Amino acid dipepetide frequency for Luteimonas sp. FCS-9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.894AlaAla: 20.894 ± 0.24	1.31AlaCys: 1.31 ± 0.035	8.704AlaAsp: 8.704 ± 0.105	6.675AlaGlu: 6.675 ± 0.097	4.62AlaPhe: 4.62 ± 0.07	12.809AlaGly: 12.809 ± 0.138	3.073AlaHis: 3.073 ± 0.062	5.662AlaIle: 5.662 ± 0.078	2.467AlaLys: 2.467 ± 0.057	17.524AlaLeu: 17.524 ± 0.19	3.26AlaMet: 3.26 ± 0.058	2.477AlaAsn: 2.477 ± 0.052	8.105AlaPro: 8.105 ± 0.1	5.917AlaGln: 5.917 ± 0.088	12.128AlaArg: 12.128 ± 0.15	6.456AlaSer: 6.456 ± 0.1	7.038AlaThr: 7.038 ± 0.105	9.401AlaVal: 9.401 ± 0.119	2.393AlaTrp: 2.393 ± 0.057	2.637AlaTyr: 2.637 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.105CysAla: 1.105 ± 0.036	0.081CysCys: 0.081 ± 0.01	0.475CysAsp: 0.475 ± 0.023	0.381CysGlu: 0.381 ± 0.019	0.255CysPhe: 0.255 ± 0.014	0.844CysGly: 0.844 ± 0.028	0.212CysHis: 0.212 ± 0.016	0.313CysIle: 0.313 ± 0.015	0.117CysLys: 0.117 ± 0.011	0.73CysLeu: 0.73 ± 0.029	0.124CysMet: 0.124 ± 0.011	0.192CysAsn: 0.192 ± 0.013	0.374CysPro: 0.374 ± 0.018	0.186CysGln: 0.186 ± 0.013	0.575CysArg: 0.575 ± 0.025	0.361CysSer: 0.361 ± 0.018	0.441CysThr: 0.441 ± 0.021	0.61CysVal: 0.61 ± 0.026	0.122CysTrp: 0.122 ± 0.012	0.16CysTyr: 0.16 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	11.213AspAla: 11.213 ± 0.123	0.443AspCys: 0.443 ± 0.022	4.43AspAsp: 4.43 ± 0.074	3.205AspGlu: 3.205 ± 0.066	1.999AspPhe: 1.999 ± 0.043	7.118AspGly: 7.118 ± 0.105	1.192AspHis: 1.192 ± 0.042	2.326AspIle: 2.326 ± 0.046	1.135AspLys: 1.135 ± 0.037	5.921AspLeu: 5.921 ± 0.073	1.066AspMet: 1.066 ± 0.039	1.192AspAsn: 1.192 ± 0.043	3.98AspPro: 3.98 ± 0.069	1.458AspGln: 1.458 ± 0.039	4.771AspArg: 4.771 ± 0.074	2.137AspSer: 2.137 ± 0.05	2.982AspThr: 2.982 ± 0.055	4.846AspVal: 4.846 ± 0.071	1.326AspTrp: 1.326 ± 0.034	1.638AspTyr: 1.638 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.559GluAla: 7.559 ± 0.109	0.273GluCys: 0.273 ± 0.015	2.625GluAsp: 2.625 ± 0.05	1.868GluGlu: 1.868 ± 0.053	1.542GluPhe: 1.542 ± 0.04	3.793GluGly: 3.793 ± 0.067	1.293GluHis: 1.293 ± 0.032	2.443GluIle: 2.443 ± 0.048	1.083GluLys: 1.083 ± 0.044	5.303GluLeu: 5.303 ± 0.086	0.969GluMet: 0.969 ± 0.034	1.022GluAsn: 1.022 ± 0.031	2.271GluPro: 2.271 ± 0.048	2.02GluGln: 2.02 ± 0.049	5.355GluArg: 5.355 ± 0.08	2.179GluSer: 2.179 ± 0.049	2.782GluThr: 2.782 ± 0.053	3.817GluVal: 3.817 ± 0.053	0.594GluTrp: 0.594 ± 0.025	1.024GluTyr: 1.024 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.703PheAla: 4.703 ± 0.067	0.299PheCys: 0.299 ± 0.017	2.993PheAsp: 2.993 ± 0.058	2.034PheGlu: 2.034 ± 0.044	1.139PhePhe: 1.139 ± 0.041	3.423PheGly: 3.423 ± 0.064	0.748PheHis: 0.748 ± 0.026	0.877PheIle: 0.877 ± 0.032	0.632PheLys: 0.632 ± 0.025	2.825PheLeu: 2.825 ± 0.06	0.567PheMet: 0.567 ± 0.023	0.883PheAsn: 0.883 ± 0.033	1.387PhePro: 1.387 ± 0.035	0.848PheGln: 0.848 ± 0.029	2.184PheArg: 2.184 ± 0.047	1.723PheSer: 1.723 ± 0.037	1.429PheThr: 1.429 ± 0.039	2.945PheVal: 2.945 ± 0.062	0.483PheTrp: 0.483 ± 0.024	0.74PheTyr: 0.74 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.857GlyAla: 10.857 ± 0.131	0.768GlyCys: 0.768 ± 0.03	5.642GlyAsp: 5.642 ± 0.08	4.892GlyGlu: 4.892 ± 0.064	3.514GlyPhe: 3.514 ± 0.069	8.195GlyGly: 8.195 ± 0.154	2.146GlyHis: 2.146 ± 0.044	4.036GlyIle: 4.036 ± 0.059	2.18GlyLys: 2.18 ± 0.055	9.354GlyLeu: 9.354 ± 0.102	2.183GlyMet: 2.183 ± 0.051	2.099GlyAsn: 2.099 ± 0.047	3.574GlyPro: 3.574 ± 0.068	2.99GlyGln: 2.99 ± 0.056	7.541GlyArg: 7.541 ± 0.091	4.193GlySer: 4.193 ± 0.091	4.873GlyThr: 4.873 ± 0.07	6.762GlyVal: 6.762 ± 0.089	1.7GlyTrp: 1.7 ± 0.041	2.338GlyTyr: 2.338 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	3.52HisAla: 3.52 ± 0.065	0.209HisCys: 0.209 ± 0.013	1.531HisAsp: 1.531 ± 0.039	0.973HisGlu: 0.973 ± 0.026	0.73HisPhe: 0.73 ± 0.028	2.372HisGly: 2.372 ± 0.059	0.563HisHis: 0.563 ± 0.026	0.595HisIle: 0.595 ± 0.022	0.361HisLys: 0.361 ± 0.02	2.081HisLeu: 2.081 ± 0.048	0.376HisMet: 0.376 ± 0.02	0.484HisAsn: 0.484 ± 0.021	1.477HisPro: 1.477 ± 0.039	0.559HisGln: 0.559 ± 0.023	1.86HisArg: 1.86 ± 0.046	0.795HisSer: 0.795 ± 0.028	0.939HisThr: 0.939 ± 0.029	1.813HisVal: 1.813 ± 0.039	0.404HisTrp: 0.404 ± 0.02	0.579HisTyr: 0.579 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.65IleAla: 6.65 ± 0.089	0.264IleCys: 0.264 ± 0.014	3.429IleAsp: 3.429 ± 0.062	2.873IleGlu: 2.873 ± 0.058	0.919IlePhe: 0.919 ± 0.028	4.255IleGly: 4.255 ± 0.06	0.719IleHis: 0.719 ± 0.028	0.933IleIle: 0.933 ± 0.036	0.82IleLys: 0.82 ± 0.033	2.691IleLeu: 2.691 ± 0.06	0.434IleMet: 0.434 ± 0.025	0.973IleAsn: 0.973 ± 0.036	1.814IlePro: 1.814 ± 0.042	0.948IleGln: 0.948 ± 0.032	2.637IleArg: 2.637 ± 0.049	1.685IleSer: 1.685 ± 0.04	1.65IleThr: 1.65 ± 0.037	3.652IleVal: 3.652 ± 0.061	0.396IleTrp: 0.396 ± 0.02	0.69IleTyr: 0.69 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.539LysAla: 2.539 ± 0.064	0.095LysCys: 0.095 ± 0.01	1.029LysAsp: 1.029 ± 0.04	0.786LysGlu: 0.786 ± 0.037	0.552LysPhe: 0.552 ± 0.025	1.538LysGly: 1.538 ± 0.045	0.386LysHis: 0.386 ± 0.019	0.822LysIle: 0.822 ± 0.03	0.604LysLys: 0.604 ± 0.028	2.143LysLeu: 2.143 ± 0.051	0.397LysMet: 0.397 ± 0.017	0.43LysAsn: 0.43 ± 0.023	1.239LysPro: 1.239 ± 0.042	0.704LysGln: 0.704 ± 0.029	1.641LysArg: 1.641 ± 0.043	0.957LysSer: 0.957 ± 0.034	1.152LysThr: 1.152 ± 0.037	1.611LysVal: 1.611 ± 0.048	0.255LysTrp: 0.255 ± 0.016	0.448LysTyr: 0.448 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.141LeuAla: 16.141 ± 0.179	0.888LeuCys: 0.888 ± 0.027	7.508LeuAsp: 7.508 ± 0.102	5.084LeuGlu: 5.084 ± 0.074	3.32LeuPhe: 3.32 ± 0.07	8.917LeuGly: 8.917 ± 0.103	2.499LeuHis: 2.499 ± 0.059	3.333LeuIle: 3.333 ± 0.064	2.047LeuLys: 2.047 ± 0.048	11.572LeuLeu: 11.572 ± 0.157	1.895LeuMet: 1.895 ± 0.049	1.821LeuAsn: 1.821 ± 0.042	6.572LeuPro: 6.572 ± 0.084	3.841LeuGln: 3.841 ± 0.06	9.854LeuArg: 9.854 ± 0.113	5.4LeuSer: 5.4 ± 0.08	4.646LeuThr: 4.646 ± 0.071	8.264LeuVal: 8.264 ± 0.106	1.378LeuTrp: 1.378 ± 0.044	2.104LeuTyr: 2.104 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.576MetAla: 2.576 ± 0.058	0.128MetCys: 0.128 ± 0.012	0.937MetAsp: 0.937 ± 0.03	0.739MetGlu: 0.739 ± 0.023	0.532MetPhe: 0.532 ± 0.026	1.46MetGly: 1.46 ± 0.039	0.466MetHis: 0.466 ± 0.023	0.76MetIle: 0.76 ± 0.024	0.539MetLys: 0.539 ± 0.026	2.295MetLeu: 2.295 ± 0.05	0.378MetMet: 0.378 ± 0.021	0.453MetAsn: 0.453 ± 0.022	1.453MetPro: 1.453 ± 0.044	0.792MetGln: 0.792 ± 0.027	1.873MetArg: 1.873 ± 0.042	1.376MetSer: 1.376 ± 0.033	1.382MetThr: 1.382 ± 0.034	1.287MetVal: 1.287 ± 0.038	0.171MetTrp: 0.171 ± 0.012	0.292MetTyr: 0.292 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.097AsnAla: 3.097 ± 0.064	0.176AsnCys: 0.176 ± 0.014	1.142AsnAsp: 1.142 ± 0.035	0.893AsnGlu: 0.893 ± 0.029	0.766AsnPhe: 0.766 ± 0.031	1.925AsnGly: 1.925 ± 0.043	0.382AsnHis: 0.382 ± 0.021	0.851AsnIle: 0.851 ± 0.033	0.41AsnLys: 0.41 ± 0.021	2.17AsnLeu: 2.17 ± 0.051	0.315AsnMet: 0.315 ± 0.017	0.52AsnAsn: 0.52 ± 0.026	1.547AsnPro: 1.547 ± 0.041	0.553AsnGln: 0.553 ± 0.024	1.578AsnArg: 1.578 ± 0.043	0.802AsnSer: 0.802 ± 0.032	1.118AsnThr: 1.118 ± 0.035	1.762AsnVal: 1.762 ± 0.051	0.32AsnTrp: 0.32 ± 0.022	0.564AsnTyr: 0.564 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	8.641ProAla: 8.641 ± 0.12	0.282ProCys: 0.282 ± 0.017	4.207ProAsp: 4.207 ± 0.067	3.186ProGlu: 3.186 ± 0.063	1.654ProPhe: 1.654 ± 0.038	5.498ProGly: 5.498 ± 0.081	1.117ProHis: 1.117 ± 0.033	1.757ProIle: 1.757 ± 0.045	0.99ProLys: 0.99 ± 0.031	5.441ProLeu: 5.441 ± 0.075	1.249ProMet: 1.249 ± 0.033	1.012ProAsn: 1.012 ± 0.033	3.461ProPro: 3.461 ± 0.078	1.969ProGln: 1.969 ± 0.047	4.082ProArg: 4.082 ± 0.075	2.493ProSer: 2.493 ± 0.051	2.546ProThr: 2.546 ± 0.051	4.645ProVal: 4.645 ± 0.062	0.899ProTrp: 0.899 ± 0.03	1.124ProTyr: 1.124 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.711GlnAla: 5.711 ± 0.086	0.233GlnCys: 0.233 ± 0.016	1.573GlnAsp: 1.573 ± 0.044	1.086GlnGlu: 1.086 ± 0.035	1.014GlnPhe: 1.014 ± 0.035	2.592GlnGly: 2.592 ± 0.05	0.695GlnHis: 0.695 ± 0.022	1.373GlnIle: 1.373 ± 0.042	0.621GlnLys: 0.621 ± 0.025	3.766GlnLeu: 3.766 ± 0.07	0.679GlnMet: 0.679 ± 0.027	0.615GlnAsn: 0.615 ± 0.027	1.987GlnPro: 1.987 ± 0.044	1.475GlnGln: 1.475 ± 0.042	3.336GlnArg: 3.336 ± 0.064	1.4GlnSer: 1.4 ± 0.042	1.606GlnThr: 1.606 ± 0.04	2.914GlnVal: 2.914 ± 0.06	0.578GlnTrp: 0.578 ± 0.029	0.692GlnTyr: 0.692 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	10.508ArgAla: 10.508 ± 0.116	0.579ArgCys: 0.579 ± 0.025	5.552ArgAsp: 5.552 ± 0.075	4.791ArgGlu: 4.791 ± 0.079	3.15ArgPhe: 3.15 ± 0.055	6.183ArgGly: 6.183 ± 0.077	2.18ArgHis: 2.18 ± 0.05	4.277ArgIle: 4.277 ± 0.06	1.547ArgLys: 1.547 ± 0.042	9.543ArgLeu: 9.543 ± 0.123	2.111ArgMet: 2.111 ± 0.041	1.873ArgAsn: 1.873 ± 0.048	4.294ArgPro: 4.294 ± 0.078	2.968ArgGln: 2.968 ± 0.054	7.398ArgArg: 7.398 ± 0.104	3.543ArgSer: 3.543 ± 0.065	4.152ArgThr: 4.152 ± 0.068	6.06ArgVal: 6.06 ± 0.088	1.53ArgTrp: 1.53 ± 0.042	2.285ArgTyr: 2.285 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.981SerAla: 5.981 ± 0.09	0.297SerCys: 0.297 ± 0.018	2.552SerAsp: 2.552 ± 0.046	2.105SerGlu: 2.105 ± 0.044	1.535SerPhe: 1.535 ± 0.039	4.8SerGly: 4.8 ± 0.072	0.966SerHis: 0.966 ± 0.035	1.886SerIle: 1.886 ± 0.049	0.941SerLys: 0.941 ± 0.031	4.607SerLeu: 4.607 ± 0.074	0.905SerMet: 0.905 ± 0.026	1.119SerAsn: 1.119 ± 0.038	2.775SerPro: 2.775 ± 0.053	1.479SerGln: 1.479 ± 0.04	3.648SerArg: 3.648 ± 0.056	2.303SerSer: 2.303 ± 0.051	2.436SerThr: 2.436 ± 0.06	3.389SerVal: 3.389 ± 0.059	0.668SerTrp: 0.668 ± 0.027	1.1SerTyr: 1.1 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.269ThrAla: 6.269 ± 0.112	0.356ThrCys: 0.356 ± 0.018	2.534ThrAsp: 2.534 ± 0.053	2.023ThrGlu: 2.023 ± 0.046	1.646ThrPhe: 1.646 ± 0.043	4.862ThrGly: 4.862 ± 0.077	1.065ThrHis: 1.065 ± 0.031	2.133ThrIle: 2.133 ± 0.051	0.753ThrLys: 0.753 ± 0.03	6.362ThrLeu: 6.362 ± 0.082	0.935ThrMet: 0.935 ± 0.03	0.914ThrAsn: 0.914 ± 0.035	3.487ThrPro: 3.487 ± 0.069	1.506ThrGln: 1.506 ± 0.036	3.882ThrArg: 3.882 ± 0.061	2.199ThrSer: 2.199 ± 0.044	2.565ThrThr: 2.565 ± 0.058	4.05ThrVal: 4.05 ± 0.061	0.791ThrTrp: 0.791 ± 0.03	0.972ThrTyr: 0.972 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.032ValAla: 11.032 ± 0.131	0.627ValCys: 0.627 ± 0.028	5.332ValAsp: 5.332 ± 0.071	4.641ValGlu: 4.641 ± 0.064	2.591ValPhe: 2.591 ± 0.054	6.165ValGly: 6.165 ± 0.108	1.701ValHis: 1.701 ± 0.041	2.706ValIle: 2.706 ± 0.056	1.351ValLys: 1.351 ± 0.041	8.278ValLeu: 8.278 ± 0.095	1.292ValMet: 1.292 ± 0.039	1.824ValAsn: 1.824 ± 0.05	4.507ValPro: 4.507 ± 0.075	2.355ValGln: 2.355 ± 0.046	6.321ValArg: 6.321 ± 0.087	3.654ValSer: 3.654 ± 0.06	3.53ValThr: 3.53 ± 0.063	6.69ValVal: 6.69 ± 0.094	0.943ValTrp: 0.943 ± 0.033	1.533ValTyr: 1.533 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.461TrpAla: 1.461 ± 0.042	0.16TrpCys: 0.16 ± 0.013	0.797TrpAsp: 0.797 ± 0.03	0.512TrpGlu: 0.512 ± 0.023	0.567TrpPhe: 0.567 ± 0.026	0.973TrpGly: 0.973 ± 0.034	0.394TrpHis: 0.394 ± 0.019	0.741TrpIle: 0.741 ± 0.026	0.345TrpLys: 0.345 ± 0.02	2.27TrpLeu: 2.27 ± 0.058	0.417TrpMet: 0.417 ± 0.02	0.423TrpAsn: 0.423 ± 0.022	0.837TrpPro: 0.837 ± 0.032	0.741TrpGln: 0.741 ± 0.026	1.729TrpArg: 1.729 ± 0.047	0.836TrpSer: 0.836 ± 0.031	0.912TrpThr: 0.912 ± 0.035	0.868TrpVal: 0.868 ± 0.03	0.308TrpTrp: 0.308 ± 0.019	0.333TrpTyr: 0.333 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.095TyrAla: 3.095 ± 0.064	0.192TyrCys: 0.192 ± 0.014	1.386TyrAsp: 1.386 ± 0.039	1.069TyrGlu: 1.069 ± 0.039	0.815TyrPhe: 0.815 ± 0.029	2.117TyrGly: 2.117 ± 0.039	0.422TyrHis: 0.422 ± 0.022	0.61TyrIle: 0.61 ± 0.026	0.386TyrLys: 0.386 ± 0.022	2.213TyrLeu: 2.213 ± 0.05	0.338TyrMet: 0.338 ± 0.019	0.562TyrAsn: 0.562 ± 0.028	1.109TyrPro: 1.109 ± 0.034	0.637TyrGln: 0.637 ± 0.026	2.129TyrArg: 2.129 ± 0.046	1.0TyrSer: 1.0 ± 0.036	1.125TyrThr: 1.125 ± 0.036	1.685TyrVal: 1.685 ± 0.043	0.363TyrTrp: 0.363 ± 0.02	0.583TyrTyr: 0.583 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3200 proteins (1065100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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