Amino acid dipepetide frequency for Ornithinimicrobium sp. H23M54

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.117AlaAla: 18.117 ± 0.195	0.895AlaCys: 0.895 ± 0.025	7.963AlaAsp: 7.963 ± 0.093	8.194AlaGlu: 8.194 ± 0.099	3.06AlaPhe: 3.06 ± 0.058	11.951AlaGly: 11.951 ± 0.125	2.652AlaHis: 2.652 ± 0.056	4.33AlaIle: 4.33 ± 0.067	2.117AlaLys: 2.117 ± 0.055	13.646AlaLeu: 13.646 ± 0.135	2.604AlaMet: 2.604 ± 0.045	1.936AlaAsn: 1.936 ± 0.038	6.263AlaPro: 6.263 ± 0.097	4.327AlaGln: 4.327 ± 0.075	8.863AlaArg: 8.863 ± 0.12	6.105AlaSer: 6.105 ± 0.08	7.793AlaThr: 7.793 ± 0.091	11.299AlaVal: 11.299 ± 0.112	1.86AlaTrp: 1.86 ± 0.04	2.391AlaTyr: 2.391 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.793CysAla: 0.793 ± 0.028	0.091CysCys: 0.091 ± 0.01	0.433CysAsp: 0.433 ± 0.02	0.342CysGlu: 0.342 ± 0.015	0.189CysPhe: 0.189 ± 0.012	0.762CysGly: 0.762 ± 0.028	0.158CysHis: 0.158 ± 0.012	0.192CysIle: 0.192 ± 0.014	0.086CysLys: 0.086 ± 0.009	0.623CysLeu: 0.623 ± 0.023	0.09CysMet: 0.09 ± 0.008	0.125CysAsn: 0.125 ± 0.012	0.45CysPro: 0.45 ± 0.019	0.21CysGln: 0.21 ± 0.013	0.5CysArg: 0.5 ± 0.021	0.409CysSer: 0.409 ± 0.018	0.438CysThr: 0.438 ± 0.02	0.539CysVal: 0.539 ± 0.02	0.108CysTrp: 0.108 ± 0.009	0.135CysTyr: 0.135 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.148AspAla: 7.148 ± 0.088	0.334AspCys: 0.334 ± 0.015	3.849AspAsp: 3.849 ± 0.072	4.252AspGlu: 4.252 ± 0.072	1.571AspPhe: 1.571 ± 0.042	6.122AspGly: 6.122 ± 0.088	1.476AspHis: 1.476 ± 0.039	2.082AspIle: 2.082 ± 0.046	1.047AspLys: 1.047 ± 0.036	7.549AspLeu: 7.549 ± 0.082	0.897AspMet: 0.897 ± 0.028	1.064AspAsn: 1.064 ± 0.038	4.838AspPro: 4.838 ± 0.073	2.102AspGln: 2.102 ± 0.046	4.622AspArg: 4.622 ± 0.061	2.861AspSer: 2.861 ± 0.06	3.343AspThr: 3.343 ± 0.057	5.382AspVal: 5.382 ± 0.083	1.038AspTrp: 1.038 ± 0.028	1.42AspTyr: 1.42 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.537GluAla: 7.537 ± 0.107	0.328GluCys: 0.328 ± 0.016	3.508GluAsp: 3.508 ± 0.062	3.779GluGlu: 3.779 ± 0.067	1.669GluPhe: 1.669 ± 0.042	4.927GluGly: 4.927 ± 0.079	1.915GluHis: 1.915 ± 0.038	2.446GluIle: 2.446 ± 0.045	1.031GluLys: 1.031 ± 0.039	6.572GluLeu: 6.572 ± 0.079	1.011GluMet: 1.011 ± 0.03	0.874GluAsn: 0.874 ± 0.026	3.4GluPro: 3.4 ± 0.063	2.876GluGln: 2.876 ± 0.058	4.915GluArg: 4.915 ± 0.076	3.11GluSer: 3.11 ± 0.048	3.228GluThr: 3.228 ± 0.06	5.731GluVal: 5.731 ± 0.088	0.851GluTrp: 0.851 ± 0.026	0.891GluTyr: 0.891 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.321PheAla: 3.321 ± 0.049	0.217PheCys: 0.217 ± 0.013	1.956PheAsp: 1.956 ± 0.04	1.493PheGlu: 1.493 ± 0.035	0.825PhePhe: 0.825 ± 0.03	2.886PheGly: 2.886 ± 0.058	0.566PheHis: 0.566 ± 0.021	0.92PheIle: 0.92 ± 0.031	0.392PheLys: 0.392 ± 0.02	2.632PheLeu: 2.632 ± 0.054	0.413PheMet: 0.413 ± 0.018	0.573PheAsn: 0.573 ± 0.025	1.302PhePro: 1.302 ± 0.037	0.629PheGln: 0.629 ± 0.025	1.587PheArg: 1.587 ± 0.037	1.455PheSer: 1.455 ± 0.042	1.888PheThr: 1.888 ± 0.043	2.459PheVal: 2.459 ± 0.044	0.436PheTrp: 0.436 ± 0.02	0.582PheTyr: 0.582 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.683GlyAla: 10.683 ± 0.108	0.723GlyCys: 0.723 ± 0.026	5.415GlyAsp: 5.415 ± 0.08	5.439GlyGlu: 5.439 ± 0.064	2.66GlyPhe: 2.66 ± 0.052	8.201GlyGly: 8.201 ± 0.106	2.113GlyHis: 2.113 ± 0.044	3.714GlyIle: 3.714 ± 0.058	1.847GlyLys: 1.847 ± 0.048	9.56GlyLeu: 9.56 ± 0.116	2.134GlyMet: 2.134 ± 0.038	1.722GlyAsn: 1.722 ± 0.044	4.812GlyPro: 4.812 ± 0.078	3.422GlyGln: 3.422 ± 0.055	6.74GlyArg: 6.74 ± 0.077	5.534GlySer: 5.534 ± 0.079	6.13GlyThr: 6.13 ± 0.098	7.929GlyVal: 7.929 ± 0.078	1.78GlyTrp: 1.78 ± 0.039	2.143GlyTyr: 2.143 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.442HisAla: 2.442 ± 0.052	0.19HisCys: 0.19 ± 0.013	1.571HisAsp: 1.571 ± 0.041	1.407HisGlu: 1.407 ± 0.036	0.569HisPhe: 0.569 ± 0.021	2.282HisGly: 2.282 ± 0.045	0.729HisHis: 0.729 ± 0.025	0.662HisIle: 0.662 ± 0.025	0.333HisLys: 0.333 ± 0.016	2.644HisLeu: 2.644 ± 0.055	0.3HisMet: 0.3 ± 0.016	0.407HisAsn: 0.407 ± 0.019	1.715HisPro: 1.715 ± 0.043	0.803HisGln: 0.803 ± 0.028	1.939HisArg: 1.939 ± 0.044	1.04HisSer: 1.04 ± 0.031	1.307HisThr: 1.307 ± 0.035	1.841HisVal: 1.841 ± 0.038	0.348HisTrp: 0.348 ± 0.015	0.465HisTyr: 0.465 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.011IleAla: 5.011 ± 0.074	0.276IleCys: 0.276 ± 0.018	2.674IleAsp: 2.674 ± 0.052	2.486IleGlu: 2.486 ± 0.059	1.021IlePhe: 1.021 ± 0.031	3.858IleGly: 3.858 ± 0.06	0.714IleHis: 0.714 ± 0.025	1.356IleIle: 1.356 ± 0.034	0.675IleLys: 0.675 ± 0.026	3.129IleLeu: 3.129 ± 0.058	0.572IleMet: 0.572 ± 0.024	0.835IleAsn: 0.835 ± 0.029	1.971IlePro: 1.971 ± 0.042	0.87IleGln: 0.87 ± 0.028	2.295IleArg: 2.295 ± 0.048	2.142IleSer: 2.142 ± 0.048	2.61IleThr: 2.61 ± 0.049	3.383IleVal: 3.383 ± 0.054	0.436IleTrp: 0.436 ± 0.022	0.751IleTyr: 0.751 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.071LysAla: 2.071 ± 0.053	0.081LysCys: 0.081 ± 0.008	1.073LysAsp: 1.073 ± 0.039	0.921LysGlu: 0.921 ± 0.028	0.417LysPhe: 0.417 ± 0.018	1.395LysGly: 1.395 ± 0.041	0.4LysHis: 0.4 ± 0.019	0.773LysIle: 0.773 ± 0.029	0.58LysLys: 0.58 ± 0.032	1.45LysLeu: 1.45 ± 0.042	0.339LysMet: 0.339 ± 0.018	0.398LysAsn: 0.398 ± 0.02	0.958LysPro: 0.958 ± 0.029	0.554LysGln: 0.554 ± 0.023	1.117LysArg: 1.117 ± 0.038	0.972LysSer: 0.972 ± 0.033	1.046LysThr: 1.046 ± 0.035	1.55LysVal: 1.55 ± 0.05	0.202LysTrp: 0.202 ± 0.013	0.323LysTyr: 0.323 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.77LeuAla: 14.77 ± 0.147	0.681LeuCys: 0.681 ± 0.026	6.656LeuAsp: 6.656 ± 0.072	5.651LeuGlu: 5.651 ± 0.07	2.399LeuPhe: 2.399 ± 0.049	9.677LeuGly: 9.677 ± 0.096	2.136LeuHis: 2.136 ± 0.044	3.9LeuIle: 3.9 ± 0.064	1.49LeuLys: 1.49 ± 0.039	10.835LeuLeu: 10.835 ± 0.129	1.852LeuMet: 1.852 ± 0.039	1.691LeuAsn: 1.691 ± 0.042	5.891LeuPro: 5.891 ± 0.069	2.822LeuGln: 2.822 ± 0.047	7.704LeuArg: 7.704 ± 0.094	5.795LeuSer: 5.795 ± 0.072	7.193LeuThr: 7.193 ± 0.082	9.969LeuVal: 9.969 ± 0.121	1.353LeuTrp: 1.353 ± 0.036	1.488LeuTyr: 1.488 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.382MetAla: 2.382 ± 0.044	0.123MetCys: 0.123 ± 0.01	1.015MetAsp: 1.015 ± 0.026	0.85MetGlu: 0.85 ± 0.028	0.514MetPhe: 0.514 ± 0.024	1.489MetGly: 1.489 ± 0.036	0.39MetHis: 0.39 ± 0.017	0.753MetIle: 0.753 ± 0.028	0.349MetLys: 0.349 ± 0.015	1.916MetLeu: 1.916 ± 0.045	0.344MetMet: 0.344 ± 0.018	0.402MetAsn: 0.402 ± 0.02	1.189MetPro: 1.189 ± 0.03	0.519MetGln: 0.519 ± 0.021	1.352MetArg: 1.352 ± 0.037	1.517MetSer: 1.517 ± 0.04	1.732MetThr: 1.732 ± 0.035	1.556MetVal: 1.556 ± 0.039	0.22MetTrp: 0.22 ± 0.013	0.26MetTyr: 0.26 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.045AsnAla: 2.045 ± 0.042	0.13AsnCys: 0.13 ± 0.011	1.021AsnAsp: 1.021 ± 0.031	0.919AsnGlu: 0.919 ± 0.031	0.582AsnPhe: 0.582 ± 0.022	1.648AsnGly: 1.648 ± 0.048	0.398AsnHis: 0.398 ± 0.02	0.659AsnIle: 0.659 ± 0.026	0.326AsnLys: 0.326 ± 0.019	1.758AsnLeu: 1.758 ± 0.045	0.319AsnMet: 0.319 ± 0.016	0.442AsnAsn: 0.442 ± 0.025	1.394AsnPro: 1.394 ± 0.037	0.52AsnGln: 0.52 ± 0.025	1.223AsnArg: 1.223 ± 0.036	0.916AsnSer: 0.916 ± 0.029	1.067AsnThr: 1.067 ± 0.035	1.346AsnVal: 1.346 ± 0.037	0.27AsnTrp: 0.27 ± 0.015	0.426AsnTyr: 0.426 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.053ProAla: 7.053 ± 0.092	0.271ProCys: 0.271 ± 0.015	4.517ProAsp: 4.517 ± 0.066	4.366ProGlu: 4.366 ± 0.066	1.488ProPhe: 1.488 ± 0.036	6.007ProGly: 6.007 ± 0.089	1.316ProHis: 1.316 ± 0.036	1.745ProIle: 1.745 ± 0.034	0.827ProLys: 0.827 ± 0.031	4.874ProLeu: 4.874 ± 0.063	1.084ProMet: 1.084 ± 0.028	0.899ProAsn: 0.899 ± 0.024	3.086ProPro: 3.086 ± 0.075	1.98ProGln: 1.98 ± 0.046	3.518ProArg: 3.518 ± 0.072	3.222ProSer: 3.222 ± 0.055	3.849ProThr: 3.849 ± 0.066	5.294ProVal: 5.294 ± 0.063	1.007ProTrp: 1.007 ± 0.034	1.038ProTyr: 1.038 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.051GlnAla: 4.051 ± 0.063	0.157GlnCys: 0.157 ± 0.012	1.953GlnAsp: 1.953 ± 0.045	2.031GlnGlu: 2.031 ± 0.05	0.858GlnPhe: 0.858 ± 0.026	2.705GlnGly: 2.705 ± 0.055	0.827GlnHis: 0.827 ± 0.026	1.541GlnIle: 1.541 ± 0.035	0.426GlnLys: 0.426 ± 0.02	3.413GlnLeu: 3.413 ± 0.055	0.664GlnMet: 0.664 ± 0.023	0.476GlnAsn: 0.476 ± 0.022	1.834GlnPro: 1.834 ± 0.044	1.454GlnGln: 1.454 ± 0.044	2.685GlnArg: 2.685 ± 0.051	1.533GlnSer: 1.533 ± 0.034	1.782GlnThr: 1.782 ± 0.039	3.53GlnVal: 3.53 ± 0.055	0.577GlnTrp: 0.577 ± 0.022	0.502GlnTyr: 0.502 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.674ArgAla: 8.674 ± 0.103	0.462ArgCys: 0.462 ± 0.022	4.343ArgAsp: 4.343 ± 0.066	4.67ArgGlu: 4.67 ± 0.064	2.019ArgPhe: 2.019 ± 0.048	5.624ArgGly: 5.624 ± 0.076	1.934ArgHis: 1.934 ± 0.041	2.818ArgIle: 2.818 ± 0.054	1.269ArgLys: 1.269 ± 0.037	7.495ArgLeu: 7.495 ± 0.09	1.651ArgMet: 1.651 ± 0.034	1.214ArgAsn: 1.214 ± 0.035	4.106ArgPro: 4.106 ± 0.069	2.54ArgGln: 2.54 ± 0.045	6.414ArgArg: 6.414 ± 0.116	4.153ArgSer: 4.153 ± 0.056	4.458ArgThr: 4.458 ± 0.062	6.067ArgVal: 6.067 ± 0.083	1.371ArgTrp: 1.371 ± 0.04	1.485ArgTyr: 1.485 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.801SerAla: 6.801 ± 0.096	0.34SerCys: 0.34 ± 0.019	3.101SerAsp: 3.101 ± 0.05	2.822SerGlu: 2.822 ± 0.058	1.545SerPhe: 1.545 ± 0.036	5.947SerGly: 5.947 ± 0.094	1.133SerHis: 1.133 ± 0.028	1.904SerIle: 1.904 ± 0.043	0.856SerLys: 0.856 ± 0.035	5.22SerLeu: 5.22 ± 0.065	1.244SerMet: 1.244 ± 0.034	0.944SerAsn: 0.944 ± 0.029	3.23SerPro: 3.23 ± 0.055	1.724SerGln: 1.724 ± 0.043	3.939SerArg: 3.939 ± 0.061	3.198SerSer: 3.198 ± 0.054	3.78SerThr: 3.78 ± 0.071	4.687SerVal: 4.687 ± 0.052	1.029SerTrp: 1.029 ± 0.032	1.137SerTyr: 1.137 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.831ThrAla: 7.831 ± 0.085	0.439ThrCys: 0.439 ± 0.022	4.099ThrAsp: 4.099 ± 0.07	3.643ThrGlu: 3.643 ± 0.066	1.837ThrPhe: 1.837 ± 0.037	6.506ThrGly: 6.506 ± 0.076	1.394ThrHis: 1.394 ± 0.036	2.451ThrIle: 2.451 ± 0.048	1.083ThrLys: 1.083 ± 0.041	6.089ThrLeu: 6.089 ± 0.074	1.154ThrMet: 1.154 ± 0.033	1.149ThrAsn: 1.149 ± 0.033	4.094ThrPro: 4.094 ± 0.055	1.834ThrGln: 1.834 ± 0.037	4.099ThrArg: 4.099 ± 0.057	3.608ThrSer: 3.608 ± 0.058	4.343ThrThr: 4.343 ± 0.077	6.046ThrVal: 6.046 ± 0.088	1.082ThrTrp: 1.082 ± 0.035	1.366ThrTyr: 1.366 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	11.392ValAla: 11.392 ± 0.12	0.655ValCys: 0.655 ± 0.027	5.614ValAsp: 5.614 ± 0.079	5.436ValGlu: 5.436 ± 0.077	2.179ValPhe: 2.179 ± 0.046	7.733ValGly: 7.733 ± 0.079	1.981ValHis: 1.981 ± 0.04	3.724ValIle: 3.724 ± 0.061	1.363ValLys: 1.363 ± 0.038	10.417ValLeu: 10.417 ± 0.115	1.682ValMet: 1.682 ± 0.034	1.584ValAsn: 1.584 ± 0.036	5.055ValPro: 5.055 ± 0.065	2.541ValGln: 2.541 ± 0.051	6.523ValArg: 6.523 ± 0.091	5.017ValSer: 5.017 ± 0.07	6.148ValThr: 6.148 ± 0.086	9.051ValVal: 9.051 ± 0.104	1.159ValTrp: 1.159 ± 0.036	1.345ValTyr: 1.345 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.701TrpAla: 1.701 ± 0.042	0.15TrpCys: 0.15 ± 0.013	0.873TrpAsp: 0.873 ± 0.03	0.792TrpGlu: 0.792 ± 0.026	0.534TrpPhe: 0.534 ± 0.021	1.19TrpGly: 1.19 ± 0.035	0.401TrpHis: 0.401 ± 0.019	0.598TrpIle: 0.598 ± 0.024	0.229TrpLys: 0.229 ± 0.014	1.962TrpLeu: 1.962 ± 0.046	0.315TrpMet: 0.315 ± 0.016	0.338TrpAsn: 0.338 ± 0.018	0.82TrpPro: 0.82 ± 0.028	0.668TrpGln: 0.668 ± 0.024	1.257TrpArg: 1.257 ± 0.033	1.043TrpSer: 1.043 ± 0.029	0.992TrpThr: 0.992 ± 0.03	1.322TrpVal: 1.322 ± 0.035	0.455TrpTrp: 0.455 ± 0.022	0.251TrpTyr: 0.251 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.547TyrAla: 2.547 ± 0.045	0.131TyrCys: 0.131 ± 0.01	1.363TyrAsp: 1.363 ± 0.041	1.107TyrGlu: 1.107 ± 0.034	0.596TyrPhe: 0.596 ± 0.024	1.791TyrGly: 1.791 ± 0.043	0.358TyrHis: 0.358 ± 0.016	0.496TyrIle: 0.496 ± 0.022	0.294TyrLys: 0.294 ± 0.016	2.17TyrLeu: 2.17 ± 0.044	0.203TyrMet: 0.203 ± 0.012	0.337TyrAsn: 0.337 ± 0.017	1.035TyrPro: 1.035 ± 0.029	0.601TyrGln: 0.601 ± 0.024	1.477TyrArg: 1.477 ± 0.039	0.95TyrSer: 0.95 ± 0.03	1.017TyrThr: 1.017 ± 0.037	1.615TyrVal: 1.615 ± 0.035	0.309TyrTrp: 0.309 ± 0.017	0.399TyrTyr: 0.399 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3622 proteins (1205281 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---