Amino acid dipepetide frequency for Collimonas fungivorans (strain Ter331)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.75AlaAla: 16.75 ± 0.168
1.161AlaCys: 1.161 ± 0.029
6.279AlaAsp: 6.279 ± 0.08
5.908AlaGlu: 5.908 ± 0.083
3.771AlaPhe: 3.771 ± 0.053
10.127AlaGly: 10.127 ± 0.123
2.277AlaHis: 2.277 ± 0.043
6.109AlaIle: 6.109 ± 0.075
4.36AlaLys: 4.36 ± 0.073
12.806AlaLeu: 12.806 ± 0.123
3.136AlaMet: 3.136 ± 0.047
3.447AlaAsn: 3.447 ± 0.066
5.235AlaPro: 5.235 ± 0.073
5.272AlaGln: 5.272 ± 0.071
6.583AlaArg: 6.583 ± 0.077
7.072AlaSer: 7.072 ± 0.117
5.827AlaThr: 5.827 ± 0.08
8.112AlaVal: 8.112 ± 0.102
1.424AlaTrp: 1.424 ± 0.033
2.744AlaTyr: 2.744 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.059CysAla: 1.059 ± 0.029
0.157CysCys: 0.157 ± 0.01
0.498CysAsp: 0.498 ± 0.019
0.416CysGlu: 0.416 ± 0.018
0.322CysPhe: 0.322 ± 0.015
0.958CysGly: 0.958 ± 0.027
0.247CysHis: 0.247 ± 0.014
0.433CysIle: 0.433 ± 0.016
0.271CysLys: 0.271 ± 0.014
0.88CysLeu: 0.88 ± 0.025
0.22CysMet: 0.22 ± 0.012
0.293CysAsn: 0.293 ± 0.014
0.417CysPro: 0.417 ± 0.018
0.316CysGln: 0.316 ± 0.016
0.6CysArg: 0.6 ± 0.022
0.586CysSer: 0.586 ± 0.019
0.452CysThr: 0.452 ± 0.017
0.642CysVal: 0.642 ± 0.021
0.115CysTrp: 0.115 ± 0.008
0.24CysTyr: 0.24 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.183AspAla: 6.183 ± 0.084
0.484AspCys: 0.484 ± 0.019
2.715AspAsp: 2.715 ± 0.062
2.643AspGlu: 2.643 ± 0.055
2.167AspPhe: 2.167 ± 0.041
4.586AspGly: 4.586 ± 0.066
1.085AspHis: 1.085 ± 0.027
2.912AspIle: 2.912 ± 0.043
2.156AspLys: 2.156 ± 0.044
4.987AspLeu: 4.987 ± 0.066
1.226AspMet: 1.226 ± 0.032
1.703AspAsn: 1.703 ± 0.042
2.646AspPro: 2.646 ± 0.042
2.019AspGln: 2.019 ± 0.038
2.941AspArg: 2.941 ± 0.047
2.858AspSer: 2.858 ± 0.049
2.476AspThr: 2.476 ± 0.052
3.536AspVal: 3.536 ± 0.049
0.831AspTrp: 0.831 ± 0.026
1.577AspTyr: 1.577 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
5.295GluAla: 5.295 ± 0.077
0.393GluCys: 0.393 ± 0.016
2.025GluAsp: 2.025 ± 0.04
2.336GluGlu: 2.336 ± 0.056
1.864GluPhe: 1.864 ± 0.041
2.895GluGly: 2.895 ± 0.046
1.234GluHis: 1.234 ± 0.032
3.208GluIle: 3.208 ± 0.056
2.284GluLys: 2.284 ± 0.053
5.384GluLeu: 5.384 ± 0.084
1.294GluMet: 1.294 ± 0.033
1.714GluAsn: 1.714 ± 0.039
1.973GluPro: 1.973 ± 0.037
2.89GluGln: 2.89 ± 0.051
3.602GluArg: 3.602 ± 0.062
2.484GluSer: 2.484 ± 0.048
2.558GluThr: 2.558 ± 0.043
3.353GluVal: 3.353 ± 0.061
0.624GluTrp: 0.624 ± 0.021
1.216GluTyr: 1.216 ± 0.032
0.001GluXaa: 0.001 ± 0.001
Phe
4.06PheAla: 4.06 ± 0.064
0.444PheCys: 0.444 ± 0.018
2.497PheAsp: 2.497 ± 0.047
1.897PheGlu: 1.897 ± 0.043
1.597PhePhe: 1.597 ± 0.036
3.522PheGly: 3.522 ± 0.056
0.87PheHis: 0.87 ± 0.024
1.891PheIle: 1.891 ± 0.041
1.428PheLys: 1.428 ± 0.034
3.344PheLeu: 3.344 ± 0.059
0.891PheMet: 0.891 ± 0.022
1.43PheAsn: 1.43 ± 0.035
1.592PhePro: 1.592 ± 0.037
1.242PheGln: 1.242 ± 0.028
1.851PheArg: 1.851 ± 0.038
2.803PheSer: 2.803 ± 0.05
2.009PheThr: 2.009 ± 0.046
2.595PheVal: 2.595 ± 0.049
0.532PheTrp: 0.532 ± 0.02
1.089PheTyr: 1.089 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.452GlyAla: 8.452 ± 0.105
0.808GlyCys: 0.808 ± 0.025
3.839GlyAsp: 3.839 ± 0.058
3.721GlyGlu: 3.721 ± 0.062
3.401GlyPhe: 3.401 ± 0.056
6.725GlyGly: 6.725 ± 0.125
1.722GlyHis: 1.722 ± 0.035
4.62GlyIle: 4.62 ± 0.07
4.138GlyLys: 4.138 ± 0.062
8.338GlyLeu: 8.338 ± 0.117
2.169GlyMet: 2.169 ± 0.044
2.983GlyAsn: 2.983 ± 0.082
2.577GlyPro: 2.577 ± 0.051
3.359GlyGln: 3.359 ± 0.054
4.506GlyArg: 4.506 ± 0.066
5.336GlySer: 5.336 ± 0.103
4.075GlyThr: 4.075 ± 0.098
6.061GlyVal: 6.061 ± 0.074
1.27GlyTrp: 1.27 ± 0.032
2.401GlyTyr: 2.401 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.544HisAla: 2.544 ± 0.048
0.27HisCys: 0.27 ± 0.014
1.173HisAsp: 1.173 ± 0.031
0.977HisGlu: 0.977 ± 0.025
0.943HisPhe: 0.943 ± 0.026
2.022HisGly: 2.022 ± 0.044
0.703HisHis: 0.703 ± 0.026
1.127HisIle: 1.127 ± 0.027
0.705HisLys: 0.705 ± 0.022
2.166HisLeu: 2.166 ± 0.044
0.534HisMet: 0.534 ± 0.02
0.634HisAsn: 0.634 ± 0.023
1.322HisPro: 1.322 ± 0.03
0.933HisGln: 0.933 ± 0.028
1.333HisArg: 1.333 ± 0.037
1.125HisSer: 1.125 ± 0.03
1.001HisThr: 1.001 ± 0.024
1.437HisVal: 1.437 ± 0.031
0.374HisTrp: 0.374 ± 0.016
0.684HisTyr: 0.684 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.913IleAla: 6.913 ± 0.09
0.524IleCys: 0.524 ± 0.018
3.391IleAsp: 3.391 ± 0.052
3.164IleGlu: 3.164 ± 0.05
1.757IlePhe: 1.757 ± 0.044
4.96IleGly: 4.96 ± 0.07
0.995IleHis: 0.995 ± 0.029
2.218IleIle: 2.218 ± 0.048
2.162IleLys: 2.162 ± 0.05
4.512IleLeu: 4.512 ± 0.067
1.11IleMet: 1.11 ± 0.027
1.855IleAsn: 1.855 ± 0.041
2.433IlePro: 2.433 ± 0.046
1.705IleGln: 1.705 ± 0.036
2.849IleArg: 2.849 ± 0.045
3.429IleSer: 3.429 ± 0.05
2.815IleThr: 2.815 ± 0.053
3.922IleVal: 3.922 ± 0.057
0.583IleTrp: 0.583 ± 0.022
1.332IleTyr: 1.332 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.15LysAla: 4.15 ± 0.066
0.204LysCys: 0.204 ± 0.012
2.059LysAsp: 2.059 ± 0.047
1.888LysGlu: 1.888 ± 0.044
1.265LysPhe: 1.265 ± 0.029
2.546LysGly: 2.546 ± 0.046
0.803LysHis: 0.803 ± 0.022
2.42LysIle: 2.42 ± 0.045
2.0LysLys: 2.0 ± 0.053
4.306LysLeu: 4.306 ± 0.068
1.168LysMet: 1.168 ± 0.026
1.553LysAsn: 1.553 ± 0.041
2.319LysPro: 2.319 ± 0.051
1.836LysGln: 1.836 ± 0.041
2.364LysArg: 2.364 ± 0.043
2.328LysSer: 2.328 ± 0.043
2.376LysThr: 2.376 ± 0.046
2.697LysVal: 2.697 ± 0.045
0.409LysTrp: 0.409 ± 0.018
0.92LysTyr: 0.92 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
13.264LeuAla: 13.264 ± 0.126
1.009LeuCys: 1.009 ± 0.028
5.458LeuAsp: 5.458 ± 0.064
5.033LeuGlu: 5.033 ± 0.077
3.868LeuPhe: 3.868 ± 0.074
7.985LeuGly: 7.985 ± 0.087
2.308LeuHis: 2.308 ± 0.041
4.993LeuIle: 4.993 ± 0.075
4.091LeuLys: 4.091 ± 0.06
11.444LeuLeu: 11.444 ± 0.151
2.419LeuMet: 2.419 ± 0.044
3.397LeuAsn: 3.397 ± 0.058
5.939LeuPro: 5.939 ± 0.072
4.65LeuGln: 4.65 ± 0.065
6.453LeuArg: 6.453 ± 0.08
7.271LeuSer: 7.271 ± 0.264
5.493LeuThr: 5.493 ± 0.07
7.038LeuVal: 7.038 ± 0.085
1.183LeuTrp: 1.183 ± 0.036
2.266LeuTyr: 2.266 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.733MetAla: 2.733 ± 0.051
0.179MetCys: 0.179 ± 0.011
1.045MetAsp: 1.045 ± 0.027
1.049MetGlu: 1.049 ± 0.03
0.807MetPhe: 0.807 ± 0.022
1.653MetGly: 1.653 ± 0.034
0.592MetHis: 0.592 ± 0.02
1.216MetIle: 1.216 ± 0.026
1.138MetLys: 1.138 ± 0.029
2.811MetLeu: 2.811 ± 0.04
0.708MetMet: 0.708 ± 0.024
0.956MetAsn: 0.956 ± 0.023
1.474MetPro: 1.474 ± 0.027
1.344MetGln: 1.344 ± 0.031
1.638MetArg: 1.638 ± 0.039
1.724MetSer: 1.724 ± 0.04
1.61MetThr: 1.61 ± 0.035
1.635MetVal: 1.635 ± 0.034
0.213MetTrp: 0.213 ± 0.014
0.469MetTyr: 0.469 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.699AsnAla: 3.699 ± 0.073
0.311AsnCys: 0.311 ± 0.016
1.677AsnAsp: 1.677 ± 0.04
1.278AsnGlu: 1.278 ± 0.031
1.214AsnPhe: 1.214 ± 0.03
3.015AsnGly: 3.015 ± 0.069
0.672AsnHis: 0.672 ± 0.019
1.845AsnIle: 1.845 ± 0.044
1.209AsnLys: 1.209 ± 0.032
3.33AsnLeu: 3.33 ± 0.055
0.787AsnMet: 0.787 ± 0.023
1.322AsnAsn: 1.322 ± 0.046
2.106AsnPro: 2.106 ± 0.04
1.36AsnGln: 1.36 ± 0.038
1.852AsnArg: 1.852 ± 0.039
2.063AsnSer: 2.063 ± 0.103
1.938AsnThr: 1.938 ± 0.046
2.424AsnVal: 2.424 ± 0.099
0.521AsnTrp: 0.521 ± 0.022
0.985AsnTyr: 0.985 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.467ProAla: 6.467 ± 0.075
0.326ProCys: 0.326 ± 0.014
2.87ProAsp: 2.87 ± 0.043
2.867ProGlu: 2.867 ± 0.043
1.821ProPhe: 1.821 ± 0.033
3.895ProGly: 3.895 ± 0.055
1.115ProHis: 1.115 ± 0.031
2.058ProIle: 2.058 ± 0.046
1.638ProLys: 1.638 ± 0.035
5.116ProLeu: 5.116 ± 0.075
1.132ProMet: 1.132 ± 0.027
1.439ProAsn: 1.439 ± 0.035
2.23ProPro: 2.23 ± 0.051
2.302ProGln: 2.302 ± 0.045
2.196ProArg: 2.196 ± 0.042
2.774ProSer: 2.774 ± 0.043
2.319ProThr: 2.319 ± 0.049
3.768ProVal: 3.768 ± 0.053
0.594ProTrp: 0.594 ± 0.021
1.218ProTyr: 1.218 ± 0.03
0.001ProXaa: 0.001 ± 0.001
Gln
5.713GlnAla: 5.713 ± 0.068
0.324GlnCys: 0.324 ± 0.016
1.928GlnAsp: 1.928 ± 0.035
1.999GlnGlu: 1.999 ± 0.042
1.564GlnPhe: 1.564 ± 0.037
3.005GlnGly: 3.005 ± 0.051
1.15GlnHis: 1.15 ± 0.034
2.346GlnIle: 2.346 ± 0.042
1.574GlnLys: 1.574 ± 0.036
4.881GlnLeu: 4.881 ± 0.065
1.061GlnMet: 1.061 ± 0.03
1.28GlnAsn: 1.28 ± 0.032
2.226GlnPro: 2.226 ± 0.041
2.82GlnGln: 2.82 ± 0.058
3.21GlnArg: 3.21 ± 0.06
2.296GlnSer: 2.296 ± 0.042
2.142GlnThr: 2.142 ± 0.039
3.191GlnVal: 3.191 ± 0.049
0.536GlnTrp: 0.536 ± 0.019
1.018GlnTyr: 1.018 ± 0.03
0.001GlnXaa: 0.001 ± 0.001
Arg
5.628ArgAla: 5.628 ± 0.075
0.499ArgCys: 0.499 ± 0.017
2.995ArgAsp: 2.995 ± 0.046
3.076ArgGlu: 3.076 ± 0.051
2.527ArgPhe: 2.527 ± 0.041
3.759ArgGly: 3.759 ± 0.062
1.69ArgHis: 1.69 ± 0.049
3.551ArgIle: 3.551 ± 0.058
2.334ArgLys: 2.334 ± 0.044
6.633ArgLeu: 6.633 ± 0.081
1.627ArgMet: 1.627 ± 0.033
1.98ArgAsn: 1.98 ± 0.036
2.576ArgPro: 2.576 ± 0.052
3.179ArgGln: 3.179 ± 0.058
4.114ArgArg: 4.114 ± 0.066
3.508ArgSer: 3.508 ± 0.051
2.675ArgThr: 2.675 ± 0.045
3.805ArgVal: 3.805 ± 0.053
0.873ArgTrp: 0.873 ± 0.024
1.782ArgTyr: 1.782 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.104SerAla: 7.104 ± 0.094
0.535SerCys: 0.535 ± 0.021
3.085SerAsp: 3.085 ± 0.056
2.697SerGlu: 2.697 ± 0.044
2.399SerPhe: 2.399 ± 0.038
5.965SerGly: 5.965 ± 0.093
1.343SerHis: 1.343 ± 0.028
3.111SerIle: 3.111 ± 0.041
2.305SerLys: 2.305 ± 0.047
6.453SerLeu: 6.453 ± 0.159
1.493SerMet: 1.493 ± 0.029
2.26SerAsn: 2.26 ± 0.101
2.759SerPro: 2.759 ± 0.044
2.306SerGln: 2.306 ± 0.045
3.352SerArg: 3.352 ± 0.052
4.189SerSer: 4.189 ± 0.11
4.068SerThr: 4.068 ± 0.463
4.16SerVal: 4.16 ± 0.064
0.899SerTrp: 0.899 ± 0.027
1.735SerTyr: 1.735 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.993ThrAla: 5.993 ± 0.095
0.419ThrCys: 0.419 ± 0.016
2.493ThrAsp: 2.493 ± 0.053
2.368ThrGlu: 2.368 ± 0.042
1.847ThrPhe: 1.847 ± 0.036
4.664ThrGly: 4.664 ± 0.177
1.019ThrHis: 1.019 ± 0.024
2.861ThrIle: 2.861 ± 0.051
1.572ThrLys: 1.572 ± 0.039
6.163ThrLeu: 6.163 ± 0.068
1.295ThrMet: 1.295 ± 0.026
1.66ThrAsn: 1.66 ± 0.095
3.261ThrPro: 3.261 ± 0.054
1.948ThrGln: 1.948 ± 0.038
2.765ThrArg: 2.765 ± 0.042
3.498ThrSer: 3.498 ± 0.262
3.035ThrThr: 3.035 ± 0.098
4.243ThrVal: 4.243 ± 0.067
0.573ThrTrp: 0.573 ± 0.021
1.27ThrTyr: 1.27 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.678ValAla: 8.678 ± 0.095
0.668ValCys: 0.668 ± 0.022
3.734ValAsp: 3.734 ± 0.06
3.663ValGlu: 3.663 ± 0.061
2.74ValPhe: 2.74 ± 0.042
5.222ValGly: 5.222 ± 0.079
1.326ValHis: 1.326 ± 0.03
3.904ValIle: 3.904 ± 0.055
2.815ValLys: 2.815 ± 0.045
7.419ValLeu: 7.419 ± 0.085
1.833ValMet: 1.833 ± 0.037
2.393ValAsn: 2.393 ± 0.049
3.189ValPro: 3.189 ± 0.05
2.66ValGln: 2.66 ± 0.041
3.881ValArg: 3.881 ± 0.054
4.525ValSer: 4.525 ± 0.077
4.104ValThr: 4.104 ± 0.069
5.496ValVal: 5.496 ± 0.078
0.815ValTrp: 0.815 ± 0.026
1.576ValTyr: 1.576 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.016TrpAla: 1.016 ± 0.023
0.142TrpCys: 0.142 ± 0.009
0.592TrpAsp: 0.592 ± 0.022
0.51TrpGlu: 0.51 ± 0.021
0.526TrpPhe: 0.526 ± 0.019
0.827TrpGly: 0.827 ± 0.027
0.336TrpHis: 0.336 ± 0.016
0.725TrpIle: 0.725 ± 0.023
0.503TrpLys: 0.503 ± 0.02
1.832TrpLeu: 1.832 ± 0.046
0.373TrpMet: 0.373 ± 0.015
0.485TrpAsn: 0.485 ± 0.017
0.584TrpPro: 0.584 ± 0.02
0.852TrpGln: 0.852 ± 0.027
0.992TrpArg: 0.992 ± 0.03
0.778TrpSer: 0.778 ± 0.027
0.604TrpThr: 0.604 ± 0.023
0.778TrpVal: 0.778 ± 0.026
0.213TrpTrp: 0.213 ± 0.013
0.322TrpTyr: 0.322 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.699TyrAla: 2.699 ± 0.038
0.265TyrCys: 0.265 ± 0.013
1.378TyrAsp: 1.378 ± 0.036
1.134TyrGlu: 1.134 ± 0.032
1.184TyrPhe: 1.184 ± 0.024
2.167TyrGly: 2.167 ± 0.036
0.517TyrHis: 0.517 ± 0.019
1.079TyrIle: 1.079 ± 0.029
0.93TyrLys: 0.93 ± 0.028
2.761TyrLeu: 2.761 ± 0.05
0.52TyrMet: 0.52 ± 0.02
0.823TyrAsn: 0.823 ± 0.027
1.286TyrPro: 1.286 ± 0.027
1.276TyrGln: 1.276 ± 0.034
1.728TyrArg: 1.728 ± 0.034
1.574TyrSer: 1.574 ± 0.04
1.368TyrThr: 1.368 ± 0.032
1.747TyrVal: 1.747 ± 0.033
0.407TyrTrp: 0.407 ± 0.018
0.761TyrTyr: 0.761 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.001XaaMet: 0.001 ± 0.001
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 4429 proteins (1527625 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski