Amino acid dipepetide frequency for Xylella phage Xfas53

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.07AlaAla: 17.07 ± 1.454
1.481AlaCys: 1.481 ± 0.433
6.009AlaAsp: 6.009 ± 0.633
6.793AlaGlu: 6.793 ± 0.798
3.745AlaPhe: 3.745 ± 0.629
9.754AlaGly: 9.754 ± 0.931
3.658AlaHis: 3.658 ± 0.553
4.006AlaIle: 4.006 ± 0.632
5.138AlaLys: 5.138 ± 0.737
13.064AlaLeu: 13.064 ± 1.373
3.484AlaMet: 3.484 ± 0.499
2.874AlaAsn: 2.874 ± 0.457
6.271AlaPro: 6.271 ± 0.701
4.964AlaGln: 4.964 ± 1.102
7.403AlaArg: 7.403 ± 1.243
7.142AlaSer: 7.142 ± 0.99
6.793AlaThr: 6.793 ± 0.596
6.88AlaVal: 6.88 ± 0.715
1.829AlaTrp: 1.829 ± 0.413
3.135AlaTyr: 3.135 ± 0.482
0.0AlaXaa: 0.0 ± 0.0
Cys
1.568CysAla: 1.568 ± 0.482
0.174CysCys: 0.174 ± 0.107
0.348CysAsp: 0.348 ± 0.155
0.523CysGlu: 0.523 ± 0.24
0.523CysPhe: 0.523 ± 0.263
1.481CysGly: 1.481 ± 0.387
0.348CysHis: 0.348 ± 0.156
0.435CysIle: 0.435 ± 0.19
0.784CysLys: 0.784 ± 0.325
1.132CysLeu: 1.132 ± 0.318
0.348CysMet: 0.348 ± 0.151
0.435CysAsn: 0.435 ± 0.215
0.61CysPro: 0.61 ± 0.244
0.435CysGln: 0.435 ± 0.147
0.784CysArg: 0.784 ± 0.274
0.348CysSer: 0.348 ± 0.19
0.697CysThr: 0.697 ± 0.275
1.045CysVal: 1.045 ± 0.34
0.087CysTrp: 0.087 ± 0.091
0.348CysTyr: 0.348 ± 0.179
0.0CysXaa: 0.0 ± 0.0
Asp
7.403AspAla: 7.403 ± 0.77
0.435AspCys: 0.435 ± 0.16
2.526AspAsp: 2.526 ± 0.49
3.135AspGlu: 3.135 ± 0.407
1.829AspPhe: 1.829 ± 0.408
4.18AspGly: 4.18 ± 0.549
0.784AspHis: 0.784 ± 0.331
2.352AspIle: 2.352 ± 0.397
2.7AspLys: 2.7 ± 0.599
4.18AspLeu: 4.18 ± 0.612
1.393AspMet: 1.393 ± 0.272
1.568AspAsn: 1.568 ± 0.395
3.222AspPro: 3.222 ± 0.588
1.481AspGln: 1.481 ± 0.271
3.222AspArg: 3.222 ± 0.453
2.787AspSer: 2.787 ± 0.497
4.006AspThr: 4.006 ± 0.428
4.268AspVal: 4.268 ± 0.498
0.871AspTrp: 0.871 ± 0.23
1.568AspTyr: 1.568 ± 0.328
0.0AspXaa: 0.0 ± 0.0
Glu
7.925GluAla: 7.925 ± 0.847
0.871GluCys: 0.871 ± 0.305
2.7GluAsp: 2.7 ± 0.545
3.048GluGlu: 3.048 ± 0.528
1.829GluPhe: 1.829 ± 0.513
4.093GluGly: 4.093 ± 0.573
0.958GluHis: 0.958 ± 0.363
2.874GluIle: 2.874 ± 0.496
1.829GluLys: 1.829 ± 0.435
5.138GluLeu: 5.138 ± 0.688
1.045GluMet: 1.045 ± 0.284
1.306GluAsn: 1.306 ± 0.31
1.568GluPro: 1.568 ± 0.394
3.484GluGln: 3.484 ± 0.635
4.442GluArg: 4.442 ± 0.618
2.177GluSer: 2.177 ± 0.487
2.439GluThr: 2.439 ± 0.398
3.571GluVal: 3.571 ± 0.589
1.132GluTrp: 1.132 ± 0.335
1.393GluTyr: 1.393 ± 0.356
0.0GluXaa: 0.0 ± 0.0
Phe
3.397PheAla: 3.397 ± 0.571
0.261PheCys: 0.261 ± 0.116
2.439PheAsp: 2.439 ± 0.374
1.568PheGlu: 1.568 ± 0.487
1.132PhePhe: 1.132 ± 0.272
2.961PheGly: 2.961 ± 0.389
0.958PheHis: 0.958 ± 0.277
1.568PheIle: 1.568 ± 0.475
0.958PheLys: 0.958 ± 0.303
2.003PheLeu: 2.003 ± 0.431
0.61PheMet: 0.61 ± 0.167
1.306PheAsn: 1.306 ± 0.284
1.568PhePro: 1.568 ± 0.476
1.481PheGln: 1.481 ± 0.322
1.219PheArg: 1.219 ± 0.375
1.742PheSer: 1.742 ± 0.444
1.393PheThr: 1.393 ± 0.415
2.439PheVal: 2.439 ± 0.444
0.348PheTrp: 0.348 ± 0.144
1.393PheTyr: 1.393 ± 0.278
0.0PheXaa: 0.0 ± 0.0
Gly
8.361GlyAla: 8.361 ± 0.84
0.697GlyCys: 0.697 ± 0.269
3.31GlyAsp: 3.31 ± 0.4
4.703GlyGlu: 4.703 ± 0.555
2.177GlyPhe: 2.177 ± 0.366
6.706GlyGly: 6.706 ± 0.78
2.003GlyHis: 2.003 ± 0.396
2.7GlyIle: 2.7 ± 0.472
3.919GlyLys: 3.919 ± 0.681
5.922GlyLeu: 5.922 ± 0.656
2.177GlyMet: 2.177 ± 0.475
2.526GlyAsn: 2.526 ± 0.445
2.177GlyPro: 2.177 ± 0.371
3.397GlyGln: 3.397 ± 0.54
6.009GlyArg: 6.009 ± 0.781
3.919GlySer: 3.919 ± 0.94
5.4GlyThr: 5.4 ± 0.818
6.706GlyVal: 6.706 ± 0.585
0.784GlyTrp: 0.784 ± 0.29
2.961GlyTyr: 2.961 ± 0.537
0.0GlyXaa: 0.0 ± 0.0
His
2.613HisAla: 2.613 ± 0.403
0.523HisCys: 0.523 ± 0.238
1.393HisAsp: 1.393 ± 0.39
0.958HisGlu: 0.958 ± 0.266
0.697HisPhe: 0.697 ± 0.24
1.829HisGly: 1.829 ± 0.37
0.697HisHis: 0.697 ± 0.232
0.958HisIle: 0.958 ± 0.303
0.697HisLys: 0.697 ± 0.358
2.439HisLeu: 2.439 ± 0.377
0.348HisMet: 0.348 ± 0.162
0.958HisAsn: 0.958 ± 0.307
1.481HisPro: 1.481 ± 0.398
1.045HisGln: 1.045 ± 0.3
2.003HisArg: 2.003 ± 0.384
1.219HisSer: 1.219 ± 0.27
2.526HisThr: 2.526 ± 0.416
2.003HisVal: 2.003 ± 0.295
0.435HisTrp: 0.435 ± 0.182
0.697HisTyr: 0.697 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
5.922IleAla: 5.922 ± 0.609
0.784IleCys: 0.784 ± 0.226
2.264IleAsp: 2.264 ± 0.418
2.264IleGlu: 2.264 ± 0.436
0.261IlePhe: 0.261 ± 0.148
3.31IleGly: 3.31 ± 0.359
0.958IleHis: 0.958 ± 0.233
1.481IleIle: 1.481 ± 0.31
2.003IleLys: 2.003 ± 0.444
2.264IleLeu: 2.264 ± 0.34
0.435IleMet: 0.435 ± 0.156
1.306IleAsn: 1.306 ± 0.277
3.397IlePro: 3.397 ± 0.48
0.697IleGln: 0.697 ± 0.239
2.787IleArg: 2.787 ± 0.412
2.177IleSer: 2.177 ± 0.552
4.18IleThr: 4.18 ± 0.654
2.787IleVal: 2.787 ± 0.486
0.348IleTrp: 0.348 ± 0.145
0.784IleTyr: 0.784 ± 0.206
0.0IleXaa: 0.0 ± 0.0
Lys
6.096LysAla: 6.096 ± 0.935
0.348LysCys: 0.348 ± 0.151
1.568LysAsp: 1.568 ± 0.316
2.264LysGlu: 2.264 ± 0.523
1.132LysPhe: 1.132 ± 0.319
3.484LysGly: 3.484 ± 0.498
1.045LysHis: 1.045 ± 0.294
0.697LysIle: 0.697 ± 0.222
2.09LysLys: 2.09 ± 0.447
3.135LysLeu: 3.135 ± 0.379
1.045LysMet: 1.045 ± 0.3
1.655LysAsn: 1.655 ± 0.44
2.177LysPro: 2.177 ± 0.444
2.09LysGln: 2.09 ± 0.323
3.31LysArg: 3.31 ± 0.547
2.003LysSer: 2.003 ± 0.43
1.916LysThr: 1.916 ± 0.338
3.31LysVal: 3.31 ± 0.518
0.697LysTrp: 0.697 ± 0.218
0.784LysTyr: 0.784 ± 0.214
0.0LysXaa: 0.0 ± 0.0
Leu
10.974LeuAla: 10.974 ± 1.028
1.132LeuCys: 1.132 ± 0.312
3.919LeuAsp: 3.919 ± 0.571
4.79LeuGlu: 4.79 ± 0.583
2.003LeuPhe: 2.003 ± 0.42
5.835LeuGly: 5.835 ± 0.901
2.177LeuHis: 2.177 ± 0.348
2.526LeuIle: 2.526 ± 0.414
3.919LeuLys: 3.919 ± 0.753
6.793LeuLeu: 6.793 ± 0.967
1.481LeuMet: 1.481 ± 0.35
2.787LeuAsn: 2.787 ± 0.533
4.964LeuPro: 4.964 ± 0.74
4.355LeuGln: 4.355 ± 0.691
7.229LeuArg: 7.229 ± 0.814
6.445LeuSer: 6.445 ± 0.932
5.4LeuThr: 5.4 ± 0.552
4.877LeuVal: 4.877 ± 0.595
1.916LeuTrp: 1.916 ± 0.381
2.003LeuTyr: 2.003 ± 0.372
0.0LeuXaa: 0.0 ± 0.0
Met
2.7MetAla: 2.7 ± 0.64
0.087MetCys: 0.087 ± 0.067
0.784MetAsp: 0.784 ± 0.27
1.045MetGlu: 1.045 ± 0.262
0.348MetPhe: 0.348 ± 0.135
1.829MetGly: 1.829 ± 0.264
0.523MetHis: 0.523 ± 0.192
1.393MetIle: 1.393 ± 0.358
0.523MetLys: 0.523 ± 0.2
2.09MetLeu: 2.09 ± 0.361
0.435MetMet: 0.435 ± 0.217
0.784MetAsn: 0.784 ± 0.268
2.09MetPro: 2.09 ± 0.412
1.045MetGln: 1.045 ± 0.335
1.916MetArg: 1.916 ± 0.459
1.481MetSer: 1.481 ± 0.406
2.264MetThr: 2.264 ± 0.434
0.697MetVal: 0.697 ± 0.294
0.523MetTrp: 0.523 ± 0.172
0.261MetTyr: 0.261 ± 0.145
0.0MetXaa: 0.0 ± 0.0
Asn
4.355AsnAla: 4.355 ± 0.566
0.261AsnCys: 0.261 ± 0.131
2.003AsnAsp: 2.003 ± 0.377
1.219AsnGlu: 1.219 ± 0.357
0.871AsnPhe: 0.871 ± 0.253
3.484AsnGly: 3.484 ± 0.521
0.697AsnHis: 0.697 ± 0.242
1.568AsnIle: 1.568 ± 0.381
1.132AsnLys: 1.132 ± 0.356
1.655AsnLeu: 1.655 ± 0.403
0.261AsnMet: 0.261 ± 0.192
1.306AsnAsn: 1.306 ± 0.358
2.352AsnPro: 2.352 ± 0.492
1.568AsnGln: 1.568 ± 0.373
2.003AsnArg: 2.003 ± 0.445
1.481AsnSer: 1.481 ± 0.325
2.352AsnThr: 2.352 ± 0.495
1.393AsnVal: 1.393 ± 0.338
0.61AsnTrp: 0.61 ± 0.198
1.132AsnTyr: 1.132 ± 0.378
0.0AsnXaa: 0.0 ± 0.0
Pro
5.835ProAla: 5.835 ± 0.619
0.958ProCys: 0.958 ± 0.279
3.135ProAsp: 3.135 ± 0.481
3.222ProGlu: 3.222 ± 0.455
2.09ProPhe: 2.09 ± 0.427
3.048ProGly: 3.048 ± 0.494
1.742ProHis: 1.742 ± 0.369
2.003ProIle: 2.003 ± 0.353
2.003ProLys: 2.003 ± 0.402
4.093ProLeu: 4.093 ± 0.698
1.219ProMet: 1.219 ± 0.349
1.306ProAsn: 1.306 ± 0.296
5.313ProPro: 5.313 ± 1.124
2.7ProGln: 2.7 ± 0.443
2.787ProArg: 2.787 ± 0.472
3.135ProSer: 3.135 ± 0.597
3.745ProThr: 3.745 ± 0.544
5.138ProVal: 5.138 ± 0.63
1.219ProTrp: 1.219 ± 0.271
1.916ProTyr: 1.916 ± 0.449
0.0ProXaa: 0.0 ± 0.0
Gln
6.793GlnAla: 6.793 ± 1.075
0.435GlnCys: 0.435 ± 0.183
2.7GlnAsp: 2.7 ± 0.543
2.526GlnGlu: 2.526 ± 0.537
1.393GlnPhe: 1.393 ± 0.394
2.7GlnGly: 2.7 ± 0.612
1.568GlnHis: 1.568 ± 0.329
1.829GlnIle: 1.829 ± 0.288
1.655GlnLys: 1.655 ± 0.305
4.877GlnLeu: 4.877 ± 0.708
1.306GlnMet: 1.306 ± 0.333
0.958GlnAsn: 0.958 ± 0.433
2.613GlnPro: 2.613 ± 0.49
3.832GlnGln: 3.832 ± 1.192
3.658GlnArg: 3.658 ± 0.663
1.393GlnSer: 1.393 ± 0.414
1.568GlnThr: 1.568 ± 0.382
1.829GlnVal: 1.829 ± 0.471
1.045GlnTrp: 1.045 ± 0.22
1.045GlnTyr: 1.045 ± 0.259
0.0GlnXaa: 0.0 ± 0.0
Arg
6.358ArgAla: 6.358 ± 0.677
1.393ArgCys: 1.393 ± 0.285
4.616ArgAsp: 4.616 ± 0.6
3.658ArgGlu: 3.658 ± 0.547
2.264ArgPhe: 2.264 ± 0.377
3.222ArgGly: 3.222 ± 0.577
1.829ArgHis: 1.829 ± 0.303
4.093ArgIle: 4.093 ± 0.614
2.439ArgLys: 2.439 ± 0.593
5.748ArgLeu: 5.748 ± 0.621
2.613ArgMet: 2.613 ± 0.466
2.177ArgAsn: 2.177 ± 0.506
2.177ArgPro: 2.177 ± 0.413
3.919ArgGln: 3.919 ± 0.557
5.4ArgArg: 5.4 ± 0.847
3.484ArgSer: 3.484 ± 0.553
4.703ArgThr: 4.703 ± 0.543
4.964ArgVal: 4.964 ± 0.75
1.655ArgTrp: 1.655 ± 0.33
2.7ArgTyr: 2.7 ± 0.466
0.0ArgXaa: 0.0 ± 0.0
Ser
5.574SerAla: 5.574 ± 0.768
0.61SerCys: 0.61 ± 0.252
3.571SerAsp: 3.571 ± 0.543
3.135SerGlu: 3.135 ± 0.513
1.132SerPhe: 1.132 ± 0.348
6.88SerGly: 6.88 ± 1.117
1.568SerHis: 1.568 ± 0.333
3.135SerIle: 3.135 ± 0.578
2.177SerLys: 2.177 ± 0.47
4.616SerLeu: 4.616 ± 0.821
1.481SerMet: 1.481 ± 0.309
2.09SerAsn: 2.09 ± 0.498
2.961SerPro: 2.961 ± 0.557
1.916SerGln: 1.916 ± 0.366
3.048SerArg: 3.048 ± 0.561
4.79SerSer: 4.79 ± 1.159
3.484SerThr: 3.484 ± 0.567
2.961SerVal: 2.961 ± 0.542
0.348SerTrp: 0.348 ± 0.159
1.568SerTyr: 1.568 ± 0.399
0.0SerXaa: 0.0 ± 0.0
Thr
6.184ThrAla: 6.184 ± 0.775
0.435ThrCys: 0.435 ± 0.202
4.18ThrAsp: 4.18 ± 0.565
2.439ThrGlu: 2.439 ± 0.528
2.264ThrPhe: 2.264 ± 0.491
4.79ThrGly: 4.79 ± 0.717
1.829ThrHis: 1.829 ± 0.521
2.7ThrIle: 2.7 ± 0.636
1.393ThrLys: 1.393 ± 0.287
6.096ThrLeu: 6.096 ± 0.54
1.045ThrMet: 1.045 ± 0.326
1.829ThrAsn: 1.829 ± 0.434
6.096ThrPro: 6.096 ± 0.753
2.526ThrGln: 2.526 ± 0.341
3.919ThrArg: 3.919 ± 0.513
4.093ThrSer: 4.093 ± 0.588
3.658ThrThr: 3.658 ± 0.583
5.313ThrVal: 5.313 ± 0.656
0.697ThrTrp: 0.697 ± 0.184
1.132ThrTyr: 1.132 ± 0.281
0.0ThrXaa: 0.0 ± 0.0
Val
7.316ValAla: 7.316 ± 0.899
1.045ValCys: 1.045 ± 0.362
3.745ValAsp: 3.745 ± 0.432
4.18ValGlu: 4.18 ± 0.623
3.048ValPhe: 3.048 ± 0.515
3.571ValGly: 3.571 ± 0.443
1.306ValHis: 1.306 ± 0.308
2.526ValIle: 2.526 ± 0.611
3.135ValLys: 3.135 ± 0.429
6.532ValLeu: 6.532 ± 0.709
1.306ValMet: 1.306 ± 0.348
2.439ValAsn: 2.439 ± 0.489
3.745ValPro: 3.745 ± 0.618
2.961ValGln: 2.961 ± 0.401
4.877ValArg: 4.877 ± 0.779
4.355ValSer: 4.355 ± 0.768
4.093ValThr: 4.093 ± 0.567
4.79ValVal: 4.79 ± 0.611
1.132ValTrp: 1.132 ± 0.257
1.916ValTyr: 1.916 ± 0.502
0.0ValXaa: 0.0 ± 0.0
Trp
1.916TrpAla: 1.916 ± 0.396
0.261TrpCys: 0.261 ± 0.147
0.523TrpAsp: 0.523 ± 0.181
0.697TrpGlu: 0.697 ± 0.185
1.132TrpPhe: 1.132 ± 0.288
1.306TrpGly: 1.306 ± 0.336
0.261TrpHis: 0.261 ± 0.112
0.61TrpIle: 0.61 ± 0.22
0.697TrpLys: 0.697 ± 0.267
1.829TrpLeu: 1.829 ± 0.33
0.261TrpMet: 0.261 ± 0.123
0.871TrpAsn: 0.871 ± 0.232
0.871TrpPro: 0.871 ± 0.288
0.61TrpGln: 0.61 ± 0.199
1.393TrpArg: 1.393 ± 0.266
0.958TrpSer: 0.958 ± 0.265
0.523TrpThr: 0.523 ± 0.178
0.958TrpVal: 0.958 ± 0.3
0.348TrpTrp: 0.348 ± 0.153
0.523TrpTyr: 0.523 ± 0.209
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.135TyrAla: 3.135 ± 0.711
0.261TyrCys: 0.261 ± 0.128
2.177TyrAsp: 2.177 ± 0.533
1.655TyrGlu: 1.655 ± 0.465
0.871TyrPhe: 0.871 ± 0.252
2.09TyrGly: 2.09 ± 0.458
0.61TyrHis: 0.61 ± 0.167
1.045TyrIle: 1.045 ± 0.254
1.655TyrLys: 1.655 ± 0.342
1.916TyrLeu: 1.916 ± 0.374
0.435TyrMet: 0.435 ± 0.164
1.219TyrAsn: 1.219 ± 0.325
0.958TyrPro: 0.958 ± 0.325
1.219TyrGln: 1.219 ± 0.285
2.003TyrArg: 2.003 ± 0.461
1.916TyrSer: 1.916 ± 0.415
1.481TyrThr: 1.481 ± 0.317
2.09TyrVal: 2.09 ± 0.498
0.523TyrTrp: 0.523 ± 0.203
0.958TyrTyr: 0.958 ± 0.32
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (11483 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski