Amino acid dipepetide frequency for Kosmotoga sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.666AlaAla: 3.666 ± 0.083	0.478AlaCys: 0.478 ± 0.022	2.551AlaAsp: 2.551 ± 0.053	3.682AlaGlu: 3.682 ± 0.07	3.054AlaPhe: 3.054 ± 0.071	4.184AlaGly: 4.184 ± 0.072	0.821AlaHis: 0.821 ± 0.032	4.866AlaIle: 4.866 ± 0.089	3.96AlaLys: 3.96 ± 0.075	6.031AlaLeu: 6.031 ± 0.09	1.518AlaMet: 1.518 ± 0.045	2.237AlaAsn: 2.237 ± 0.053	1.39AlaPro: 1.39 ± 0.041	1.269AlaGln: 1.269 ± 0.038	2.517AlaArg: 2.517 ± 0.05	3.493AlaSer: 3.493 ± 0.066	2.838AlaThr: 2.838 ± 0.074	4.263AlaVal: 4.263 ± 0.08	0.471AlaTrp: 0.471 ± 0.023	2.063AlaTyr: 2.063 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.416CysAla: 0.416 ± 0.024	0.093CysCys: 0.093 ± 0.011	0.474CysAsp: 0.474 ± 0.024	0.576CysGlu: 0.576 ± 0.029	0.378CysPhe: 0.378 ± 0.019	0.808CysGly: 0.808 ± 0.034	0.148CysHis: 0.148 ± 0.014	0.575CysIle: 0.575 ± 0.024	0.543CysLys: 0.543 ± 0.025	0.621CysLeu: 0.621 ± 0.027	0.141CysMet: 0.141 ± 0.013	0.379CysAsn: 0.379 ± 0.024	0.456CysPro: 0.456 ± 0.026	0.154CysGln: 0.154 ± 0.013	0.347CysArg: 0.347 ± 0.024	0.575CysSer: 0.575 ± 0.029	0.411CysThr: 0.411 ± 0.02	0.476CysVal: 0.476 ± 0.023	0.096CysTrp: 0.096 ± 0.01	0.256CysTyr: 0.256 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.622AspAla: 2.622 ± 0.062	0.453AspCys: 0.453 ± 0.029	2.68AspAsp: 2.68 ± 0.06	4.577AspGlu: 4.577 ± 0.091	3.241AspPhe: 3.241 ± 0.067	3.33AspGly: 3.33 ± 0.07	0.839AspHis: 0.839 ± 0.031	5.201AspIle: 5.201 ± 0.075	4.082AspLys: 4.082 ± 0.07	4.988AspLeu: 4.988 ± 0.083	1.288AspMet: 1.288 ± 0.033	2.927AspAsn: 2.927 ± 0.061	2.139AspPro: 2.139 ± 0.056	1.018AspGln: 1.018 ± 0.029	2.228AspArg: 2.228 ± 0.052	3.278AspSer: 3.278 ± 0.062	2.468AspThr: 2.468 ± 0.057	3.684AspVal: 3.684 ± 0.069	0.592AspTrp: 0.592 ± 0.027	2.795AspTyr: 2.795 ± 0.068	0.0AspXaa: 0.0 ± 0.0
Glu	3.989GluAla: 3.989 ± 0.075	0.449GluCys: 0.449 ± 0.023	4.128GluAsp: 4.128 ± 0.077	6.832GluGlu: 6.832 ± 0.116	3.291GluPhe: 3.291 ± 0.066	4.275GluGly: 4.275 ± 0.071	1.107GluHis: 1.107 ± 0.042	7.386GluIle: 7.386 ± 0.101	8.248GluLys: 8.248 ± 0.117	7.688GluLeu: 7.688 ± 0.099	2.122GluMet: 2.122 ± 0.049	5.051GluAsn: 5.051 ± 0.082	2.127GluPro: 2.127 ± 0.051	1.832GluGln: 1.832 ± 0.047	3.384GluArg: 3.384 ± 0.066	3.922GluSer: 3.922 ± 0.062	3.844GluThr: 3.844 ± 0.07	4.574GluVal: 4.574 ± 0.07	0.661GluTrp: 0.661 ± 0.03	3.048GluTyr: 3.048 