Amino acid dipepetide frequency for Scardovia wiggsiae F0424

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.81AlaAla: 13.81 ± 0.246
0.942AlaCys: 0.942 ± 0.042
6.948AlaAsp: 6.948 ± 0.142
5.927AlaGlu: 5.927 ± 0.133
3.177AlaPhe: 3.177 ± 0.086
9.876AlaGly: 9.876 ± 0.178
2.261AlaHis: 2.261 ± 0.083
4.858AlaIle: 4.858 ± 0.112
3.559AlaLys: 3.559 ± 0.121
8.979AlaLeu: 8.979 ± 0.167
2.397AlaMet: 2.397 ± 0.074
2.713AlaAsn: 2.713 ± 0.081
3.692AlaPro: 3.692 ± 0.112
4.911AlaGln: 4.911 ± 0.124
6.182AlaArg: 6.182 ± 0.135
6.696AlaSer: 6.696 ± 0.144
3.787AlaThr: 3.787 ± 0.097
9.402AlaVal: 9.402 ± 0.173
1.139AlaTrp: 1.139 ± 0.056
2.966AlaTyr: 2.966 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
1.003CysAla: 1.003 ± 0.05
0.112CysCys: 0.112 ± 0.016
0.472CysAsp: 0.472 ± 0.028
0.494CysGlu: 0.494 ± 0.035
0.305CysPhe: 0.305 ± 0.03
0.863CysGly: 0.863 ± 0.041
0.171CysHis: 0.171 ± 0.022
0.621CysIle: 0.621 ± 0.043
0.209CysLys: 0.209 ± 0.022
0.626CysLeu: 0.626 ± 0.036
0.235CysMet: 0.235 ± 0.022
0.198CysAsn: 0.198 ± 0.022
0.408CysPro: 0.408 ± 0.031
0.2CysGln: 0.2 ± 0.019
0.56CysArg: 0.56 ± 0.034
0.65CysSer: 0.65 ± 0.038
0.586CysThr: 0.586 ± 0.043
0.61CysVal: 0.61 ± 0.04
0.09CysTrp: 0.09 ± 0.014
0.222CysTyr: 0.222 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
6.149AspAla: 6.149 ± 0.145
0.419AspCys: 0.419 ± 0.032
3.932AspAsp: 3.932 ± 0.115
3.855AspGlu: 3.855 ± 0.11
2.336AspPhe: 2.336 ± 0.066
5.209AspGly: 5.209 ± 0.127
0.988AspHis: 0.988 ± 0.048
4.755AspIle: 4.755 ± 0.097
2.691AspLys: 2.691 ± 0.084
4.472AspLeu: 4.472 ± 0.114
1.66AspMet: 1.66 ± 0.052
2.206AspAsn: 2.206 ± 0.068
3.765AspPro: 3.765 ± 0.093
1.436AspGln: 1.436 ± 0.056
3.431AspArg: 3.431 ± 0.087
4.812AspSer: 4.812 ± 0.114
4.287AspThr: 4.287 ± 0.097
3.831AspVal: 3.831 ± 0.109
0.764AspTrp: 0.764 ± 0.046
1.864AspTyr: 1.864 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
5.914GluAla: 5.914 ± 0.134
0.443GluCys: 0.443 ± 0.03
3.455GluAsp: 3.455 ± 0.094
3.501GluGlu: 3.501 ± 0.101
1.772GluPhe: 1.772 ± 0.07
4.366GluGly: 4.366 ± 0.127
1.181GluHis: 1.181 ± 0.053
3.247GluIle: 3.247 ± 0.085
2.953GluLys: 2.953 ± 0.108
4.823GluLeu: 4.823 ± 0.119
1.3GluMet: 1.3 ± 0.054
2.32GluAsn: 2.32 ± 0.084
2.143GluPro: 2.143 ± 0.064
2.364GluGln: 2.364 ± 0.079
3.297GluArg: 3.297 ± 0.086
3.166GluSer: 3.166 ± 0.092
2.983GluThr: 2.983 ± 0.081
3.315GluVal: 3.315 ± 0.091
0.661GluTrp: 0.661 ± 0.04
1.833GluTyr: 1.833 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.506PheAla: 3.506 ± 0.091
0.321PheCys: 0.321 ± 0.027
2.314PheAsp: 2.314 ± 0.076
1.758PheGlu: 1.758 ± 0.065
1.35PhePhe: 1.35 ± 0.065
2.931PheGly: 2.931 ± 0.085
0.751PheHis: 0.751 ± 0.039
2.476PheIle: 2.476 ± 0.081
1.076PheLys: 1.076 ± 0.055
2.847PheLeu: 2.847 ± 0.086
0.85PheMet: 0.85 ± 0.043
1.33PheAsn: 1.33 ± 0.049
1.42PhePro: 1.42 ± 0.06
0.808PheGln: 0.808 ± 0.047
1.725PheArg: 1.725 ± 0.061
2.766PheSer: 2.766 ± 0.091
2.505PheThr: 2.505 ± 0.072
2.377PheVal: 2.377 ± 0.077
0.391PheTrp: 0.391 ± 0.03
1.016PheTyr: 1.016 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
6.985GlyAla: 6.985 ± 0.143
0.716GlyCys: 0.716 ± 0.045
4.142GlyAsp: 4.142 ± 0.108
3.989GlyGlu: 3.989 ± 0.105
3.201GlyPhe: 3.201 ± 0.076
5.945GlyGly: 5.945 ± 0.153
1.886GlyHis: 1.886 ± 0.063
5.846GlyIle: 5.846 ± 0.126
4.388GlyLys: 4.388 ± 0.105
6.755GlyLeu: 6.755 ± 0.133
2.204GlyMet: 2.204 ± 0.079
3.128GlyAsn: 3.128 ± 0.098
2.83GlyPro: 2.83 ± 0.086
3.141GlyGln: 3.141 ± 0.09
5.205GlyArg: 5.205 ± 0.121
6.985GlySer: 6.985 ± 0.152
5.716GlyThr: 5.716 ± 0.129
5.231GlyVal: 5.231 ± 0.125
1.124GlyTrp: 1.124 ± 0.051
2.926GlyTyr: 2.926 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
1.952HisAla: 1.952 ± 0.061
0.191HisCys: 0.191 ± 0.019
1.447HisAsp: 1.447 ± 0.059
1.003HisGlu: 1.003 ± 0.049
0.645HisPhe: 0.645 ± 0.039
1.82HisGly: 1.82 ± 0.065
0.562HisHis: 0.562 ± 0.037
1.473HisIle: 1.473 ± 0.055
0.852HisLys: 0.852 ± 0.049
1.497HisLeu: 1.497 ± 0.064
0.586HisMet: 0.586 ± 0.038
0.863HisAsn: 0.863 ± 0.049
1.361HisPro: 1.361 ± 0.051
0.681HisGln: 0.681 ± 0.043
1.348HisArg: 1.348 ± 0.054
1.473HisSer: 1.473 ± 0.062
1.477HisThr: 1.477 ± 0.061
1.455HisVal: 1.455 ± 0.059
0.237HisTrp: 0.237 ± 0.025
0.639HisTyr: 0.639 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.568IleAla: 6.568 ± 0.152
0.628IleCys: 0.628 ± 0.045
3.934IleAsp: 3.934 ± 0.099
3.058IleGlu: 3.058 ± 0.094
2.103IlePhe: 2.103 ± 0.085
4.669IleGly: 4.669 ± 0.112
1.236IleHis: 1.236 ± 0.059
4.0IleIle: 4.0 ± 0.125
1.993IleLys: 1.993 ± 0.081
4.942IleLeu: 4.942 ± 0.123
1.401IleMet: 1.401 ± 0.063
2.094IleAsn: 2.094 ± 0.071
3.278IlePro: 3.278 ± 0.088
1.616IleGln: 1.616 ± 0.064
3.787IleArg: 3.787 ± 0.087
4.783IleSer: 4.783 ± 0.109
3.993IleThr: 3.993 ± 0.092
4.276IleVal: 4.276 ± 0.096
0.577IleTrp: 0.577 ± 0.038
1.414IleTyr: 1.414 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
4.676LysAla: 4.676 ± 0.12
0.16LysCys: 0.16 ± 0.019
2.854LysAsp: 2.854 ± 0.088
2.463LysGlu: 2.463 ± 0.09
1.058LysPhe: 1.058 ± 0.049
3.313LysGly: 3.313 ± 0.095
0.9LysHis: 0.9 ± 0.043
2.331LysIle: 2.331 ± 0.082
2.709LysLys: 2.709 ± 0.099
3.486LysLeu: 3.486 ± 0.105
0.979LysMet: 0.979 ± 0.048
1.93LysAsn: 1.93 ± 0.07
2.066LysPro: 2.066 ± 0.069
1.412LysGln: 1.412 ± 0.062
2.29LysArg: 2.29 ± 0.084
2.529LysSer: 2.529 ± 0.082
2.634LysThr: 2.634 ± 0.081
2.711LysVal: 2.711 ± 0.074
0.485LysTrp: 0.485 ± 0.034
1.346LysTyr: 1.346 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
8.891LeuAla: 8.891 ± 0.154
0.959LeuCys: 0.959 ± 0.054
5.429LeuAsp: 5.429 ± 0.124
4.259LeuGlu: 4.259 ± 0.127
3.098LeuPhe: 3.098 ± 0.1
6.43LeuGly: 6.43 ± 0.14
1.813LeuHis: 1.813 ± 0.069
5.08LeuIle: 5.08 ± 0.126
3.712LeuLys: 3.712 ± 0.103
7.045LeuLeu: 7.045 ± 0.18
1.899LeuMet: 1.899 ± 0.068
2.737LeuAsn: 2.737 ± 0.079
4.136LeuPro: 4.136 ± 0.088
2.639LeuGln: 2.639 ± 0.091
5.255LeuArg: 5.255 ± 0.122
6.737LeuSer: 6.737 ± 0.126
4.599LeuThr: 4.599 ± 0.113
5.339LeuVal: 5.339 ± 0.128
1.036LeuTrp: 1.036 ± 0.053
2.25LeuTyr: 2.25 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.777MetAla: 2.777 ± 0.081
0.195MetCys: 0.195 ± 0.022
1.576MetAsp: 1.576 ± 0.066
1.28MetGlu: 1.28 ± 0.056
0.696MetPhe: 0.696 ± 0.04
1.912MetGly: 1.912 ± 0.067
0.542MetHis: 0.542 ± 0.032
1.174MetIle: 1.174 ± 0.055
1.087MetLys: 1.087 ± 0.047
2.026MetLeu: 2.026 ± 0.063
0.52MetMet: 0.52 ± 0.032
0.72MetAsn: 0.72 ± 0.04
1.403MetPro: 1.403 ± 0.051
0.819MetGln: 0.819 ± 0.041
1.635MetArg: 1.635 ± 0.069
1.671MetSer: 1.671 ± 0.062
1.326MetThr: 1.326 ± 0.061
1.71MetVal: 1.71 ± 0.057
0.277MetTrp: 0.277 ± 0.026
0.562MetTyr: 0.562 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.299AsnAla: 3.299 ± 0.103
0.228AsnCys: 0.228 ± 0.02
2.031AsnAsp: 2.031 ± 0.063
1.677AsnGlu: 1.677 ± 0.07
1.087AsnPhe: 1.087 ± 0.045
3.284AsnGly: 3.284 ± 0.113
0.547AsnHis: 0.547 ± 0.033
2.305AsnIle: 2.305 ± 0.074
1.401AsnLys: 1.401 ± 0.062
2.36AsnLeu: 2.36 ± 0.081
0.814AsnMet: 0.814 ± 0.046
1.545AsnAsn: 1.545 ± 0.077
2.059AsnPro: 2.059 ± 0.07
0.88AsnGln: 0.88 ± 0.047
2.123AsnArg: 2.123 ± 0.076
2.54AsnSer: 2.54 ± 0.093
2.439AsnThr: 2.439 ± 0.076
2.118AsnVal: 2.118 ± 0.067
0.395AsnTrp: 0.395 ± 0.03
1.03AsnTyr: 1.03 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
5.238ProAla: 5.238 ± 0.134
0.274ProCys: 0.274 ± 0.025
3.464ProAsp: 3.464 ± 0.096
3.37ProGlu: 3.37 ± 0.106
1.556ProPhe: 1.556 ± 0.068
4.186ProGly: 4.186 ± 0.103
1.15ProHis: 1.15 ± 0.055
1.763ProIle: 1.763 ± 0.071
1.592ProLys: 1.592 ± 0.073
3.607ProLeu: 3.607 ± 0.097
0.85ProMet: 0.85 ± 0.043
1.172ProAsn: 1.172 ± 0.052
1.343ProPro: 1.343 ± 0.067
2.316ProGln: 2.316 ± 0.079
2.303ProArg: 2.303 ± 0.067
3.598ProSer: 3.598 ± 0.113
1.899ProThr: 1.899 ± 0.071
4.07ProVal: 4.07 ± 0.096
0.687ProTrp: 0.687 ± 0.037
1.486ProTyr: 1.486 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
3.899GlnAla: 3.899 ± 0.102
0.283GlnCys: 0.283 ± 0.026
2.248GlnAsp: 2.248 ± 0.08
2.228GlnGlu: 2.228 ± 0.079
1.144GlnPhe: 1.144 ± 0.053
2.847GlnGly: 2.847 ± 0.088
0.782GlnHis: 0.782 ± 0.04
2.169GlnIle: 2.169 ± 0.067
1.837GlnLys: 1.837 ± 0.068
3.449GlnLeu: 3.449 ± 0.098
0.937GlnMet: 0.937 ± 0.051
1.251GlnAsn: 1.251 ± 0.057
1.855GlnPro: 1.855 ± 0.078
1.842GlnGln: 1.842 ± 0.094
2.208GlnArg: 2.208 ± 0.079
2.105GlnSer: 2.105 ± 0.067
1.644GlnThr: 1.644 ± 0.069
2.112GlnVal: 2.112 ± 0.073
0.674GlnTrp: 0.674 ± 0.046
1.203GlnTyr: 1.203 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
4.933ArgAla: 4.933 ± 0.12
0.498ArgCys: 0.498 ± 0.035
3.622ArgAsp: 3.622 ± 0.096
3.793ArgGlu: 3.793 ± 0.099
2.165ArgPhe: 2.165 ± 0.072
3.991ArgGly: 3.991 ± 0.099
1.556ArgHis: 1.556 ± 0.064
4.103ArgIle: 4.103 ± 0.1
3.214ArgLys: 3.214 ± 0.086
5.139ArgLeu: 5.139 ± 0.112
1.673ArgMet: 1.673 ± 0.058
2.257ArgAsn: 2.257 ± 0.07
2.52ArgPro: 2.52 ± 0.082
2.748ArgGln: 2.748 ± 0.08
4.803ArgArg: 4.803 ± 0.125
4.101ArgSer: 4.101 ± 0.101
3.471ArgThr: 3.471 ± 0.093
3.635ArgVal: 3.635 ± 0.096
0.751ArgTrp: 0.751 ± 0.043
2.037ArgTyr: 2.037 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
7.732SerAla: 7.732 ± 0.145
0.555SerCys: 0.555 ± 0.047
4.459SerAsp: 4.459 ± 0.095
3.659SerGlu: 3.659 ± 0.103
2.52SerPhe: 2.52 ± 0.08
7.207SerGly: 7.207 ± 0.163
1.721SerHis: 1.721 ± 0.067
3.813SerIle: 3.813 ± 0.095
2.334SerLys: 2.334 ± 0.078
6.241SerLeu: 6.241 ± 0.139
1.732SerMet: 1.732 ± 0.053
2.017SerAsn: 2.017 ± 0.079
3.286SerPro: 3.286 ± 0.093
3.102SerGln: 3.102 ± 0.104
4.862SerArg: 4.862 ± 0.119
6.022SerSer: 6.022 ± 0.172
3.769SerThr: 3.769 ± 0.109
5.082SerVal: 5.082 ± 0.126
0.926SerTrp: 0.926 ± 0.05
2.059SerTyr: 2.059 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
6.575ThrAla: 6.575 ± 0.13
0.415ThrCys: 0.415 ± 0.03
3.769ThrAsp: 3.769 ± 0.086
2.709ThrGlu: 2.709 ± 0.079
1.921ThrPhe: 1.921 ± 0.074
5.626ThrGly: 5.626 ± 0.11
1.216ThrHis: 1.216 ± 0.057
2.917ThrIle: 2.917 ± 0.083
1.791ThrLys: 1.791 ± 0.071
4.852ThrLeu: 4.852 ± 0.118
1.227ThrMet: 1.227 ± 0.054
1.688ThrAsn: 1.688 ± 0.076
2.863ThrPro: 2.863 ± 0.099
1.932ThrGln: 1.932 ± 0.072
3.003ThrArg: 3.003 ± 0.089
3.475ThrSer: 3.475 ± 0.098
2.59ThrThr: 2.59 ± 0.085
5.881ThrVal: 5.881 ± 0.13
0.702ThrTrp: 0.702 ± 0.047
1.693ThrTyr: 1.693 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
6.237ValAla: 6.237 ± 0.116
0.828ValCys: 0.828 ± 0.047
4.206ValAsp: 4.206 ± 0.104
3.807ValGlu: 3.807 ± 0.092
2.788ValPhe: 2.788 ± 0.087
4.325ValGly: 4.325 ± 0.116
1.464ValHis: 1.464 ± 0.065
4.898ValIle: 4.898 ± 0.111
3.098ValLys: 3.098 ± 0.093
6.584ValLeu: 6.584 ± 0.171
1.644ValMet: 1.644 ± 0.057
2.358ValAsn: 2.358 ± 0.074
3.651ValPro: 3.651 ± 0.078
2.334ValGln: 2.334 ± 0.074
4.316ValArg: 4.316 ± 0.101
5.986ValSer: 5.986 ± 0.114
4.426ValThr: 4.426 ± 0.098
4.834ValVal: 4.834 ± 0.127
0.874ValTrp: 0.874 ± 0.044
2.064ValTyr: 2.064 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
1.089TrpAla: 1.089 ± 0.062
0.156TrpCys: 0.156 ± 0.021
0.839TrpAsp: 0.839 ± 0.04
0.617TrpGlu: 0.617 ± 0.038
0.511TrpPhe: 0.511 ± 0.031
0.907TrpGly: 0.907 ± 0.053
0.303TrpHis: 0.303 ± 0.026
0.768TrpIle: 0.768 ± 0.04
0.632TrpLys: 0.632 ± 0.039
1.256TrpLeu: 1.256 ± 0.054
0.356TrpMet: 0.356 ± 0.025
0.498TrpAsn: 0.498 ± 0.033
0.411TrpPro: 0.411 ± 0.031
0.56TrpGln: 0.56 ± 0.032
0.771TrpArg: 0.771 ± 0.045
0.764TrpSer: 0.764 ± 0.039
0.632TrpThr: 0.632 ± 0.033
0.746TrpVal: 0.746 ± 0.044
0.312TrpTrp: 0.312 ± 0.027
0.36TrpTyr: 0.36 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.99TyrAla: 2.99 ± 0.075
0.31TyrCys: 0.31 ± 0.023
1.721TyrAsp: 1.721 ± 0.062
1.589TyrGlu: 1.589 ± 0.055
1.089TyrPhe: 1.089 ± 0.054
2.637TyrGly: 2.637 ± 0.083
0.531TyrHis: 0.531 ± 0.039
1.752TyrIle: 1.752 ± 0.062
1.205TyrLys: 1.205 ± 0.059
2.36TyrLeu: 2.36 ± 0.073
0.643TyrMet: 0.643 ± 0.043
1.135TyrAsn: 1.135 ± 0.052
1.436TyrPro: 1.436 ± 0.066
0.979TyrGln: 0.979 ± 0.053
1.905TyrArg: 1.905 ± 0.062
2.241TyrSer: 2.241 ± 0.077
2.081TyrThr: 2.081 ± 0.084
1.98TyrVal: 1.98 ± 0.081
0.384TyrTrp: 0.384 ± 0.031
0.953TyrTyr: 0.953 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1242 proteins (455528 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski