 0.029	0.89PheAsn: 0.89 ± 0.024	1.639PhePro: 1.639 ± 0.035	0.975PheGln: 0.975 ± 0.031	2.581PheArg: 2.581 ± 0.045	2.104PheSer: 2.104 ± 0.044	1.942PheThr: 1.942 ± 0.043	2.903PheVal: 2.903 ± 0.051	0.619PheTrp: 0.619 ± 0.024	0.897PheTyr: 0.897 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.703GlyAla: 9.703 ± 0.102	0.872GlyCys: 0.872 ± 0.025	4.951GlyAsp: 4.951 ± 0.074	5.037GlyGlu: 5.037 ± 0.066	3.68GlyPhe: 3.68 ± 0.055	7.7GlyGly: 7.7 ± 0.09	1.955GlyHis: 1.955 ± 0.044	4.484GlyIle: 4.484 ± 0.062	2.764GlyLys: 2.764 ± 0.054	9.33GlyLeu: 9.33 ± 0.096	2.555GlyMet: 2.555 ± 0.045	1.897GlyAsn: 1.897 ± 0.041	3.862GlyPro: 3.862 ± 0.056	2.791GlyGln: 2.791 ± 0.051	6.671GlyArg: 6.671 ± 0.081	4.462GlySer: 4.462 ± 0.062	5.055GlyThr: 5.055 ± 0.076	6.723GlyVal: 6.723 ± 0.068	1.562GlyTrp: 1.562 ± 0.035	2.239GlyTyr: 2.239 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.293HisAla: 2.293 ± 0.05	0.233HisCys: 0.233 ± 0.014	1.291HisAsp: 1.291 ± 0.033	1.131HisGlu: 1.131 ± 0.031	0.808HisPhe: 0.808 ± 0.025	1.907HisGly: 1.907 ± 0.044	0.542HisHis: 0.542 ± 0.023	0.907HisIle: 0.907 ± 0.027	0.415HisLys: 0.415 ± 0.018	2.106HisLeu: 2.106 ± 0.041	0.497HisMet: 0.497 ± 0.019	0.41HisAsn: 0.41 ± 0.018	1.359HisPro: 1.359 ± 0.033	0.497HisGln: 0.497 ± 0.02	1.493HisArg: 1.493 ± 0.037	0.905HisSer: 0.905 ± 0.024	0.798HisThr: 0.798 ± 0.026	1.612HisVal: 1.612 ± 0.036	0.36HisTrp: 0.36 ± 0.016	0.509HisTyr: 0.509 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.703IleAla: 6.703 ± 0.077	0.506IleCys: 0.506 ± 0.02	3.555IleAsp: 3.555 ± 0.046	3.596IleGlu: 3.596 ± 0.061	1.766IlePhe: 1.766 ± 0.043	4.579IleGly: 4.579 ± 0.06	0.857IleHis: 0.857 ± 0.026	1.768IleIle: 1.768 ± 0.04	0.995IleLys: 0.995 ± 0.03	5.172IleLeu: 5.172 ± 0.073	0.909IleMet: 0.909 ± 0.025	1.051IleAsn: 1.051 ± 0.029	2.208IlePro: 2.208 ± 0.045	1.113IleGln: 1.113 ± 0.029	3.353IleArg: 3.353 ± 0.054	2.638IleSer: 2.638 ± 0.05	2.335IleThr: 2.335 ± 0.043	4.2IleVal: 4.2 ± 0.065	0.644IleTrp: 0.644 ± 0.021	1.029IleTyr: 1.029 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.416LysAla: 3.416 ± 0.064	0.158LysCys: 0.158 ± 0.011	1.598LysAsp: 1.598 ± 0.041	1.391LysGlu: 1.391 ± 0.038	0.72LysPhe: 0.72 ± 0.025	2.58LysGly: 2.58 ± 0.053	0.501LysHis: 0.501 ± 0.019	1.364LysIle: 1.364 ± 0.032	1.018LysLys: 1.018 ± 0.033	2.532LysLeu: 