Amino acid dipepetide frequency for Candidatus Marinimicrobia bacterium MT.SAG.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.699AlaAla: 5.699 ± 0.147
0.416AlaCys: 0.416 ± 0.029
3.868AlaAsp: 3.868 ± 0.092
4.98AlaGlu: 4.98 ± 0.123
2.841AlaPhe: 2.841 ± 0.072
5.337AlaGly: 5.337 ± 0.111
1.109AlaHis: 1.109 ± 0.047
5.361AlaIle: 5.361 ± 0.108
4.011AlaLys: 4.011 ± 0.101
6.957AlaLeu: 6.957 ± 0.143
1.656AlaMet: 1.656 ± 0.064
2.512AlaAsn: 2.512 ± 0.069
1.941AlaPro: 1.941 ± 0.066
1.752AlaGln: 1.752 ± 0.057
2.793AlaArg: 2.793 ± 0.089
4.274AlaSer: 4.274 ± 0.093
3.237AlaThr: 3.237 ± 0.093
4.943AlaVal: 4.943 ± 0.102
0.637AlaTrp: 0.637 ± 0.038
2.168AlaTyr: 2.168 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.446CysAla: 0.446 ± 0.029
0.07CysCys: 0.07 ± 0.012
0.374CysAsp: 0.374 ± 0.029
0.358CysGlu: 0.358 ± 0.027
0.195CysPhe: 0.195 ± 0.023
0.709CysGly: 0.709 ± 0.043
0.233CysHis: 0.233 ± 0.037
0.47CysIle: 0.47 ± 0.034
0.315CysLys: 0.315 ± 0.027
0.466CysLeu: 0.466 ± 0.032
0.115CysMet: 0.115 ± 0.016
0.225CysAsn: 0.225 ± 0.021
0.348CysPro: 0.348 ± 0.032
0.143CysGln: 0.143 ± 0.017
0.291CysArg: 0.291 ± 0.025
0.506CysSer: 0.506 ± 0.03
0.307CysThr: 0.307 ± 0.028
0.4CysVal: 0.4 ± 0.032
0.054CysTrp: 0.054 ± 0.011
0.217CysTyr: 0.217 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.639AspAla: 3.639 ± 0.091
0.287AspCys: 0.287 ± 0.025
3.464AspAsp: 3.464 ± 0.101
4.507AspGlu: 4.507 ± 0.106
2.942AspPhe: 2.942 ± 0.079
4.196AspGly: 4.196 ± 0.101
0.9AspHis: 0.9 ± 0.043
4.785AspIle: 4.785 ± 0.106
3.814AspLys: 3.814 ± 0.101
5.733AspLeu: 5.733 ± 0.1
1.393AspMet: 1.393 ± 0.052
2.47AspAsn: 2.47 ± 0.077
2.355AspPro: 2.355 ± 0.075
1.294AspGln: 1.294 ± 0.05
2.62AspArg: 2.62 ± 0.063
4.521AspSer: 4.521 ± 0.107
2.743AspThr: 2.743 ± 0.085
3.466AspVal: 3.466 ± 0.08
0.723AspTrp: 0.723 ± 0.048
2.184AspTyr: 2.184 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.55GluAla: 4.55 ± 0.12
0.424GluCys: 0.424 ± 0.031
3.79GluAsp: 3.79 ± 0.104
6.115GluGlu: 6.115 ± 0.159
3.157GluPhe: 3.157 ± 0.087
4.531GluGly: 4.531 ± 0.11
1.095GluHis: 1.095 ± 0.048
6.181GluIle: 6.181 ± 0.115
5.582GluLys: 5.582 ± 0.137
7.329GluLeu: 7.329 ± 0.149
2.056GluMet: 2.056 ± 0.064
3.792GluAsn: 3.792 ± 0.104
2.078GluPro: 2.078 ± 0.064
1.819GluGln: 1.819 ± 0.065
3.549GluArg: 3.549 ± 0.088
4.961GluSer: 4.961 ± 0.111
3.249GluThr: 3.249 ± 0.091
4.598GluVal: 4.598 ± 0.116
0.784GluTrp: 0.784 ± 0.047
2.608GluTyr: 2.608 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.864PheAla: 2.864 ± 0.08
0.313PheCys: 0.313 ± 0.027
3.109PheAsp: 3.109 ± 0.089
2.918PheGlu: 2.918 ± 0.079
2.076PhePhe: 2.076 ± 0.076
3.802PheGly: 3.802 ± 0.1
0.84PheHis: 0.84 ± 0.033
3.531PheIle: 3.531 ± 0.089
2.751PheLys: 2.751 ± 0.075
4.314PheLeu: 4.314 ± 0.106
1.129PheMet: 1.129 ± 0.054
2.345PheAsn: 2.345 ± 0.069
1.708PhePro: 1.708 ± 0.054
1.178PheGln: 1.178 ± 0.057
2.07PheArg: 2.07 ± 0.065
3.917PheSer: 3.917 ± 0.098
2.454PheThr: 2.454 ± 0.075
2.673PheVal: 2.673 ± 0.081
0.522PheTrp: 0.522 ± 0.04
1.646PheTyr: 1.646 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.959GlyAla: 4.959 ± 0.127
0.599GlyCys: 0.599 ± 0.048
4.184GlyAsp: 4.184 ± 0.104
4.978GlyGlu: 4.978 ± 0.111
3.611GlyPhe: 3.611 ± 0.095
5.584GlyGly: 5.584 ± 0.151
1.246GlyHis: 1.246 ± 0.049
6.607GlyIle: 6.607 ± 0.147
4.988GlyLys: 4.988 ± 0.112
6.501GlyLeu: 6.501 ± 0.126
1.991GlyMet: 1.991 ± 0.075
3.211GlyAsn: 3.211 ± 0.098
1.768GlyPro: 1.768 ± 0.065
1.68GlyGln: 1.68 ± 0.057
3.131GlyArg: 3.131 ± 0.078
5.227GlySer: 5.227 ± 0.126
4.067GlyThr: 4.067 ± 0.111
5.042GlyVal: 5.042 ± 0.113
0.963GlyTrp: 0.963 ± 0.054
2.779GlyTyr: 2.779 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
0.955HisAla: 0.955 ± 0.048
0.143HisCys: 0.143 ± 0.018
0.892HisAsp: 0.892 ± 0.039
1.053HisGlu: 1.053 ± 0.046
0.844HisPhe: 0.844 ± 0.04
1.224HisGly: 1.224 ± 0.058
0.39HisHis: 0.39 ± 0.03
1.248HisIle: 1.248 ± 0.056
1.035HisLys: 1.035 ± 0.044
1.835HisLeu: 1.835 ± 0.057
0.37HisMet: 0.37 ± 0.026
0.611HisAsn: 0.611 ± 0.035
0.969HisPro: 0.969 ± 0.048
0.47HisGln: 0.47 ± 0.028
0.774HisArg: 0.774 ± 0.036
1.302HisSer: 1.302 ± 0.051
0.942HisThr: 0.942 ± 0.043
0.866HisVal: 0.866 ± 0.037
0.239HisTrp: 0.239 ± 0.021
0.673HisTyr: 0.673 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.964IleAla: 5.964 ± 0.114
0.502IleCys: 0.502 ± 0.032
5.068IleAsp: 5.068 ± 0.103
6.049IleGlu: 6.049 ± 0.121
3.577IlePhe: 3.577 ± 0.092
6.111IleGly: 6.111 ± 0.137
1.381IleHis: 1.381 ± 0.055
6.306IleIle: 6.306 ± 0.143
4.947IleLys: 4.947 ± 0.12
7.58IleLeu: 7.58 ± 0.167
1.632IleMet: 1.632 ± 0.071
3.601IleAsn: 3.601 ± 0.088
3.545IlePro: 3.545 ± 0.084
1.983IleGln: 1.983 ± 0.066
3.941IleArg: 3.941 ± 0.082
6.78IleSer: 6.78 ± 0.118
4.22IleThr: 4.22 ± 0.096
5.016IleVal: 5.016 ± 0.102
0.782IleTrp: 0.782 ± 0.043
2.813IleTyr: 2.813 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
3.999LysAla: 3.999 ± 0.106
0.372LysCys: 0.372 ± 0.03
3.436LysAsp: 3.436 ± 0.089
5.275LysGlu: 5.275 ± 0.142
2.775LysPhe: 2.775 ± 0.078
4.099LysGly: 4.099 ± 0.085
1.043LysHis: 1.043 ± 0.045
6.008LysIle: 6.008 ± 0.113
5.329LysLys: 5.329 ± 0.163
5.966LysLeu: 5.966 ± 0.119
1.875LysMet: 1.875 ± 0.062
3.334LysAsn: 3.334 ± 0.077
2.325LysPro: 2.325 ± 0.084
1.608LysGln: 1.608 ± 0.055
3.456LysArg: 3.456 ± 0.091
4.817LysSer: 4.817 ± 0.108
3.267LysThr: 3.267 ± 0.083
3.927LysVal: 3.927 ± 0.1
0.655LysTrp: 0.655 ± 0.035
2.594LysTyr: 2.594 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
5.918LeuAla: 5.918 ± 0.114
0.541LeuCys: 0.541 ± 0.032
5.078LeuAsp: 5.078 ± 0.099
6.364LeuGlu: 6.364 ± 0.131
4.728LeuPhe: 4.728 ± 0.113
6.593LeuGly: 6.593 ± 0.129
1.588LeuHis: 1.588 ± 0.068
7.938LeuIle: 7.938 ± 0.151
6.935LeuLys: 6.935 ± 0.136
10.029LeuLeu: 10.029 ± 0.195
2.486LeuMet: 2.486 ± 0.075
5.006LeuAsn: 5.006 ± 0.118
3.989LeuPro: 3.989 ± 0.096
2.544LeuGln: 2.544 ± 0.068
4.793LeuArg: 4.793 ± 0.099
8.378LeuSer: 8.378 ± 0.144
5.506LeuThr: 5.506 ± 0.114
5.355LeuVal: 5.355 ± 0.122
0.846LeuTrp: 0.846 ± 0.047
2.894LeuTyr: 2.894 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
1.809MetAla: 1.809 ± 0.062
0.131MetCys: 0.131 ± 0.02
1.254MetAsp: 1.254 ± 0.048
1.636MetGlu: 1.636 ± 0.057
0.918MetPhe: 0.918 ± 0.047
1.815MetGly: 1.815 ± 0.059
0.356MetHis: 0.356 ± 0.029
1.875MetIle: 1.875 ± 0.062
1.983MetLys: 1.983 ± 0.068
2.271MetLeu: 2.271 ± 0.067
0.756MetMet: 0.756 ± 0.038
1.455MetAsn: 1.455 ± 0.058
0.973MetPro: 0.973 ± 0.05
0.663MetGln: 0.663 ± 0.032
1.226MetArg: 1.226 ± 0.05
1.708MetSer: 1.708 ± 0.063
1.463MetThr: 1.463 ± 0.055
1.63MetVal: 1.63 ± 0.061
0.195MetTrp: 0.195 ± 0.02
0.575MetTyr: 0.575 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.759AsnAla: 2.759 ± 0.075
0.322AsnCys: 0.322 ± 0.025
2.598AsnAsp: 2.598 ± 0.076
3.008AsnGlu: 3.008 ± 0.092
2.166AsnPhe: 2.166 ± 0.078
3.402AsnGly: 3.402 ± 0.093
0.739AsnHis: 0.739 ± 0.04
4.089AsnIle: 4.089 ± 0.092
2.729AsnLys: 2.729 ± 0.071
4.839AsnLeu: 4.839 ± 0.099
1.186AsnMet: 1.186 ± 0.047
2.212AsnAsn: 2.212 ± 0.075
2.413AsnPro: 2.413 ± 0.074
1.139AsnGln: 1.139 ± 0.048
2.371AsnArg: 2.371 ± 0.074
3.583AsnSer: 3.583 ± 0.087
2.02AsnThr: 2.02 ± 0.068
2.851AsnVal: 2.851 ± 0.083
0.599AsnTrp: 0.599 ± 0.035
1.786AsnTyr: 1.786 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.281ProAla: 2.281 ± 0.077
0.191ProCys: 0.191 ± 0.018
2.584ProAsp: 2.584 ± 0.075
3.396ProGlu: 3.396 ± 0.093
1.851ProPhe: 1.851 ± 0.059
2.781ProGly: 2.781 ± 0.078
0.633ProHis: 0.633 ± 0.036
2.819ProIle: 2.819 ± 0.07
2.106ProLys: 2.106 ± 0.074
3.354ProLeu: 3.354 ± 0.089
0.836ProMet: 0.836 ± 0.037
1.796ProAsn: 1.796 ± 0.064
1.342ProPro: 1.342 ± 0.054
0.89ProGln: 0.89 ± 0.043
1.332ProArg: 1.332 ± 0.049
2.429ProSer: 2.429 ± 0.085
1.887ProThr: 1.887 ± 0.061
2.608ProVal: 2.608 ± 0.084
0.418ProTrp: 0.418 ± 0.033
1.184ProTyr: 1.184 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.606GlnAla: 1.606 ± 0.054
0.151GlnCys: 0.151 ± 0.017
1.186GlnAsp: 1.186 ± 0.054
1.718GlnGlu: 1.718 ± 0.061
1.234GlnPhe: 1.234 ± 0.05
1.517GlnGly: 1.517 ± 0.056
0.356GlnHis: 0.356 ± 0.027
2.082GlnIle: 2.082 ± 0.067
1.831GlnLys: 1.831 ± 0.057
2.608GlnLeu: 2.608 ± 0.071
0.675GlnMet: 0.675 ± 0.039
1.326GlnAsn: 1.326 ± 0.056
0.892GlnPro: 0.892 ± 0.043
0.729GlnGln: 0.729 ± 0.044
1.286GlnArg: 1.286 ± 0.058
1.748GlnSer: 1.748 ± 0.059
1.324GlnThr: 1.324 ± 0.05
1.509GlnVal: 1.509 ± 0.055
0.249GlnTrp: 0.249 ± 0.023
0.86GlnTyr: 0.86 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.087ArgAla: 3.087 ± 0.078
0.233ArgCys: 0.233 ± 0.022
2.448ArgAsp: 2.448 ± 0.076
3.476ArgGlu: 3.476 ± 0.097
2.194ArgPhe: 2.194 ± 0.07
2.99ArgGly: 2.99 ± 0.081
0.762ArgHis: 0.762 ± 0.038
3.886ArgIle: 3.886 ± 0.091
3.454ArgLys: 3.454 ± 0.092
4.638ArgLeu: 4.638 ± 0.096
1.306ArgMet: 1.306 ± 0.055
2.22ArgAsn: 2.22 ± 0.068
1.318ArgPro: 1.318 ± 0.047
1.222ArgGln: 1.222 ± 0.052
2.618ArgArg: 2.618 ± 0.081
3.235ArgSer: 3.235 ± 0.07
2.279ArgThr: 2.279 ± 0.062
2.964ArgVal: 2.964 ± 0.082
0.557ArgTrp: 0.557 ± 0.03
1.752ArgTyr: 1.752 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.142SerAla: 5.142 ± 0.097
0.486SerCys: 0.486 ± 0.034
4.632SerAsp: 4.632 ± 0.112
5.414SerGlu: 5.414 ± 0.113
3.436SerPhe: 3.436 ± 0.098
6.187SerGly: 6.187 ± 0.151
1.198SerHis: 1.198 ± 0.044
5.91SerIle: 5.91 ± 0.122
4.648SerLys: 4.648 ± 0.099
7.218SerLeu: 7.218 ± 0.125
1.7SerMet: 1.7 ± 0.058
3.288SerAsn: 3.288 ± 0.094
2.564SerPro: 2.564 ± 0.078
1.712SerGln: 1.712 ± 0.061
3.137SerArg: 3.137 ± 0.085
5.737SerSer: 5.737 ± 0.145
3.758SerThr: 3.758 ± 0.091
5.229SerVal: 5.229 ± 0.104
0.876SerTrp: 0.876 ± 0.054
2.45SerTyr: 2.45 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
3.716ThrAla: 3.716 ± 0.083
0.305ThrCys: 0.305 ± 0.027
3.332ThrAsp: 3.332 ± 0.099
3.396ThrGlu: 3.396 ± 0.083
2.506ThrPhe: 2.506 ± 0.084
4.435ThrGly: 4.435 ± 0.098
0.88ThrHis: 0.88 ± 0.039
4.296ThrIle: 4.296 ± 0.096
2.745ThrLys: 2.745 ± 0.084
5.546ThrLeu: 5.546 ± 0.122
1.067ThrMet: 1.067 ± 0.042
2.218ThrAsn: 2.218 ± 0.068
2.154ThrPro: 2.154 ± 0.074
1.24ThrGln: 1.24 ± 0.052
1.927ThrArg: 1.927 ± 0.059
3.239ThrSer: 3.239 ± 0.09
2.89ThrThr: 2.89 ± 0.082
3.635ThrVal: 3.635 ± 0.079
0.504ThrTrp: 0.504 ± 0.039
1.646ThrTyr: 1.646 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.298ValAla: 4.298 ± 0.105
0.452ValCys: 0.452 ± 0.031
3.756ValAsp: 3.756 ± 0.093
4.539ValGlu: 4.539 ± 0.103
2.661ValPhe: 2.661 ± 0.081
4.602ValGly: 4.602 ± 0.121
1.063ValHis: 1.063 ± 0.051
5.377ValIle: 5.377 ± 0.122
4.136ValLys: 4.136 ± 0.098
5.755ValLeu: 5.755 ± 0.11
1.485ValMet: 1.485 ± 0.056
2.898ValAsn: 2.898 ± 0.073
2.345ValPro: 2.345 ± 0.074
1.559ValGln: 1.559 ± 0.059
2.986ValArg: 2.986 ± 0.081
4.738ValSer: 4.738 ± 0.109
3.782ValThr: 3.782 ± 0.097
4.441ValVal: 4.441 ± 0.122
0.647ValTrp: 0.647 ± 0.04
2.136ValTyr: 2.136 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.677TrpAla: 0.677 ± 0.042
0.066TrpCys: 0.066 ± 0.011
0.762TrpAsp: 0.762 ± 0.045
0.699TrpGlu: 0.699 ± 0.038
0.537TrpPhe: 0.537 ± 0.033
0.742TrpGly: 0.742 ± 0.037
0.273TrpHis: 0.273 ± 0.023
0.735TrpIle: 0.735 ± 0.044
0.746TrpLys: 0.746 ± 0.04
1.063TrpLeu: 1.063 ± 0.046
0.283TrpMet: 0.283 ± 0.022
0.748TrpAsn: 0.748 ± 0.042
0.267TrpPro: 0.267 ± 0.027
0.303TrpGln: 0.303 ± 0.026
0.541TrpArg: 0.541 ± 0.031
0.727TrpSer: 0.727 ± 0.039
0.563TrpThr: 0.563 ± 0.038
0.693TrpVal: 0.693 ± 0.038
0.167TrpTrp: 0.167 ± 0.022
0.315TrpTyr: 0.315 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.128TyrAla: 2.128 ± 0.07
0.239TyrCys: 0.239 ± 0.021
2.225TyrAsp: 2.225 ± 0.071
2.369TyrGlu: 2.369 ± 0.074
1.909TyrPhe: 1.909 ± 0.07
2.458TyrGly: 2.458 ± 0.078
0.75TyrHis: 0.75 ± 0.035
2.291TyrIle: 2.291 ± 0.067
2.076TyrLys: 2.076 ± 0.071
3.505TyrLeu: 3.505 ± 0.09
0.691TyrMet: 0.691 ± 0.037
1.545TyrAsn: 1.545 ± 0.063
1.425TyrPro: 1.425 ± 0.053
0.959TyrGln: 0.959 ± 0.041
1.801TyrArg: 1.801 ± 0.054
2.892TyrSer: 2.892 ± 0.084
1.72TyrThr: 1.72 ± 0.05
1.811TyrVal: 1.811 ± 0.061
0.49TyrTrp: 0.49 ± 0.031
1.411TyrTyr: 1.411 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1565 proteins (497638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski