Amino acid dipepetide frequency for Ponticoccus marisrubri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.551AlaAla: 18.551 ± 0.18	1.237AlaCys: 1.237 ± 0.033	6.888AlaAsp: 6.888 ± 0.084	9.368AlaGlu: 9.368 ± 0.121	4.235AlaPhe: 4.235 ± 0.063	11.434AlaGly: 11.434 ± 0.099	2.564AlaHis: 2.564 ± 0.047	5.32AlaIle: 5.32 ± 0.073	2.803AlaLys: 2.803 ± 0.045	15.748AlaLeu: 15.748 ± 0.163	3.855AlaMet: 3.855 ± 0.057	2.392AlaAsn: 2.392 ± 0.04	6.921AlaPro: 6.921 ± 0.095	4.982AlaGln: 4.982 ± 0.071	10.848AlaArg: 10.848 ± 0.125	5.133AlaSer: 5.133 ± 0.07	6.053AlaThr: 6.053 ± 0.072	8.449AlaVal: 8.449 ± 0.102	1.601AlaTrp: 1.601 ± 0.04	2.543AlaTyr: 2.543 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.213CysAla: 1.213 ± 0.03	0.114CysCys: 0.114 ± 0.01	0.659CysAsp: 0.659 ± 0.025	0.441CysGlu: 0.441 ± 0.019	0.33CysPhe: 0.33 ± 0.015	0.942CysGly: 0.942 ± 0.029	0.301CysHis: 0.301 ± 0.017	0.385CysIle: 0.385 ± 0.018	0.153CysLys: 0.153 ± 0.011	0.931CysLeu: 0.931 ± 0.026	0.15CysMet: 0.15 ± 0.01	0.201CysAsn: 0.201 ± 0.014	0.524CysPro: 0.524 ± 0.024	0.212CysGln: 0.212 ± 0.012	0.65CysArg: 0.65 ± 0.024	0.387CysSer: 0.387 ± 0.017	0.468CysThr: 0.468 ± 0.021	0.617CysVal: 0.617 ± 0.022	0.111CysTrp: 0.111 ± 0.009	0.2CysTyr: 0.2 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.621AspAla: 7.621 ± 0.093	0.527AspCys: 0.527 ± 0.02	3.288AspAsp: 3.288 ± 0.068	3.829AspGlu: 3.829 ± 0.187	2.211AspPhe: 2.211 ± 0.041	5.851AspGly: 5.851 ± 0.079	1.362AspHis: 1.362 ± 0.036	2.799AspIle: 2.799 ± 0.05	1.395AspLys: 1.395 ± 0.032	6.353AspLeu: 6.353 ± 0.074	1.667AspMet: 1.667 ± 0.036	1.215AspAsn: 1.215 ± 0.035	4.306AspPro: 4.306 ± 0.061	1.615AspGln: 1.615 ± 0.039	4.993AspArg: 4.993 ± 0.067	2.337AspSer: 2.337 ± 0.046	3.244AspThr: 3.244 ± 0.062	4.003AspVal: 4.003 ± 0.055	1.297AspTrp: 1.297 ± 0.033	1.461AspTyr: 1.461 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	9.292GluAla: 9.292 ± 0.115	0.348GluCys: 0.348 ± 0.017	3.587GluAsp: 3.587 ± 0.062	3.771GluGlu: 3.771 ± 0.069	1.683GluPhe: 1.683 ± 0.04	5.363GluGly: 5.363 ± 0.141	1.07GluHis: 1.07 ± 0.029	3.827GluIle: 3.827 ± 0.051	1.703GluLys: 1.703 ± 0.045	5.248GluLeu: 5.248 ± 0.074	1.947GluMet: 1.947 ± 0.046	1.482GluAsn: 1.482 ± 0.045	2.61GluPro: 2.61 ± 0.052	1.919GluGln: 1.919 ± 0.042	4.491GluArg: 4.491 ± 0.071	2.085GluSer: 2.085 ± 0.04	4.285GluThr: 4.285 ± 0.061	4.342GluVal: 4.342 ± 0.062	0.688GluTrp: 0.688 ± 0.025	0.98GluTyr: 0.98 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.429PheAla: 4.429 ± 0.058	0.414PheCys: 0.414 ± 0.018	2.975PheAsp: 2.975 ± 0.051	2.193PheGlu: 2.193 ± 0.043	1.37PhePhe: 1.37 ± 0.036	3.594PheGly: 3.594 ± 0.061	0.804PheHis: 0.804 ± 0.023	1.421PheIle: 1.421 ± 0.032	0.741PheLys: 0.741 ± 0.025	3.38PheLeu: 3.38 ± 0.058	0.765PheMet: 0.765 ± 0.027	0.946PheAsn: 0.946 ± 0.028	1.587PhePro: 1.587 ± 0.038	0.955PheGln: 0.955 ± 0.024	2.322PheArg: 2.322 ± 0.043	1.769PheSer: 1.769 ± 0.037	2.036PheThr: 2.036 ± 0.039	2.525PheVal: 2.525 ± 0.047	0.581PheTrp: 0.581 ± 0.024	0.892PheTyr: 0.892 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.952GlyAla: 10.952 ± 0.099	0.877GlyCys: 0.877 ± 0.028	4.987GlyAsp: 4.987 ± 0.124	4.678GlyGlu: 4.678 ± 0.066	3.728GlyPhe: 3.728 ± 0.059	7.695GlyGly: 7.695 ± 0.107	2.053GlyHis: 2.053 ± 0.035	4.229GlyIle: 4.229 ± 0.066	2.453GlyLys: 2.453 ± 0.045	9.709GlyLeu: 9.709 ± 0.11	2.602GlyMet: 2.602 ± 0.048	2.013GlyAsn: 2.013 ± 0.075	4.321GlyPro: 4.321 ± 0.055	3.383GlyGln: 3.383 ± 0.057	6.476GlyArg: 6.476 ± 0.088	3.917GlySer: 3.917 ± 0.052	5.023GlyThr: 5.023 ± 0.065	6.274GlyVal: 6.274 ± 0.071	1.658GlyTrp: 1.658 ± 0.033	2.31GlyTyr: 2.31 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.644HisAla: 2.644 ± 0.046	0.248HisCys: 0.248 ± 0.014	1.396HisAsp: 1.396 ± 0.036	1.064HisGlu: 1.064 ± 0.03	0.813HisPhe: 0.813 ± 0.031	2.095HisGly: 2.095 ± 0.043	0.574HisHis: 0.574 ± 0.022	0.751HisIle: 0.751 ± 0.02	0.468HisLys: 0.468 ± 0.02	2.156HisLeu: 2.156 ± 0.047	0.543HisMet: 0.543 ± 0.02	0.393HisAsn: 0.393 ± 0.016	1.45HisPro: 1.45 ± 0.038	0.509HisGln: 0.509 ± 0.022	1.471HisArg: 1.471 ± 0.038	0.764HisSer: 0.764 ± 0.024	0.741HisThr: 0.741 ± 0.024	1.806HisVal: 1.806 ± 0.036	0.353HisTrp: 0.353 ± 0.016	0.551HisTyr: 0.551 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.596IleAla: 6.596 ± 0.083	0.562IleCys: 0.562 ± 0.017	3.262IleAsp: 3.262 ± 0.051	3.285IleGlu: 3.285 ± 0.05	1.522IlePhe: 1.522 ± 0.033	4.481IleGly: 4.481 ± 0.069	0.901IleHis: 0.901 ± 0.026	1.743IleIle: 1.743 ± 0.047	1.049IleLys: 1.049 ± 0.03	4.52IleLeu: 4.52 ± 0.071	0.929IleMet: 0.929 ± 0.025	1.106IleAsn: 1.106 ± 0.031	2.182IlePro: 2.182 ± 0.046	0.985IleGln: 0.985 ± 0.025	3.247IleArg: 3.247 ± 0.048	2.412IleSer: 2.412 ± 0.05	2.573IleThr: 2.573 ± 0.046	3.537IleVal: 3.537 ± 0.062	0.65IleTrp: 0.65 ± 0.024	1.033IleTyr: 1.033 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.174LysAla: 3.174 ± 0.052	0.152LysCys: 0.152 ± 0.011	1.331LysAsp: 1.331 ± 0.039	1.233LysGlu: 1.233 ± 0.033	0.666LysPhe: 0.666 ± 0.025	2.282LysGly: 2.282 ± 0.05	0.471LysHis: 0.471 ± 0.017	1.202LysIle: 1.202 ± 0.034	0.915LysLys: 0.915 ± 0.035	2.441LysLeu: 2.441 ± 0.042	0.664LysMet: 0.664 ± 0.027	0.5LysAsn: 0.5 ± 0.021	1.534LysPro: 1.534 ± 0.035	0.692LysGln: 0.692 ± 0.021	1.853LysArg: 1.853 ± 0.043	1.353LysSer: 1.353 ± 0.038	1.575LysThr: 1.575 ± 0.034	1.793LysVal: 1.793 ± 0.036	0.316LysTrp: 0.316 ± 0.018	0.533LysTyr: 0.533 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.757LeuAla: 13.757 ± 0.138	1.041LeuCys: 1.041 ± 0.029	6.59LeuAsp: 6.59 ± 0.076	5.593LeuGlu: 5.593 ± 0.072	3.595LeuPhe: 3.595 ± 0.062	8.897LeuGly: 8.897 ± 0.109	1.952LeuHis: 1.952 ± 0.04	4.56LeuIle: 4.56 ± 0.067	2.659LeuLys: 2.659 ± 0.053	9.125LeuLeu: 9.125 ± 0.113	2.695LeuMet: 2.695 ± 0.052	2.404LeuAsn: 2.404 ± 0.039	5.939LeuPro: 5.939 ± 0.071	3.024LeuGln: 3.024 ± 0.044	7.84LeuArg: 7.84 ± 0.086	6.616LeuSer: 6.616 ± 0.075	5.793LeuThr: 5.793 ± 0.079	7.442LeuVal: 7.442 ± 0.085	1.439LeuTrp: 1.439 ± 0.038	2.031LeuTyr: 2.031 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.625MetAla: 3.625 ± 0.05	0.176MetCys: 0.176 ± 0.012	1.388MetAsp: 1.388 ± 0.034	1.294MetGlu: 1.294 ± 0.033	0.736MetPhe: 0.736 ± 0.026	2.266MetGly: 2.266 ± 0.042	0.42MetHis: 0.42 ± 0.017	1.393MetIle: 1.393 ± 0.035	0.892MetLys: 0.892 ± 0.027	2.545MetLeu: 2.545 ± 0.047	0.699MetMet: 0.699 ± 0.026	0.75MetAsn: 0.75 ± 0.028	1.479MetPro: 1.479 ± 0.035	0.984MetGln: 0.984 ± 0.026	1.963MetArg: 1.963 ± 0.042	1.747MetSer: 1.747 ± 0.03	2.075MetThr: 2.075 ± 0.042	1.866MetVal: 1.866 ± 0.042	0.243MetTrp: 0.243 ± 0.013	0.343MetTyr: 0.343 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.834AsnAla: 2.834 ± 0.055	0.233AsnCys: 0.233 ± 0.014	1.35AsnAsp: 1.35 ± 0.055	1.082AsnGlu: 1.082 ± 0.072	0.815AsnPhe: 0.815 ± 0.027	2.009AsnGly: 2.009 ± 0.046	0.453AsnHis: 0.453 ± 0.021	1.193AsnIle: 1.193 ± 0.031	0.507AsnLys: 0.507 ± 0.021	2.214AsnLeu: 2.214 ± 0.042	0.628AsnMet: 0.628 ± 0.025	0.587AsnAsn: 0.587 ± 0.026	1.657AsnPro: 1.657 ± 0.037	0.589AsnGln: 0.589 ± 0.021	1.602AsnArg: 1.602 ± 0.034	0.956AsnSer: 0.956 ± 0.031	1.174AsnThr: 1.174 ± 0.031	1.632AsnVal: 1.632 ± 0.039	0.386AsnTrp: 0.386 ± 0.019	0.592AsnTyr: 0.592 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.755ProAla: 6.755 ± 0.104	0.396ProCys: 0.396 ± 0.018	4.327ProAsp: 4.327 ± 0.057	4.727ProGlu: 4.727 ± 0.071	1.969ProPhe: 1.969 ± 0.037	5.394ProGly: 5.394 ± 0.071	1.126ProHis: 1.126 ± 0.032	1.971ProIle: 1.971 ± 0.045	1.302ProLys: 1.302 ± 0.035	4.844ProLeu: 4.844 ± 0.068	1.292ProMet: 1.292 ± 0.033	1.131ProAsn: 1.131 ± 0.028	2.665ProPro: 2.665 ± 0.056	1.806ProGln: 1.806 ± 0.038	3.491ProArg: 3.491 ± 0.059	2.309ProSer: 2.309 ± 0.045	2.205ProThr: 2.205 ± 0.035	4.729ProVal: 4.729 ± 0.065	0.778ProTrp: 0.778 ± 0.026	1.161ProTyr: 1.161 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.525GlnAla: 4.525 ± 0.065	0.178GlnCys: 0.178 ± 0.013	1.839GlnAsp: 1.839 ± 0.041	1.62GlnGlu: 1.62 ± 0.041	1.019GlnPhe: 1.019 ± 0.028	2.889GlnGly: 2.889 ± 0.058	0.56GlnHis: 0.56 ± 0.021	1.836GlnIle: 1.836 ± 0.041	0.846GlnLys: 0.846 ± 0.028	2.873GlnLeu: 2.873 ± 0.05	1.031GlnMet: 1.031 ± 0.026	0.779GlnAsn: 0.779 ± 0.02	1.668GlnPro: 1.668 ± 0.036	1.057GlnGln: 1.057 ± 0.032	2.13GlnArg: 2.13 ± 0.043	1.658GlnSer: 1.658 ± 0.035	1.702GlnThr: 1.702 ± 0.035	2.616GlnVal: 2.616 ± 0.041	0.373GlnTrp: 0.373 ± 0.019	0.575GlnTyr: 0.575 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.773ArgAla: 9.773 ± 0.116	0.517ArgCys: 0.517 ± 0.02	4.904ArgAsp: 4.904 ± 0.064	4.018ArgGlu: 4.018 ± 0.059	2.853ArgPhe: 2.853 ± 0.043	5.097ArgGly: 5.097 ± 0.059	1.81ArgHis: 1.81 ± 0.039	4.056ArgIle: 4.056 ± 0.055	2.014ArgLys: 2.014 ± 0.049	8.335ArgLeu: 8.335 ± 0.092	2.059ArgMet: 2.059 ± 0.039	1.718ArgAsn: 1.718 ± 0.036	3.964ArgPro: 3.964 ± 0.055	2.539ArgGln: 2.539 ± 0.048	5.74ArgArg: 5.74 ± 0.075	3.124ArgSer: 3.124 ± 0.052	3.054ArgThr: 3.054 ± 0.04	5.239ArgVal: 5.239 ± 0.073	1.053ArgTrp: 1.053 ± 0.03	1.592ArgTyr: 1.592 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.439SerAla: 5.439 ± 0.061	0.416SerCys: 0.416 ± 0.018	2.993SerAsp: 2.993 ± 0.045	2.758SerGlu: 2.758 ± 0.046	2.083SerPhe: 2.083 ± 0.041	5.04SerGly: 5.04 ± 0.069	1.023SerHis: 1.023 ± 0.026	2.064SerIle: 2.064 ± 0.038	1.146SerLys: 1.146 ± 0.033	4.533SerLeu: 4.533 ± 0.065	1.257SerMet: 1.257 ± 0.029	1.136SerAsn: 1.136 ± 0.034	2.341SerPro: 2.341 ± 0.04	1.397SerGln: 1.397 ± 0.034	3.253SerArg: 3.253 ± 0.053	2.092SerSer: 2.092 ± 0.037	2.242SerThr: 2.242 ± 0.037	3.532SerVal: 3.532 ± 0.056	0.706SerTrp: 0.706 ± 0.027	1.195SerTyr: 1.195 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.35ThrAla: 6.35 ± 0.079	0.502ThrCys: 0.502 ± 0.02	3.097ThrAsp: 3.097 ± 0.057	3.176ThrGlu: 3.176 ± 0.051	1.834ThrPhe: 1.834 ± 0.039	5.761ThrGly: 5.761 ± 0.068	1.143ThrHis: 1.143 ± 0.03	2.351ThrIle: 2.351 ± 0.046	1.06ThrLys: 1.06 ± 0.028	6.3ThrLeu: 6.3 ± 0.081	1.127ThrMet: 1.127 ± 0.03	1.07ThrAsn: 1.07 ± 0.03	3.58ThrPro: 3.58 ± 0.043	1.542ThrGln: 1.542 ± 0.035	3.972ThrArg: 3.972 ± 0.058	2.207ThrSer: 2.207 ± 0.041	2.598ThrThr: 2.598 ± 0.053	4.229ThrVal: 4.229 ± 0.064	0.727ThrTrp: 0.727 ± 0.027	1.166ThrTyr: 1.166 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.261ValAla: 9.261 ± 0.096	0.655ValCys: 0.655 ± 0.02	4.133ValAsp: 4.133 ± 0.06	4.638ValGlu: 4.638 ± 0.076	2.867ValPhe: 2.867 ± 0.052	5.148ValGly: 5.148 ± 0.074	1.322ValHis: 1.322 ± 0.035	3.957ValIle: 3.957 ± 0.055	1.737ValLys: 1.737 ± 0.041	7.803ValLeu: 7.803 ± 0.074	2.048ValMet: 2.048 ± 0.043	1.813ValAsn: 1.813 ± 0.044	3.811ValPro: 3.811 ± 0.058	2.202ValGln: 2.202 ± 0.041	4.283ValArg: 4.283 ± 0.061	3.954ValSer: 3.954 ± 0.058	5.026ValThr: 5.026 ± 0.075	5.564ValVal: 5.564 ± 0.077	0.948ValTrp: 0.948 ± 0.029	1.424ValTyr: 1.424 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.54TrpAla: 1.54 ± 0.042	0.144TrpCys: 0.144 ± 0.011	0.847TrpAsp: 0.847 ± 0.022	0.684TrpGlu: 0.684 ± 0.021	0.527TrpPhe: 0.527 ± 0.021	1.032TrpGly: 1.032 ± 0.03	0.356TrpHis: 0.356 ± 0.018	0.723TrpIle: 0.723 ± 0.026	0.364TrpLys: 0.364 ± 0.018	1.727TrpLeu: 1.727 ± 0.038	0.431TrpMet: 0.431 ± 0.018	0.355TrpAsn: 0.355 ± 0.018	0.797TrpPro: 0.797 ± 0.022	0.75TrpGln: 0.75 ± 0.025	1.178TrpArg: 1.178 ± 0.029	0.82TrpSer: 0.82 ± 0.027	0.822TrpThr: 0.822 ± 0.028	0.882TrpVal: 0.882 ± 0.031	0.242TrpTrp: 0.242 ± 0.016	0.274TrpTyr: 0.274 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.596TyrAla: 2.596 ± 0.045	0.254TyrCys: 0.254 ± 0.014	1.534TyrAsp: 1.534 ± 0.036	1.268TyrGlu: 1.268 ± 0.036	0.845TyrPhe: 0.845 ± 0.029	2.071TyrGly: 2.071 ± 0.041	0.525TyrHis: 0.525 ± 0.02	0.794TyrIle: 0.794 ± 0.025	0.471TyrLys: 0.471 ± 0.023	2.209TyrLeu: 2.209 ± 0.048	0.494TyrMet: 0.494 ± 0.018	0.5TyrAsn: 0.5 ± 0.021	1.041TyrPro: 1.041 ± 0.027	0.633TyrGln: 0.633 ± 0.024	1.655TyrArg: 1.655 ± 0.041	1.006TyrSer: 1.006 ± 0.026	1.103TyrThr: 1.103 ± 0.033	1.514TyrVal: 1.514 ± 0.034	0.342TyrTrp: 0.342 ± 0.016	0.545TyrTyr: 0.545 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4264 proteins (1336786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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