Amino acid dipepetide frequency for Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.368AlaAla: 4.368 ± 0.215
0.335AlaCys: 0.335 ± 0.034
3.136AlaAsp: 3.136 ± 0.107
2.641AlaGlu: 2.641 ± 0.125
2.391AlaPhe: 2.391 ± 0.1
2.634AlaGly: 2.634 ± 0.117
0.775AlaHis: 0.775 ± 0.051
5.259AlaIle: 5.259 ± 0.172
6.054AlaLys: 6.054 ± 0.16
5.198AlaLeu: 5.198 ± 0.165
0.904AlaMet: 0.904 ± 0.066
4.822AlaAsn: 4.822 ± 0.137
1.917AlaPro: 1.917 ± 0.108
2.272AlaGln: 2.272 ± 0.095
1.981AlaArg: 1.981 ± 0.102
4.446AlaSer: 4.446 ± 0.155
3.681AlaThr: 3.681 ± 0.155
2.932AlaVal: 2.932 ± 0.117
0.41AlaTrp: 0.41 ± 0.038
2.397AlaTyr: 2.397 ± 0.088
0.0AlaXaa: 0.0 ± 0.0
Cys
0.325CysAla: 0.325 ± 0.031
0.027CysCys: 0.027 ± 0.011
0.264CysAsp: 0.264 ± 0.033
0.349CysGlu: 0.349 ± 0.04
0.298CysPhe: 0.298 ± 0.03
0.332CysGly: 0.332 ± 0.036
0.146CysHis: 0.146 ± 0.024
0.427CysIle: 0.427 ± 0.049
0.345CysLys: 0.345 ± 0.033
0.572CysLeu: 0.572 ± 0.049
0.105CysMet: 0.105 ± 0.017
0.284CysAsn: 0.284 ± 0.029
0.129CysPro: 0.129 ± 0.02
0.166CysGln: 0.166 ± 0.025
0.105CysArg: 0.105 ± 0.019
0.403CysSer: 0.403 ± 0.031
0.383CysThr: 0.383 ± 0.034
0.278CysVal: 0.278 ± 0.03
0.037CysTrp: 0.037 ± 0.012
0.22CysTyr: 0.22 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.743AspAla: 2.743 ± 0.109
0.376AspCys: 0.376 ± 0.037
3.217AspAsp: 3.217 ± 0.155
3.738AspGlu: 3.738 ± 0.142
3.274AspPhe: 3.274 ± 0.103
2.404AspGly: 2.404 ± 0.093
1.233AspHis: 1.233 ± 0.072
3.44AspIle: 3.44 ± 0.134
4.595AspLys: 4.595 ± 0.145
6.992AspLeu: 6.992 ± 0.177
0.66AspMet: 0.66 ± 0.054
3.935AspAsn: 3.935 ± 0.123
2.174AspPro: 2.174 ± 0.102
4.013AspGln: 4.013 ± 0.195
1.605AspArg: 1.605 ± 0.086
3.528AspSer: 3.528 ± 0.102
2.448AspThr: 2.448 ± 0.088
2.811AspVal: 2.811 ± 0.114
0.521AspTrp: 0.521 ± 0.044
3.078AspTyr: 3.078 ± 0.113
0.0AspXaa: 0.0 ± 0.0
Glu
3.18GluAla: 3.18 ± 0.131
0.21GluCys: 0.21 ± 0.025
2.326GluAsp: 2.326 ± 0.109
3.962GluGlu: 3.962 ± 0.299
2.621GluPhe: 2.621 ± 0.102
2.181GluGly: 2.181 ± 0.101
0.928GluHis: 0.928 ± 0.067
5.333GluIle: 5.333 ± 0.199
5.089GluLys: 5.089 ± 0.179
6.667GluLeu: 6.667 ± 0.201
1.199GluMet: 1.199 ± 0.063
3.962GluAsn: 3.962 ± 0.135
1.588GluPro: 1.588 ± 0.112
3.122GluGln: 3.122 ± 0.198
1.937GluArg: 1.937 ± 0.116
2.963GluSer: 2.963 ± 0.118
2.77GluThr: 2.77 ± 0.122
3.451GluVal: 3.451 ± 0.174
0.467GluTrp: 0.467 ± 0.042
2.093GluTyr: 2.093 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.587PheAla: 2.587 ± 0.115
0.298PheCys: 0.298 ± 0.033
3.816PheAsp: 3.816 ± 0.133
2.425PheGlu: 2.425 ± 0.095
2.631PhePhe: 2.631 ± 0.164
2.78PheGly: 2.78 ± 0.103
0.545PheHis: 0.545 ± 0.046
4.294PheIle: 4.294 ± 0.178
4.348PheLys: 4.348 ± 0.109
4.402PheLeu: 4.402 ± 0.191
0.765PheMet: 0.765 ± 0.057
4.206PheAsn: 4.206 ± 0.126
1.09PhePro: 1.09 ± 0.054
1.216PheGln: 1.216 ± 0.075
1.209PheArg: 1.209 ± 0.074
4.091PheSer: 4.091 ± 0.136
2.157PheThr: 2.157 ± 0.098
3.667PheVal: 3.667 ± 0.127
0.542PheTrp: 0.542 ± 0.053
2.177PheTyr: 2.177 ± 0.094
0.0PheXaa: 0.0 ± 0.0
Gly
2.641GlyAla: 2.641 ± 0.126
0.288GlyCys: 0.288 ± 0.033
2.408GlyAsp: 2.408 ± 0.103
2.171GlyGlu: 2.171 ± 0.092
2.692GlyPhe: 2.692 ± 0.108
3.342GlyGly: 3.342 ± 0.159
0.714GlyHis: 0.714 ± 0.057
4.348GlyIle: 4.348 ± 0.169
2.821GlyLys: 2.821 ± 0.131
4.934GlyLeu: 4.934 ± 0.14
1.104GlyMet: 1.104 ± 0.062
3.007GlyAsn: 3.007 ± 0.142
1.084GlyPro: 1.084 ± 0.07
1.5GlyGln: 1.5 ± 0.072
1.392GlyArg: 1.392 ± 0.075
3.549GlySer: 3.549 ± 0.136
2.689GlyThr: 2.689 ± 0.116
3.081GlyVal: 3.081 ± 0.129
0.44GlyTrp: 0.44 ± 0.036
2.55GlyTyr: 2.55 ± 0.109
0.0GlyXaa: 0.0 ± 0.0
His
0.792HisAla: 0.792 ± 0.055
0.105HisCys: 0.105 ± 0.02
0.935HisAsp: 0.935 ± 0.06
0.911HisGlu: 0.911 ± 0.06
0.752HisPhe: 0.752 ± 0.051
0.664HisGly: 0.664 ± 0.048
0.342HisHis: 0.342 ± 0.042
0.975HisIle: 0.975 ± 0.062
1.341HisLys: 1.341 ± 0.069
1.453HisLeu: 1.453 ± 0.077
0.237HisMet: 0.237 ± 0.024
1.07HisAsn: 1.07 ± 0.063
0.599HisPro: 0.599 ± 0.052
0.714HisGln: 0.714 ± 0.048
0.44HisArg: 0.44 ± 0.041
0.914HisSer: 0.914 ± 0.056
0.565HisThr: 0.565 ± 0.045
0.782HisVal: 0.782 ± 0.05
0.088HisTrp: 0.088 ± 0.016
0.691HisTyr: 0.691 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
4.449IleAla: 4.449 ± 0.15
0.477IleCys: 0.477 ± 0.043
5.164IleAsp: 5.164 ± 0.146
4.297IleGlu: 4.297 ± 0.134
3.948IlePhe: 3.948 ± 0.179
4.399IleGly: 4.399 ± 0.145
1.161IleHis: 1.161 ± 0.059
7.006IleIle: 7.006 ± 0.209
8.195IleLys: 8.195 ± 0.218
6.999IleLeu: 6.999 ± 0.203
1.216IleMet: 1.216 ± 0.068
7.629IleAsn: 7.629 ± 0.206
2.479IlePro: 2.479 ± 0.112
2.421IleGln: 2.421 ± 0.082
2.8IleArg: 2.8 ± 0.092
6.085IleSer: 6.085 ± 0.165
4.382IleThr: 4.382 ± 0.116
4.961IleVal: 4.961 ± 0.165
0.637IleTrp: 0.637 ± 0.049
3.738IleTyr: 3.738 ± 0.132
0.0IleXaa: 0.0 ± 0.0
Lys
5.133LysAla: 5.133 ± 0.158
0.312LysCys: 0.312 ± 0.036
4.446LysAsp: 4.446 ± 0.146
5.767LysGlu: 5.767 ± 0.198
3.647LysPhe: 3.647 ± 0.117
2.655LysGly: 2.655 ± 0.109
1.419LysHis: 1.419 ± 0.078
7.876LysIle: 7.876 ± 0.22
9.353LysLys: 9.353 ± 0.264
8.367LysLeu: 8.367 ± 0.205
1.761LysMet: 1.761 ± 0.078
7.226LysAsn: 7.226 ± 0.196
3.004LysPro: 3.004 ± 0.129
4.473LysGln: 4.473 ± 0.173
3.251LysArg: 3.251 ± 0.121
4.785LysSer: 4.785 ± 0.136
5.973LysThr: 5.973 ± 0.145
5.174LysVal: 5.174 ± 0.145
0.677LysTrp: 0.677 ± 0.044
3.728LysTyr: 3.728 ± 0.116
0.0LysXaa: 0.0 ± 0.0
Leu
6.217LeuAla: 6.217 ± 0.133
0.41LeuCys: 0.41 ± 0.04
5.946LeuAsp: 5.946 ± 0.166
5.469LeuGlu: 5.469 ± 0.189
4.808LeuPhe: 4.808 ± 0.207
4.219LeuGly: 4.219 ± 0.137
1.175LeuHis: 1.175 ± 0.066
9.173LeuIle: 9.173 ± 0.245
9.119LeuLys: 9.119 ± 0.221
8.503LeuLeu: 8.503 ± 0.203
1.676LeuMet: 1.676 ± 0.069
8.228LeuAsn: 8.228 ± 0.195
2.553LeuPro: 2.553 ± 0.098
2.712LeuGln: 2.712 ± 0.104
3.014LeuArg: 3.014 ± 0.108
7.897LeuSer: 7.897 ± 0.182
6.034LeuThr: 6.034 ± 0.159
6.617LeuVal: 6.617 ± 0.149
0.606LeuTrp: 0.606 ± 0.048
3.518LeuTyr: 3.518 ± 0.121
0.0LeuXaa: 0.0 ± 0.0
Met
1.046MetAla: 1.046 ± 0.061
0.051MetCys: 0.051 ± 0.014
0.806MetAsp: 0.806 ± 0.054
0.549MetGlu: 0.549 ± 0.045
0.819MetPhe: 0.819 ± 0.054
0.86MetGly: 0.86 ± 0.073
0.196MetHis: 0.196 ± 0.023
1.788MetIle: 1.788 ± 0.08
1.531MetLys: 1.531 ± 0.071
1.554MetLeu: 1.554 ± 0.074
0.515MetMet: 0.515 ± 0.049
1.453MetAsn: 1.453 ± 0.07
0.65MetPro: 0.65 ± 0.05
0.65MetGln: 0.65 ± 0.052
0.606MetArg: 0.606 ± 0.049
1.229MetSer: 1.229 ± 0.067
0.806MetThr: 0.806 ± 0.056
1.012MetVal: 1.012 ± 0.068
0.081MetTrp: 0.081 ± 0.017
0.66MetTyr: 0.66 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
4.168AsnAla: 4.168 ± 0.135
0.315AsnCys: 0.315 ± 0.031
4.473AsnAsp: 4.473 ± 0.144
4.602AsnGlu: 4.602 ± 0.128
3.847AsnPhe: 3.847 ± 0.119
3.437AsnGly: 3.437 ± 0.141
1.222AsnHis: 1.222 ± 0.076
5.083AsnIle: 5.083 ± 0.124
8.005AsnLys: 8.005 ± 0.223
7.927AsnLeu: 7.927 ± 0.179
1.226AsnMet: 1.226 ± 0.069
7.582AsnAsn: 7.582 ± 0.244
3.671AsnPro: 3.671 ± 0.136
4.961AsnGln: 4.961 ± 0.171
2.309AsnArg: 2.309 ± 0.082
5.127AsnSer: 5.127 ± 0.156
3.884AsnThr: 3.884 ± 0.146
4.009AsnVal: 4.009 ± 0.118
1.053AsnTrp: 1.053 ± 0.06
3.427AsnTyr: 3.427 ± 0.128
0.0AsnXaa: 0.0 ± 0.0
Pro
1.954ProAla: 1.954 ± 0.126
0.081ProCys: 0.081 ± 0.018
1.493ProAsp: 1.493 ± 0.075
2.069ProGlu: 2.069 ± 0.095
1.28ProPhe: 1.28 ± 0.071
1.608ProGly: 1.608 ± 0.075
0.41ProHis: 0.41 ± 0.036
2.611ProIle: 2.611 ± 0.106
2.75ProLys: 2.75 ± 0.115
2.614ProLeu: 2.614 ± 0.09
0.752ProMet: 0.752 ± 0.067
3.075ProAsn: 3.075 ± 0.136
0.779ProPro: 0.779 ± 0.072
1.239ProGln: 1.239 ± 0.089
0.897ProArg: 0.897 ± 0.074
2.36ProSer: 2.36 ± 0.088
3.01ProThr: 3.01 ± 0.142
1.94ProVal: 1.94 ± 0.105
0.207ProTrp: 0.207 ± 0.028
1.419ProTyr: 1.419 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
2.912GlnAla: 2.912 ± 0.103
0.102GlnCys: 0.102 ± 0.018
2.028GlnAsp: 2.028 ± 0.094
2.753GlnGlu: 2.753 ± 0.143
1.886GlnPhe: 1.886 ± 0.088
1.497GlnGly: 1.497 ± 0.068
0.481GlnHis: 0.481 ± 0.041
3.542GlnIle: 3.542 ± 0.123
3.671GlnLys: 3.671 ± 0.147
4.487GlnLeu: 4.487 ± 0.151
0.65GlnMet: 0.65 ± 0.058
3.024GlnAsn: 3.024 ± 0.131
1.981GlnPro: 1.981 ± 0.151
2.106GlnGln: 2.106 ± 0.167
1.649GlnArg: 1.649 ± 0.088
2.387GlnSer: 2.387 ± 0.108
2.787GlnThr: 2.787 ± 0.105
2.072GlnVal: 2.072 ± 0.101
0.362GlnTrp: 0.362 ± 0.038
1.757GlnTyr: 1.757 ± 0.093
0.0GlnXaa: 0.0 ± 0.0
Arg
1.652ArgAla: 1.652 ± 0.082
0.169ArgCys: 0.169 ± 0.024
1.608ArgAsp: 1.608 ± 0.07
1.717ArgGlu: 1.717 ± 0.101
1.544ArgPhe: 1.544 ± 0.076
1.277ArgGly: 1.277 ± 0.07
0.481ArgHis: 0.481 ± 0.046
2.838ArgIle: 2.838 ± 0.098
2.678ArgLys: 2.678 ± 0.108
2.997ArgLeu: 2.997 ± 0.105
0.698ArgMet: 0.698 ± 0.051
2.364ArgAsn: 2.364 ± 0.105
1.067ArgPro: 1.067 ± 0.075
1.165ArgGln: 1.165 ± 0.066
1.233ArgArg: 1.233 ± 0.064
2.32ArgSer: 2.32 ± 0.084
2.16ArgThr: 2.16 ± 0.101
1.771ArgVal: 1.771 ± 0.087
0.318ArgTrp: 0.318 ± 0.032
1.534ArgTyr: 1.534 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
4.365SerAla: 4.365 ± 0.16
0.616SerCys: 0.616 ± 0.041
4.267SerAsp: 4.267 ± 0.124
3.891SerGlu: 3.891 ± 0.137
4.195SerPhe: 4.195 ± 0.132
3.826SerGly: 3.826 ± 0.144
0.735SerHis: 0.735 ± 0.045
5.249SerIle: 5.249 ± 0.181
5.333SerLys: 5.333 ± 0.14
7.487SerLeu: 7.487 ± 0.175
1.029SerMet: 1.029 ± 0.061
5.191SerAsn: 5.191 ± 0.174
1.862SerPro: 1.862 ± 0.083
2.35SerGln: 2.35 ± 0.085
2.16SerArg: 2.16 ± 0.093
6.153SerSer: 6.153 ± 0.184
4.426SerThr: 4.426 ± 0.179
4.246SerVal: 4.246 ± 0.123
0.86SerTrp: 0.86 ± 0.053
2.953SerTyr: 2.953 ± 0.122
0.0SerXaa: 0.0 ± 0.0
Thr
3.627ThrAla: 3.627 ± 0.168
0.22ThrCys: 0.22 ± 0.028
3.02ThrAsp: 3.02 ± 0.11
2.428ThrGlu: 2.428 ± 0.087
2.726ThrPhe: 2.726 ± 0.11
2.936ThrGly: 2.936 ± 0.137
0.677ThrHis: 0.677 ± 0.049
4.554ThrIle: 4.554 ± 0.122
5.221ThrLys: 5.221 ± 0.143
5.655ThrLeu: 5.655 ± 0.209
0.792ThrMet: 0.792 ± 0.05
5.079ThrAsn: 5.079 ± 0.164
2.77ThrPro: 2.77 ± 0.149
2.123ThrGln: 2.123 ± 0.092
1.805ThrArg: 1.805 ± 0.081
4.443ThrSer: 4.443 ± 0.171
4.477ThrThr: 4.477 ± 0.208
3.254ThrVal: 3.254 ± 0.107
0.43ThrTrp: 0.43 ± 0.042
2.045ThrTyr: 2.045 ± 0.098
0.0ThrXaa: 0.0 ± 0.0
Val
3.745ValAla: 3.745 ± 0.128
0.437ValCys: 0.437 ± 0.042
3.965ValAsp: 3.965 ± 0.127
3.566ValGlu: 3.566 ± 0.214
3.014ValPhe: 3.014 ± 0.12
3.23ValGly: 3.23 ± 0.114
0.887ValHis: 0.887 ± 0.063
4.944ValIle: 4.944 ± 0.147
4.551ValLys: 4.551 ± 0.114
5.062ValLeu: 5.062 ± 0.145
0.931ValMet: 0.931 ± 0.055
4.73ValAsn: 4.73 ± 0.125
1.852ValPro: 1.852 ± 0.091
1.964ValGln: 1.964 ± 0.094
1.595ValArg: 1.595 ± 0.077
4.73ValSer: 4.73 ± 0.127
2.97ValThr: 2.97 ± 0.111
4.084ValVal: 4.084 ± 0.156
0.481ValTrp: 0.481 ± 0.041
2.384ValTyr: 2.384 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.454TrpAla: 0.454 ± 0.037
0.058TrpCys: 0.058 ± 0.012
0.43TrpAsp: 0.43 ± 0.04
0.328TrpGlu: 0.328 ± 0.034
0.515TrpPhe: 0.515 ± 0.047
0.305TrpGly: 0.305 ± 0.036
0.119TrpHis: 0.119 ± 0.02
0.914TrpIle: 0.914 ± 0.059
0.765TrpLys: 0.765 ± 0.052
0.86TrpLeu: 0.86 ± 0.057
0.149TrpMet: 0.149 ± 0.023
0.718TrpAsn: 0.718 ± 0.047
0.176TrpPro: 0.176 ± 0.026
0.227TrpGln: 0.227 ± 0.024
0.264TrpArg: 0.264 ± 0.034
0.708TrpSer: 0.708 ± 0.053
0.701TrpThr: 0.701 ± 0.059
0.444TrpVal: 0.444 ± 0.039
0.119TrpTrp: 0.119 ± 0.023
0.44TrpTyr: 0.44 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.194TyrAla: 2.194 ± 0.075
0.308TyrCys: 0.308 ± 0.035
3.037TyrAsp: 3.037 ± 0.122
2.421TyrGlu: 2.421 ± 0.11
2.357TyrPhe: 2.357 ± 0.112
2.167TyrGly: 2.167 ± 0.099
0.725TyrHis: 0.725 ± 0.043
2.79TyrIle: 2.79 ± 0.112
3.261TyrLys: 3.261 ± 0.117
5.164TyrLeu: 5.164 ± 0.166
0.491TyrMet: 0.491 ± 0.04
2.743TyrAsn: 2.743 ± 0.108
1.124TyrPro: 1.124 ± 0.059
2.739TyrGln: 2.739 ± 0.124
1.338TyrArg: 1.338 ± 0.074
3.078TyrSer: 3.078 ± 0.112
1.981TyrThr: 1.981 ± 0.082
2.536TyrVal: 2.536 ± 0.102
0.356TyrTrp: 0.356 ± 0.045
2.12TyrTyr: 2.12 ± 0.097
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 761 proteins (295319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski