Amino acid dipepetide frequency for Enterococcus faecalis (strain ATCC 700802 / V583)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.909AlaAla: 5.909 ± 0.125	0.525AlaCys: 0.525 ± 0.026	3.597AlaAsp: 3.597 ± 0.074	5.33AlaGlu: 5.33 ± 0.081	3.341AlaPhe: 3.341 ± 0.061	5.079AlaGly: 5.079 ± 0.086	1.149AlaHis: 1.149 ± 0.036	5.851AlaIle: 5.851 ± 0.097	5.193AlaLys: 5.193 ± 0.1	7.369AlaLeu: 7.369 ± 0.096	2.026AlaMet: 2.026 ± 0.052	3.242AlaAsn: 3.242 ± 0.062	2.219AlaPro: 2.219 ± 0.052	3.001AlaGln: 3.001 ± 0.061	2.503AlaArg: 2.503 ± 0.051	4.053AlaSer: 4.053 ± 0.067	4.713AlaThr: 4.713 ± 0.091	5.264AlaVal: 5.264 ± 0.09	0.621AlaTrp: 0.621 ± 0.025	2.552AlaTyr: 2.552 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.4CysAla: 0.4 ± 0.022	0.095CysCys: 0.095 ± 0.011	0.327CysAsp: 0.327 ± 0.02	0.388CysGlu: 0.388 ± 0.019	0.358CysPhe: 0.358 ± 0.019	0.6CysGly: 0.6 ± 0.026	0.184CysHis: 0.184 ± 0.015	0.425CysIle: 0.425 ± 0.021	0.254CysLys: 0.254 ± 0.018	0.773CysLeu: 0.773 ± 0.03	0.174CysMet: 0.174 ± 0.015	0.241CysAsn: 0.241 ± 0.017	0.267CysPro: 0.267 ± 0.02	0.336CysGln: 0.336 ± 0.02	0.268CysArg: 0.268 ± 0.019	0.465CysSer: 0.465 ± 0.025	0.342CysThr: 0.342 ± 0.02	0.404CysVal: 0.404 ± 0.022	0.062CysTrp: 0.062 ± 0.008	0.27CysTyr: 0.27 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.268AspAla: 3.268 ± 0.06	0.39AspCys: 0.39 ± 0.021	2.253AspAsp: 2.253 ± 0.048	3.936AspGlu: 3.936 ± 0.09	2.684AspPhe: 2.684 ± 0.054	3.36AspGly: 3.36 ± 0.073	0.846AspHis: 0.846 ± 0.032	3.467AspIle: 3.467 ± 0.057	3.287AspLys: 3.287 ± 0.059	4.858AspLeu: 4.858 ± 0.077	1.233AspMet: 1.233 ± 0.039	2.073AspAsn: 2.073 ± 0.054	1.84AspPro: 1.84 ± 0.052	2.065AspGln: 2.065 ± 0.054	1.781AspArg: 1.781 ± 0.05	2.657AspSer: 2.657 ± 0.049	2.817AspThr: 2.817 ± 0.064	3.588AspVal: 3.588 ± 0.066	0.611AspTrp: 0.611 ± 0.025	2.314AspTyr: 2.314 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.833GluAla: 5.833 ± 0.093	0.366GluCys: 0.366 ± 0.02	3.259GluAsp: 3.259 ± 0.073	6.793GluGlu: 6.793 ± 0.119	2.464GluPhe: 2.464 ± 0.053	3.786GluGly: 3.786 ± 0.066	1.102GluHis: 1.102 ± 0.033	5.4GluIle: 5.4 ± 0.092	7.182GluLys: 7.182 ± 0.092	6.977GluLeu: 6.977 ± 0.105	2.255GluMet: 2.255 ± 0.051	4.141GluAsn: 4.141 ± 0.069	2.088GluPro: 2.088 ± 0.065	3.768GluGln: 3.768 ± 0.067	3.168GluArg: 3.168 ± 0.075	3.288GluSer: 3.288 ± 0.071	4.847GluThr: 4.847 ± 0.091	4.988GluVal: 4.988 ± 0.085	0.674GluTrp: 0.674 ± 0.033	2.236GluTyr: 2.236 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.088PheAla: 3.088 ± 0.07	0.399PheCys: 0.399 ± 0.022	2.593PheAsp: 2.593 ± 0.054	2.865PheGlu: 2.865 ± 0.063	2.608PhePhe: 2.608 ± 0.07	3.195PheGly: 3.195 ± 0.069	0.792PheHis: 0.792 ± 0.031	3.393PheIle: 3.393 ± 0.067	2.487PheLys: 2.487 ± 0.054	4.733PheLeu: 4.733 ± 0.084	1.13PheMet: 1.13 ± 0.035	2.033PheAsn: 2.033 ± 0.045	1.618PhePro: 1.618 ± 0.046	1.781PheGln: 1.781 ± 0.041	1.399PheArg: 1.399 ± 0.038	3.392PheSer: 3.392 ± 0.063	2.728PheThr: 2.728 ± 0.062	3.31PheVal: 3.31 ± 0.064	0.493PheTrp: 0.493 ± 0.024	1.948PheTyr: 1.948 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.671GlyAla: 4.671 ± 0.095	0.519GlyCys: 0.519 ± 0.027	2.955GlyAsp: 2.955 ± 0.061	4.117GlyGlu: 4.117 ± 0.075	3.088GlyPhe: 3.088 ± 0.063	4.418GlyGly: 4.418 ± 0.101	1.152GlyHis: 1.152 ± 0.032	5.49GlyIle: 5.49 ± 0.076	4.866GlyLys: 4.866 ± 0.077	6.408GlyLeu: 6.408 ± 0.092	1.852GlyMet: 1.852 ± 0.055	2.919GlyAsn: 2.919 ± 0.078	1.468GlyPro: 1.468 ± 0.043	2.618GlyGln: 2.618 ± 0.05	2.394GlyArg: 2.394 ± 0.058	3.693GlySer: 3.693 ± 0.072	4.405GlyThr: 4.405 ± 0.119	4.606GlyVal: 4.606 ± 0.088	0.683GlyTrp: 0.683 ± 0.029	2.666GlyTyr: 2.666 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.092HisAla: 1.092 ± 0.036	0.156HisCys: 0.156 ± 0.013	0.781HisAsp: 0.781 ± 0.029	1.147HisGlu: 1.147 ± 0.034	0.963HisPhe: 0.963 ± 0.034	1.188HisGly: 1.188 ± 0.034	0.436HisHis: 0.436 ± 0.026	1.039HisIle: 1.039 ± 0.038	0.762HisLys: 0.762 ± 0.029	1.89HisLeu: 1.89 ± 0.048	0.365HisMet: 0.365 ± 0.02	0.581HisAsn: 0.581 ± 0.024	0.849HisPro: 0.849 ± 0.033	0.931HisGln: 0.931 ± 0.032	0.731HisArg: 0.731 ± 0.03	1.045HisSer: 1.045 ± 0.032	0.909HisThr: 0.909 ± 0.033	1.146HisVal: 1.146 ± 0.031	0.209HisTrp: 0.209 ± 0.014	0.822HisTyr: 0.822 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.625IleAla: 5.625 ± 0.086	0.576IleCys: 0.576 ± 0.027	4.235IleAsp: 4.235 ± 0.07	5.14IleGlu: 5.14 ± 0.082	3.278IlePhe: 3.278 ± 0.069	5.175IleGly: 5.175 ± 0.092	1.319IleHis: 1.319 ± 0.046	5.0IleIle: 5.0 ± 0.086	4.191IleLys: 4.191 ± 0.074	6.823IleLeu: 6.823 ± 0.11	1.569IleMet: 1.569 ± 0.041	3.216IleAsn: 3.216 ± 0.057	3.069IlePro: 3.069 ± 0.054	3.22IleGln: 3.22 ± 0.064	2.755IleArg: 2.755 ± 0.059	4.643IleSer: 4.643 ± 0.079	4.295IleThr: 4.295 ± 0.079	5.109IleVal: 5.109 ± 0.081	0.601IleTrp: 0.601 ± 0.025	2.534IleTyr: 2.534 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.805LysAla: 4.805 ± 0.088	0.257LysCys: 0.257 ± 0.018	3.696LysAsp: 3.696 ± 0.074	7.479LysGlu: 7.479 ± 0.112	2.064LysPhe: 2.064 ± 0.047	3.909LysGly: 3.909 ± 0.082	1.042LysHis: 1.042 ± 0.035	5.212LysIle: 5.212 ± 0.076	6.804LysLys: 6.804 ± 0.119	5.242LysLeu: 5.242 ± 0.073	2.336LysMet: 2.336 ± 0.045	4.233LysAsn: 4.233 ± 0.077	2.087LysPro: 2.087 ± 0.056	3.576LysGln: 3.576 ± 0.076	3.088LysArg: 3.088 ± 0.059	3.21LysSer: 3.21 ± 0.061	4.181LysThr: 4.181 ± 0.068	4.653LysVal: 4.653 ± 0.073	0.624LysTrp: 0.624 ± 0.029	2.271LysTyr: 2.271 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	8.258LeuAla: 8.258 ± 0.094	0.63LeuCys: 0.63 ± 0.025	4.758LeuAsp: 4.758 ± 0.088	6.396LeuGlu: 6.396 ± 0.101	4.926LeuPhe: 4.926 ± 0.093	6.466LeuGly: 6.466 ± 0.101	1.51LeuHis: 1.51 ± 0.04	6.719LeuIle: 6.719 ± 0.122	6.558LeuLys: 6.558 ± 0.105	10.204LeuLeu: 10.204 ± 0.151	2.501LeuMet: 2.501 ± 0.052	4.558LeuAsn: 4.558 ± 0.078	4.129LeuPro: 4.129 ± 0.067	3.588LeuGln: 3.588 ± 0.075	3.444LeuArg: 3.444 ± 0.065	6.706LeuSer: 6.706 ± 0.092	6.461LeuThr: 6.461 ± 0.075	6.533LeuVal: 6.533 ± 0.091	0.736LeuTrp: 0.736 ± 0.03	3.027LeuTyr: 3.027 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.99MetAla: 1.99 ± 0.054	0.152MetCys: 0.152 ± 0.013	1.347MetAsp: 1.347 ± 0.042	1.689MetGlu: 1.689 ± 0.043	0.949MetPhe: 0.949 ± 0.037	1.652MetGly: 1.652 ± 0.049	0.377MetHis: 0.377 ± 0.02	2.036MetIle: 2.036 ± 0.053	2.435MetLys: 2.435 ± 0.042	2.21MetLeu: 2.21 ± 0.049	0.757MetMet: 0.757 ± 0.03	1.583MetAsn: 1.583 ± 0.038	0.951MetPro: 0.951 ± 0.037	0.948MetGln: 0.948 ± 0.031	0.91MetArg: 0.91 ± 0.031	1.547MetSer: 1.547 ± 0.035	1.788MetThr: 1.788 ± 0.045	1.677MetVal: 1.677 ± 0.041	0.175MetTrp: 0.175 ± 0.013	0.779MetTyr: 0.779 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.906AsnAla: 2.906 ± 0.06	0.318AsnCys: 0.318 ± 0.02	2.33AsnAsp: 2.33 ± 0.049	3.49AsnGlu: 3.49 ± 0.061	2.035AsnPhe: 2.035 ± 0.046	3.415AsnGly: 3.415 ± 0.073	0.975AsnHis: 0.975 ± 0.032	3.062AsnIle: 3.062 ± 0.061	3.186AsnLys: 3.186 ± 0.073	4.093AsnLeu: 4.093 ± 0.065	1.14AsnMet: 1.14 ± 0.033	2.383AsnAsn: 2.383 ± 0.072	2.159AsnPro: 2.159 ± 0.048	2.875AsnGln: 2.875 ± 0.059	1.964AsnArg: 1.964 ± 0.047	2.421AsnSer: 2.421 ± 0.056	2.495AsnThr: 2.495 ± 0.061	3.17AsnVal: 3.17 ± 0.056	0.509AsnTrp: 0.509 ± 0.023	2.114AsnTyr: 2.114 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.54ProAla: 2.54 ± 0.065	0.179ProCys: 0.179 ± 0.015	1.873ProAsp: 1.873 ± 0.047	3.337ProGlu: 3.337 ± 0.072	1.803ProPhe: 1.803 ± 0.044	1.904ProGly: 1.904 ± 0.049	0.612ProHis: 0.612 ± 0.028	2.647ProIle: 2.647 ± 0.06	2.488ProLys: 2.488 ± 0.049	3.398ProLeu: 3.398 ± 0.064	0.841ProMet: 0.841 ± 0.029	1.737ProAsn: 1.737 ± 0.043	0.773ProPro: 0.773 ± 0.033	1.465ProGln: 1.465 ± 0.043	1.012ProArg: 1.012 ± 0.029	1.995ProSer: 1.995 ± 0.053	2.682ProThr: 2.682 ± 0.077	2.688ProVal: 2.688 ± 0.061	0.303ProTrp: 0.303 ± 0.021	1.389ProTyr: 1.389 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.932GlnAla: 3.932 ± 0.083	0.201GlnCys: 0.201 ± 0.014	1.613GlnAsp: 1.613 ± 0.041	3.851GlnGlu: 3.851 ± 0.086	1.777GlnPhe: 1.777 ± 0.044	2.465GlnGly: 2.465 ± 0.048	0.753GlnHis: 0.753 ± 0.032	2.615GlnIle: 2.615 ± 0.056	3.455GlnLys: 3.455 ± 0.075	5.096GlnLeu: 5.096 ± 0.083	1.12GlnMet: 1.12 ± 0.04	1.842GlnAsn: 1.842 ± 0.051	1.718GlnPro: 1.718 ± 0.049	2.825GlnGln: 2.825 ± 0.081	2.006GlnArg: 2.006 ± 0.045	2.188GlnSer: 2.188 ± 0.049	2.962GlnThr: 2.962 ± 0.066	2.99GlnVal: 2.99 ± 0.059	0.48GlnTrp: 0.48 ± 0.024	1.35GlnTyr: 1.35 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.184ArgAla: 2.184 ± 0.048	0.285ArgCys: 0.285 ± 0.018	1.631ArgAsp: 1.631 ± 0.041	2.739ArgGlu: 2.739 ± 0.052	1.889ArgPhe: 1.889 ± 0.046	2.112ArgGly: 2.112 ± 0.052	0.676ArgHis: 0.676 ± 0.027	2.7ArgIle: 2.7 ± 0.063	2.941ArgLys: 2.941 ± 0.065	4.113ArgLeu: 4.113 ± 0.074	1.174ArgMet: 1.174 ± 0.04	1.802ArgAsn: 1.802 ± 0.044	1.241ArgPro: 1.241 ± 0.043	1.883ArgGln: 1.883 ± 0.055	1.737ArgArg: 1.737 ± 0.057	1.958ArgSer: 1.958 ± 0.046	1.913ArgThr: 1.913 ± 0.042	2.397ArgVal: 2.397 ± 0.058	0.393ArgTrp: 0.393 ± 0.024	1.63ArgTyr: 1.63 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.909SerAla: 3.909 ± 0.071	0.395SerCys: 0.395 ± 0.022	2.835SerAsp: 2.835 ± 0.053	3.969SerGlu: 3.969 ± 0.077	3.152SerPhe: 3.152 ± 0.06	4.237SerGly: 4.237 ± 0.085	0.928SerHis: 0.928 ± 0.037	4.336SerIle: 4.336 ± 0.072	3.657SerLys: 3.657 ± 0.063	6.002SerLeu: 6.002 ± 0.087	1.468SerMet: 1.468 ± 0.042	2.503SerAsn: 2.503 ± 0.062	1.836SerPro: 1.836 ± 0.045	2.405SerGln: 2.405 ± 0.054	1.926SerArg: 1.926 ± 0.053	3.698SerSer: 3.698 ± 0.094	3.279SerThr: 3.279 ± 0.068	4.1SerVal: 4.1 ± 0.07	0.689SerTrp: 0.689 ± 0.028	2.328SerTyr: 2.328 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.631ThrAla: 4.631 ± 0.107	0.319ThrCys: 0.319 ± 0.02	3.074ThrAsp: 3.074 ± 0.061	4.423ThrGlu: 4.423 ± 0.075	2.998ThrPhe: 2.998 ± 0.068	4.378ThrGly: 4.378 ± 0.105	1.083ThrHis: 1.083 ± 0.031	5.08ThrIle: 5.08 ± 0.08	4.172ThrLys: 4.172 ± 0.076	5.972ThrLeu: 5.972 ± 0.089	1.413ThrMet: 1.413 ± 0.039	2.926ThrAsn: 2.926 ± 0.07	2.792ThrPro: 2.792 ± 0.072	2.212ThrGln: 2.212 ± 0.049	1.884ThrArg: 1.884 ± 0.048	3.489ThrSer: 3.489 ± 0.081	4.125ThrThr: 4.125 ± 0.11	4.657ThrVal: 4.657 ± 0.106	0.555ThrTrp: 0.555 ± 0.027	2.2ThrTyr: 2.2 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	5.686ValAla: 5.686 ± 0.092	0.515ValCys: 0.515 ± 0.028	3.714ValAsp: 3.714 ± 0.071	4.546ValGlu: 4.546 ± 0.072	3.012ValPhe: 3.012 ± 0.063	4.661ValGly: 4.661 ± 0.077	1.113ValHis: 1.113 ± 0.037	5.169ValIle: 5.169 ± 0.088	4.451ValLys: 4.451 ± 0.078	6.596ValLeu: 6.596 ± 0.097	1.609ValMet: 1.609 ± 0.047	3.005ValAsn: 3.005 ± 0.072	2.862ValPro: 2.862 ± 0.055	2.606ValGln: 2.606 ± 0.05	2.356ValArg: 2.356 ± 0.05	4.462ValSer: 4.462 ± 0.077	4.858ValThr: 4.858 ± 0.098	5.086ValVal: 5.086 ± 0.097	0.538ValTrp: 0.538 ± 0.024	2.327ValTyr: 2.327 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.516TrpAla: 0.516 ± 0.025	0.064TrpCys: 0.064 ± 0.008	0.44TrpAsp: 0.44 ± 0.02	0.553TrpGlu: 0.553 ± 0.029	0.526TrpPhe: 0.526 ± 0.028	0.581TrpGly: 0.581 ± 0.024	0.227TrpHis: 0.227 ± 0.015	0.583TrpIle: 0.583 ± 0.028	0.543TrpLys: 0.543 ± 0.026	1.231TrpLeu: 1.231 ± 0.041	0.236TrpMet: 0.236 ± 0.015	0.479TrpAsn: 0.479 ± 0.025	0.241TrpPro: 0.241 ± 0.015	0.68TrpGln: 0.68 ± 0.028	0.442TrpArg: 0.442 ± 0.022	0.604TrpSer: 0.604 ± 0.026	0.533TrpThr: 0.533 ± 0.028	0.53TrpVal: 0.53 ± 0.023	0.119TrpTrp: 0.119 ± 0.011	0.346TrpTyr: 0.346 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.055	0.288TyrCys: 0.288 ± 0.017	2.017TyrAsp: 2.017 ± 0.041	2.427TyrGlu: 2.427 ± 0.049	2.067TyrPhe: 2.067 ± 0.051	2.41TyrGly: 2.41 ± 0.052	0.767TyrHis: 0.767 ± 0.029	2.146TyrIle: 2.146 ± 0.05	1.857TyrLys: 1.857 ± 0.05	4.122TyrLeu: 4.122 ± 0.071	0.751TyrMet: 0.751 ± 0.032	1.547TyrAsn: 1.547 ± 0.039	1.457TyrPro: 1.457 ± 0.045	2.456TyrGln: 2.456 ± 0.062	1.629TyrArg: 1.629 ± 0.042	2.139TyrSer: 2.139 ± 0.046	2.048TyrThr: 2.048 ± 0.056	2.278TyrVal: 2.278 ± 0.053	0.399TyrTrp: 0.399 ± 0.027	1.553TyrTyr: 1.553 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3240 proteins (953506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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