2.532 ± 0.052	0.699LysMet: 0.699 ± 0.026	0.663LysAsn: 0.663 ± 0.023	1.544LysPro: 1.544 ± 0.033	0.615LysGln: 0.615 ± 0.022	2.066LysArg: 2.066 ± 0.043	1.59LysSer: 1.59 ± 0.042	1.683LysThr: 1.683 ± 0.032	2.113LysVal: 2.113 ± 0.041	0.338LysTrp: 0.338 ± 0.017	0.53LysTyr: 0.53 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.526LeuAla: 13.526 ± 0.133	0.958LeuCys: 0.958 ± 0.026	6.397LeuAsp: 6.397 ± 0.073	5.254LeuGlu: 5.254 ± 0.069	3.582LeuPhe: 3.582 ± 0.064	8.65LeuGly: 8.65 ± 0.086	1.89LeuHis: 1.89 ± 0.04	4.934LeuIle: 4.934 ± 0.067	3.025LeuLys: 3.025 ± 0.055	9.055LeuLeu: 9.055 ± 0.107	2.493LeuMet: 2.493 ± 0.047	2.44LeuAsn: 2.44 ± 0.044	5.693LeuPro: 5.693 ± 0.075	2.365LeuGln: 2.365 ± 0.045	7.157LeuArg: 7.157 ± 0.082	6.896LeuSer: 6.896 ± 0.077	6.041LeuThr: 6.041 ± 0.075	7.717LeuVal: 7.717 ± 0.082	1.412LeuTrp: 1.412 ± 0.037	1.961LeuTyr: 1.961 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.215MetAla: 3.215 ± 0.049	0.163MetCys: 0.163 ± 0.01	1.396MetAsp: 1.396 ± 0.031	1.263MetGlu: 1.263 ± 0.037	0.795MetPhe: 0.795 ± 0.024	2.009MetGly: 2.009 ± 0.042	0.471MetHis: 0.471 ± 0.021	1.437MetIle: 1.437 ± 0.033	0.981MetLys: 0.981 ± 0.029	2.395MetLeu: 2.395 ± 0.048	0.679MetMet: 0.679 ± 0.025	0.815MetAsn: 0.815 ± 0.03	1.507MetPro: 1.507 ± 0.032	0.768MetGln: 0.768 ± 0.025	1.956MetArg: 1.956 ± 0.043	1.708MetSer: 1.708 ± 0.037	2.266MetThr: 2.266 ± 0.043	1.827MetVal: 1.827 ± 0.036	0.239MetTrp: 0.239 ± 0.015	0.321MetTyr: 0.321 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.866AsnAla: 2.866 ± 0.047	0.225AsnCys: 0.225 ± 0.013	1.291AsnAsp: 1.291 ± 0.037	1.175AsnGlu: 1.175 ± 0.034	0.857AsnPhe: 0.857 ± 0.026	2.117AsnGly: 2.117 ± 0.045	0.455AsnHis: 0.455 ± 0.02	1.159AsnIle: 1.159 ± 0.029	0.501AsnLys: 0.501 ± 0.022	2.197AsnLeu: 2.197 ± 0.044	0.626AsnMet: 0.626 ± 0.024	0.561AsnAsn: 0.561 ± 0.023	1.66AsnPro: 1.66 ± 0.042	0.594AsnGln: 0.594 ± 0.022	1.647AsnArg: 1.647 ± 0.038	1.039AsnSer: 1.039 ± 0.029	1.086AsnThr: 1.086 ± 0.025	1.777AsnVal: 1.777 ± 0.039	0.385AsnTrp: 0.385 ± 0.02	0.55AsnTyr: 0.55 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.767ProAla: 5.767 ± 0.082	0.344ProCys: 0.344 ± 0.018	4.171ProAsp: 4.171 ± 0.062	4.157ProGlu: 4.157 ± 0.064	2.022ProPhe: 2.022 ± 0.04	4.737ProGly: 4.737 ± 0.06	1.077ProHis: 1.077 ± 0.031	2.157ProIle: 2.157 ± 0.045	1.487ProLys: 1.487 ± 0.037	4.726ProLeu: 4.726 ± 0.071	1.289ProMet: 1.289 ± 0.029	1.141ProAsn: 1.141 ± 0.03	2.44ProPro: 2.44 ± 0.057	1.412ProGln: 1.412 ± 0.036	3.13ProArg: 3.13 ± 0.061	2.775ProSer: 2.775 ± 0.05	2.469ProThr: 2.469 ± 0.045	4.423ProVal: 4.423 ± 0.059	0.734ProTrp: 0.734 ± 0.023	1.086ProTyr: 1.086 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.374GlnAla: 3.374 ± 0.051	0.196GlnCys: 0.196 ± 0.012	1.565GlnAsp: 1.565 ± 0.036	1.347GlnGlu: 1.347 ± 0.035	0.898GlnPhe: 0.898 ± 0.028	2.378GlnGly: 2.378 ± 0.045	0.536GlnHis: 0.536 ± 0.019	1.555GlnIle: 1.555 ± 0.033	0.923GlnLys: 0.923 ± 0.031	2.259GlnLeu: 2.259 ± 0.045	0.841GlnMet: 0.841 ± 0.025	0.697GlnAsn: 0.697 ± 0.023	1.391GlnPro: 1.391 ± 0.032	0.807GlnGln: 0.807 ± 0.036	1.93GlnArg: 1.93 ± 0.046	1.619GlnSer: 1.619 ± 0.033	1.561GlnThr: 1.561 ± 0.032	2.226GlnVal: 2.226 ± 0.036	0.337GlnTrp: 0.337 ± 0.017	0.5GlnTyr: 0.5 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.415ArgAla: 8.415 ± 0.081	0.511ArgCys: 0.511 ± 0.02	4.632ArgAsp: 4.632 ± 0.062	4.335ArgGlu: 4.335 ± 0.059	2.912ArgPhe: 2.912 ± 0.051	4.953ArgGly: 4.953 ± 0.065	1.741ArgHis: 1.741 ± 0.042	4.168ArgIle: 4.168 ± 0.062	2.151ArgLys: 2.151 ± 0.044	8.281ArgLeu: 8.281 ± 0.106	2.096ArgMet: 2.096 ± 0.036	1.806ArgAsn: 1.806 ± 0.038	3.877ArgPro: 3.877 ± 0.057	2.283ArgGln: 2.283 ± 0.048	6.092ArgArg: 6.092 ± 0.087	3.72ArgSer: 3.72 ± 0.058	3.784ArgThr: 3.784 ± 0.058	5.293ArgVal: 5.293 ± 0.069	1.028ArgTrp: 1.028 ± 0.03	1.588ArgTyr: 1.588 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.795SerAla: 5.795 ± 0.067	0.419SerCys: 0.419 ± 0.022	3.422SerAsp: 3.422 ± 0.055	3.141SerGlu: 3.141 ± 0.05	2.18SerPhe: 2.18 ± 0.046	5.486SerGly: 5.486 ± 0.07	1.066SerHis: 1.066 ± 0.031	2.476SerIle: 2.476 ± 0.044	1.366SerLys: 1.366 ± 0.033	5.34SerLeu: 5.34 ± 0.067	1.32SerMet: 1.32 ± 0.038	1.225SerAsn: 1.225 ± 0.033	2.68SerPro: 2.68 ± 0.046	1.432SerGln: 1.432 ± 0.038	3.802SerArg: 3.802 ± 0.062	2.768SerSer: 2.768 ± 0.057	2.64SerThr: 2.64 ± 0.05	4.091SerVal: 4.091 ± 0.066	0.702SerTrp: 0.702 ± 0.022	1.212SerTyr: 1.212 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.227ThrAla: 6.227 ± 0.068	0.487ThrCys: 0.487 ± 0.02	3.356ThrAsp: 3.356 ± 0.054	3.14ThrGlu: 3.14 ± 0.045	2.162ThrPhe: 2.162 ± 0.041	5.537ThrGly: 5.537 ± 0.064	1.099ThrHis: 1.099 ± 0.031	2.637ThrIle: 2.637 ± 0.047	1.245ThrLys: 1.245 ± 0.033	6.266ThrLeu: 6.266 ± 0.081	1.273ThrMet: 1.273 ± 0.03	1.212ThrAsn: 1.212 ± 0.037	3.425ThrPro: 3.425 ± 0.059	1.391ThrGln: 1.391 ± 0.033	3.797ThrArg: 3.797 ± 0.057	2.834ThrSer: 2.834 ± 0.049	2.868ThrThr: 2.868 ± 0.053	4.601ThrVal: 4.601 ± 0.06	0.803ThrTrp: 0.803 ± 0.027	1.269ThrTyr: 1.269 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.642ValAla: 9.642 ± 0.094	0.649ValCys: 0.649 ± 0.021	4.195ValAsp: 4.195 ± 0.064	4.961ValGlu: 4.961 ± 0.066	2.933ValPhe: 2.933 ± 0.047	5.835ValGly: 5.835 ± 0.065	1.373ValHis: 1.373 ± 0.039	4.05ValIle: 4.05 ± 0.063	1.93ValLys: 1.93 ± 0.045	7.893ValLeu: 7.893 ± 0.09	2.052ValMet: 2.052 ± 0.037	1.825ValAsn: 1.825 ± 0.038	3.921ValPro: 3.921 ± 0.058	1.916ValGln: 1.916 ± 0.039	5.248ValArg: 5.248 ± 0.075	4.578ValSer: 4.578 ± 0.055	5.183ValThr: 5.183 ± 0.069	6.188ValVal: 6.188 ± 0.083	1.095ValTrp: 1.095 ± 0.033	1.527ValTyr: 1.527 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.402TrpAla: 1.402 ± 0.038	0.143TrpCys: 0.143 ± 0.01	0.795TrpAsp: 0.795 ± 0.026	0.726TrpGlu: 0.726 ± 0.023	0.598TrpPhe: 0.598 ± 0.023	1.085TrpGly: 1.085 ± 0.031	0.372TrpHis: 0.372 ± 0.016	0.808TrpIle: 0.808 ± 0.027	0.453TrpLys: 0.453 ± 0.02	1.718TrpLeu: 1.718 ± 0.035	0.422TrpMet: 0.422 ± 0.017	0.446TrpAsn: 0.446 ± 0.019	0.746TrpPro: 0.746 ± 0.024	0.503TrpGln: 0.503 ± 0.018	1.192TrpArg: 1.192 ± 0.029	0.862TrpSer: 0.862 ± 0.027	0.938TrpThr: 0.938 ± 0.033	0.922TrpVal: 0.922 ± 0.024	0.255TrpTrp: 0.255 ± 0.015	0.276TrpTyr: 0.276 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.435TyrAla: 2.435 ± 0.042	0.214TyrCys: 0.214 ± 0.013	1.566TyrAsp: 1.566 ± 0.036	1.249TyrGlu: 1.249 ± 0.035	0.836TyrPhe: 0.836 ± 0.023	2.076TyrGly: 2.076 ± 0.042	0.48TyrHis: 0.48 ± 0.02	0.824TyrIle: 0.824 ± 0.023	0.466TyrLys: 0.466 ± 0.02	2.161TyrLeu: 2.161 ± 0.046	0.447TyrMet: 0.447 ± 0.018	0.5TyrAsn: 0.5 ± 0.019	1.049TyrPro: 1.049 ± 0.028	0.571TyrGln: 0.571 ± 0.021	1.615TyrArg: 1.615 ± 0.037	1.124TyrSer: 1.124 ± 0.029	1.018TyrThr: 1.018 ± 0.029	1.56TyrVal: 1.56 ± 0.032	0.368TyrTrp: 0.368 ± 0.019	0.531TyrTyr: 0.531 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4315 proteins (1295017 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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