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.74PheAla: 2.74 ± 0.054	0.449PheCys: 0.449 ± 0.023	3.179PheAsp: 3.179 ± 0.061	3.638PheGlu: 3.638 ± 0.066	2.746PhePhe: 2.746 ± 0.066	3.594PheGly: 3.594 ± 0.062	0.764PheHis: 0.764 ± 0.03	4.141PheIle: 4.141 ± 0.071	3.224PheLys: 3.224 ± 0.061	5.138PheLeu: 5.138 ± 0.091	1.217PheMet: 1.217 ± 0.043	2.416PheAsn: 2.416 ± 0.051	1.846PhePro: 1.846 ± 0.045	1.063PheGln: 1.063 ± 0.032	1.918PheArg: 1.918 ± 0.048	4.269PheSer: 4.269 ± 0.075	2.61PheThr: 2.61 ± 0.054	3.475PheVal: 3.475 ± 0.069	0.56PheTrp: 0.56 ± 0.027	1.985PheTyr: 1.985 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	3.596GlyAla: 3.596 ± 0.076	0.662GlyCys: 0.662 ± 0.029	3.293GlyAsp: 3.293 ± 0.06	4.462GlyGlu: 4.462 ± 0.078	3.605GlyPhe: 3.605 ± 0.064	4.148GlyGly: 4.148 ± 0.085	1.101GlyHis: 1.101 ± 0.033	6.209GlyIle: 6.209 ± 0.091	5.486GlyLys: 5.486 ± 0.094	5.85GlyLeu: 5.85 ± 0.09	1.71GlyMet: 1.71 ± 0.045	3.22GlyAsn: 3.22 ± 0.069	1.632GlyPro: 1.632 ± 0.043	1.391GlyGln: 1.391 ± 0.037	2.552GlyArg: 2.552 ± 0.051	3.94GlySer: 3.94 ± 0.071	3.705GlyThr: 3.705 ± 0.069	4.252GlyVal: 4.252 ± 0.083	0.799GlyTrp: 0.799 ± 0.029	3.099GlyTyr: 3.099 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.777HisAla: 0.777 ± 0.028	0.188HisCys: 0.188 ± 0.014	0.832HisAsp: 0.832 ± 0.029	1.133HisGlu: 1.133 ± 0.034	0.915HisPhe: 0.915 ± 0.03	1.155HisGly: 1.155 ± 0.036	0.342HisHis: 0.342 ± 0.021	1.284HisIle: 1.284 ± 0.041	0.979HisLys: 0.979 ± 0.033	1.498HisLeu: 1.498 ± 0.044	0.362HisMet: 0.362 ± 0.021	0.801HisAsn: 0.801 ± 0.032	0.78HisPro: 0.78 ± 0.03	0.345HisGln: 0.345 ± 0.019	0.661HisArg: 0.661 ± 0.028	1.044HisSer: 1.044 ± 0.035	0.745HisThr: 0.745 ± 0.029	0.907HisVal: 0.907 ± 0.031	0.22HisTrp: 0.22 ± 0.019	0.73HisTyr: 0.73 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.386IleAla: 5.386 ± 0.084	0.644IleCys: 0.644 ± 0.025	5.432IleAsp: 5.432 ± 0.08	6.765IleGlu: 6.765 ± 0.093	4.371IlePhe: 4.371 ± 0.081	5.426IleGly: 5.426 ± 0.118	1.281IleHis: 1.281 ± 0.042	7.338IleIle: 7.338 ± 0.109	6.562IleLys: 6.562 ± 0.092	7.659IleLeu: 7.659 ± 0.108	1.868IleMet: 1.868 ± 0.043	4.691IleAsn: 4.691 ± 0.071	3.622IlePro: 3.622 ± 0.061	1.734IleGln: 1.734 ± 0.037	3.171IleArg: 3.171 ± 0.06	6.301IleSer: 6.301 ± 0.084	4.933IleThr: 4.933 ± 0.082	5.757IleVal: 5.757 ± 0.078	0.808IleTrp: 0.808 ± 0.029	3.236IleTyr: 3.236 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.594LysAla: 4.594 ± 0.076	0.527LysCys: 0.527 ± 0.026	4.341LysAsp: 4.341 ± 0.063	7.49LysGlu: 7.49 ± 0.117	2.716LysPhe: 2.716 ± 0.054	4.794LysGly: 4.794 ± 0.076	1.378LysHis: 1.378 ± 0.041	7.26LysIle: 7.26 ± 0.099	8.185LysLys: 8.185 ± 0.126	7.322LysLeu: 7.322 ± 0.098	2.045LysMet: 2.045 ± 0.045	5.238LysAsn: 5.238 ± 0.083	2.653LysPro: 2.653 ± 0.056	1.975LysGln: 1.975 ± 0.05	3.714LysArg: 3.714 ± 0.067	4.49LysSer: 4.49 ± 0.076	4.286LysThr: 4.286 ± 0.066	4.713LysVal: 4.713 ± 0.076	0.781LysTrp: 0.781 ± 0.032	3.266LysTyr: 3.266 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	5.466LeuAla: 5.466 ± 0.08	0.722LeuCys: 0.722 ± 0.028	4.972LeuAsp: 4.972 ± 0.065	7.026LeuGlu: 7.026 ± 0.093	4.859LeuPhe: 4.859 ± 0.08	6.013LeuGly: 6.013 ± 0.096	1.364LeuHis: 1.364 ± 0.038	7.748LeuIle: 7.748 ± 0.099	8.452LeuLys: 8.452 ± 0.111	9.296LeuLeu: 9.296 ± 0.136	2.225LeuMet: 2.225 ± 0.047	5.145LeuAsn: 5.145 ± 0.077	3.652LeuPro: 3.652 ± 0.06	2.196LeuGln: 2.196 ± 0.046	3.888LeuArg: 3.888 ± 0.066	7.516LeuSer: 7.516 ± 0.092	4.828LeuThr: 4.828 ± 0.077	5.784LeuVal: 5.784 ± 0.087	0.865LeuTrp: 0.865 ± 0.033	3.193LeuTyr: 3.193 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.472MetAla: 1.472 ± 0.041	0.167MetCys: 0.167 ± 0.013	1.254MetAsp: 1.254 ± 0.035	1.683MetGlu: 1.683 ± 0.044	0.985MetPhe: 0.985 ± 0.034	1.647MetGly: 1.647 ± 0.041	0.368MetHis: 0.368 ± 0.019	2.117MetIle: 2.117 ± 0.052	2.597MetLys: 2.597 ± 0.055	2.24MetLeu: 2.24 ± 0.054	0.588MetMet: 0.588 ± 0.024	1.497MetAsn: 1.497 ± 0.038	0.857MetPro: 0.857 ± 0.033	0.564MetGln: 0.564 ± 0.028	1.098MetArg: 1.098 ± 0.033	1.488MetSer: 1.488 ± 0.037	1.193MetThr: 1.193 ± 0.033	1.552MetVal: 1.552 ± 0.047	0.188MetTrp: 0.188 ± 0.015	0.764MetTyr: 0.764 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.806AsnAla: 2.806 ± 0.053	0.456AsnCys: 0.456 ± 0.024	2.744AsnAsp: 2.744 ± 0.066	4.33AsnGlu: 4.33 ± 0.074	2.651AsnPhe: 2.651 ± 0.059	3.189AsnGly: 3.189 ± 0.07	0.829AsnHis: 0.829 ± 0.03	5.024AsnIle: 5.024 ± 0.082	4.271AsnLys: 4.271 ± 0.071	4.701AsnLeu: 4.701 ± 0.071	1.236AsnMet: 1.236 ± 0.036	3.256AsnAsn: 3.256 ± 0.068	2.443AsnPro: 2.443 ± 0.054	1.23AsnGln: 1.23 ± 0.036	2.204AsnArg: 2.204 ± 0.051	3.177AsnSer: 3.177 ± 0.058	2.498AsnThr: 2.498 ± 0.047	3.423AsnVal: 3.423 ± 0.069	0.64AsnTrp: 0.64 ± 0.029	2.477AsnTyr: 2.477 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	1.821ProAla: 1.821 ± 0.046	0.23ProCys: 0.23 ± 0.017	2.515ProAsp: 2.515 ± 0.058	3.783ProGlu: 3.783 ± 0.08	1.904ProPhe: 1.904 ± 0.045	2.518ProGly: 2.518 ± 0.056	0.599ProHis: 0.599 ± 0.029	2.391ProIle: 2.391 ± 0.048	2.102ProLys: 2.102 ± 0.052	3.288ProLeu: 3.288 ± 0.072	0.713ProMet: 0.713 ± 0.026	1.407ProAsn: 1.407 ± 0.04	1.132ProPro: 1.132 ± 0.033	0.779ProGln: 0.779 ± 0.029	1.108ProArg: 1.108 ± 0.035	2.278ProSer: 2.278 ± 0.052	1.72ProThr: 1.72 ± 0.046	2.965ProVal: 2.965 ± 0.055	0.407ProTrp: 0.407 ± 0.026	1.546ProTyr: 1.546 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.142GlnAla: 1.142 ± 0.032	0.171GlnCys: 0.171 ± 0.013	0.983GlnAsp: 0.983 ± 0.033	1.732GlnGlu: 1.732 ± 0.045	0.961GlnPhe: 0.961 ± 0.035	1.275GlnGly: 1.275 ± 0.035	0.413GlnHis: 0.413 ± 0.021	2.049GlnIle: 2.049 ± 0.047	2.102GlnLys: 2.102 ± 0.044	2.317GlnLeu: 2.317 ± 0.047	0.688GlnMet: 0.688 ± 0.031	1.321GlnAsn: 1.321 ± 0.039	0.691GlnPro: 0.691 ± 0.029	0.641GlnGln: 0.641 ± 0.028	1.013GlnArg: 1.013 ± 0.035	1.266GlnSer: 1.266 ± 0.034	1.041GlnThr: 1.041 ± 0.035	1.258GlnVal: 1.258 ± 0.039	0.268GlnTrp: 0.268 ± 0.019	0.939GlnTyr: 0.939 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.003ArgAla: 2.003 ± 0.046	0.326ArgCys: 0.326 ± 0.02	1.987ArgAsp: 1.987 ± 0.048	3.22ArgGlu: 3.22 ± 0.065	2.185ArgPhe: 2.185 ± 0.048	2.307ArgGly: 2.307 ± 0.054	0.596ArgHis: 0.596 ± 0.027	3.896ArgIle: 3.896 ± 0.073	4.094ArgLys: 4.094 ± 0.079	3.829ArgLeu: 3.829 ± 0.07	1.138ArgMet: 1.138 ± 0.034	2.399ArgAsn: 2.399 ± 0.05	1.101ArgPro: 1.101 ± 0.034	0.907ArgGln: 0.907 ± 0.03	1.97ArgArg: 1.97 ± 0.056	2.232ArgSer: 2.232 ± 0.05	1.983ArgThr: 1.983 ± 0.045	2.59ArgVal: 2.59 ± 0.051	0.438ArgTrp: 0.438 ± 0.023	1.831ArgTyr: 1.831 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.346SerAla: 3.346 ± 0.068	0.548SerCys: 0.548 ± 0.028	3.444SerAsp: 3.444 ± 0.065	4.829SerGlu: 4.829 ± 0.076	3.921SerPhe: 3.921 ± 0.071	4.799SerGly: 4.799 ± 0.081	1.042SerHis: 1.042 ± 0.04	5.444SerIle: 5.444 ± 0.084	4.959SerLys: 4.959 ± 0.069	6.34SerLeu: 6.34 ± 0.084	1.56SerMet: 1.56 ± 0.04	3.089SerAsn: 3.089 ± 0.06	2.283SerPro: 2.283 ± 0.05	1.515SerGln: 1.515 ± 0.039	2.711SerArg: 2.711 ± 0.061	4.448SerSer: 4.448 ± 0.07	3.21SerThr: 3.21 ± 0.06	4.381SerVal: 4.381 ± 0.07	0.763SerTrp: 0.763 ± 0.03	2.624SerTyr: 2.624 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.01ThrAla: 3.01 ± 0.058	0.325ThrCys: 0.325 ± 0.019	2.78ThrAsp: 2.78 ± 0.066	3.625ThrGlu: 3.625 ± 0.068	2.72ThrPhe: 2.72 ± 0.057	4.13ThrGly: 4.13 ± 0.067	0.867ThrHis: 0.867 ± 0.031	4.271ThrIle: 4.271 ± 0.071	3.308ThrLys: 3.308 ± 0.058	5.011ThrLeu: 5.011 ± 0.087	1.179ThrMet: 1.179 ± 0.034	2.348ThrAsn: 2.348 ± 0.058	2.068ThrPro: 2.068 ± 0.053	1.036ThrGln: 1.036 ± 0.038	1.869ThrArg: 1.869 ± 0.048	3.205ThrSer: 3.205 ± 0.066	2.813ThrThr: 2.813 ± 0.063	3.833ThrVal: 3.833 ± 0.077	0.497ThrTrp: 0.497 ± 0.029	1.972ThrTyr: 1.972 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	3.962ValAla: 3.962 ± 0.075	0.528ValCys: 0.528 ± 0.027	3.892ValAsp: 3.892 ± 0.069	4.927ValGlu: 4.927 ± 0.07	3.594ValPhe: 3.594 ± 0.069	3.798ValGly: 3.798 ± 0.066	0.971ValHis: 0.971 ± 0.03	5.728ValIle: 5.728 ± 0.086	4.919ValLys: 4.919 ± 0.064	6.346ValLeu: 6.346 ± 0.073	1.587ValMet: 1.587 ± 0.042	3.445ValAsn: 3.445 ± 0.069	2.429ValPro: 2.429 ± 0.053	1.393ValGln: 1.393 ± 0.035	2.471ValArg: 2.471 ± 0.056	4.624ValSer: 4.624 ± 0.069	3.312ValThr: 3.312 ± 0.074	4.8ValVal: 4.8 ± 0.079	0.552ValTrp: 0.552 ± 0.024	2.381ValTyr: 2.381 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.492TrpAla: 0.492 ± 0.026	0.085TrpCys: 0.085 ± 0.01	0.592TrpAsp: 0.592 ± 0.029	0.713TrpGlu: 0.713 ± 0.029	0.498TrpPhe: 0.498 ± 0.024	0.671TrpGly: 0.671 ± 0.03	0.185TrpHis: 0.185 ± 0.014	0.854TrpIle: 0.854 ± 0.031	0.961TrpLys: 0.961 ± 0.035	1.04TrpLeu: 1.04 ± 0.033	0.255TrpMet: 0.255 ± 0.016	0.63TrpAsn: 0.63 ± 0.031	0.314TrpPro: 0.314 ± 0.021	0.289TrpGln: 0.289 ± 0.017	0.397TrpArg: 0.397 ± 0.02	0.616TrpSer: 0.616 ± 0.029	0.506TrpThr: 0.506 ± 0.027	0.547TrpVal: 0.547 ± 0.024	0.156TrpTrp: 0.156 ± 0.012	0.407TrpTyr: 0.407 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.047TyrAla: 2.047 ± 0.048	0.42TyrCys: 0.42 ± 0.021	2.36TyrAsp: 2.36 ± 0.051	2.935TyrGlu: 2.935 ± 0.064	2.375TyrPhe: 2.375 ± 0.051	2.65TyrGly: 2.65 ± 0.063	0.683TyrHis: 0.683 ± 0.028	3.204TyrIle: 3.204 ± 0.06	2.735TyrLys: 2.735 ± 0.052	4.004TyrLeu: 4.004 ± 0.062	0.878TyrMet: 0.878 ± 0.03	2.087TyrAsn: 2.087 ± 0.052	1.592TyrPro: 1.592 ± 0.04	0.938TyrGln: 0.938 ± 0.031	1.812TyrArg: 1.812 ± 0.054	3.093TyrSer: 3.093 ± 0.057	1.924TyrThr: 1.924 ± 0.05	2.427TyrVal: 2.427 ± 0.054	0.448TyrTrp: 0.448 ± 0.026	1.976TyrTyr: 1.976 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2971 proteins (932970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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