Amino acid dipepetide frequency for Streptococcus phage Javan590

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.726AlaAla: 4.726 ± 0.972
0.503AlaCys: 0.503 ± 0.25
4.424AlaAsp: 4.424 ± 0.74
5.429AlaGlu: 5.429 ± 0.878
3.016AlaPhe: 3.016 ± 0.555
3.418AlaGly: 3.418 ± 0.738
0.704AlaHis: 0.704 ± 0.303
5.932AlaIle: 5.932 ± 0.948
4.524AlaLys: 4.524 ± 0.691
6.837AlaLeu: 6.837 ± 0.981
2.614AlaMet: 2.614 ± 0.481
3.72AlaAsn: 3.72 ± 0.46
1.709AlaPro: 1.709 ± 0.367
3.217AlaGln: 3.217 ± 0.602
3.519AlaArg: 3.519 ± 0.543
4.524AlaSer: 4.524 ± 0.566
3.418AlaThr: 3.418 ± 0.48
5.027AlaVal: 5.027 ± 0.688
0.704AlaTrp: 0.704 ± 0.258
2.614AlaTyr: 2.614 ± 0.518
0.0AlaXaa: 0.0 ± 0.0
Cys
0.101CysAla: 0.101 ± 0.09
0.0CysCys: 0.0 ± 0.0
0.402CysAsp: 0.402 ± 0.205
0.402CysGlu: 0.402 ± 0.227
0.101CysPhe: 0.101 ± 0.09
0.201CysGly: 0.201 ± 0.14
0.201CysHis: 0.201 ± 0.12
0.503CysIle: 0.503 ± 0.199
0.603CysLys: 0.603 ± 0.223
0.302CysLeu: 0.302 ± 0.158
0.0CysMet: 0.0 ± 0.0
0.101CysAsn: 0.101 ± 0.094
0.101CysPro: 0.101 ± 0.1
0.402CysGln: 0.402 ± 0.179
0.402CysArg: 0.402 ± 0.218
0.302CysSer: 0.302 ± 0.153
0.503CysThr: 0.503 ± 0.234
0.603CysVal: 0.603 ± 0.25
0.0CysTrp: 0.0 ± 0.0
0.201CysTyr: 0.201 ± 0.13
0.0CysXaa: 0.0 ± 0.0
Asp
4.022AspAla: 4.022 ± 0.776
0.503AspCys: 0.503 ± 0.177
2.715AspAsp: 2.715 ± 0.701
4.122AspGlu: 4.122 ± 0.644
4.022AspPhe: 4.022 ± 0.702
3.921AspGly: 3.921 ± 0.763
0.704AspHis: 0.704 ± 0.235
3.318AspIle: 3.318 ± 0.826
6.033AspLys: 6.033 ± 0.861
4.424AspLeu: 4.424 ± 0.638
2.111AspMet: 2.111 ± 0.487
4.625AspAsn: 4.625 ± 0.788
2.312AspPro: 2.312 ± 0.401
1.307AspGln: 1.307 ± 0.401
2.111AspArg: 2.111 ± 0.42
2.312AspSer: 2.312 ± 0.376
2.715AspThr: 2.715 ± 0.553
3.821AspVal: 3.821 ± 0.618
1.408AspTrp: 1.408 ± 0.353
3.117AspTyr: 3.117 ± 0.583
0.0AspXaa: 0.0 ± 0.0
Glu
4.927GluAla: 4.927 ± 0.726
0.402GluCys: 0.402 ± 0.175
3.72GluAsp: 3.72 ± 0.566
6.234GluGlu: 6.234 ± 1.108
3.217GluPhe: 3.217 ± 0.572
4.826GluGly: 4.826 ± 0.617
1.508GluHis: 1.508 ± 0.376
6.636GluIle: 6.636 ± 0.676
5.53GluLys: 5.53 ± 0.742
7.842GluLeu: 7.842 ± 1.086
2.011GluMet: 2.011 ± 0.39
4.022GluAsn: 4.022 ± 0.538
2.212GluPro: 2.212 ± 0.688
4.323GluGln: 4.323 ± 0.738
3.418GluArg: 3.418 ± 0.582
3.418GluSer: 3.418 ± 0.899
3.62GluThr: 3.62 ± 0.66
5.932GluVal: 5.932 ± 0.823
0.804GluTrp: 0.804 ± 0.26
2.514GluTyr: 2.514 ± 0.584
0.0GluXaa: 0.0 ± 0.0
Phe
3.117PheAla: 3.117 ± 0.461
0.201PheCys: 0.201 ± 0.129
3.418PheAsp: 3.418 ± 0.515
4.022PheGlu: 4.022 ± 0.79
2.514PhePhe: 2.514 ± 0.573
2.514PheGly: 2.514 ± 0.663
0.603PheHis: 0.603 ± 0.222
3.418PheIle: 3.418 ± 0.671
3.418PheLys: 3.418 ± 0.462
3.62PheLeu: 3.62 ± 0.803
0.905PheMet: 0.905 ± 0.279
3.318PheAsn: 3.318 ± 0.44
0.704PhePro: 0.704 ± 0.263
1.91PheGln: 1.91 ± 0.408
1.709PheArg: 1.709 ± 0.466
2.312PheSer: 2.312 ± 0.479
2.312PheThr: 2.312 ± 0.541
2.715PheVal: 2.715 ± 0.409
0.503PheTrp: 0.503 ± 0.198
1.307PheTyr: 1.307 ± 0.478
0.0PheXaa: 0.0 ± 0.0
Gly
2.916GlyAla: 2.916 ± 0.649
0.402GlyCys: 0.402 ± 0.226
3.418GlyAsp: 3.418 ± 0.584
2.815GlyGlu: 2.815 ± 0.561
1.91GlyPhe: 1.91 ± 0.557
4.424GlyGly: 4.424 ± 0.827
1.307GlyHis: 1.307 ± 0.297
5.429GlyIle: 5.429 ± 0.708
5.831GlyLys: 5.831 ± 0.875
4.726GlyLeu: 4.726 ± 0.855
1.91GlyMet: 1.91 ± 0.55
3.217GlyAsn: 3.217 ± 0.547
0.603GlyPro: 0.603 ± 0.25
2.514GlyGln: 2.514 ± 0.549
2.614GlyArg: 2.614 ± 0.462
3.217GlySer: 3.217 ± 0.709
4.424GlyThr: 4.424 ± 1.002
3.217GlyVal: 3.217 ± 0.488
0.704GlyTrp: 0.704 ± 0.242
3.217GlyTyr: 3.217 ± 0.448
0.0GlyXaa: 0.0 ± 0.0
His
0.603HisAla: 0.603 ± 0.274
0.302HisCys: 0.302 ± 0.205
1.307HisAsp: 1.307 ± 0.47
0.804HisGlu: 0.804 ± 0.236
0.704HisPhe: 0.704 ± 0.31
1.005HisGly: 1.005 ± 0.312
0.201HisHis: 0.201 ± 0.139
2.011HisIle: 2.011 ± 0.361
0.905HisLys: 0.905 ± 0.566
1.609HisLeu: 1.609 ± 0.453
0.402HisMet: 0.402 ± 0.195
1.106HisAsn: 1.106 ± 0.353
0.503HisPro: 0.503 ± 0.261
0.704HisGln: 0.704 ± 0.288
0.603HisArg: 0.603 ± 0.223
1.81HisSer: 1.81 ± 0.542
0.804HisThr: 0.804 ± 0.292
1.106HisVal: 1.106 ± 0.341
0.201HisTrp: 0.201 ± 0.14
0.905HisTyr: 0.905 ± 0.329
0.0HisXaa: 0.0 ± 0.0
Ile
5.731IleAla: 5.731 ± 0.811
0.503IleCys: 0.503 ± 0.212
5.027IleAsp: 5.027 ± 0.66
5.932IleGlu: 5.932 ± 0.738
2.212IlePhe: 2.212 ± 0.47
4.524IleGly: 4.524 ± 0.622
1.408IleHis: 1.408 ± 0.335
4.122IleIle: 4.122 ± 0.685
7.139IleLys: 7.139 ± 0.816
5.932IleLeu: 5.932 ± 0.76
1.609IleMet: 1.609 ± 0.469
4.927IleAsn: 4.927 ± 0.688
2.111IlePro: 2.111 ± 0.47
2.916IleGln: 2.916 ± 0.639
3.62IleArg: 3.62 ± 0.648
2.916IleSer: 2.916 ± 0.712
4.122IleThr: 4.122 ± 0.62
5.731IleVal: 5.731 ± 0.784
0.603IleTrp: 0.603 ± 0.258
1.91IleTyr: 1.91 ± 0.471
0.0IleXaa: 0.0 ± 0.0
Lys
5.027LysAla: 5.027 ± 0.735
0.201LysCys: 0.201 ± 0.131
4.524LysAsp: 4.524 ± 0.729
6.435LysGlu: 6.435 ± 0.782
3.318LysPhe: 3.318 ± 0.605
5.53LysGly: 5.53 ± 0.706
1.81LysHis: 1.81 ± 0.519
5.429LysIle: 5.429 ± 0.795
6.234LysLys: 6.234 ± 0.933
6.937LysLeu: 6.937 ± 0.747
2.111LysMet: 2.111 ± 0.52
4.323LysAsn: 4.323 ± 0.659
4.022LysPro: 4.022 ± 0.666
4.424LysGln: 4.424 ± 0.792
3.921LysArg: 3.921 ± 0.713
3.921LysSer: 3.921 ± 0.637
5.128LysThr: 5.128 ± 0.639
3.016LysVal: 3.016 ± 0.537
1.408LysTrp: 1.408 ± 0.509
2.312LysTyr: 2.312 ± 0.463
0.0LysXaa: 0.0 ± 0.0
Leu
7.742LeuAla: 7.742 ± 0.85
0.402LeuCys: 0.402 ± 0.192
4.726LeuAsp: 4.726 ± 0.66
8.245LeuGlu: 8.245 ± 1.003
3.217LeuPhe: 3.217 ± 0.736
3.72LeuGly: 3.72 ± 0.606
1.709LeuHis: 1.709 ± 0.41
5.731LeuIle: 5.731 ± 1.006
8.144LeuLys: 8.144 ± 0.806
5.932LeuLeu: 5.932 ± 0.757
2.312LeuMet: 2.312 ± 0.416
4.424LeuAsn: 4.424 ± 0.707
3.217LeuPro: 3.217 ± 0.561
3.318LeuGln: 3.318 ± 0.568
2.916LeuArg: 2.916 ± 0.638
5.128LeuSer: 5.128 ± 0.79
5.731LeuThr: 5.731 ± 0.708
4.625LeuVal: 4.625 ± 0.653
0.804LeuTrp: 0.804 ± 0.312
2.514LeuTyr: 2.514 ± 0.539
0.0LeuXaa: 0.0 ± 0.0
Met
3.117MetAla: 3.117 ± 0.495
0.101MetCys: 0.101 ± 0.1
0.905MetAsp: 0.905 ± 0.291
1.81MetGlu: 1.81 ± 0.371
1.207MetPhe: 1.207 ± 0.332
0.905MetGly: 0.905 ± 0.272
0.402MetHis: 0.402 ± 0.229
2.011MetIle: 2.011 ± 0.438
1.81MetLys: 1.81 ± 0.457
1.91MetLeu: 1.91 ± 0.45
0.704MetMet: 0.704 ± 0.279
1.307MetAsn: 1.307 ± 0.397
1.005MetPro: 1.005 ± 0.356
0.603MetGln: 0.603 ± 0.277
1.106MetArg: 1.106 ± 0.279
2.614MetSer: 2.614 ± 0.565
2.614MetThr: 2.614 ± 0.563
1.005MetVal: 1.005 ± 0.371
0.302MetTrp: 0.302 ± 0.195
0.603MetTyr: 0.603 ± 0.233
0.0MetXaa: 0.0 ± 0.0
Asn
3.418AsnAla: 3.418 ± 0.641
0.201AsnCys: 0.201 ± 0.18
2.514AsnAsp: 2.514 ± 0.46
3.62AsnGlu: 3.62 ± 0.705
2.212AsnPhe: 2.212 ± 0.515
6.234AsnGly: 6.234 ± 0.756
0.704AsnHis: 0.704 ± 0.224
3.117AsnIle: 3.117 ± 0.524
4.927AsnLys: 4.927 ± 0.69
5.027AsnLeu: 5.027 ± 0.761
1.609AsnMet: 1.609 ± 0.339
2.815AsnAsn: 2.815 ± 0.502
2.011AsnPro: 2.011 ± 0.422
2.715AsnGln: 2.715 ± 0.558
2.413AsnArg: 2.413 ± 0.69
3.921AsnSer: 3.921 ± 0.465
3.519AsnThr: 3.519 ± 0.728
4.022AsnVal: 4.022 ± 0.538
1.207AsnTrp: 1.207 ± 0.355
1.508AsnTyr: 1.508 ± 0.392
0.0AsnXaa: 0.0 ± 0.0
Pro
2.212ProAla: 2.212 ± 0.446
0.201ProCys: 0.201 ± 0.13
1.609ProAsp: 1.609 ± 0.34
2.614ProGlu: 2.614 ± 0.553
1.307ProPhe: 1.307 ± 0.437
1.408ProGly: 1.408 ± 0.288
0.603ProHis: 0.603 ± 0.27
2.715ProIle: 2.715 ± 0.47
2.212ProLys: 2.212 ± 0.445
1.91ProLeu: 1.91 ± 0.427
0.101ProMet: 0.101 ± 0.11
1.91ProAsn: 1.91 ± 0.447
0.503ProPro: 0.503 ± 0.276
1.408ProGln: 1.408 ± 0.371
1.408ProArg: 1.408 ± 0.372
1.609ProSer: 1.609 ± 0.473
1.709ProThr: 1.709 ± 0.337
2.413ProVal: 2.413 ± 0.431
0.402ProTrp: 0.402 ± 0.226
0.905ProTyr: 0.905 ± 0.293
0.0ProXaa: 0.0 ± 0.0
Gln
4.826GlnAla: 4.826 ± 0.685
0.201GlnCys: 0.201 ± 0.143
2.212GlnAsp: 2.212 ± 0.427
3.117GlnGlu: 3.117 ± 0.657
2.514GlnPhe: 2.514 ± 0.461
1.207GlnGly: 1.207 ± 0.385
0.804GlnHis: 0.804 ± 0.258
2.815GlnIle: 2.815 ± 0.616
2.715GlnLys: 2.715 ± 0.559
3.821GlnLeu: 3.821 ± 0.671
0.704GlnMet: 0.704 ± 0.282
3.016GlnAsn: 3.016 ± 0.659
1.106GlnPro: 1.106 ± 0.348
2.514GlnGln: 2.514 ± 0.525
2.514GlnArg: 2.514 ± 0.623
2.011GlnSer: 2.011 ± 0.45
2.614GlnThr: 2.614 ± 0.454
2.715GlnVal: 2.715 ± 0.472
0.302GlnTrp: 0.302 ± 0.16
1.81GlnTyr: 1.81 ± 0.454
0.0GlnXaa: 0.0 ± 0.0
Arg
3.117ArgAla: 3.117 ± 0.634
0.0ArgCys: 0.0 ± 0.0
2.614ArgAsp: 2.614 ± 0.564
3.418ArgGlu: 3.418 ± 0.65
1.207ArgPhe: 1.207 ± 0.334
2.111ArgGly: 2.111 ± 0.336
0.905ArgHis: 0.905 ± 0.294
3.318ArgIle: 3.318 ± 0.569
4.524ArgLys: 4.524 ± 0.69
3.62ArgLeu: 3.62 ± 0.73
1.307ArgMet: 1.307 ± 0.397
2.715ArgAsn: 2.715 ± 0.461
1.307ArgPro: 1.307 ± 0.378
2.111ArgGln: 2.111 ± 0.619
2.212ArgArg: 2.212 ± 0.613
2.312ArgSer: 2.312 ± 0.505
2.312ArgThr: 2.312 ± 0.538
2.312ArgVal: 2.312 ± 0.542
0.402ArgTrp: 0.402 ± 0.225
2.614ArgTyr: 2.614 ± 0.46
0.0ArgXaa: 0.0 ± 0.0
Ser
3.117SerAla: 3.117 ± 0.473
0.201SerCys: 0.201 ± 0.181
3.921SerAsp: 3.921 ± 0.59
6.234SerGlu: 6.234 ± 1.235
2.514SerPhe: 2.514 ± 0.547
4.122SerGly: 4.122 ± 0.678
0.905SerHis: 0.905 ± 0.252
3.418SerIle: 3.418 ± 0.515
4.424SerLys: 4.424 ± 0.622
5.128SerLeu: 5.128 ± 0.655
1.91SerMet: 1.91 ± 0.406
3.62SerAsn: 3.62 ± 0.612
1.307SerPro: 1.307 ± 0.406
2.011SerGln: 2.011 ± 0.435
2.111SerArg: 2.111 ± 0.474
3.117SerSer: 3.117 ± 0.782
2.916SerThr: 2.916 ± 0.531
4.022SerVal: 4.022 ± 0.957
0.201SerTrp: 0.201 ± 0.117
2.413SerTyr: 2.413 ± 0.654
0.0SerXaa: 0.0 ± 0.0
Thr
4.223ThrAla: 4.223 ± 0.774
0.201ThrCys: 0.201 ± 0.157
4.424ThrAsp: 4.424 ± 1.005
4.223ThrGlu: 4.223 ± 0.566
3.418ThrPhe: 3.418 ± 0.535
2.715ThrGly: 2.715 ± 0.482
1.207ThrHis: 1.207 ± 0.386
6.133ThrIle: 6.133 ± 0.856
3.117ThrLys: 3.117 ± 0.526
4.726ThrLeu: 4.726 ± 0.732
1.91ThrMet: 1.91 ± 0.423
2.413ThrAsn: 2.413 ± 0.52
1.81ThrPro: 1.81 ± 0.518
1.81ThrGln: 1.81 ± 0.448
2.413ThrArg: 2.413 ± 0.563
2.815ThrSer: 2.815 ± 0.469
3.217ThrThr: 3.217 ± 0.65
4.826ThrVal: 4.826 ± 0.806
0.603ThrTrp: 0.603 ± 0.232
2.413ThrTyr: 2.413 ± 0.587
0.0ThrXaa: 0.0 ± 0.0
Val
4.524ValAla: 4.524 ± 0.765
0.302ValCys: 0.302 ± 0.156
4.323ValAsp: 4.323 ± 0.575
4.625ValGlu: 4.625 ± 0.629
2.815ValPhe: 2.815 ± 0.489
3.016ValGly: 3.016 ± 0.679
1.408ValHis: 1.408 ± 0.386
4.022ValIle: 4.022 ± 0.664
4.826ValLys: 4.826 ± 0.662
5.027ValLeu: 5.027 ± 0.718
1.207ValMet: 1.207 ± 0.362
3.418ValAsn: 3.418 ± 0.521
1.609ValPro: 1.609 ± 0.519
2.011ValGln: 2.011 ± 0.412
2.715ValArg: 2.715 ± 0.537
6.837ValSer: 6.837 ± 1.004
3.921ValThr: 3.921 ± 0.605
3.62ValVal: 3.62 ± 0.636
1.207ValTrp: 1.207 ± 0.331
1.508ValTyr: 1.508 ± 0.349
0.0ValXaa: 0.0 ± 0.0
Trp
1.106TrpAla: 1.106 ± 0.39
0.101TrpCys: 0.101 ± 0.093
0.503TrpAsp: 0.503 ± 0.205
0.804TrpGlu: 0.804 ± 0.311
0.704TrpPhe: 0.704 ± 0.257
0.503TrpGly: 0.503 ± 0.209
0.101TrpHis: 0.101 ± 0.102
0.804TrpIle: 0.804 ± 0.339
0.905TrpLys: 0.905 ± 0.296
2.011TrpLeu: 2.011 ± 0.489
0.201TrpMet: 0.201 ± 0.134
0.905TrpAsn: 0.905 ± 0.34
0.201TrpPro: 0.201 ± 0.153
0.603TrpGln: 0.603 ± 0.215
0.201TrpArg: 0.201 ± 0.133
0.804TrpSer: 0.804 ± 0.285
1.106TrpThr: 1.106 ± 0.31
0.503TrpVal: 0.503 ± 0.185
0.0TrpTrp: 0.0 ± 0.0
0.101TrpTyr: 0.101 ± 0.113
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.011TyrAla: 2.011 ± 0.535
0.503TyrCys: 0.503 ± 0.274
2.916TyrAsp: 2.916 ± 0.546
2.312TyrGlu: 2.312 ± 0.53
2.413TyrPhe: 2.413 ± 0.411
2.514TyrGly: 2.514 ± 0.523
0.402TyrHis: 0.402 ± 0.19
2.111TyrIle: 2.111 ± 0.434
2.212TyrLys: 2.212 ± 0.444
3.217TyrLeu: 3.217 ± 0.692
0.302TyrMet: 0.302 ± 0.158
1.81TyrAsn: 1.81 ± 0.571
0.804TyrPro: 0.804 ± 0.255
2.715TyrGln: 2.715 ± 0.574
2.514TyrArg: 2.514 ± 0.537
1.709TyrSer: 1.709 ± 0.491
1.91TyrThr: 1.91 ± 0.524
1.709TyrVal: 1.709 ± 0.386
0.402TyrTrp: 0.402 ± 0.227
2.011TyrTyr: 2.011 ± 0.377
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (9947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski