Amino acid dipepetide frequency for Gilliamella apicola SCGC AB-598-I20

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.599AlaAla: 5.599 ± 0.128
0.917AlaCys: 0.917 ± 0.04
3.725AlaAsp: 3.725 ± 0.092
4.394AlaGlu: 4.394 ± 0.109
3.141AlaPhe: 3.141 ± 0.083
4.882AlaGly: 4.882 ± 0.123
1.22AlaHis: 1.22 ± 0.05
6.78AlaIle: 6.78 ± 0.098
5.371AlaLys: 5.371 ± 0.124
7.895AlaLeu: 7.895 ± 0.11
2.064AlaMet: 2.064 ± 0.07
3.993AlaAsn: 3.993 ± 0.086
2.132AlaPro: 2.132 ± 0.054
3.332AlaGln: 3.332 ± 0.091
2.741AlaArg: 2.741 ± 0.072
4.3AlaSer: 4.3 ± 0.091
4.028AlaThr: 4.028 ± 0.088
4.73AlaVal: 4.73 ± 0.11
0.698AlaTrp: 0.698 ± 0.035
2.362AlaTyr: 2.362 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.81CysAla: 0.81 ± 0.035
0.178CysCys: 0.178 ± 0.016
0.632CysAsp: 0.632 ± 0.032
0.598CysGlu: 0.598 ± 0.032
0.577CysPhe: 0.577 ± 0.025
0.862CysGly: 0.862 ± 0.044
0.322CysHis: 0.322 ± 0.025
0.857CysIle: 0.857 ± 0.038
0.549CysLys: 0.549 ± 0.027
1.176CysLeu: 1.176 ± 0.046
0.248CysMet: 0.248 ± 0.02
0.502CysAsn: 0.502 ± 0.028
0.421CysPro: 0.421 ± 0.029
0.58CysGln: 0.58 ± 0.027
0.439CysArg: 0.439 ± 0.025
0.721CysSer: 0.721 ± 0.037
0.454CysThr: 0.454 ± 0.028
0.672CysVal: 0.672 ± 0.033
0.147CysTrp: 0.147 ± 0.016
0.468CysTyr: 0.468 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.444AspAla: 3.444 ± 0.077
0.591AspCys: 0.591 ± 0.034
3.084AspAsp: 3.084 ± 0.089
3.813AspGlu: 3.813 ± 0.087
2.481AspPhe: 2.481 ± 0.068
3.296AspGly: 3.296 ± 0.082
1.001AspHis: 1.001 ± 0.041
4.893AspIle: 4.893 ± 0.11
4.106AspLys: 4.106 ± 0.093
4.937AspLeu: 4.937 ± 0.096
1.259AspMet: 1.259 ± 0.046
3.429AspAsn: 3.429 ± 0.076
1.898AspPro: 1.898 ± 0.059
1.822AspGln: 1.822 ± 0.062
1.947AspArg: 1.947 ± 0.062
3.063AspSer: 3.063 ± 0.08
2.261AspThr: 2.261 ± 0.062
3.28AspVal: 3.28 ± 0.09
0.666AspTrp: 0.666 ± 0.034
2.328AspTyr: 2.328 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
3.727GluAla: 3.727 ± 0.103
0.465GluCys: 0.465 ± 0.027
2.465GluAsp: 2.465 ± 0.065
3.011GluGlu: 3.011 ± 0.093
2.149GluPhe: 2.149 ± 0.057
2.737GluGly: 2.737 ± 0.074
1.247GluHis: 1.247 ± 0.044
4.514GluIle: 4.514 ± 0.091
4.467GluLys: 4.467 ± 0.094
6.39GluLeu: 6.39 ± 0.104
1.489GluMet: 1.489 ± 0.05
3.311GluAsn: 3.311 ± 0.07
1.672GluPro: 1.672 ± 0.056
3.884GluGln: 3.884 ± 0.124
2.588GluArg: 2.588 ± 0.075
3.107GluSer: 3.107 ± 0.074
2.601GluThr: 2.601 ± 0.069
3.325GluVal: 3.325 ± 0.087
0.585GluTrp: 0.585 ± 0.034
1.876GluTyr: 1.876 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.387PheAla: 3.387 ± 0.082
0.611PheCys: 0.611 ± 0.035
2.783PheAsp: 2.783 ± 0.066
2.187PheGlu: 2.187 ± 0.065
2.19PhePhe: 2.19 ± 0.088
2.984PheGly: 2.984 ± 0.08
0.765PheHis: 0.765 ± 0.034
4.019PheIle: 4.019 ± 0.106
2.475PheLys: 2.475 ± 0.069
3.957PheLeu: 3.957 ± 0.095
1.006PheMet: 1.006 ± 0.042
2.754PheAsn: 2.754 ± 0.072
1.467PhePro: 1.467 ± 0.054
1.275PheGln: 1.275 ± 0.045
1.429PheArg: 1.429 ± 0.048
3.358PheSer: 3.358 ± 0.081
2.336PheThr: 2.336 ± 0.071
2.643PheVal: 2.643 ± 0.076
0.546PheTrp: 0.546 ± 0.035
1.845PheTyr: 1.845 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.558GlyAla: 4.558 ± 0.116
0.888GlyCys: 0.888 ± 0.04
3.15GlyAsp: 3.15 ± 0.081
3.335GlyGlu: 3.335 ± 0.082
3.23GlyPhe: 3.23 ± 0.081
4.265GlyGly: 4.265 ± 0.126
1.362GlyHis: 1.362 ± 0.05
5.588GlyIle: 5.588 ± 0.127
4.283GlyLys: 4.283 ± 0.106
6.249GlyLeu: 6.249 ± 0.107
1.665GlyMet: 1.665 ± 0.058
2.906GlyAsn: 2.906 ± 0.091
1.388GlyPro: 1.388 ± 0.057
2.422GlyGln: 2.422 ± 0.061
2.496GlyArg: 2.496 ± 0.072
3.716GlySer: 3.716 ± 0.092
3.027GlyThr: 3.027 ± 0.069
4.401GlyVal: 4.401 ± 0.092
0.821GlyTrp: 0.821 ± 0.04
2.664GlyTyr: 2.664 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.344HisAla: 1.344 ± 0.047
0.311HisCys: 0.311 ± 0.022
1.029HisAsp: 1.029 ± 0.044
0.928HisGlu: 0.928 ± 0.041
1.077HisPhe: 1.077 ± 0.049
1.299HisGly: 1.299 ± 0.046
0.653HisHis: 0.653 ± 0.038
1.521HisIle: 1.521 ± 0.051
1.097HisLys: 1.097 ± 0.045
2.077HisLeu: 2.077 ± 0.063
0.437HisMet: 0.437 ± 0.026
1.063HisAsn: 1.063 ± 0.038
0.964HisPro: 0.964 ± 0.041
1.033HisGln: 1.033 ± 0.043
0.811HisArg: 0.811 ± 0.036
1.221HisSer: 1.221 ± 0.046
0.931HisThr: 0.931 ± 0.033
1.098HisVal: 1.098 ± 0.041
0.293HisTrp: 0.293 ± 0.023
0.972HisTyr: 0.972 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
7.292IleAla: 7.292 ± 0.114
1.085IleCys: 1.085 ± 0.041
5.369IleAsp: 5.369 ± 0.107
5.277IleGlu: 5.277 ± 0.108
3.356IlePhe: 3.356 ± 0.094
5.77IleGly: 5.77 ± 0.121
1.506IleHis: 1.506 ± 0.056
6.941IleIle: 6.941 ± 0.125
5.425IleLys: 5.425 ± 0.097
7.554IleLeu: 7.554 ± 0.125
1.761IleMet: 1.761 ± 0.051
5.104IleAsn: 5.104 ± 0.117
3.332IlePro: 3.332 ± 0.079
2.616IleGln: 2.616 ± 0.078
2.877IleArg: 2.877 ± 0.076
5.603IleSer: 5.603 ± 0.105
4.825IleThr: 4.825 ± 0.09
5.203IleVal: 5.203 ± 0.105
0.753IleTrp: 0.753 ± 0.033
2.732IleTyr: 2.732 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.937LysAla: 4.937 ± 0.133
0.462LysCys: 0.462 ± 0.03
3.196LysAsp: 3.196 ± 0.068
3.627LysGlu: 3.627 ± 0.089
2.102LysPhe: 2.102 ± 0.063
3.505LysGly: 3.505 ± 0.082
1.288LysHis: 1.288 ± 0.043
5.339LysIle: 5.339 ± 0.09
4.777LysLys: 4.777 ± 0.095
6.602LysLeu: 6.602 ± 0.107
1.647LysMet: 1.647 ± 0.053
3.858LysAsn: 3.858 ± 0.092
2.522LysPro: 2.522 ± 0.067
4.247LysGln: 4.247 ± 0.104
2.818LysArg: 2.818 ± 0.073
3.884LysSer: 3.884 ± 0.067
3.724LysThr: 3.724 ± 0.08
3.941LysVal: 3.941 ± 0.089
0.674LysTrp: 0.674 ± 0.036
2.232LysTyr: 2.232 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
8.704LeuAla: 8.704 ± 0.136
1.203LeuCys: 1.203 ± 0.04
5.363LeuAsp: 5.363 ± 0.096
5.086LeuGlu: 5.086 ± 0.116
4.793LeuPhe: 4.793 ± 0.112
6.33LeuGly: 6.33 ± 0.128
1.727LeuHis: 1.727 ± 0.057
8.345LeuIle: 8.345 ± 0.151
6.374LeuLys: 6.374 ± 0.108
10.904LeuLeu: 10.904 ± 0.187
2.473LeuMet: 2.473 ± 0.062
5.625LeuAsn: 5.625 ± 0.117
4.589LeuPro: 4.589 ± 0.09
3.678LeuGln: 3.678 ± 0.074
3.606LeuArg: 3.606 ± 0.093
7.815LeuSer: 7.815 ± 0.146
6.404LeuThr: 6.404 ± 0.109
6.262LeuVal: 6.262 ± 0.102
1.067LeuTrp: 1.067 ± 0.051
3.055LeuTyr: 3.055 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
1.973MetAla: 1.973 ± 0.059
0.188MetCys: 0.188 ± 0.017
1.046MetAsp: 1.046 ± 0.039
0.98MetGlu: 0.98 ± 0.036
0.899MetPhe: 0.899 ± 0.035
1.55MetGly: 1.55 ± 0.064
0.447MetHis: 0.447 ± 0.025
1.949MetIle: 1.949 ± 0.064
1.552MetLys: 1.552 ± 0.044
2.588MetLeu: 2.588 ± 0.072
0.75MetMet: 0.75 ± 0.038
1.304MetAsn: 1.304 ± 0.043
1.101MetPro: 1.101 ± 0.047
1.205MetGln: 1.205 ± 0.046
0.944MetArg: 0.944 ± 0.04
1.71MetSer: 1.71 ± 0.054
1.406MetThr: 1.406 ± 0.042
1.595MetVal: 1.595 ± 0.052
0.164MetTrp: 0.164 ± 0.015
0.716MetTyr: 0.716 ± 0.051
0.0MetXaa: 0.0 ± 0.0
Asn
3.589AsnAla: 3.589 ± 0.085
0.565AsnCys: 0.565 ± 0.029
2.941AsnAsp: 2.941 ± 0.068
3.039AsnGlu: 3.039 ± 0.07
2.127AsnPhe: 2.127 ± 0.071
3.356AsnGly: 3.356 ± 0.098
1.325AsnHis: 1.325 ± 0.056
4.641AsnIle: 4.641 ± 0.096
3.831AsnLys: 3.831 ± 0.095
5.382AsnLeu: 5.382 ± 0.098
1.226AsnMet: 1.226 ± 0.048
3.597AsnAsn: 3.597 ± 0.101
2.235AsnPro: 2.235 ± 0.081
3.244AsnGln: 3.244 ± 0.088
2.128AsnArg: 2.128 ± 0.064
3.601AsnSer: 3.601 ± 0.101
2.598AsnThr: 2.598 ± 0.063
3.006AsnVal: 3.006 ± 0.07
0.688AsnTrp: 0.688 ± 0.031
2.245AsnTyr: 2.245 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
2.609ProAla: 2.609 ± 0.07
0.335ProCys: 0.335 ± 0.024
2.091ProAsp: 2.091 ± 0.055
2.658ProGlu: 2.658 ± 0.074
1.787ProPhe: 1.787 ± 0.055
1.704ProGly: 1.704 ± 0.058
0.755ProHis: 0.755 ± 0.035
3.129ProIle: 3.129 ± 0.073
2.3ProLys: 2.3 ± 0.069
3.763ProLeu: 3.763 ± 0.084
0.865ProMet: 0.865 ± 0.04
2.247ProAsn: 2.247 ± 0.054
1.004ProPro: 1.004 ± 0.041
1.45ProGln: 1.45 ± 0.049
1.053ProArg: 1.053 ± 0.046
2.115ProSer: 2.115 ± 0.063
2.13ProThr: 2.13 ± 0.059
2.481ProVal: 2.481 ± 0.064
0.411ProTrp: 0.411 ± 0.032
1.367ProTyr: 1.367 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
3.612GlnAla: 3.612 ± 0.099
0.4GlnCys: 0.4 ± 0.026
2.141GlnAsp: 2.141 ± 0.061
2.465GlnGlu: 2.465 ± 0.073
2.028GlnPhe: 2.028 ± 0.054
2.559GlnGly: 2.559 ± 0.071
0.967GlnHis: 0.967 ± 0.043
3.557GlnIle: 3.557 ± 0.099
3.045GlnLys: 3.045 ± 0.081
5.384GlnLeu: 5.384 ± 0.121
1.011GlnMet: 1.011 ± 0.04
2.365GlnAsn: 2.365 ± 0.075
1.581GlnPro: 1.581 ± 0.054
2.932GlnGln: 2.932 ± 0.093
1.817GlnArg: 1.817 ± 0.058
2.758GlnSer: 2.758 ± 0.071
2.349GlnThr: 2.349 ± 0.063
2.626GlnVal: 2.626 ± 0.068
0.547GlnTrp: 0.547 ± 0.03
1.806GlnTyr: 1.806 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
2.438ArgAla: 2.438 ± 0.061
0.42ArgCys: 0.42 ± 0.029
2.036ArgAsp: 2.036 ± 0.062
2.221ArgGlu: 2.221 ± 0.072
2.031ArgPhe: 2.031 ± 0.062
2.034ArgGly: 2.034 ± 0.059
0.901ArgHis: 0.901 ± 0.041
3.123ArgIle: 3.123 ± 0.072
2.413ArgLys: 2.413 ± 0.071
4.117ArgLeu: 4.117 ± 0.111
0.943ArgMet: 0.943 ± 0.043
1.893ArgAsn: 1.893 ± 0.055
1.267ArgPro: 1.267 ± 0.045
1.999ArgGln: 1.999 ± 0.056
1.908ArgArg: 1.908 ± 0.065
2.132ArgSer: 2.132 ± 0.054
1.837ArgThr: 1.837 ± 0.056
2.29ArgVal: 2.29 ± 0.063
0.449ArgTrp: 0.449 ± 0.027
1.689ArgTyr: 1.689 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
4.594SerAla: 4.594 ± 0.083
0.68SerCys: 0.68 ± 0.039
3.56SerAsp: 3.56 ± 0.078
3.38SerGlu: 3.38 ± 0.086
2.98SerPhe: 2.98 ± 0.076
4.381SerGly: 4.381 ± 0.109
1.367SerHis: 1.367 ± 0.051
5.23SerIle: 5.23 ± 0.099
3.74SerLys: 3.74 ± 0.078
6.822SerLeu: 6.822 ± 0.12
1.537SerMet: 1.537 ± 0.047
3.168SerAsn: 3.168 ± 0.078
2.201SerPro: 2.201 ± 0.062
2.974SerGln: 2.974 ± 0.077
2.48SerArg: 2.48 ± 0.07
4.375SerSer: 4.375 ± 0.134
3.298SerThr: 3.298 ± 0.08
3.9SerVal: 3.9 ± 0.09
0.726SerTrp: 0.726 ± 0.03
2.316SerTyr: 2.316 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.826ThrAla: 3.826 ± 0.087
0.502ThrCys: 0.502 ± 0.03
2.928ThrAsp: 2.928 ± 0.073
2.841ThrGlu: 2.841 ± 0.07
2.067ThrPhe: 2.067 ± 0.063
3.708ThrGly: 3.708 ± 0.085
1.063ThrHis: 1.063 ± 0.042
4.764ThrIle: 4.764 ± 0.09
3.236ThrLys: 3.236 ± 0.078
5.841ThrLeu: 5.841 ± 0.092
1.15ThrMet: 1.15 ± 0.046
2.724ThrAsn: 2.724 ± 0.092
2.457ThrPro: 2.457 ± 0.062
2.164ThrGln: 2.164 ± 0.073
1.819ThrArg: 1.819 ± 0.058
3.141ThrSer: 3.141 ± 0.076
2.988ThrThr: 2.988 ± 0.084
3.468ThrVal: 3.468 ± 0.072
0.547ThrTrp: 0.547 ± 0.03
1.613ThrTyr: 1.613 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.869ValAla: 4.869 ± 0.109
0.729ValCys: 0.729 ± 0.033
3.523ValAsp: 3.523 ± 0.083
3.693ValGlu: 3.693 ± 0.083
2.456ValPhe: 2.456 ± 0.069
4.221ValGly: 4.221 ± 0.105
0.923ValHis: 0.923 ± 0.034
5.677ValIle: 5.677 ± 0.098
4.067ValLys: 4.067 ± 0.081
6.019ValLeu: 6.019 ± 0.103
1.605ValMet: 1.605 ± 0.046
3.291ValAsn: 3.291 ± 0.08
2.188ValPro: 2.188 ± 0.059
1.764ValGln: 1.764 ± 0.061
2.119ValArg: 2.119 ± 0.068
4.135ValSer: 4.135 ± 0.083
3.487ValThr: 3.487 ± 0.091
4.216ValVal: 4.216 ± 0.11
0.622ValTrp: 0.622 ± 0.028
1.974ValTyr: 1.974 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.604TrpAla: 0.604 ± 0.03
0.159TrpCys: 0.159 ± 0.016
0.552TrpAsp: 0.552 ± 0.031
0.402TrpGlu: 0.402 ± 0.027
0.643TrpPhe: 0.643 ± 0.032
0.701TrpGly: 0.701 ± 0.034
0.329TrpHis: 0.329 ± 0.022
0.846TrpIle: 0.846 ± 0.037
0.46TrpLys: 0.46 ± 0.026
1.651TrpLeu: 1.651 ± 0.062
0.275TrpMet: 0.275 ± 0.018
0.42TrpAsn: 0.42 ± 0.026
0.343TrpPro: 0.343 ± 0.026
0.936TrpGln: 0.936 ± 0.049
0.541TrpArg: 0.541 ± 0.027
0.661TrpSer: 0.661 ± 0.034
0.434TrpThr: 0.434 ± 0.03
0.59TrpVal: 0.59 ± 0.031
0.152TrpTrp: 0.152 ± 0.017
0.546TrpTyr: 0.546 ± 0.047
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.386TyrAla: 2.386 ± 0.064
0.523TyrCys: 0.523 ± 0.028
1.983TyrAsp: 1.983 ± 0.063
1.676TyrGlu: 1.676 ± 0.059
1.9TyrPhe: 1.9 ± 0.054
2.269TyrGly: 2.269 ± 0.06
0.993TyrHis: 0.993 ± 0.044
2.669TyrIle: 2.669 ± 0.069
1.816TyrLys: 1.816 ± 0.063
4.096TyrLeu: 4.096 ± 0.09
0.656TyrMet: 0.656 ± 0.035
1.812TyrAsn: 1.812 ± 0.071
1.492TyrPro: 1.492 ± 0.045
2.394TyrGln: 2.394 ± 0.068
1.579TyrArg: 1.579 ± 0.048
2.295TyrSer: 2.295 ± 0.069
1.728TyrThr: 1.728 ± 0.066
1.851TyrVal: 1.851 ± 0.049
0.687TyrTrp: 0.687 ± 0.054
1.56TyrTyr: 1.56 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2312 proteins (617385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski