Amino acid dipepetide frequency for Bacillus marisflavi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.829AlaAla: 5.829 ± 0.086	0.574AlaCys: 0.574 ± 0.024	3.71AlaAsp: 3.71 ± 0.052	4.604AlaGlu: 4.604 ± 0.065	3.563AlaPhe: 3.563 ± 0.062	5.979AlaGly: 5.979 ± 0.081	1.417AlaHis: 1.417 ± 0.04	5.618AlaIle: 5.618 ± 0.077	4.087AlaLys: 4.087 ± 0.07	7.499AlaLeu: 7.499 ± 0.094	2.21AlaMet: 2.21 ± 0.046	2.158AlaAsn: 2.158 ± 0.041	2.323AlaPro: 2.323 ± 0.042	2.012AlaGln: 2.012 ± 0.062	2.928AlaArg: 2.928 ± 0.047	4.541AlaSer: 4.541 ± 0.068	3.343AlaThr: 3.343 ± 0.07	5.626AlaVal: 5.626 ± 0.077	0.644AlaTrp: 0.644 ± 0.025	2.335AlaTyr: 2.335 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.402CysAla: 0.402 ± 0.018	0.071CysCys: 0.071 ± 0.009	0.374CysAsp: 0.374 ± 0.019	0.462CysGlu: 0.462 ± 0.025	0.288CysPhe: 0.288 ± 0.016	0.65CysGly: 0.65 ± 0.027	0.203CysHis: 0.203 ± 0.014	0.463CysIle: 0.463 ± 0.02	0.286CysLys: 0.286 ± 0.017	0.677CysLeu: 0.677 ± 0.028	0.18CysMet: 0.18 ± 0.011	0.217CysAsn: 0.217 ± 0.014	0.345CysPro: 0.345 ± 0.018	0.193CysGln: 0.193 ± 0.014	0.359CysArg: 0.359 ± 0.018	0.5CysSer: 0.5 ± 0.023	0.398CysThr: 0.398 ± 0.017	0.397CysVal: 0.397 ± 0.017	0.058CysTrp: 0.058 ± 0.008	0.214CysTyr: 0.214 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.777AspAla: 3.777 ± 0.067	0.383AspCys: 0.383 ± 0.018	2.839AspAsp: 2.839 ± 0.056	4.974AspGlu: 4.974 ± 0.07	2.378AspPhe: 2.378 ± 0.042	4.146AspGly: 4.146 ± 0.063	1.555AspHis: 1.555 ± 0.04	3.773AspIle: 3.773 ± 0.059	2.825AspLys: 2.825 ± 0.057	5.482AspLeu: 5.482 ± 0.072	1.482AspMet: 1.482 ± 0.037	1.417AspAsn: 1.417 ± 0.038	2.472AspPro: 2.472 ± 0.049	2.261AspGln: 2.261 ± 0.052	3.038AspArg: 3.038 ± 0.054	2.855AspSer: 2.855 ± 0.049	2.499AspThr: 2.499 ± 0.054	4.17AspVal: 4.17 ± 0.064	0.715AspTrp: 0.715 ± 0.026	2.159AspTyr: 2.159 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.922GluAla: 5.922 ± 0.084	0.402GluCys: 0.402 ± 0.018	4.385GluAsp: 4.385 ± 0.073	8.026GluGlu: 8.026 ± 0.121	2.506GluPhe: 2.506 ± 0.046	5.562GluGly: 5.562 ± 0.076	1.565GluHis: 1.565 ± 0.037	4.83GluIle: 4.83 ± 0.072	5.844GluLys: 5.844 ± 0.075	7.206GluLeu: 7.206 ± 0.097	2.33GluMet: 2.33 ± 0.05	2.891GluAsn: 2.891 ± 0.051	2.137GluPro: 2.137 ± 0.041	2.804GluGln: 2.804 ± 0.047	4.187GluArg: 4.187 ± 0.074	3.823GluSer: 3.823 ± 0.069	3.905GluThr: 3.905 ± 0.062	5.357GluVal: 5.357 ± 0.069	1.057GluTrp: 1.057 ± 0.036	2.247GluTyr: 2.247 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.948PheAla: 2.948 ± 0.047	0.322PheCys: 0.322 ± 0.017	2.45PheAsp: 2.45 ± 0.047	2.627PheGlu: 2.627 ± 0.047	2.306PhePhe: 2.306 ± 0.052	3.332PheGly: 3.332 ± 0.063	1.171PheHis: 1.171 ± 0.035	3.601PheIle: 3.601 ± 0.061	2.289PheLys: 2.289 ± 0.046	4.691PheLeu: 4.691 ± 0.066	1.297PheMet: 1.297 ± 0.035	1.676PheAsn: 1.676 ± 0.041	1.741PhePro: 1.741 ± 0.039	1.513PheGln: 1.513 ± 0.034	1.702PheArg: 1.702 ± 0.039	3.186PheSer: 3.186 ± 0.062	2.682PheThr: 2.682 ± 0.042	2.954PheVal: 2.954 ± 0.059	0.46PheTrp: 0.46 ± 0.021	1.636PheTyr: 1.636 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.393GlyAla: 5.393 ± 0.106	0.655GlyCys: 0.655 ± 0.024	3.894GlyAsp: 3.894 ± 0.062	5.462GlyGlu: 5.462 ± 0.084	3.601GlyPhe: 3.601 ± 0.059	5.591GlyGly: 5.591 ± 0.09	1.542GlyHis: 1.542 ± 0.037	6.11GlyIle: 6.11 ± 0.077	5.246GlyLys: 5.246 ± 0.069	7.192GlyLeu: 7.192 ± 0.082	2.552GlyMet: 2.552 ± 0.043	2.595GlyAsn: 2.595 ± 0.06	1.976GlyPro: 1.976 ± 0.059	2.197GlyGln: 2.197 ± 0.046	3.315GlyArg: 3.315 ± 0.057	4.505GlySer: 4.505 ± 0.07	4.412GlyThr: 4.412 ± 0.076	5.738GlyVal: 5.738 ± 0.075	0.89GlyTrp: 0.89 ± 0.028	2.904GlyTyr: 2.904 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.469HisAla: 1.469 ± 0.034	0.204HisCys: 0.204 ± 0.013	1.224HisAsp: 1.224 ± 0.034	1.589HisGlu: 1.589 ± 0.033	1.127HisPhe: 1.127 ± 0.032	1.655HisGly: 1.655 ± 0.041	0.833HisHis: 0.833 ± 0.028	1.481HisIle: 1.481 ± 0.038	0.98HisLys: 0.98 ± 0.034	2.387HisLeu: 2.387 ± 0.052	0.615HisMet: 0.615 ± 0.024	0.627HisAsn: 0.627 ± 0.023	1.307HisPro: 1.307 ± 0.041	0.856HisGln: 0.856 ± 0.029	1.109HisArg: 1.109 ± 0.031	1.399HisSer: 1.399 ± 0.036	1.142HisThr: 1.142 ± 0.026	1.489HisVal: 1.489 ± 0.038	0.267HisTrp: 0.267 ± 0.017	0.962HisTyr: 0.962 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.473IleAla: 5.473 ± 0.089	0.546IleCys: 0.546 ± 0.021	4.081IleAsp: 4.081 ± 0.063	4.979IleGlu: 4.979 ± 0.076	2.923IlePhe: 2.923 ± 0.057	6.012IleGly: 6.012 ± 0.09	1.756IleHis: 1.756 ± 0.041	5.18IleIle: 5.18 ± 0.083	3.71IleLys: 3.71 ± 0.061	7.286IleLeu: 7.286 ± 0.096	1.88IleMet: 1.88 ± 0.04	2.437IleAsn: 2.437 ± 0.044	3.394IlePro: 3.394 ± 0.054	2.63IleGln: 2.63 ± 0.052	3.41IleArg: 3.41 ± 0.058	4.672IleSer: 4.672 ± 0.068	4.065IleThr: 4.065 ± 0.06	5.157IleVal: 5.157 ± 0.073	0.628IleTrp: 0.628 ± 0.026	2.046IleTyr: 2.046 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.648LysAla: 4.648 ± 0.065	0.266LysCys: 0.266 ± 0.016	4.013LysAsp: 4.013 ± 0.062	6.834LysGlu: 6.834 ± 0.09	1.517LysPhe: 1.517 ± 0.037	4.972LysGly: 4.972 ± 0.071	1.224LysHis: 1.224 ± 0.033	3.616LysIle: 3.616 ± 0.061	5.252LysLys: 5.252 ± 0.092	4.998LysLeu: 4.998 ± 0.072	1.856LysMet: 1.856 ± 0.045	2.478LysAsn: 2.478 ± 0.05	2.076LysPro: 2.076 ± 0.044	2.454LysGln: 2.454 ± 0.054	3.389LysArg: 3.389 ± 0.062	3.271LysSer: 3.271 ± 0.055	3.319LysThr: 3.319 ± 0.06	4.484LysVal: 4.484 ± 0.066	0.828LysTrp: 0.828 ± 0.027	1.593LysTyr: 1.593 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	7.192LeuAla: 7.192 ± 0.084	0.628LeuCys: 0.628 ± 0.024	5.269LeuAsp: 5.269 ± 0.071	6.671LeuGlu: 6.671 ± 0.092	4.868LeuPhe: 4.868 ± 0.073	6.726LeuGly: 6.726 ± 0.08	2.197LeuHis: 2.197 ± 0.051	6.965LeuIle: 6.965 ± 0.086	6.357LeuLys: 6.357 ± 0.09	10.18LeuLeu: 10.18 ± 0.13	2.835LeuMet: 2.835 ± 0.05	3.611LeuAsn: 3.611 ± 0.054	4.177LeuPro: 4.177 ± 0.06	3.334LeuGln: 3.334 ± 0.056	3.722LeuArg: 3.722 ± 0.055	7.338LeuSer: 7.338 ± 0.079	5.72LeuThr: 5.72 ± 0.075	6.522LeuVal: 6.522 ± 0.08	0.857LeuTrp: 0.857 ± 0.029	3.218LeuTyr: 3.218 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.041	0.157MetCys: 0.157 ± 0.01	1.775MetAsp: 1.775 ± 0.041	2.357MetGlu: 2.357 ± 0.05	1.059MetPhe: 1.059 ± 0.03	1.999MetGly: 1.999 ± 0.046	0.421MetHis: 0.421 ± 0.019	2.225MetIle: 2.225 ± 0.047	2.887MetLys: 2.887 ± 0.046	2.47MetLeu: 2.47 ± 0.048	0.979MetMet: 0.979 ± 0.029	1.565MetAsn: 1.565 ± 0.033	0.968MetPro: 0.968 ± 0.029	0.781MetGln: 0.781 ± 0.025	1.188MetArg: 1.188 ± 0.032	1.683MetSer: 1.683 ± 0.037	1.945MetThr: 1.945 ± 0.048	2.013MetVal: 2.013 ± 0.041	0.211MetTrp: 0.211 ± 0.013	0.665MetTyr: 0.665 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.368AsnAla: 2.368 ± 0.05	0.224AsnCys: 0.224 ± 0.014	1.867AsnAsp: 1.867 ± 0.043	2.867AsnGlu: 2.867 ± 0.054	1.2AsnPhe: 1.2 ± 0.029	3.187AsnGly: 3.187 ± 0.068	0.891AsnHis: 0.891 ± 0.026	2.418AsnIle: 2.418 ± 0.048	1.983AsnLys: 1.983 ± 0.048	3.224AsnLeu: 3.224 ± 0.055	1.012AsnMet: 1.012 ± 0.028	1.135AsnAsn: 1.135 ± 0.039	1.96AsnPro: 1.96 ± 0.044	1.473AsnGln: 1.473 ± 0.037	1.912AsnArg: 1.912 ± 0.044	1.652AsnSer: 1.652 ± 0.035	1.751AsnThr: 1.751 ± 0.038	2.689AsnVal: 2.689 ± 0.053	0.415AsnTrp: 0.415 ± 0.018	1.11AsnTyr: 1.11 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.55ProAla: 2.55 ± 0.049	0.195ProCys: 0.195 ± 0.013	2.513ProAsp: 2.513 ± 0.054	3.189ProGlu: 3.189 ± 0.055	2.181ProPhe: 2.181 ± 0.048	2.793ProGly: 2.793 ± 0.059	0.973ProHis: 0.973 ± 0.028	2.6ProIle: 2.6 ± 0.048	2.002ProLys: 2.002 ± 0.045	3.784ProLeu: 3.784 ± 0.065	0.871ProMet: 0.871 ± 0.028	1.285ProAsn: 1.285 ± 0.032	1.126ProPro: 1.126 ± 0.035	1.139ProGln: 1.139 ± 0.051	1.243ProArg: 1.243 ± 0.037	2.557ProSer: 2.557 ± 0.046	1.849ProThr: 1.849 ± 0.034	3.236ProVal: 3.236 ± 0.059	0.4ProTrp: 0.4 ± 0.018	1.472ProTyr: 1.472 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.566GlnAla: 2.566 ± 0.051	0.19GlnCys: 0.19 ± 0.013	1.759GlnAsp: 1.759 ± 0.041	2.76GlnGlu: 2.76 ± 0.049	1.377GlnPhe: 1.377 ± 0.032	2.453GlnGly: 2.453 ± 0.141	0.76GlnHis: 0.76 ± 0.026	1.984GlnIle: 1.984 ± 0.042	2.296GlnLys: 2.296 ± 0.05	3.314GlnLeu: 3.314 ± 0.049	1.008GlnMet: 1.008 ± 0.031	1.194GlnAsn: 1.194 ± 0.033	1.15GlnPro: 1.15 ± 0.032	1.402GlnGln: 1.402 ± 0.041	1.487GlnArg: 1.487 ± 0.038	2.199GlnSer: 2.199 ± 0.041	1.794GlnThr: 1.794 ± 0.036	2.195GlnVal: 2.195 ± 0.04	0.457GlnTrp: 0.457 ± 0.019	1.14GlnTyr: 1.14 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.571ArgAla: 2.571 ± 0.05	0.289ArgCys: 0.289 ± 0.016	2.481ArgAsp: 2.481 ± 0.049	3.746ArgGlu: 3.746 ± 0.066	2.289ArgPhe: 2.289 ± 0.046	2.811ArgGly: 2.811 ± 0.061	1.085ArgHis: 1.085 ± 0.036	3.301ArgIle: 3.301 ± 0.061	3.326ArgLys: 3.326 ± 0.063	4.415ArgLeu: 4.415 ± 0.07	1.631ArgMet: 1.631 ± 0.038	1.789ArgAsn: 1.789 ± 0.036	1.47ArgPro: 1.47 ± 0.038	1.52ArgGln: 1.52 ± 0.04	2.151ArgArg: 2.151 ± 0.053	2.76ArgSer: 2.76 ± 0.046	2.312ArgThr: 2.312 ± 0.04	3.007ArgVal: 3.007 ± 0.048	0.505ArgTrp: 0.505 ± 0.021	1.674ArgTyr: 1.674 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.982SerAla: 3.982 ± 0.064	0.388SerCys: 0.388 ± 0.018	3.062SerAsp: 3.062 ± 0.055	3.956SerGlu: 3.956 ± 0.063	3.395SerPhe: 3.395 ± 0.062	5.109SerGly: 5.109 ± 0.071	1.395SerHis: 1.395 ± 0.034	5.125SerIle: 5.125 ± 0.071	3.471SerLys: 3.471 ± 0.065	6.555SerLeu: 6.555 ± 0.09	2.016SerMet: 2.016 ± 0.039	1.993SerAsn: 1.993 ± 0.043	2.424SerPro: 2.424 ± 0.045	1.75SerGln: 1.75 ± 0.036	2.7SerArg: 2.7 ± 0.048	4.247SerSer: 4.247 ± 0.071	3.302SerThr: 3.302 ± 0.052	4.371SerVal: 4.371 ± 0.061	0.679SerTrp: 0.679 ± 0.026	2.179SerTyr: 2.179 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.969ThrAla: 3.969 ± 0.06	0.371ThrCys: 0.371 ± 0.018	2.996ThrAsp: 2.996 ± 0.049	3.337ThrGlu: 3.337 ± 0.062	2.723ThrPhe: 2.723 ± 0.048	4.611ThrGly: 4.611 ± 0.086	1.103ThrHis: 1.103 ± 0.03	4.499ThrIle: 4.499 ± 0.065	2.912ThrLys: 2.912 ± 0.056	5.482ThrLeu: 5.482 ± 0.067	1.41ThrMet: 1.41 ± 0.03	1.885ThrAsn: 1.885 ± 0.039	2.316ThrPro: 2.316 ± 0.045	1.304ThrGln: 1.304 ± 0.037	2.082ThrArg: 2.082 ± 0.044	3.387ThrSer: 3.387 ± 0.061	2.739ThrThr: 2.739 ± 0.051	4.277ThrVal: 4.277 ± 0.08	0.484ThrTrp: 0.484 ± 0.022	1.945ThrTyr: 1.945 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.043ValAla: 5.043 ± 0.07	0.541ValCys: 0.541 ± 0.023	3.974ValAsp: 3.974 ± 0.061	5.278ValGlu: 5.278 ± 0.075	3.102ValPhe: 3.102 ± 0.06	4.873ValGly: 4.873 ± 0.073	1.531ValHis: 1.531 ± 0.041	5.456ValIle: 5.456 ± 0.068	4.75ValLys: 4.75 ± 0.066	7.17ValLeu: 7.17 ± 0.092	2.033ValMet: 2.033 ± 0.045	2.743ValAsn: 2.743 ± 0.047	2.891ValPro: 2.891 ± 0.05	2.291ValGln: 2.291 ± 0.039	3.026ValArg: 3.026 ± 0.058	4.77ValSer: 4.77 ± 0.07	4.302ValThr: 4.302 ± 0.069	5.22ValVal: 5.22 ± 0.075	0.65ValTrp: 0.65 ± 0.025	2.195ValTyr: 2.195 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.637TrpAla: 0.637 ± 0.023	0.084TrpCys: 0.084 ± 0.009	0.583TrpAsp: 0.583 ± 0.023	0.719TrpGlu: 0.719 ± 0.026	0.524TrpPhe: 0.524 ± 0.024	0.759TrpGly: 0.759 ± 0.029	0.224TrpHis: 0.224 ± 0.013	0.867TrpIle: 0.867 ± 0.029	0.813TrpLys: 0.813 ± 0.028	1.116TrpLeu: 1.116 ± 0.028	0.393TrpMet: 0.393 ± 0.016	0.506TrpAsn: 0.506 ± 0.021	0.263TrpPro: 0.263 ± 0.015	0.315TrpGln: 0.315 ± 0.016	0.444TrpArg: 0.444 ± 0.02	0.671TrpSer: 0.671 ± 0.025	0.587TrpThr: 0.587 ± 0.025	0.746TrpVal: 0.746 ± 0.029	0.165TrpTrp: 0.165 ± 0.012	0.352TrpTyr: 0.352 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.142TyrAla: 2.142 ± 0.04	0.247TyrCys: 0.247 ± 0.015	1.951TyrAsp: 1.951 ± 0.04	2.55TyrGlu: 2.55 ± 0.055	1.655TyrPhe: 1.655 ± 0.038	2.548TyrGly: 2.548 ± 0.041	0.877TyrHis: 0.877 ± 0.026	2.154TyrIle: 2.154 ± 0.049	1.773TyrLys: 1.773 ± 0.038	3.259TyrLeu: 3.259 ± 0.053	0.875TyrMet: 0.875 ± 0.027	1.136TyrAsn: 1.136 ± 0.028	1.443TyrPro: 1.443 ± 0.04	1.255TyrGln: 1.255 ± 0.037	1.743TyrArg: 1.743 ± 0.042	2.083TyrSer: 2.083 ± 0.044	1.766TyrThr: 1.766 ± 0.037	2.193TyrVal: 2.193 ± 0.042	0.398TyrTrp: 0.398 ± 0.019	1.302TyrTyr: 1.302 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4143 proteins (1204750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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