Amino acid dipepetide frequency for Bacteroides stercoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.523AlaAla: 6.523 ± 0.099	1.088AlaCys: 1.088 ± 0.031	4.645AlaAsp: 4.645 ± 0.069	5.005AlaGlu: 5.005 ± 0.07	3.267AlaPhe: 3.267 ± 0.057	5.844AlaGly: 5.844 ± 0.092	1.251AlaHis: 1.251 ± 0.035	4.574AlaIle: 4.574 ± 0.073	4.064AlaLys: 4.064 ± 0.064	7.032AlaLeu: 7.032 ± 0.084	1.978AlaMet: 1.978 ± 0.042	3.112AlaAsn: 3.112 ± 0.061	2.454AlaPro: 2.454 ± 0.044	2.756AlaGln: 2.756 ± 0.056	3.435AlaArg: 3.435 ± 0.059	4.401AlaSer: 4.401 ± 0.06	4.017AlaThr: 4.017 ± 0.07	5.273AlaVal: 5.273 ± 0.08	0.831AlaTrp: 0.831 ± 0.033	2.98AlaTyr: 2.98 ± 0.055	0.001AlaXaa: 0.001 ± 0.001
Cys	0.816CysAla: 0.816 ± 0.029	0.243CysCys: 0.243 ± 0.017	0.612CysAsp: 0.612 ± 0.022	0.719CysGlu: 0.719 ± 0.022	0.659CysPhe: 0.659 ± 0.027	1.083CysGly: 1.083 ± 0.036	0.313CysHis: 0.313 ± 0.017	0.981CysIle: 0.981 ± 0.032	0.695CysLys: 0.695 ± 0.024	1.158CysLeu: 1.158 ± 0.038	0.327CysMet: 0.327 ± 0.019	0.575CysAsn: 0.575 ± 0.02	0.551CysPro: 0.551 ± 0.024	0.347CysGln: 0.347 ± 0.02	0.705CysArg: 0.705 ± 0.026	0.827CysSer: 0.827 ± 0.03	0.775CysThr: 0.775 ± 0.03	0.746CysVal: 0.746 ± 0.024	0.167CysTrp: 0.167 ± 0.011	0.537CysTyr: 0.537 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.228AspAla: 4.228 ± 0.068	0.641AspCys: 0.641 ± 0.023	2.651AspAsp: 2.651 ± 0.051	3.914AspGlu: 3.914 ± 0.071	3.016AspPhe: 3.016 ± 0.052	4.071AspGly: 4.071 ± 0.08	0.737AspHis: 0.737 ± 0.025	4.182AspIle: 4.182 ± 0.063	3.978AspLys: 3.978 ± 0.053	4.503AspLeu: 4.503 ± 0.064	1.695AspMet: 1.695 ± 0.036	2.873AspAsn: 2.873 ± 0.052	1.724AspPro: 1.724 ± 0.039	1.045AspGln: 1.045 ± 0.03	2.496AspArg: 2.496 ± 0.058	3.027AspSer: 3.027 ± 0.055	2.847AspThr: 2.847 ± 0.056	3.617AspVal: 3.617 ± 0.067	0.86AspTrp: 0.86 ± 0.027	2.913AspTyr: 2.913 ± 0.05	0.001AspXaa: 0.001 ± 0.001
Glu	4.942GluAla: 4.942 ± 0.072	0.666GluCys: 0.666 ± 0.022	3.257GluAsp: 3.257 ± 0.06	5.149GluGlu: 5.149 ± 0.092	2.478GluPhe: 2.478 ± 0.042	4.113GluGly: 4.113 ± 0.065	1.352GluHis: 1.352 ± 0.037	4.416GluIle: 4.416 ± 0.076	5.033GluLys: 5.033 ± 0.079	6.402GluLeu: 6.402 ± 0.086	2.071GluMet: 2.071 ± 0.041	3.594GluAsn: 3.594 ± 0.059	1.786GluPro: 1.786 ± 0.036	2.719GluGln: 2.719 ± 0.049	3.348GluArg: 3.348 ± 0.065	3.076GluSer: 3.076 ± 0.052	3.401GluThr: 3.401 ± 0.052	4.225GluVal: 4.225 ± 0.066	0.86GluTrp: 0.86 ± 0.027	2.879GluTyr: 2.879 ± 0.051	0.001GluXaa: 0.001 ± 0.001
Phe	3.211PheAla: 3.211 ± 0.059	0.701PheCys: 0.701 ± 0.022	2.664PheAsp: 2.664 ± 0.05	2.404PheGlu: 2.404 ± 0.047	2.179PhePhe: 2.179 ± 0.054	3.24PheGly: 3.24 ± 0.065	0.919PheHis: 0.919 ± 0.028	3.157PheIle: 3.157 ± 0.055	2.384PheLys: 2.384 ± 0.055	4.102PheLeu: 4.102 ± 0.07	1.246PheMet: 1.246 ± 0.034	2.345PheAsn: 2.345 ± 0.042	1.733PhePro: 1.733 ± 0.039	1.194PheGln: 1.194 ± 0.036	2.225PheArg: 2.225 ± 0.044	3.242PheSer: 3.242 ± 0.054	2.794PheThr: 2.794 ± 0.05	2.836PheVal: 2.836 ± 0.056	0.542PheTrp: 0.542 ± 0.022	1.972PheTyr: 1.972 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.61GlyAla: 4.61 ± 0.078	0.992GlyCys: 0.992 ± 0.036	3.471GlyAsp: 3.471 ± 0.063	4.338GlyGlu: 4.338 ± 0.072	3.17GlyPhe: 3.17 ± 0.054	4.804GlyGly: 4.804 ± 0.079	1.26GlyHis: 1.26 ± 0.036	5.474GlyIle: 5.474 ± 0.083	5.41GlyLys: 5.41 ± 0.067	5.787GlyLeu: 5.787 ± 0.076	2.306GlyMet: 2.306 ± 0.047	3.632GlyAsn: 3.632 ± 0.075	1.279GlyPro: 1.279 ± 0.032	2.078GlyGln: 2.078 ± 0.047	2.98GlyArg: 2.98 ± 0.055	4.057GlySer: 4.057 ± 0.072	4.365GlyThr: 4.365 ± 0.058	4.913GlyVal: 4.913 ± 0.077	1.001GlyTrp: 1.001 ± 0.031	3.466GlyTyr: 3.466 ± 0.062	0.002GlyXaa: 0.002 ± 0.001
His	1.215HisAla: 1.215 ± 0.035	0.329HisCys: 0.329 ± 0.017	0.87HisAsp: 0.87 ± 0.026	0.974HisGlu: 0.974 ± 0.026	1.025HisPhe: 1.025 ± 0.031	1.278HisGly: 1.278 ± 0.037	0.465HisHis: 0.465 ± 0.028	1.429HisIle: 1.429 ± 0.038	1.024HisLys: 1.024 ± 0.03	1.738HisLeu: 1.738 ± 0.041	0.373HisMet: 0.373 ± 0.02	0.952HisAsn: 0.952 ± 0.029	1.088HisPro: 1.088 ± 0.031	0.575HisGln: 0.575 ± 0.025	0.942HisArg: 0.942 ± 0.03	1.079HisSer: 1.079 ± 0.033	1.149HisThr: 1.149 ± 0.033	1.079HisVal: 1.079 ± 0.034	0.217HisTrp: 0.217 ± 0.014	0.902HisTyr: 0.902 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.323IleAla: 5.323 ± 0.082	1.003IleCys: 1.003 ± 0.034	4.077IleAsp: 4.077 ± 0.061	4.282IleGlu: 4.282 ± 0.08	2.79IlePhe: 2.79 ± 0.053	4.793IleGly: 4.793 ± 0.065	1.329IleHis: 1.329 ± 0.036	4.518IleIle: 4.518 ± 0.082	3.917IleLys: 3.917 ± 0.066	5.944IleLeu: 5.944 ± 0.095	1.481IleMet: 1.481 ± 0.041	3.291IleAsn: 3.291 ± 0.062	3.106IlePro: 3.106 ± 0.056	2.161IleGln: 2.161 ± 0.043	3.625IleArg: 3.625 ± 0.061	4.5IleSer: 4.5 ± 0.07	4.067IleThr: 4.067 ± 0.074	4.254IleVal: 4.254 ± 0.071	0.683IleTrp: 0.683 ± 0.025	2.654IleTyr: 2.654 ± 0.046	0.002IleXaa: 0.002 ± 0.001
Lys	4.888LysAla: 4.888 ± 0.072	0.554LysCys: 0.554 ± 0.021	3.937LysAsp: 3.937 ± 0.067	5.685LysGlu: 5.685 ± 0.078	2.125LysPhe: 2.125 ± 0.048	4.411LysGly: 4.411 ± 0.064	1.206LysHis: 1.206 ± 0.034	4.039LysIle: 4.039 ± 0.065	4.787LysLys: 4.787 ± 0.093	5.289LysLeu: 5.289 ± 0.075	2.025LysMet: 2.025 ± 0.042	3.403LysAsn: 3.403 ± 0.065	2.149LysPro: 2.149 ± 0.049	2.539LysGln: 2.539 ± 0.043	3.194LysArg: 3.194 ± 0.058	3.195LysSer: 3.195 ± 0.058	3.469LysThr: 3.469 ± 0.058	4.071LysVal: 4.071 ± 0.07	0.757LysTrp: 0.757 ± 0.031	2.89LysTyr: 2.89 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	6.782LeuAla: 6.782 ± 0.083	1.385LeuCys: 1.385 ± 0.04	4.659LeuAsp: 4.659 ± 0.067	5.152LeuGlu: 5.152 ± 0.08	4.406LeuPhe: 4.406 ± 0.088	5.652LeuGly: 5.652 ± 0.08	1.897LeuHis: 1.897 ± 0.047	5.467LeuIle: 5.467 ± 0.092	6.288LeuLys: 6.288 ± 0.08	9.187LeuLeu: 9.187 ± 0.139	2.432LeuMet: 2.432 ± 0.05	4.723LeuAsn: 4.723 ± 0.078	4.161LeuPro: 4.161 ± 0.063	3.543LeuGln: 3.543 ± 0.07	4.312LeuArg: 4.312 ± 0.07	6.516LeuSer: 6.516 ± 0.081	5.262LeuThr: 5.262 ± 0.069	5.229LeuVal: 5.229 ± 0.086	1.037LeuTrp: 1.037 ± 0.036	3.586LeuTyr: 3.586 ± 0.059	0.003LeuXaa: 0.003 ± 0.002
Met	2.099MetAla: 2.099 ± 0.049	0.258MetCys: 0.258 ± 0.018	1.516MetAsp: 1.516 ± 0.038	1.842MetGlu: 1.842 ± 0.039	1.055MetPhe: 1.055 ± 0.031	1.821MetGly: 1.821 ± 0.035	0.424MetHis: 0.424 ± 0.021	1.602MetIle: 1.602 ± 0.04	2.559MetLys: 2.559 ± 0.045	2.637MetLeu: 2.637 ± 0.05	0.745MetMet: 0.745 ± 0.031	1.575MetAsn: 1.575 ± 0.035	1.175MetPro: 1.175 ± 0.033	1.165MetGln: 1.165 ± 0.032	1.402MetArg: 1.402 ± 0.041	1.538MetSer: 1.538 ± 0.037	1.495MetThr: 1.495 ± 0.031	1.53MetVal: 1.53 ± 0.038	0.255MetTrp: 0.255 ± 0.015	0.935MetTyr: 0.935 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.539AsnAla: 3.539 ± 0.055	0.552AsnCys: 0.552 ± 0.026	2.561AsnAsp: 2.561 ± 0.055	3.06AsnGlu: 3.06 ± 0.059	2.199AsnPhe: 2.199 ± 0.049	3.976AsnGly: 3.976 ± 0.074	0.875AsnHis: 0.875 ± 0.027	3.888AsnIle: 3.888 ± 0.068	3.008AsnLys: 3.008 ± 0.058	4.411AsnLeu: 4.411 ± 0.061	1.361AsnMet: 1.361 ± 0.036	2.584AsnAsn: 2.584 ± 0.054	2.473AsnPro: 2.473 ± 0.048	1.458AsnGln: 1.458 ± 0.043	2.671AsnArg: 2.671 ± 0.048	2.836AsnSer: 2.836 ± 0.055	2.667AsnThr: 2.667 ± 0.052	3.242AsnVal: 3.242 ± 0.06	0.627AsnTrp: 0.627 ± 0.027	2.232AsnTyr: 2.232 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.103ProAla: 3.103 ± 0.06	0.409ProCys: 0.409 ± 0.019	2.655ProAsp: 2.655 ± 0.049	3.376ProGlu: 3.376 ± 0.047	1.824ProPhe: 1.824 ± 0.046	2.527ProGly: 2.527 ± 0.057	0.734ProHis: 0.734 ± 0.023	2.181ProIle: 2.181 ± 0.048	1.924ProLys: 1.924 ± 0.044	3.328ProLeu: 3.328 ± 0.059	0.946ProMet: 0.946 ± 0.027	1.622ProAsn: 1.622 ± 0.033	0.782ProPro: 0.782 ± 0.027	1.506ProGln: 1.506 ± 0.038	1.311ProArg: 1.311 ± 0.032	2.016ProSer: 2.016 ± 0.042	1.929ProThr: 1.929 ± 0.039	3.102ProVal: 3.102 ± 0.06	0.417ProTrp: 0.417 ± 0.021	1.77ProTyr: 1.77 ± 0.039	0.001ProXaa: 0.001 ± 0.001
Gln	2.596GlnAla: 2.596 ± 0.048	0.32GlnCys: 0.32 ± 0.019	1.626GlnAsp: 1.626 ± 0.036	2.483GlnGlu: 2.483 ± 0.048	1.259GlnPhe: 1.259 ± 0.035	2.065GlnGly: 2.065 ± 0.039	0.653GlnHis: 0.653 ± 0.028	2.297GlnIle: 2.297 ± 0.036	2.328GlnLys: 2.328 ± 0.046	3.2GlnLeu: 3.2 ± 0.06	1.008GlnMet: 1.008 ± 0.028	1.741GlnAsn: 1.741 ± 0.045	1.307GlnPro: 1.307 ± 0.036	1.541GlnGln: 1.541 ± 0.039	1.708GlnArg: 1.708 ± 0.041	1.918GlnSer: 1.918 ± 0.04	1.988GlnThr: 1.988 ± 0.036	2.128GlnVal: 2.128 ± 0.046	0.456GlnTrp: 0.456 ± 0.024	1.465GlnTyr: 1.465 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.04ArgAla: 3.04 ± 0.057	0.499ArgCys: 0.499 ± 0.023	2.196ArgAsp: 2.196 ± 0.04	3.209ArgGlu: 3.209 ± 0.062	2.358ArgPhe: 2.358 ± 0.045	2.477ArgGly: 2.477 ± 0.049	1.013ArgHis: 1.013 ± 0.028	3.908ArgIle: 3.908 ± 0.062	3.551ArgLys: 3.551 ± 0.064	4.694ArgLeu: 4.694 ± 0.074	1.648ArgMet: 1.648 ± 0.042	2.631ArgAsn: 2.631 ± 0.047	1.683ArgPro: 1.683 ± 0.046	1.896ArgGln: 1.896 ± 0.047	2.456ArgArg: 2.456 ± 0.06	2.481ArgSer: 2.481 ± 0.05	2.666ArgThr: 2.666 ± 0.048	2.717ArgVal: 2.717 ± 0.045	0.682ArgTrp: 0.682 ± 0.027	2.293ArgTyr: 2.293 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.34SerAla: 4.34 ± 0.067	0.824SerCys: 0.824 ± 0.027	3.209SerAsp: 3.209 ± 0.05	3.362SerGlu: 3.362 ± 0.046	3.124SerPhe: 3.124 ± 0.059	4.647SerGly: 4.647 ± 0.079	1.072SerHis: 1.072 ± 0.033	4.072SerIle: 4.072 ± 0.062	3.147SerLys: 3.147 ± 0.057	5.856SerLeu: 5.856 ± 0.077	1.503SerMet: 1.503 ± 0.035	2.643SerAsn: 2.643 ± 0.051	2.3SerPro: 2.3 ± 0.051	1.806SerGln: 1.806 ± 0.047	2.719SerArg: 2.719 ± 0.045	3.753SerSer: 3.753 ± 0.071	3.15SerThr: 3.15 ± 0.052	4.333SerVal: 4.333 ± 0.064	0.773SerTrp: 0.773 ± 0.031	2.722SerTyr: 2.722 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.488ThrAla: 4.488 ± 0.071	0.641ThrCys: 0.641 ± 0.023	3.629ThrAsp: 3.629 ± 0.056	3.504ThrGlu: 3.504 ± 0.061	2.699ThrPhe: 2.699 ± 0.054	4.558ThrGly: 4.558 ± 0.07	0.947ThrHis: 0.947 ± 0.03	3.638ThrIle: 3.638 ± 0.07	2.703ThrLys: 2.703 ± 0.05	5.536ThrLeu: 5.536 ± 0.069	1.227ThrMet: 1.227 ± 0.035	2.416ThrAsn: 2.416 ± 0.054	2.852ThrPro: 2.852 ± 0.052	1.678ThrGln: 1.678 ± 0.036	2.294ThrArg: 2.294 ± 0.053	3.114ThrSer: 3.114 ± 0.053	2.988ThrThr: 2.988 ± 0.057	4.423ThrVal: 4.423 ± 0.067	0.633ThrTrp: 0.633 ± 0.026	2.377ThrTyr: 2.377 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.901ValAla: 4.901 ± 0.079	1.007ValCys: 1.007 ± 0.03	3.572ValAsp: 3.572 ± 0.059	4.029ValGlu: 4.029 ± 0.066	2.859ValPhe: 2.859 ± 0.059	4.043ValGly: 4.043 ± 0.067	1.127ValHis: 1.127 ± 0.033	4.319ValIle: 4.319 ± 0.06	4.214ValLys: 4.214 ± 0.066	5.968ValLeu: 5.968 ± 0.068	1.714ValMet: 1.714 ± 0.04	3.344ValAsn: 3.344 ± 0.058	2.685ValPro: 2.685 ± 0.048	2.05ValGln: 2.05 ± 0.042	3.222ValArg: 3.222 ± 0.053	4.488ValSer: 4.488 ± 0.068	3.906ValThr: 3.906 ± 0.064	4.353ValVal: 4.353 ± 0.073	0.67ValTrp: 0.67 ± 0.025	2.737ValTyr: 2.737 ± 0.048	0.003ValXaa: 0.003 ± 0.002
Trp	0.768TrpAla: 0.768 ± 0.025	0.168TrpCys: 0.168 ± 0.012	0.714TrpAsp: 0.714 ± 0.028	0.797TrpGlu: 0.797 ± 0.026	0.542TrpPhe: 0.542 ± 0.021	0.933TrpGly: 0.933 ± 0.03	0.266TrpHis: 0.266 ± 0.015	0.785TrpIle: 0.785 ± 0.032	0.911TrpLys: 0.911 ± 0.031	1.125TrpLeu: 1.125 ± 0.037	0.455TrpMet: 0.455 ± 0.02	0.769TrpAsn: 0.769 ± 0.026	0.24TrpPro: 0.24 ± 0.017	0.52TrpGln: 0.52 ± 0.023	0.568TrpArg: 0.568 ± 0.025	0.655TrpSer: 0.655 ± 0.026	0.671TrpThr: 0.671 ± 0.027	0.649TrpVal: 0.649 ± 0.023	0.202TrpTrp: 0.202 ± 0.013	0.499TrpTyr: 0.499 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.116TyrAla: 3.116 ± 0.053	0.553TyrCys: 0.553 ± 0.022	2.499TyrAsp: 2.499 ± 0.048	2.483TyrGlu: 2.483 ± 0.046	2.055TyrPhe: 2.055 ± 0.042	3.059TyrGly: 3.059 ± 0.053	0.862TyrHis: 0.862 ± 0.033	2.869TyrIle: 2.869 ± 0.05	2.687TyrLys: 2.687 ± 0.053	3.78TyrLeu: 3.78 ± 0.059	1.085TyrMet: 1.085 ± 0.033	2.394TyrAsn: 2.394 ± 0.059	1.937TyrPro: 1.937 ± 0.046	1.511TyrGln: 1.511 ± 0.042	2.482TyrArg: 2.482 ± 0.056	2.637TyrSer: 2.637 ± 0.05	2.739TyrThr: 2.739 ± 0.054	2.489TyrVal: 2.489 ± 0.044	0.57TyrTrp: 0.57 ± 0.023	2.057TyrTyr: 2.057 ± 0.045	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.004XaaVal: 0.004 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.05XaaXaa: 0.05 ± 0.018

Statistics based on 3155 proteins (1141124 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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