Amino acid dipepetide frequency for Human papillomavirus 45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.719AlaAla: 5.719 ± 1.118
1.76AlaCys: 1.76 ± 1.07
4.839AlaAsp: 4.839 ± 1.37
3.52AlaGlu: 3.52 ± 1.527
2.64AlaPhe: 2.64 ± 1.217
3.08AlaGly: 3.08 ± 1.182
1.76AlaHis: 1.76 ± 0.685
2.2AlaIle: 2.2 ± 0.808
2.64AlaLys: 2.64 ± 1.37
4.399AlaLeu: 4.399 ± 1.206
1.76AlaMet: 1.76 ± 0.593
1.32AlaAsn: 1.32 ± 0.352
0.44AlaPro: 0.44 ± 0.424
3.96AlaGln: 3.96 ± 1.377
3.08AlaArg: 3.08 ± 1.3
5.279AlaSer: 5.279 ± 1.983
5.719AlaThr: 5.719 ± 1.633
2.64AlaVal: 2.64 ± 0.935
0.44AlaTrp: 0.44 ± 0.424
1.32AlaTyr: 1.32 ± 0.564
0.0AlaXaa: 0.0 ± 0.0
Cys
1.32CysAla: 1.32 ± 0.665
0.88CysCys: 0.88 ± 0.918
0.88CysAsp: 0.88 ± 0.918
1.76CysGlu: 1.76 ± 0.752
0.88CysPhe: 0.88 ± 0.443
0.88CysGly: 0.88 ± 0.443
0.44CysHis: 0.44 ± 0.506
2.2CysIle: 2.2 ± 1.43
2.64CysLys: 2.64 ± 0.841
1.76CysLeu: 1.76 ± 0.575
0.88CysMet: 0.88 ± 0.443
2.2CysAsn: 2.2 ± 0.98
1.76CysPro: 1.76 ± 0.658
1.76CysGln: 1.76 ± 0.747
0.44CysArg: 0.44 ± 0.336
2.64CysSer: 2.64 ± 1.328
1.32CysThr: 1.32 ± 0.545
3.08CysVal: 3.08 ± 1.089
0.88CysTrp: 0.88 ± 0.435
0.44CysTyr: 0.44 ± 0.674
0.0CysXaa: 0.0 ± 0.0
Asp
1.32AspAla: 1.32 ± 1.007
2.64AspCys: 2.64 ± 0.892
4.399AspAsp: 4.399 ± 0.801
2.64AspGlu: 2.64 ± 1.601
2.64AspPhe: 2.64 ± 0.973
3.52AspGly: 3.52 ± 1.172
0.88AspHis: 0.88 ± 0.847
3.08AspIle: 3.08 ± 1.359
3.52AspLys: 3.52 ± 0.734
6.159AspLeu: 6.159 ± 1.335
1.76AspMet: 1.76 ± 0.987
3.08AspAsn: 3.08 ± 0.976
4.839AspPro: 4.839 ± 1.071
0.88AspGln: 0.88 ± 0.553
0.44AspArg: 0.44 ± 0.336
6.159AspSer: 6.159 ± 1.004
7.479AspThr: 7.479 ± 2.22
3.52AspVal: 3.52 ± 1.35
0.88AspTrp: 0.88 ± 0.671
1.32AspTyr: 1.32 ± 1.1
0.0AspXaa: 0.0 ± 0.0
Glu
0.88GluAla: 0.88 ± 0.652
0.44GluCys: 0.44 ± 0.424
2.2GluAsp: 2.2 ± 0.824
3.08GluGlu: 3.08 ± 1.618
0.88GluPhe: 0.88 ± 0.671
2.64GluGly: 2.64 ± 1.556
0.88GluHis: 0.88 ± 0.489
3.52GluIle: 3.52 ± 0.979
3.08GluLys: 3.08 ± 1.192
4.839GluLeu: 4.839 ± 1.968
0.0GluMet: 0.0 ± 0.0
3.08GluAsn: 3.08 ± 0.909
3.96GluPro: 3.96 ± 1.932
2.64GluGln: 2.64 ± 0.84
1.76GluArg: 1.76 ± 1.068
2.64GluSer: 2.64 ± 1.184
4.399GluThr: 4.399 ± 1.556
4.399GluVal: 4.399 ± 0.423
0.88GluTrp: 0.88 ± 0.443
0.44GluTyr: 0.44 ± 0.367
0.0GluXaa: 0.0 ± 0.0
Phe
2.2PheAla: 2.2 ± 0.67
0.44PheCys: 0.44 ± 0.367
3.52PheAsp: 3.52 ± 1.104
1.32PheGlu: 1.32 ± 0.775
1.76PhePhe: 1.76 ± 0.537
2.2PheGly: 2.2 ± 1.097
0.88PheHis: 0.88 ± 0.551
1.76PheIle: 1.76 ± 0.987
3.52PheLys: 3.52 ± 1.212
5.279PheLeu: 5.279 ± 0.961
0.44PheMet: 0.44 ± 0.424
0.44PheAsn: 0.44 ± 0.367
2.2PhePro: 2.2 ± 0.684
0.88PheGln: 0.88 ± 0.435
1.32PheArg: 1.32 ± 0.934
1.76PheSer: 1.76 ± 0.859
3.52PheThr: 3.52 ± 1.466
3.08PheVal: 3.08 ± 0.812
1.32PheTrp: 1.32 ± 0.731
1.76PheTyr: 1.76 ± 0.712
0.0PheXaa: 0.0 ± 0.0
Gly
1.76GlyAla: 1.76 ± 0.583
1.76GlyCys: 1.76 ± 0.618
4.399GlyAsp: 4.399 ± 1.543
2.2GlyGlu: 2.2 ± 0.542
1.32GlyPhe: 1.32 ± 0.775
4.399GlyGly: 4.399 ± 1.513
1.76GlyHis: 1.76 ± 1.072
5.279GlyIle: 5.279 ± 0.802
1.76GlyLys: 1.76 ± 0.57
3.96GlyLeu: 3.96 ± 1.029
0.88GlyMet: 0.88 ± 0.435
3.96GlyAsn: 3.96 ± 1.307
3.08GlyPro: 3.08 ± 1.6
2.2GlyGln: 2.2 ± 0.879
2.64GlyArg: 2.64 ± 1.371
4.399GlySer: 4.399 ± 1.28
7.479GlyThr: 7.479 ± 2.87
3.08GlyVal: 3.08 ± 0.895
0.44GlyTrp: 0.44 ± 0.336
2.2GlyTyr: 2.2 ± 0.551
0.0GlyXaa: 0.0 ± 0.0
His
2.64HisAla: 2.64 ± 0.769
0.44HisCys: 0.44 ± 0.336
0.44HisAsp: 0.44 ± 0.424
0.44HisGlu: 0.44 ± 0.336
1.76HisPhe: 1.76 ± 0.537
2.64HisGly: 2.64 ± 0.741
0.44HisHis: 0.44 ± 0.424
0.88HisIle: 0.88 ± 0.443
2.2HisLys: 2.2 ± 0.671
1.76HisLeu: 1.76 ± 0.896
0.0HisMet: 0.0 ± 0.0
2.2HisAsn: 2.2 ± 1.177
0.88HisPro: 0.88 ± 0.43
0.44HisGln: 0.44 ± 0.424
0.88HisArg: 0.88 ± 0.847
1.32HisSer: 1.32 ± 0.545
0.88HisThr: 0.88 ± 0.421
1.76HisVal: 1.76 ± 0.752
0.88HisTrp: 0.88 ± 0.489
1.32HisTyr: 1.32 ± 0.799
0.0HisXaa: 0.0 ± 0.0
Ile
1.76IleAla: 1.76 ± 1.537
1.76IleCys: 1.76 ± 1.072
3.08IleAsp: 3.08 ± 1.573
3.08IleGlu: 3.08 ± 1.123
3.08IlePhe: 3.08 ± 1.218
3.08IleGly: 3.08 ± 1.488
1.76IleHis: 1.76 ± 0.267
4.839IleIle: 4.839 ± 1.283
1.76IleLys: 1.76 ± 0.618
4.839IleLeu: 4.839 ± 0.71
0.0IleMet: 0.0 ± 0.0
2.2IleAsn: 2.2 ± 0.938
1.76IlePro: 1.76 ± 0.749
1.76IleGln: 1.76 ± 0.951
2.2IleArg: 2.2 ± 1.027
7.039IleSer: 7.039 ± 2.282
3.96IleThr: 3.96 ± 0.778
2.64IleVal: 2.64 ± 0.863
0.44IleTrp: 0.44 ± 0.424
2.2IleTyr: 2.2 ± 0.462
0.0IleXaa: 0.0 ± 0.0
Lys
2.64LysAla: 2.64 ± 0.864
3.52LysCys: 3.52 ± 1.128
3.96LysAsp: 3.96 ± 1.456
2.2LysGlu: 2.2 ± 0.889
2.64LysPhe: 2.64 ± 1.785
3.08LysGly: 3.08 ± 1.161
0.44LysHis: 0.44 ± 0.336
1.76LysIle: 1.76 ± 0.614
3.08LysLys: 3.08 ± 0.976
2.2LysLeu: 2.2 ± 0.72
0.88LysMet: 0.88 ± 0.48
3.52LysAsn: 3.52 ± 1.236
2.2LysPro: 2.2 ± 0.846
3.08LysGln: 3.08 ± 1.295
5.719LysArg: 5.719 ± 0.811
2.64LysSer: 2.64 ± 0.93
3.52LysThr: 3.52 ± 1.523
1.76LysVal: 1.76 ± 0.267
0.88LysTrp: 0.88 ± 0.671
3.08LysTyr: 3.08 ± 0.959
0.0LysXaa: 0.0 ± 0.0
Leu
3.08LeuAla: 3.08 ± 1.434
3.96LeuCys: 3.96 ± 2.049
5.279LeuAsp: 5.279 ± 0.551
3.52LeuGlu: 3.52 ± 1.157
3.52LeuPhe: 3.52 ± 0.754
3.96LeuGly: 3.96 ± 1.766
2.64LeuHis: 2.64 ± 0.839
2.64LeuIle: 2.64 ± 0.853
6.599LeuLys: 6.599 ± 2.073
4.839LeuLeu: 4.839 ± 1.977
0.0LeuMet: 0.0 ± 0.322
1.76LeuAsn: 1.76 ± 1.068
3.08LeuPro: 3.08 ± 1.265
7.919LeuGln: 7.919 ± 1.34
5.279LeuArg: 5.279 ± 1.794
6.159LeuSer: 6.159 ± 1.858
5.719LeuThr: 5.719 ± 0.535
3.08LeuVal: 3.08 ± 0.773
1.32LeuTrp: 1.32 ± 0.478
3.08LeuTyr: 3.08 ± 0.803
0.0LeuXaa: 0.0 ± 0.0
Met
3.08MetAla: 3.08 ± 0.931
0.88MetCys: 0.88 ± 0.443
0.88MetAsp: 0.88 ± 0.43
0.44MetGlu: 0.44 ± 0.367
0.88MetPhe: 0.88 ± 0.43
0.44MetGly: 0.44 ± 0.367
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.44MetLys: 0.44 ± 0.424
1.32MetLeu: 1.32 ± 1.007
0.44MetMet: 0.44 ± 0.389
1.32MetAsn: 1.32 ± 0.445
0.44MetPro: 0.44 ± 0.424
0.44MetGln: 0.44 ± 0.424
0.88MetArg: 0.88 ± 0.435
1.76MetSer: 1.76 ± 0.87
0.44MetThr: 0.44 ± 0.424
1.76MetVal: 1.76 ± 0.537
0.44MetTrp: 0.44 ± 0.424
0.44MetTyr: 0.44 ± 0.674
0.0MetXaa: 0.0 ± 0.0
Asn
2.64AsnAla: 2.64 ± 1.12
1.32AsnCys: 1.32 ± 0.662
2.64AsnAsp: 2.64 ± 1.036
0.88AsnGlu: 0.88 ± 0.761
1.32AsnPhe: 1.32 ± 0.685
2.2AsnGly: 2.2 ± 1.097
0.44AsnHis: 0.44 ± 0.424
2.64AsnIle: 2.64 ± 0.502
4.839AsnLys: 4.839 ± 1.066
0.88AsnLeu: 0.88 ± 0.553
0.88AsnMet: 0.88 ± 0.435
1.32AsnAsn: 1.32 ± 0.839
4.399AsnPro: 4.399 ± 0.507
1.32AsnGln: 1.32 ± 0.797
0.88AsnArg: 0.88 ± 0.435
5.279AsnSer: 5.279 ± 2.085
6.599AsnThr: 6.599 ± 2.409
3.08AsnVal: 3.08 ± 0.773
0.88AsnTrp: 0.88 ± 0.435
0.88AsnTyr: 0.88 ± 0.443
0.0AsnXaa: 0.0 ± 0.0
Pro
6.599ProAla: 6.599 ± 1.279
0.0ProCys: 0.0 ± 0.0
3.08ProAsp: 3.08 ± 1.244
2.2ProGlu: 2.2 ± 1.097
1.32ProPhe: 1.32 ± 0.685
1.32ProGly: 1.32 ± 1.1
0.88ProHis: 0.88 ± 0.671
3.96ProIle: 3.96 ± 0.888
3.96ProLys: 3.96 ± 0.977
7.039ProLeu: 7.039 ± 1.484
0.44ProMet: 0.44 ± 0.424
1.32ProAsn: 1.32 ± 0.754
6.159ProPro: 6.159 ± 1.943
1.76ProGln: 1.76 ± 2.106
1.76ProArg: 1.76 ± 0.267
5.279ProSer: 5.279 ± 2.603
5.719ProThr: 5.719 ± 2.908
2.64ProVal: 2.64 ± 1.222
0.88ProTrp: 0.88 ± 0.831
3.08ProTyr: 3.08 ± 1.182
0.0ProXaa: 0.0 ± 0.0
Gln
3.52GlnAla: 3.52 ± 1.269
1.76GlnCys: 1.76 ± 0.938
2.64GlnAsp: 2.64 ± 1.239
1.76GlnGlu: 1.76 ± 0.939
2.2GlnPhe: 2.2 ± 0.407
1.32GlnGly: 1.32 ± 0.685
1.32GlnHis: 1.32 ± 0.799
1.76GlnIle: 1.76 ± 1.269
1.32GlnLys: 1.32 ± 0.545
6.599GlnLeu: 6.599 ± 2.3
2.2GlnMet: 2.2 ± 0.752
1.76GlnAsn: 1.76 ± 0.762
1.32GlnPro: 1.32 ± 0.677
0.88GlnGln: 0.88 ± 0.831
2.64GlnArg: 2.64 ± 0.744
2.2GlnSer: 2.2 ± 0.462
2.2GlnThr: 2.2 ± 0.957
2.2GlnVal: 2.2 ± 0.663
1.32GlnTrp: 1.32 ± 0.632
3.08GlnTyr: 3.08 ± 0.742
0.0GlnXaa: 0.0 ± 0.0
Arg
3.52ArgAla: 3.52 ± 1.496
1.32ArgCys: 1.32 ± 1.003
0.88ArgAsp: 0.88 ± 0.553
2.64ArgGlu: 2.64 ± 1.038
1.76ArgPhe: 1.76 ± 0.981
1.32ArgGly: 1.32 ± 0.564
2.2ArgHis: 2.2 ± 0.941
1.76ArgIle: 1.76 ± 0.95
3.52ArgLys: 3.52 ± 0.535
6.159ArgLeu: 6.159 ± 0.886
0.0ArgMet: 0.0 ± 0.0
1.32ArgAsn: 1.32 ± 0.662
4.399ArgPro: 4.399 ± 0.816
1.76ArgGln: 1.76 ± 0.938
6.159ArgArg: 6.159 ± 2.49
2.2ArgSer: 2.2 ± 0.71
2.64ArgThr: 2.64 ± 0.771
3.96ArgVal: 3.96 ± 1.585
0.0ArgTrp: 0.0 ± 0.0
1.76ArgTyr: 1.76 ± 0.768
0.0ArgXaa: 0.0 ± 0.0
Ser
4.399SerAla: 4.399 ± 1.497
0.44SerCys: 0.44 ± 0.367
6.159SerAsp: 6.159 ± 1.626
3.52SerGlu: 3.52 ± 1.834
3.52SerPhe: 3.52 ± 1.447
7.919SerGly: 7.919 ± 3.828
2.2SerHis: 2.2 ± 1.365
5.719SerIle: 5.719 ± 0.83
3.08SerLys: 3.08 ± 1.508
3.96SerLeu: 3.96 ± 0.893
1.32SerMet: 1.32 ± 0.754
5.719SerAsn: 5.719 ± 1.86
2.64SerPro: 2.64 ± 0.704
2.2SerGln: 2.2 ± 0.615
4.399SerArg: 4.399 ± 1.089
7.919SerSer: 7.919 ± 2.911
10.119SerThr: 10.119 ± 2.648
4.839SerVal: 4.839 ± 0.816
0.0SerTrp: 0.0 ± 0.0
2.2SerTyr: 2.2 ± 0.615
0.0SerXaa: 0.0 ± 0.0
Thr
3.96ThrAla: 3.96 ± 1.029
3.52ThrCys: 3.52 ± 0.603
4.839ThrAsp: 4.839 ± 1.632
4.839ThrGlu: 4.839 ± 1.603
2.64ThrPhe: 2.64 ± 1.085
6.599ThrGly: 6.599 ± 1.722
1.76ThrHis: 1.76 ± 0.761
3.96ThrIle: 3.96 ± 1.148
2.2ThrLys: 2.2 ± 0.873
7.039ThrLeu: 7.039 ± 1.982
1.32ThrMet: 1.32 ± 0.88
2.64ThrAsn: 2.64 ± 0.973
6.599ThrPro: 6.599 ± 2.284
4.399ThrGln: 4.399 ± 1.016
1.76ThrArg: 1.76 ± 0.647
7.919ThrSer: 7.919 ± 2.616
5.719ThrThr: 5.719 ± 2.374
7.919ThrVal: 7.919 ± 1.04
1.32ThrTrp: 1.32 ± 0.799
3.08ThrTyr: 3.08 ± 0.697
0.0ThrXaa: 0.0 ± 0.0
Val
3.96ValAla: 3.96 ± 1.057
1.32ValCys: 1.32 ± 1.373
4.839ValAsp: 4.839 ± 1.443
3.52ValGlu: 3.52 ± 1.088
1.76ValPhe: 1.76 ± 0.87
3.08ValGly: 3.08 ± 1.195
1.76ValHis: 1.76 ± 0.761
2.2ValIle: 2.2 ± 0.551
0.0ValLys: 0.0 ± 0.0
1.76ValLeu: 1.76 ± 0.792
2.2ValMet: 2.2 ± 0.832
2.64ValAsn: 2.64 ± 0.973
6.599ValPro: 6.599 ± 2.413
3.96ValGln: 3.96 ± 1.525
3.08ValArg: 3.08 ± 0.882
5.279ValSer: 5.279 ± 1.346
4.399ValThr: 4.399 ± 0.693
3.96ValVal: 3.96 ± 1.433
0.88ValTrp: 0.88 ± 0.489
4.399ValTyr: 4.399 ± 1.911
0.0ValXaa: 0.0 ± 0.0
Trp
1.32TrpAla: 1.32 ± 0.731
0.44TrpCys: 0.44 ± 0.674
0.88TrpAsp: 0.88 ± 0.545
0.88TrpGlu: 0.88 ± 0.847
0.44TrpPhe: 0.44 ± 0.336
0.88TrpGly: 0.88 ± 0.443
0.88TrpHis: 0.88 ± 0.489
0.88TrpIle: 0.88 ± 0.671
0.44TrpLys: 0.44 ± 0.336
0.88TrpLeu: 0.88 ± 0.435
0.0TrpMet: 0.0 ± 0.0
1.32TrpAsn: 1.32 ± 0.754
1.32TrpPro: 1.32 ± 0.775
0.44TrpGln: 0.44 ± 0.424
0.88TrpArg: 0.88 ± 0.435
0.88TrpSer: 0.88 ± 0.421
1.76TrpThr: 1.76 ± 0.752
0.44TrpVal: 0.44 ± 0.336
0.0TrpTrp: 0.0 ± 0.0
0.88TrpTyr: 0.88 ± 0.421
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.2TyrAla: 2.2 ± 0.663
0.44TyrCys: 0.44 ± 0.506
1.32TyrAsp: 1.32 ± 1.1
2.2TyrGlu: 2.2 ± 0.965
2.64TyrPhe: 2.64 ± 0.507
4.399TyrGly: 4.399 ± 1.064
0.88TyrHis: 0.88 ± 0.43
2.2TyrIle: 2.2 ± 0.869
2.2TyrLys: 2.2 ± 0.542
2.2TyrLeu: 2.2 ± 0.668
0.88TyrMet: 0.88 ± 0.443
2.2TyrAsn: 2.2 ± 1.047
1.32TyrPro: 1.32 ± 0.677
1.32TyrGln: 1.32 ± 0.545
3.08TyrArg: 3.08 ± 1.037
3.52TyrSer: 3.52 ± 1.314
0.44TyrThr: 0.44 ± 0.424
1.76TyrVal: 1.76 ± 0.794
1.76TyrTrp: 1.76 ± 0.752
3.08TyrTyr: 3.08 ± 1.7
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski