Amino acid dipepetide frequency for Altererythrobacter xiamenensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.928AlaAla: 14.928 ± 0.18	1.006AlaCys: 1.006 ± 0.033	6.845AlaAsp: 6.845 ± 0.092	8.495AlaGlu: 8.495 ± 0.119	4.146AlaPhe: 4.146 ± 0.077	10.003AlaGly: 10.003 ± 0.121	2.026AlaHis: 2.026 ± 0.054	6.778AlaIle: 6.778 ± 0.095	4.46AlaLys: 4.46 ± 0.079	12.769AlaLeu: 12.769 ± 0.156	3.849AlaMet: 3.849 ± 0.071	3.381AlaAsn: 3.381 ± 0.062	5.215AlaPro: 5.215 ± 0.09	4.267AlaGln: 4.267 ± 0.076	8.03AlaArg: 8.03 ± 0.128	6.644AlaSer: 6.644 ± 0.088	5.71AlaThr: 5.71 ± 0.083	7.563AlaVal: 7.563 ± 0.092	1.438AlaTrp: 1.438 ± 0.048	2.382AlaTyr: 2.382 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.004CysAla: 1.004 ± 0.039	0.094CysCys: 0.094 ± 0.012	0.603CysAsp: 0.603 ± 0.025	0.517CysGlu: 0.517 ± 0.025	0.28CysPhe: 0.28 ± 0.019	0.861CysGly: 0.861 ± 0.033	0.211CysHis: 0.211 ± 0.015	0.388CysIle: 0.388 ± 0.023	0.216CysLys: 0.216 ± 0.015	0.656CysLeu: 0.656 ± 0.024	0.172CysMet: 0.172 ± 0.013	0.272CysAsn: 0.272 ± 0.016	0.407CysPro: 0.407 ± 0.024	0.221CysGln: 0.221 ± 0.016	0.491CysArg: 0.491 ± 0.024	0.421CysSer: 0.421 ± 0.022	0.369CysThr: 0.369 ± 0.02	0.538CysVal: 0.538 ± 0.026	0.089CysTrp: 0.089 ± 0.01	0.184CysTyr: 0.184 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.311AspAla: 7.311 ± 0.099	0.526AspCys: 0.526 ± 0.023	3.764AspAsp: 3.764 ± 0.081	4.528AspGlu: 4.528 ± 0.084	2.484AspPhe: 2.484 ± 0.056	5.841AspGly: 5.841 ± 0.116	1.295AspHis: 1.295 ± 0.039	3.179AspIle: 3.179 ± 0.056	2.032AspLys: 2.032 ± 0.056	5.68AspLeu: 5.68 ± 0.085	1.688AspMet: 1.688 ± 0.045	1.689AspAsn: 1.689 ± 0.042	3.744AspPro: 3.744 ± 0.07	1.859AspGln: 1.859 ± 0.042	4.419AspArg: 4.419 ± 0.069	2.568AspSer: 2.568 ± 0.057	2.955AspThr: 2.955 ± 0.061	4.009AspVal: 4.009 ± 0.071	1.205AspTrp: 1.205 ± 0.04	1.699AspTyr: 1.699 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.601GluAla: 8.601 ± 0.119	0.407GluCys: 0.407 ± 0.022	4.071GluAsp: 4.071 ± 0.076	5.105GluGlu: 5.105 ± 0.098	2.011GluPhe: 2.011 ± 0.048	5.721GluGly: 5.721 ± 0.085	1.343GluHis: 1.343 ± 0.042	3.658GluIle: 3.658 ± 0.066	2.901GluLys: 2.901 ± 0.064	6.325GluLeu: 6.325 ± 0.095	1.882GluMet: 1.882 ± 0.043	2.058GluAsn: 2.058 ± 0.045	3.193GluPro: 3.193 ± 0.066	2.598GluGln: 2.598 ± 0.05	5.621GluArg: 5.621 ± 0.098	2.977GluSer: 2.977 ± 0.053	3.782GluThr: 3.782 ± 0.071	4.46GluVal: 4.46 ± 0.067	1.061GluTrp: 1.061 ± 0.034	1.421GluTyr: 1.421 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	4.868PheAla: 4.868 ± 0.099	0.329PheCys: 0.329 ± 0.02	2.899PheAsp: 2.899 ± 0.059	2.578PheGlu: 2.578 ± 0.055	1.463PhePhe: 1.463 ± 0.052	3.783PheGly: 3.783 ± 0.068	0.679PheHis: 0.679 ± 0.028	1.68PheIle: 1.68 ± 0.049	0.993PheLys: 0.993 ± 0.037	3.141PheLeu: 3.141 ± 0.077	0.829PheMet: 0.829 ± 0.03	1.093PheAsn: 1.093 ± 0.037	1.535PhePro: 1.535 ± 0.038	0.926PheGln: 0.926 ± 0.03	2.075PheArg: 2.075 ± 0.057	2.224PheSer: 2.224 ± 0.044	2.132PheThr: 2.132 ± 0.053	2.671PheVal: 2.671 ± 0.055	0.557PheTrp: 0.557 ± 0.03	0.992PheTyr: 0.992 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.176GlyAla: 9.176 ± 0.111	0.806GlyCys: 0.806 ± 0.027	5.363GlyAsp: 5.363 ± 0.09	6.315GlyGlu: 6.315 ± 0.099	3.749GlyPhe: 3.749 ± 0.063	7.712GlyGly: 7.712 ± 0.125	1.755GlyHis: 1.755 ± 0.049	4.516GlyIle: 4.516 ± 0.081	3.526GlyLys: 3.526 ± 0.072	8.3GlyLeu: 8.3 ± 0.116	2.507GlyMet: 2.507 ± 0.053	2.498GlyAsn: 2.498 ± 0.065	3.414GlyPro: 3.414 ± 0.064	2.867GlyGln: 2.867 ± 0.057	5.502GlyArg: 5.502 ± 0.085	5.142GlySer: 5.142 ± 0.077	4.666GlyThr: 4.666 ± 0.083	5.748GlyVal: 5.748 ± 0.099	1.532GlyTrp: 1.532 ± 0.039	2.241GlyTyr: 2.241 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.17HisAla: 2.17 ± 0.055	0.228HisCys: 0.228 ± 0.016	1.185HisAsp: 1.185 ± 0.039	1.208HisGlu: 1.208 ± 0.042	0.857HisPhe: 0.857 ± 0.029	1.786HisGly: 1.786 ± 0.055	0.524HisHis: 0.524 ± 0.026	0.901HisIle: 0.901 ± 0.03	0.561HisLys: 0.561 ± 0.025	1.716HisLeu: 1.716 ± 0.049	0.45HisMet: 0.45 ± 0.024	0.463HisAsn: 0.463 ± 0.023	1.226HisPro: 1.226 ± 0.038	0.544HisGln: 0.544 ± 0.026	1.333HisArg: 1.333 ± 0.038	1.007HisSer: 1.007 ± 0.038	0.786HisThr: 0.786 ± 0.029	1.28HisVal: 1.28 ± 0.041	0.364HisTrp: 0.364 ± 0.021	0.571HisTyr: 0.571 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.634IleAla: 7.634 ± 0.099	0.458IleCys: 0.458 ± 0.021	3.981IleAsp: 3.981 ± 0.064	4.266IleGlu: 4.266 ± 0.071	1.785IlePhe: 1.785 ± 0.05	5.212IleGly: 5.212 ± 0.081	0.908IleHis: 0.908 ± 0.033	2.324IleIle: 2.324 ± 0.062	1.486IleLys: 1.486 ± 0.044	4.041IleLeu: 4.041 ± 0.076	1.018IleMet: 1.018 ± 0.038	1.411IleAsn: 1.411 ± 0.042	2.418IlePro: 2.418 ± 0.048	1.188IleGln: 1.188 ± 0.035	3.076IleArg: 3.076 ± 0.055	2.818IleSer: 2.818 ± 0.058	2.593IleThr: 2.593 ± 0.053	3.893IleVal: 3.893 ± 0.066	0.67IleTrp: 0.67 ± 0.029	1.048IleTyr: 1.048 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.061LysAla: 4.061 ± 0.085	0.194LysCys: 0.194 ± 0.013	1.817LysAsp: 1.817 ± 0.053	1.832LysGlu: 1.832 ± 0.05	0.985LysPhe: 0.985 ± 0.031	2.833LysGly: 2.833 ± 0.06	0.668LysHis: 0.668 ± 0.032	1.614LysIle: 1.614 ± 0.044	1.51LysLys: 1.51 ± 0.06	3.641LysLeu: 3.641 ± 0.068	0.844LysMet: 0.844 ± 0.03	0.913LysAsn: 0.913 ± 0.032	2.145LysPro: 2.145 ± 0.055	1.114LysGln: 1.114 ± 0.038	2.611LysArg: 2.611 ± 0.059	1.973LysSer: 1.973 ± 0.058	1.857LysThr: 1.857 ± 0.048	2.367LysVal: 2.367 ± 0.049	0.473LysTrp: 0.473 ± 0.022	0.703LysTyr: 0.703 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.97LeuAla: 12.97 ± 0.157	0.715LeuCys: 0.715 ± 0.031	6.216LeuAsp: 6.216 ± 0.099	6.096LeuGlu: 6.096 ± 0.083	3.58LeuPhe: 3.58 ± 0.078	8.194LeuGly: 8.194 ± 0.108	1.621LeuHis: 1.621 ± 0.039	4.675LeuIle: 4.675 ± 0.073	3.139LeuLys: 3.139 ± 0.065	8.639LeuLeu: 8.639 ± 0.136	2.167LeuMet: 2.167 ± 0.053	2.348LeuAsn: 2.348 ± 0.064	5.056LeuPro: 5.056 ± 0.083	2.564LeuGln: 2.564 ± 0.057	6.146LeuArg: 6.146 ± 0.086	5.946LeuSer: 5.946 ± 0.1	5.277LeuThr: 5.277 ± 0.08	7.218LeuVal: 7.218 ± 0.097	1.103LeuTrp: 1.103 ± 0.042	1.881LeuTyr: 1.881 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.331MetAla: 3.331 ± 0.064	0.164MetCys: 0.164 ± 0.014	1.27MetAsp: 1.27 ± 0.034	1.406MetGlu: 1.406 ± 0.047	0.739MetPhe: 0.739 ± 0.03	1.984MetGly: 1.984 ± 0.052	0.484MetHis: 0.484 ± 0.027	1.372MetIle: 1.372 ± 0.04	1.052MetLys: 1.052 ± 0.03	2.684MetLeu: 2.684 ± 0.057	0.692MetMet: 0.692 ± 0.032	0.817MetAsn: 0.817 ± 0.03	1.506MetPro: 1.506 ± 0.045	0.814MetGln: 0.814 ± 0.03	1.872MetArg: 1.872 ± 0.044	1.681MetSer: 1.681 ± 0.044	1.675MetThr: 1.675 ± 0.043	1.63MetVal: 1.63 ± 0.042	0.266MetTrp: 0.266 ± 0.018	0.286MetTyr: 0.286 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.42AsnAla: 3.42 ± 0.067	0.284AsnCys: 0.284 ± 0.018	1.528AsnAsp: 1.528 ± 0.051	1.606AsnGlu: 1.606 ± 0.045	1.088AsnPhe: 1.088 ± 0.037	2.5AsnGly: 2.5 ± 0.059	0.534AsnHis: 0.534 ± 0.028	1.472AsnIle: 1.472 ± 0.037	0.708AsnLys: 0.708 ± 0.031	2.564AsnLeu: 2.564 ± 0.053	0.632AsnMet: 0.632 ± 0.027	0.768AsnAsn: 0.768 ± 0.035	1.881AsnPro: 1.881 ± 0.046	0.842AsnGln: 0.842 ± 0.035	1.921AsnArg: 1.921 ± 0.052	1.465AsnSer: 1.465 ± 0.036	1.361AsnThr: 1.361 ± 0.048	1.919AsnVal: 1.919 ± 0.051	0.512AsnTrp: 0.512 ± 0.023	0.733AsnTyr: 0.733 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.576ProAla: 5.576 ± 0.085	0.3ProCys: 0.3 ± 0.015	3.868ProAsp: 3.868 ± 0.071	4.337ProGlu: 4.337 ± 0.08	1.914ProPhe: 1.914 ± 0.044	4.362ProGly: 4.362 ± 0.073	1.023ProHis: 1.023 ± 0.032	2.5ProIle: 2.5 ± 0.052	1.575ProLys: 1.575 ± 0.05	4.471ProLeu: 4.471 ± 0.078	1.196ProMet: 1.196 ± 0.036	1.277ProAsn: 1.277 ± 0.036	2.385ProPro: 2.385 ± 0.078	1.804ProGln: 1.804 ± 0.039	2.775ProArg: 2.775 ± 0.059	2.629ProSer: 2.629 ± 0.054	2.387ProThr: 2.387 ± 0.051	3.843ProVal: 3.843 ± 0.068	0.618ProTrp: 0.618 ± 0.021	1.129ProTyr: 1.129 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.775GlnAla: 3.775 ± 0.07	0.254GlnCys: 0.254 ± 0.019	1.661GlnAsp: 1.661 ± 0.045	1.767GlnGlu: 1.767 ± 0.044	1.264GlnPhe: 1.264 ± 0.036	2.474GlnGly: 2.474 ± 0.052	0.639GlnHis: 0.639 ± 0.029	1.825GlnIle: 1.825 ± 0.039	1.018GlnLys: 1.018 ± 0.033	3.236GlnLeu: 3.236 ± 0.061	0.919GlnMet: 0.919 ± 0.034	0.823GlnAsn: 0.823 ± 0.029	1.68GlnPro: 1.68 ± 0.043	1.252GlnGln: 1.252 ± 0.046	2.371GlnArg: 2.371 ± 0.055	1.868GlnSer: 1.868 ± 0.048	1.608GlnThr: 1.608 ± 0.042	2.301GlnVal: 2.301 ± 0.049	0.47GlnTrp: 0.47 ± 0.021	0.654GlnTyr: 0.654 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.265ArgAla: 7.265 ± 0.107	0.469ArgCys: 0.469 ± 0.025	4.108ArgAsp: 4.108 ± 0.067	5.026ArgGlu: 5.026 ± 0.084	3.0ArgPhe: 3.0 ± 0.061	4.71ArgGly: 4.71 ± 0.077	1.385ArgHis: 1.385 ± 0.043	3.884ArgIle: 3.884 ± 0.071	2.488ArgLys: 2.488 ± 0.057	7.012ArgLeu: 7.012 ± 0.096	1.845ArgMet: 1.845 ± 0.048	1.895ArgAsn: 1.895 ± 0.048	2.971ArgPro: 2.971 ± 0.061	2.351ArgGln: 2.351 ± 0.047	4.732ArgArg: 4.732 ± 0.095	3.567ArgSer: 3.567 ± 0.071	3.107ArgThr: 3.107 ± 0.057	4.285ArgVal: 4.285 ± 0.078	1.07ArgTrp: 1.07 ± 0.037	1.732ArgTyr: 1.732 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.219SerAla: 6.219 ± 0.095	0.446SerCys: 0.446 ± 0.02	3.606SerAsp: 3.606 ± 0.07	3.809SerGlu: 3.809 ± 0.065	2.234SerPhe: 2.234 ± 0.052	5.769SerGly: 5.769 ± 0.09	0.988SerHis: 0.988 ± 0.037	2.794SerIle: 2.794 ± 0.059	1.743SerLys: 1.743 ± 0.042	5.205SerLeu: 5.205 ± 0.082	1.334SerMet: 1.334 ± 0.041	1.621SerAsn: 1.621 ± 0.042	2.754SerPro: 2.754 ± 0.055	1.836SerGln: 1.836 ± 0.047	3.392SerArg: 3.392 ± 0.067	3.066SerSer: 3.066 ± 0.061	2.674SerThr: 2.674 ± 0.059	3.571SerVal: 3.571 ± 0.064	0.801SerTrp: 0.801 ± 0.033	1.42SerTyr: 1.42 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.744ThrAla: 5.744 ± 0.076	0.402ThrCys: 0.402 ± 0.021	3.024ThrAsp: 3.024 ± 0.077	2.969ThrGlu: 2.969 ± 0.056	1.955ThrPhe: 1.955 ± 0.049	5.057ThrGly: 5.057 ± 0.086	0.948ThrHis: 0.948 ± 0.03	3.006ThrIle: 3.006 ± 0.059	1.487ThrLys: 1.487 ± 0.046	5.247ThrLeu: 5.247 ± 0.075	1.209ThrMet: 1.209 ± 0.034	1.355ThrAsn: 1.355 ± 0.039	3.115ThrPro: 3.115 ± 0.063	1.542ThrGln: 1.542 ± 0.041	3.29ThrArg: 3.29 ± 0.062	2.905ThrSer: 2.905 ± 0.052	2.595ThrThr: 2.595 ± 0.073	3.939ThrVal: 3.939 ± 0.076	0.615ThrTrp: 0.615 ± 0.031	1.258ThrTyr: 1.258 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	8.149ValAla: 8.149 ± 0.099	0.535ValCys: 0.535 ± 0.023	4.293ValAsp: 4.293 ± 0.081	5.157ValGlu: 5.157 ± 0.083	2.338ValPhe: 2.338 ± 0.052	5.379ValGly: 5.379 ± 0.089	1.242ValHis: 1.242 ± 0.041	3.959ValIle: 3.959 ± 0.074	2.093ValLys: 2.093 ± 0.058	6.368ValLeu: 6.368 ± 0.092	1.714ValMet: 1.714 ± 0.05	1.951ValAsn: 1.951 ± 0.066	3.626ValPro: 3.626 ± 0.068	1.952ValGln: 1.952 ± 0.043	4.3ValArg: 4.3 ± 0.073	4.104ValSer: 4.104 ± 0.073	4.232ValThr: 4.232 ± 0.075	4.916ValVal: 4.916 ± 0.086	0.864ValTrp: 0.864 ± 0.031	1.324ValTyr: 1.324 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.295TrpAla: 1.295 ± 0.037	0.111TrpCys: 0.111 ± 0.01	0.77TrpAsp: 0.77 ± 0.031	0.783TrpGlu: 0.783 ± 0.027	0.593TrpPhe: 0.593 ± 0.028	1.023TrpGly: 1.023 ± 0.038	0.386TrpHis: 0.386 ± 0.018	0.733TrpIle: 0.733 ± 0.03	0.511TrpLys: 0.511 ± 0.024	1.737TrpLeu: 1.737 ± 0.045	0.371TrpMet: 0.371 ± 0.022	0.459TrpAsn: 0.459 ± 0.019	0.684TrpPro: 0.684 ± 0.031	0.657TrpGln: 0.657 ± 0.027	1.145TrpArg: 1.145 ± 0.044	0.913TrpSer: 0.913 ± 0.036	0.779TrpThr: 0.779 ± 0.028	0.847TrpVal: 0.847 ± 0.034	0.247TrpTrp: 0.247 ± 0.019	0.277TrpTyr: 0.277 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.437TyrAla: 2.437 ± 0.058	0.267TyrCys: 0.267 ± 0.018	1.606TyrAsp: 1.606 ± 0.046	1.4TyrGlu: 1.4 ± 0.04	0.984TyrPhe: 0.984 ± 0.037	2.133TyrGly: 2.133 ± 0.046	0.501TyrHis: 0.501 ± 0.022	0.966TyrIle: 0.966 ± 0.033	0.653TyrLys: 0.653 ± 0.033	2.117TyrLeu: 2.117 ± 0.058	0.405TyrMet: 0.405 ± 0.021	0.645TyrAsn: 0.645 ± 0.028	1.014TyrPro: 1.014 ± 0.034	0.663TyrGln: 0.663 ± 0.026	1.798TyrArg: 1.798 ± 0.05	1.363TyrSer: 1.363 ± 0.038	1.117TyrThr: 1.117 ± 0.034	1.501TyrVal: 1.501 ± 0.039	0.367TyrTrp: 0.367 ± 0.021	0.639TyrTyr: 0.639 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2951 proteins (930223 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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