Amino acid dipepetide frequency for Klebsiella phage SJM3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.699AlaAla: 13.699 ± 1.143
0.672AlaCys: 0.672 ± 0.236
6.462AlaAsp: 6.462 ± 0.486
8.116AlaGlu: 8.116 ± 1.041
3.619AlaPhe: 3.619 ± 0.484
8.426AlaGly: 8.426 ± 0.762
1.551AlaHis: 1.551 ± 0.261
5.583AlaIle: 5.583 ± 0.425
6.514AlaLys: 6.514 ± 0.703
8.323AlaLeu: 8.323 ± 0.571
3.05AlaMet: 3.05 ± 0.466
3.619AlaAsn: 3.619 ± 0.443
3.412AlaPro: 3.412 ± 0.436
4.963AlaGln: 4.963 ± 0.555
6.617AlaArg: 6.617 ± 0.766
5.066AlaSer: 5.066 ± 0.467
5.842AlaThr: 5.842 ± 0.42
5.79AlaVal: 5.79 ± 0.494
1.706AlaTrp: 1.706 ± 0.274
3.05AlaTyr: 3.05 ± 0.336
0.0AlaXaa: 0.0 ± 0.0
Cys
0.982CysAla: 0.982 ± 0.294
0.052CysCys: 0.052 ± 0.054
0.569CysAsp: 0.569 ± 0.188
0.414CysGlu: 0.414 ± 0.195
0.207CysPhe: 0.207 ± 0.108
0.724CysGly: 0.724 ± 0.225
0.362CysHis: 0.362 ± 0.169
0.62CysIle: 0.62 ± 0.202
0.517CysLys: 0.517 ± 0.238
0.62CysLeu: 0.62 ± 0.209
0.362CysMet: 0.362 ± 0.185
0.207CysAsn: 0.207 ± 0.113
0.517CysPro: 0.517 ± 0.183
0.362CysGln: 0.362 ± 0.145
0.465CysArg: 0.465 ± 0.207
0.465CysSer: 0.465 ± 0.224
0.258CysThr: 0.258 ± 0.108
0.414CysVal: 0.414 ± 0.18
0.258CysTrp: 0.258 ± 0.167
0.517CysTyr: 0.517 ± 0.201
0.0CysXaa: 0.0 ± 0.0
Asp
7.186AspAla: 7.186 ± 0.631
0.465AspCys: 0.465 ± 0.189
3.412AspAsp: 3.412 ± 0.476
4.963AspGlu: 4.963 ± 0.55
1.603AspPhe: 1.603 ± 0.252
5.997AspGly: 5.997 ± 0.592
0.982AspHis: 0.982 ± 0.263
3.67AspIle: 3.67 ± 0.417
2.74AspLys: 2.74 ± 0.331
4.498AspLeu: 4.498 ± 0.441
1.603AspMet: 1.603 ± 0.26
2.171AspAsn: 2.171 ± 0.384
3.102AspPro: 3.102 ± 0.333
2.223AspGln: 2.223 ± 0.331
3.153AspArg: 3.153 ± 0.403
2.636AspSer: 2.636 ± 0.362
3.05AspThr: 3.05 ± 0.353
3.825AspVal: 3.825 ± 0.408
1.447AspTrp: 1.447 ± 0.302
1.706AspTyr: 1.706 ± 0.266
0.0AspXaa: 0.0 ± 0.0
Glu
6.772GluAla: 6.772 ± 0.893
0.62GluCys: 0.62 ± 0.217
3.309GluAsp: 3.309 ± 0.484
6.255GluGlu: 6.255 ± 0.83
1.654GluPhe: 1.654 ± 0.339
4.498GluGly: 4.498 ± 0.467
1.086GluHis: 1.086 ± 0.225
3.67GluIle: 3.67 ± 0.437
5.014GluLys: 5.014 ± 0.566
6.565GluLeu: 6.565 ± 0.605
1.706GluMet: 1.706 ± 0.285
2.792GluAsn: 2.792 ± 0.355
2.843GluPro: 2.843 ± 0.44
4.601GluGln: 4.601 ± 0.615
5.893GluArg: 5.893 ± 0.534
3.412GluSer: 3.412 ± 0.378
2.895GluThr: 2.895 ± 0.549
3.619GluVal: 3.619 ± 0.41
1.551GluTrp: 1.551 ± 0.296
2.171GluTyr: 2.171 ± 0.298
0.0GluXaa: 0.0 ± 0.0
Phe
2.947PheAla: 2.947 ± 0.305
0.31PheCys: 0.31 ± 0.142
1.861PheAsp: 1.861 ± 0.225
2.481PheGlu: 2.481 ± 0.338
1.137PhePhe: 1.137 ± 0.303
2.636PheGly: 2.636 ± 0.328
0.62PheHis: 0.62 ± 0.183
1.913PheIle: 1.913 ± 0.433
1.603PheLys: 1.603 ± 0.345
1.654PheLeu: 1.654 ± 0.202
1.034PheMet: 1.034 ± 0.223
1.913PheAsn: 1.913 ± 0.311
1.447PhePro: 1.447 ± 0.238
1.034PheGln: 1.034 ± 0.227
1.241PheArg: 1.241 ± 0.222
2.275PheSer: 2.275 ± 0.381
1.964PheThr: 1.964 ± 0.294
1.758PheVal: 1.758 ± 0.203
0.569PheTrp: 0.569 ± 0.185
1.189PheTyr: 1.189 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
6.565GlyAla: 6.565 ± 0.624
0.672GlyCys: 0.672 ± 0.24
5.17GlyAsp: 5.17 ± 0.561
4.653GlyGlu: 4.653 ± 0.415
2.74GlyPhe: 2.74 ± 0.377
6.203GlyGly: 6.203 ± 0.678
0.62GlyHis: 0.62 ± 0.21
3.981GlyIle: 3.981 ± 0.377
4.342GlyLys: 4.342 ± 0.452
5.066GlyLeu: 5.066 ± 0.513
2.636GlyMet: 2.636 ± 0.38
3.153GlyAsn: 3.153 ± 0.421
2.12GlyPro: 2.12 ± 0.277
3.722GlyGln: 3.722 ± 0.397
4.756GlyArg: 4.756 ± 0.551
5.687GlySer: 5.687 ± 0.565
5.221GlyThr: 5.221 ± 0.615
4.601GlyVal: 4.601 ± 0.54
1.603GlyTrp: 1.603 ± 0.242
2.998GlyTyr: 2.998 ± 0.508
0.0GlyXaa: 0.0 ± 0.0
His
1.344HisAla: 1.344 ± 0.288
0.362HisCys: 0.362 ± 0.144
1.189HisAsp: 1.189 ± 0.267
0.982HisGlu: 0.982 ± 0.213
0.827HisPhe: 0.827 ± 0.234
1.292HisGly: 1.292 ± 0.307
0.517HisHis: 0.517 ± 0.166
1.086HisIle: 1.086 ± 0.294
0.827HisLys: 0.827 ± 0.272
1.396HisLeu: 1.396 ± 0.229
0.258HisMet: 0.258 ± 0.107
0.827HisAsn: 0.827 ± 0.242
0.879HisPro: 0.879 ± 0.204
0.724HisGln: 0.724 ± 0.175
1.189HisArg: 1.189 ± 0.283
0.879HisSer: 0.879 ± 0.184
0.827HisThr: 0.827 ± 0.219
1.034HisVal: 1.034 ± 0.253
0.414HisTrp: 0.414 ± 0.194
0.31HisTyr: 0.31 ± 0.108
0.0HisXaa: 0.0 ± 0.0
Ile
5.118IleAla: 5.118 ± 0.422
0.31IleCys: 0.31 ± 0.155
3.929IleAsp: 3.929 ± 0.433
3.412IleGlu: 3.412 ± 0.362
1.499IlePhe: 1.499 ± 0.38
3.825IleGly: 3.825 ± 0.396
1.086IleHis: 1.086 ± 0.222
2.275IleIle: 2.275 ± 0.324
2.533IleLys: 2.533 ± 0.434
3.257IleLeu: 3.257 ± 0.408
0.982IleMet: 0.982 ± 0.201
2.223IleAsn: 2.223 ± 0.343
2.947IlePro: 2.947 ± 0.504
1.861IleGln: 1.861 ± 0.345
3.05IleArg: 3.05 ± 0.481
3.464IleSer: 3.464 ± 0.384
3.825IleThr: 3.825 ± 0.453
2.998IleVal: 2.998 ± 0.386
0.569IleTrp: 0.569 ± 0.164
1.086IleTyr: 1.086 ± 0.212
0.0IleXaa: 0.0 ± 0.0
Lys
7.341LysAla: 7.341 ± 0.764
0.465LysCys: 0.465 ± 0.197
2.895LysAsp: 2.895 ± 0.422
3.412LysGlu: 3.412 ± 0.369
1.499LysPhe: 1.499 ± 0.272
3.774LysGly: 3.774 ± 0.469
0.775LysHis: 0.775 ± 0.255
2.378LysIle: 2.378 ± 0.384
3.257LysLys: 3.257 ± 0.578
4.084LysLeu: 4.084 ± 0.538
1.964LysMet: 1.964 ± 0.3
1.964LysAsn: 1.964 ± 0.312
3.05LysPro: 3.05 ± 0.482
2.585LysGln: 2.585 ± 0.295
4.239LysArg: 4.239 ± 0.666
1.861LysSer: 1.861 ± 0.328
2.998LysThr: 2.998 ± 0.349
2.947LysVal: 2.947 ± 0.42
0.827LysTrp: 0.827 ± 0.164
1.913LysTyr: 1.913 ± 0.343
0.0LysXaa: 0.0 ± 0.0
Leu
8.116LeuAla: 8.116 ± 0.564
0.672LeuCys: 0.672 ± 0.232
4.549LeuAsp: 4.549 ± 0.4
5.376LeuGlu: 5.376 ± 0.522
1.964LeuPhe: 1.964 ± 0.307
5.376LeuGly: 5.376 ± 0.507
1.344LeuHis: 1.344 ± 0.283
2.947LeuIle: 2.947 ± 0.412
4.136LeuLys: 4.136 ± 0.515
5.066LeuLeu: 5.066 ± 0.536
1.603LeuMet: 1.603 ± 0.236
2.792LeuAsn: 2.792 ± 0.365
3.722LeuPro: 3.722 ± 0.389
3.205LeuGln: 3.205 ± 0.37
5.531LeuArg: 5.531 ± 0.526
5.221LeuSer: 5.221 ± 0.618
4.084LeuThr: 4.084 ± 0.44
4.446LeuVal: 4.446 ± 0.561
1.189LeuTrp: 1.189 ± 0.344
2.481LeuTyr: 2.481 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
2.74MetAla: 2.74 ± 0.412
0.517MetCys: 0.517 ± 0.197
1.447MetAsp: 1.447 ± 0.25
1.344MetGlu: 1.344 ± 0.283
0.982MetPhe: 0.982 ± 0.203
1.447MetGly: 1.447 ± 0.277
0.31MetHis: 0.31 ± 0.115
1.241MetIle: 1.241 ± 0.237
1.447MetLys: 1.447 ± 0.273
1.603MetLeu: 1.603 ± 0.302
0.724MetMet: 0.724 ± 0.179
1.447MetAsn: 1.447 ± 0.218
1.551MetPro: 1.551 ± 0.328
1.654MetGln: 1.654 ± 0.385
1.913MetArg: 1.913 ± 0.357
2.068MetSer: 2.068 ± 0.389
2.016MetThr: 2.016 ± 0.344
1.292MetVal: 1.292 ± 0.245
0.569MetTrp: 0.569 ± 0.158
0.517MetTyr: 0.517 ± 0.179
0.0MetXaa: 0.0 ± 0.0
Asn
4.394AsnAla: 4.394 ± 0.448
0.414AsnCys: 0.414 ± 0.198
1.964AsnAsp: 1.964 ± 0.307
2.74AsnGlu: 2.74 ± 0.343
0.775AsnPhe: 0.775 ± 0.196
3.67AsnGly: 3.67 ± 0.474
0.931AsnHis: 0.931 ± 0.21
1.706AsnIle: 1.706 ± 0.304
1.809AsnLys: 1.809 ± 0.334
2.74AsnLeu: 2.74 ± 0.299
1.603AsnMet: 1.603 ± 0.233
1.861AsnAsn: 1.861 ± 0.446
2.688AsnPro: 2.688 ± 0.335
1.964AsnGln: 1.964 ± 0.426
2.585AsnArg: 2.585 ± 0.555
1.809AsnSer: 1.809 ± 0.239
2.223AsnThr: 2.223 ± 0.299
2.947AsnVal: 2.947 ± 0.323
0.569AsnTrp: 0.569 ± 0.214
1.034AsnTyr: 1.034 ± 0.215
0.0AsnXaa: 0.0 ± 0.0
Pro
5.48ProAla: 5.48 ± 0.511
0.517ProCys: 0.517 ± 0.193
3.567ProAsp: 3.567 ± 0.474
4.032ProGlu: 4.032 ± 0.58
1.447ProPhe: 1.447 ± 0.267
4.446ProGly: 4.446 ± 0.423
0.982ProHis: 0.982 ± 0.23
1.654ProIle: 1.654 ± 0.271
2.378ProLys: 2.378 ± 0.438
2.792ProLeu: 2.792 ± 0.364
0.775ProMet: 0.775 ± 0.187
2.068ProAsn: 2.068 ± 0.38
2.016ProPro: 2.016 ± 0.406
2.12ProGln: 2.12 ± 0.28
2.275ProArg: 2.275 ± 0.334
3.722ProSer: 3.722 ± 0.421
2.688ProThr: 2.688 ± 0.381
3.205ProVal: 3.205 ± 0.513
0.465ProTrp: 0.465 ± 0.154
1.344ProTyr: 1.344 ± 0.26
0.0ProXaa: 0.0 ± 0.0
Gln
5.221GlnAla: 5.221 ± 0.77
0.465GlnCys: 0.465 ± 0.188
2.481GlnAsp: 2.481 ± 0.347
3.153GlnGlu: 3.153 ± 0.502
1.551GlnPhe: 1.551 ± 0.29
3.05GlnGly: 3.05 ± 0.428
0.569GlnHis: 0.569 ± 0.192
2.275GlnIle: 2.275 ± 0.347
2.74GlnLys: 2.74 ± 0.352
3.981GlnLeu: 3.981 ± 0.353
1.137GlnMet: 1.137 ± 0.213
1.706GlnAsn: 1.706 ± 0.296
2.947GlnPro: 2.947 ± 0.486
5.635GlnGln: 5.635 ± 1.163
3.412GlnArg: 3.412 ± 0.4
2.843GlnSer: 2.843 ± 0.408
2.016GlnThr: 2.016 ± 0.328
2.481GlnVal: 2.481 ± 0.306
1.086GlnTrp: 1.086 ± 0.208
1.809GlnTyr: 1.809 ± 0.291
0.0GlnXaa: 0.0 ± 0.0
Arg
6.876ArgAla: 6.876 ± 0.824
0.879ArgCys: 0.879 ± 0.297
4.446ArgAsp: 4.446 ± 0.562
4.808ArgGlu: 4.808 ± 0.588
2.171ArgPhe: 2.171 ± 0.417
4.187ArgGly: 4.187 ± 0.417
1.189ArgHis: 1.189 ± 0.297
3.981ArgIle: 3.981 ± 0.503
3.67ArgLys: 3.67 ± 0.512
5.531ArgLeu: 5.531 ± 0.512
2.068ArgMet: 2.068 ± 0.285
2.636ArgAsn: 2.636 ± 0.343
2.43ArgPro: 2.43 ± 0.386
3.515ArgGln: 3.515 ± 0.447
4.291ArgArg: 4.291 ± 0.568
2.481ArgSer: 2.481 ± 0.323
3.722ArgThr: 3.722 ± 0.398
3.36ArgVal: 3.36 ± 0.431
0.879ArgTrp: 0.879 ± 0.291
1.654ArgTyr: 1.654 ± 0.276
0.0ArgXaa: 0.0 ± 0.0
Ser
5.635SerAla: 5.635 ± 0.533
0.362SerCys: 0.362 ± 0.137
3.309SerAsp: 3.309 ± 0.352
4.239SerGlu: 4.239 ± 0.427
2.068SerPhe: 2.068 ± 0.265
5.221SerGly: 5.221 ± 0.714
1.189SerHis: 1.189 ± 0.21
3.36SerIle: 3.36 ± 0.409
2.481SerLys: 2.481 ± 0.341
4.291SerLeu: 4.291 ± 0.551
1.603SerMet: 1.603 ± 0.258
2.016SerAsn: 2.016 ± 0.319
3.153SerPro: 3.153 ± 0.421
2.585SerGln: 2.585 ± 0.383
2.895SerArg: 2.895 ± 0.388
3.929SerSer: 3.929 ± 0.427
3.67SerThr: 3.67 ± 0.443
3.309SerVal: 3.309 ± 0.336
0.775SerTrp: 0.775 ± 0.222
1.654SerTyr: 1.654 ± 0.321
0.0SerXaa: 0.0 ± 0.0
Thr
6.255ThrAla: 6.255 ± 0.472
0.207ThrCys: 0.207 ± 0.107
3.619ThrAsp: 3.619 ± 0.382
4.187ThrGlu: 4.187 ± 0.465
1.758ThrPhe: 1.758 ± 0.292
4.394ThrGly: 4.394 ± 0.619
0.827ThrHis: 0.827 ± 0.275
2.481ThrIle: 2.481 ± 0.336
2.533ThrLys: 2.533 ± 0.361
4.498ThrLeu: 4.498 ± 0.43
0.931ThrMet: 0.931 ± 0.18
2.275ThrAsn: 2.275 ± 0.384
3.567ThrPro: 3.567 ± 0.376
2.533ThrGln: 2.533 ± 0.409
3.102ThrArg: 3.102 ± 0.401
3.619ThrSer: 3.619 ± 0.415
2.947ThrThr: 2.947 ± 0.42
3.981ThrVal: 3.981 ± 0.496
1.034ThrTrp: 1.034 ± 0.221
1.344ThrTyr: 1.344 ± 0.275
0.0ThrXaa: 0.0 ± 0.0
Val
5.635ValAla: 5.635 ± 0.538
0.414ValCys: 0.414 ± 0.165
3.05ValAsp: 3.05 ± 0.381
3.929ValGlu: 3.929 ± 0.429
1.964ValPhe: 1.964 ± 0.266
3.515ValGly: 3.515 ± 0.502
1.034ValHis: 1.034 ± 0.254
2.843ValIle: 2.843 ± 0.461
3.981ValLys: 3.981 ± 0.43
3.67ValLeu: 3.67 ± 0.583
1.758ValMet: 1.758 ± 0.331
2.998ValAsn: 2.998 ± 0.463
3.257ValPro: 3.257 ± 0.37
2.74ValGln: 2.74 ± 0.382
3.981ValArg: 3.981 ± 0.419
3.412ValSer: 3.412 ± 0.405
3.722ValThr: 3.722 ± 0.481
3.981ValVal: 3.981 ± 0.509
0.775ValTrp: 0.775 ± 0.232
1.913ValTyr: 1.913 ± 0.28
0.0ValXaa: 0.0 ± 0.0
Trp
1.137TrpAla: 1.137 ± 0.272
0.207TrpCys: 0.207 ± 0.116
1.241TrpAsp: 1.241 ± 0.211
1.137TrpGlu: 1.137 ± 0.23
0.879TrpPhe: 0.879 ± 0.241
1.086TrpGly: 1.086 ± 0.254
0.414TrpHis: 0.414 ± 0.152
1.137TrpIle: 1.137 ± 0.285
0.569TrpLys: 0.569 ± 0.165
2.016TrpLeu: 2.016 ± 0.384
0.569TrpMet: 0.569 ± 0.179
0.465TrpAsn: 0.465 ± 0.137
0.775TrpPro: 0.775 ± 0.251
1.086TrpGln: 1.086 ± 0.24
1.396TrpArg: 1.396 ± 0.296
0.931TrpSer: 0.931 ± 0.194
0.672TrpThr: 0.672 ± 0.202
0.827TrpVal: 0.827 ± 0.21
0.517TrpTrp: 0.517 ± 0.181
0.414TrpTyr: 0.414 ± 0.127
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.636TyrAla: 2.636 ± 0.458
0.31TyrCys: 0.31 ± 0.143
1.964TyrAsp: 1.964 ± 0.276
1.292TyrGlu: 1.292 ± 0.309
1.241TyrPhe: 1.241 ± 0.21
2.74TyrGly: 2.74 ± 0.333
0.775TyrHis: 0.775 ± 0.299
1.447TyrIle: 1.447 ± 0.292
1.189TyrLys: 1.189 ± 0.266
2.171TyrLeu: 2.171 ± 0.332
0.414TyrMet: 0.414 ± 0.15
1.292TyrAsn: 1.292 ± 0.191
1.551TyrPro: 1.551 ± 0.268
1.447TyrGln: 1.447 ± 0.306
2.792TyrArg: 2.792 ± 0.374
1.964TyrSer: 1.964 ± 0.326
1.447TyrThr: 1.447 ± 0.352
1.758TyrVal: 1.758 ± 0.288
0.672TyrTrp: 0.672 ± 0.18
0.569TyrTyr: 0.569 ± 0.189
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (19345 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski