Amino acid dipepetide frequency for Wenzhou crab virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.8AlaAla: 14.8 ± 3.47
1.345AlaCys: 1.345 ± 1.317
5.382AlaAsp: 5.382 ± 0.542
4.036AlaGlu: 4.036 ± 0.291
2.691AlaPhe: 2.691 ± 1.275
8.409AlaGly: 8.409 ± 1.513
2.018AlaHis: 2.018 ± 1.259
3.364AlaIle: 3.364 ± 1.094
3.7AlaLys: 3.7 ± 1.102
9.418AlaLeu: 9.418 ± 2.672
1.682AlaMet: 1.682 ± 0.765
2.018AlaAsn: 2.018 ± 1.214
5.045AlaPro: 5.045 ± 1.594
2.691AlaGln: 2.691 ± 0.978
8.409AlaArg: 8.409 ± 0.864
8.745AlaSer: 8.745 ± 3.401
5.718AlaThr: 5.718 ± 1.16
8.409AlaVal: 8.409 ± 1.31
2.018AlaTrp: 2.018 ± 0.967
3.027AlaTyr: 3.027 ± 0.933
0.0AlaXaa: 0.0 ± 0.0
Cys
1.345CysAla: 1.345 ± 0.669
0.336CysCys: 0.336 ± 0.608
0.673CysAsp: 0.673 ± 0.608
0.673CysGlu: 0.673 ± 1.215
0.336CysPhe: 0.336 ± 0.612
2.355CysGly: 2.355 ± 1.792
0.0CysHis: 0.0 ± 0.0
0.336CysIle: 0.336 ± 0.291
0.336CysLys: 0.336 ± 0.291
0.673CysLeu: 0.673 ± 0.874
0.336CysMet: 0.336 ± 0.291
0.336CysAsn: 0.336 ± 0.23
0.673CysPro: 0.673 ± 0.549
1.009CysGln: 1.009 ± 0.483
0.336CysArg: 0.336 ± 0.612
0.673CysSer: 0.673 ± 0.619
0.0CysThr: 0.0 ± 0.0
1.345CysVal: 1.345 ± 0.781
0.673CysTrp: 0.673 ± 0.344
1.345CysTyr: 1.345 ± 0.581
0.0CysXaa: 0.0 ± 0.0
Asp
3.7AspAla: 3.7 ± 1.133
0.673AspCys: 0.673 ± 0.33
2.018AspAsp: 2.018 ± 1.057
3.7AspGlu: 3.7 ± 0.973
0.336AspPhe: 0.336 ± 0.291
4.373AspGly: 4.373 ± 0.908
2.018AspHis: 2.018 ± 0.539
2.018AspIle: 2.018 ± 0.639
0.673AspLys: 0.673 ± 0.26
6.391AspLeu: 6.391 ± 1.488
0.673AspMet: 0.673 ± 0.538
2.018AspAsn: 2.018 ± 0.445
3.7AspPro: 3.7 ± 1.571
2.018AspGln: 2.018 ± 0.781
2.355AspArg: 2.355 ± 0.711
3.027AspSer: 3.027 ± 1.118
2.691AspThr: 2.691 ± 1.144
5.045AspVal: 5.045 ± 1.101
2.355AspTrp: 2.355 ± 0.893
1.009AspTyr: 1.009 ± 0.824
0.0AspXaa: 0.0 ± 0.0
Glu
6.054GluAla: 6.054 ± 2.367
0.336GluCys: 0.336 ± 0.291
2.355GluAsp: 2.355 ± 0.547
2.355GluGlu: 2.355 ± 1.04
1.009GluPhe: 1.009 ± 0.574
6.727GluGly: 6.727 ± 2.067
0.673GluHis: 0.673 ± 0.581
1.009GluIle: 1.009 ± 0.55
1.682GluLys: 1.682 ± 0.875
4.709GluLeu: 4.709 ± 1.179
0.336GluMet: 0.336 ± 0.49
0.0GluAsn: 0.0 ± 0.0
4.709GluPro: 4.709 ± 0.682
1.682GluGln: 1.682 ± 0.736
3.364GluArg: 3.364 ± 1.556
3.7GluSer: 3.7 ± 1.454
0.673GluThr: 0.673 ± 0.33
3.027GluVal: 3.027 ± 0.588
1.009GluTrp: 1.009 ± 0.55
0.336GluTyr: 0.336 ± 0.23
0.0GluXaa: 0.0 ± 0.0
Phe
0.336PheAla: 0.336 ± 0.275
0.336PheCys: 0.336 ± 0.612
1.009PheAsp: 1.009 ± 0.824
2.691PheGlu: 2.691 ± 1.144
1.345PhePhe: 1.345 ± 0.799
1.009PheGly: 1.009 ± 0.528
0.0PheHis: 0.0 ± 0.0
0.673PheIle: 0.673 ± 0.608
1.345PheLys: 1.345 ± 0.521
2.018PheLeu: 2.018 ± 1.013
0.336PheMet: 0.336 ± 0.608
0.336PheAsn: 0.336 ± 0.608
1.345PhePro: 1.345 ± 0.453
2.018PheGln: 2.018 ± 0.639
2.355PheArg: 2.355 ± 1.221
3.027PheSer: 3.027 ± 0.94
1.682PheThr: 1.682 ± 1.137
1.682PheVal: 1.682 ± 0.498
0.336PheTrp: 0.336 ± 0.23
1.009PheTyr: 1.009 ± 0.672
0.0PheXaa: 0.0 ± 0.0
Gly
9.754GlyAla: 9.754 ± 2.056
2.018GlyCys: 2.018 ± 1.044
4.373GlyAsp: 4.373 ± 1.69
2.691GlyGlu: 2.691 ± 1.556
1.009GlyPhe: 1.009 ± 1.375
5.382GlyGly: 5.382 ± 1.77
1.682GlyHis: 1.682 ± 0.764
2.355GlyIle: 2.355 ± 0.548
1.682GlyLys: 1.682 ± 0.553
6.727GlyLeu: 6.727 ± 1.096
1.682GlyMet: 1.682 ± 0.57
1.682GlyAsn: 1.682 ± 0.764
6.727GlyPro: 6.727 ± 0.919
3.7GlyGln: 3.7 ± 1.649
4.373GlyArg: 4.373 ± 0.816
6.727GlySer: 6.727 ± 1.189
6.054GlyThr: 6.054 ± 0.513
6.391GlyVal: 6.391 ± 0.66
3.027GlyTrp: 3.027 ± 0.978
3.7GlyTyr: 3.7 ± 1.022
0.0GlyXaa: 0.0 ± 0.0
His
1.345HisAla: 1.345 ± 0.515
0.0HisCys: 0.0 ± 0.0
1.009HisAsp: 1.009 ± 1.188
1.009HisGlu: 1.009 ± 0.55
0.0HisPhe: 0.0 ± 0.0
1.682HisGly: 1.682 ± 0.751
0.673HisHis: 0.673 ± 0.582
0.336HisIle: 0.336 ± 0.291
0.673HisLys: 0.673 ± 0.344
3.027HisLeu: 3.027 ± 1.338
1.009HisMet: 1.009 ± 0.55
1.009HisAsn: 1.009 ± 1.188
2.018HisPro: 2.018 ± 0.615
1.009HisGln: 1.009 ± 0.489
1.682HisArg: 1.682 ± 1.099
1.009HisSer: 1.009 ± 0.574
1.345HisThr: 1.345 ± 0.876
1.009HisVal: 1.009 ± 0.574
0.673HisTrp: 0.673 ± 0.26
0.336HisTyr: 0.336 ± 0.275
0.0HisXaa: 0.0 ± 0.0
Ile
3.027IleAla: 3.027 ± 1.114
0.0IleCys: 0.0 ± 0.0
2.691IleAsp: 2.691 ± 0.752
1.009IleGlu: 1.009 ± 0.286
1.345IlePhe: 1.345 ± 0.472
2.355IleGly: 2.355 ± 0.642
1.345IleHis: 1.345 ± 0.588
2.018IleIle: 2.018 ± 0.579
1.345IleLys: 1.345 ± 0.66
3.027IleLeu: 3.027 ± 0.851
0.336IleMet: 0.336 ± 0.275
0.673IleAsn: 0.673 ± 0.26
4.373IlePro: 4.373 ± 1.595
1.682IleGln: 1.682 ± 0.553
1.682IleArg: 1.682 ± 1.087
2.018IleSer: 2.018 ± 1.047
2.691IleThr: 2.691 ± 0.489
2.691IleVal: 2.691 ± 0.446
0.0IleTrp: 0.0 ± 0.0
0.673IleTyr: 0.673 ± 0.618
0.0IleXaa: 0.0 ± 0.0
Lys
4.709LysAla: 4.709 ± 1.606
0.673LysCys: 0.673 ± 0.549
1.682LysAsp: 1.682 ± 0.825
1.345LysGlu: 1.345 ± 0.515
0.673LysPhe: 0.673 ± 0.26
2.691LysGly: 2.691 ± 1.09
1.345LysHis: 1.345 ± 1.099
0.336LysIle: 0.336 ± 0.275
0.336LysLys: 0.336 ± 0.291
2.691LysLeu: 2.691 ± 0.805
0.336LysMet: 0.336 ± 0.275
1.009LysAsn: 1.009 ± 0.69
2.691LysPro: 2.691 ± 0.535
0.336LysGln: 0.336 ± 0.275
2.018LysArg: 2.018 ± 0.856
0.673LysSer: 0.673 ± 0.26
2.018LysThr: 2.018 ± 0.761
0.673LysVal: 0.673 ± 0.26
1.009LysTrp: 1.009 ± 0.286
0.336LysTyr: 0.336 ± 0.23
0.0LysXaa: 0.0 ± 0.0
Leu
11.773LeuAla: 11.773 ± 2.958
0.336LeuCys: 0.336 ± 0.275
3.364LeuAsp: 3.364 ± 0.944
3.364LeuGlu: 3.364 ± 1.106
3.364LeuPhe: 3.364 ± 1.077
9.418LeuGly: 9.418 ± 1.314
1.682LeuHis: 1.682 ± 0.589
3.364LeuIle: 3.364 ± 1.671
2.355LeuLys: 2.355 ± 0.706
8.745LeuLeu: 8.745 ± 1.703
1.682LeuMet: 1.682 ± 0.72
1.345LeuAsn: 1.345 ± 1.169
10.427LeuPro: 10.427 ± 0.543
2.691LeuGln: 2.691 ± 1.109
5.045LeuArg: 5.045 ± 1.645
9.418LeuSer: 9.418 ± 1.875
7.4LeuThr: 7.4 ± 1.523
6.727LeuVal: 6.727 ± 0.794
1.345LeuTrp: 1.345 ± 0.625
3.364LeuTyr: 3.364 ± 0.484
0.0LeuXaa: 0.0 ± 0.0
Met
1.345MetAla: 1.345 ± 0.689
0.336MetCys: 0.336 ± 0.608
0.336MetAsp: 0.336 ± 0.275
1.009MetGlu: 1.009 ± 0.873
0.673MetPhe: 0.673 ± 0.344
1.682MetGly: 1.682 ± 0.644
0.0MetHis: 0.0 ± 0.0
0.336MetIle: 0.336 ± 0.23
0.0MetLys: 0.0 ± 0.0
1.682MetLeu: 1.682 ± 1.305
0.673MetMet: 0.673 ± 0.619
0.336MetAsn: 0.336 ± 0.608
0.673MetPro: 0.673 ± 0.46
1.009MetGln: 1.009 ± 0.574
1.682MetArg: 1.682 ± 1.103
2.018MetSer: 2.018 ± 0.63
1.682MetThr: 1.682 ± 1.186
1.682MetVal: 1.682 ± 0.644
0.336MetTrp: 0.336 ± 0.275
0.673MetTyr: 0.673 ± 0.549
0.0MetXaa: 0.0 ± 0.0
Asn
2.355AsnAla: 2.355 ± 0.944
0.0AsnCys: 0.0 ± 0.0
1.009AsnAsp: 1.009 ± 0.602
1.009AsnGlu: 1.009 ± 0.83
0.336AsnPhe: 0.336 ± 0.275
0.673AsnGly: 0.673 ± 0.46
0.336AsnHis: 0.336 ± 0.275
0.673AsnIle: 0.673 ± 0.26
0.336AsnLys: 0.336 ± 0.23
2.355AsnLeu: 2.355 ± 1.703
0.336AsnMet: 0.336 ± 0.23
0.673AsnAsn: 0.673 ± 0.603
1.682AsnPro: 1.682 ± 0.463
1.682AsnGln: 1.682 ± 0.799
2.355AsnArg: 2.355 ± 1.12
1.009AsnSer: 1.009 ± 1.209
0.336AsnThr: 0.336 ± 0.275
1.345AsnVal: 1.345 ± 0.608
1.345AsnTrp: 1.345 ± 0.521
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.727ProAla: 6.727 ± 1.981
1.345ProCys: 1.345 ± 0.521
4.373ProAsp: 4.373 ± 1.656
4.373ProGlu: 4.373 ± 0.149
0.673ProPhe: 0.673 ± 0.581
7.064ProGly: 7.064 ± 1.186
1.009ProHis: 1.009 ± 0.534
3.7ProIle: 3.7 ± 0.915
1.345ProLys: 1.345 ± 0.453
7.4ProLeu: 7.4 ± 1.297
0.0ProMet: 0.0 ± 0.0
2.691ProAsn: 2.691 ± 1.128
10.764ProPro: 10.764 ± 1.238
2.691ProGln: 2.691 ± 1.325
5.718ProArg: 5.718 ± 1.42
7.064ProSer: 7.064 ± 1.676
5.718ProThr: 5.718 ± 1.681
6.054ProVal: 6.054 ± 1.512
1.682ProTrp: 1.682 ± 0.644
2.355ProTyr: 2.355 ± 1.221
0.0ProXaa: 0.0 ± 0.0
Gln
3.364GlnAla: 3.364 ± 1.129
1.009GlnCys: 1.009 ± 0.68
2.018GlnAsp: 2.018 ± 0.978
1.009GlnGlu: 1.009 ± 0.552
0.673GlnPhe: 0.673 ± 0.26
4.036GlnGly: 4.036 ± 1.239
1.009GlnHis: 1.009 ± 0.55
0.673GlnIle: 0.673 ± 0.582
1.345GlnLys: 1.345 ± 0.716
3.7GlnLeu: 3.7 ± 0.684
0.673GlnMet: 0.673 ± 0.26
0.336GlnAsn: 0.336 ± 0.612
4.373GlnPro: 4.373 ± 1.143
2.691GlnGln: 2.691 ± 0.756
3.364GlnArg: 3.364 ± 1.205
3.364GlnSer: 3.364 ± 2.281
0.336GlnThr: 0.336 ± 0.291
3.364GlnVal: 3.364 ± 0.484
1.345GlnTrp: 1.345 ± 0.66
1.682GlnTyr: 1.682 ± 1.091
0.0GlnXaa: 0.0 ± 0.0
Arg
7.736ArgAla: 7.736 ± 1.194
1.682ArgCys: 1.682 ± 0.774
4.036ArgAsp: 4.036 ± 1.382
3.7ArgGlu: 3.7 ± 0.693
2.691ArgPhe: 2.691 ± 0.936
5.382ArgGly: 5.382 ± 1.215
1.345ArgHis: 1.345 ± 0.564
3.027ArgIle: 3.027 ± 1.073
0.336ArgLys: 0.336 ± 0.275
6.054ArgLeu: 6.054 ± 3.427
2.018ArgMet: 2.018 ± 0.548
2.691ArgAsn: 2.691 ± 1.224
2.691ArgPro: 2.691 ± 0.953
2.355ArgGln: 2.355 ± 0.921
4.373ArgArg: 4.373 ± 0.827
4.036ArgSer: 4.036 ± 1.064
3.7ArgThr: 3.7 ± 1.819
2.691ArgVal: 2.691 ± 0.805
2.691ArgTrp: 2.691 ± 1.114
3.7ArgTyr: 3.7 ± 0.636
0.0ArgXaa: 0.0 ± 0.0
Ser
6.727SerAla: 6.727 ± 2.063
1.009SerCys: 1.009 ± 0.83
3.364SerAsp: 3.364 ± 1.15
4.036SerGlu: 4.036 ± 2.636
0.673SerPhe: 0.673 ± 0.344
6.391SerGly: 6.391 ± 1.377
2.691SerHis: 2.691 ± 1.316
3.7SerIle: 3.7 ± 0.977
4.709SerLys: 4.709 ± 1.138
9.754SerLeu: 9.754 ± 1.173
1.682SerMet: 1.682 ± 0.565
0.673SerAsn: 0.673 ± 0.33
4.373SerPro: 4.373 ± 1.09
3.7SerGln: 3.7 ± 1.465
3.364SerArg: 3.364 ± 0.936
6.391SerSer: 6.391 ± 2.886
6.054SerThr: 6.054 ± 1.873
5.382SerVal: 5.382 ± 1.285
1.682SerTrp: 1.682 ± 0.484
2.018SerTyr: 2.018 ± 0.845
0.0SerXaa: 0.0 ± 0.0
Thr
4.709ThrAla: 4.709 ± 1.13
1.009ThrCys: 1.009 ± 0.793
4.709ThrAsp: 4.709 ± 1.506
3.027ThrGlu: 3.027 ± 0.933
2.355ThrPhe: 2.355 ± 0.889
3.7ThrGly: 3.7 ± 1.138
1.009ThrHis: 1.009 ± 0.672
1.682ThrIle: 1.682 ± 0.571
3.7ThrLys: 3.7 ± 1.193
6.727ThrLeu: 6.727 ± 1.499
2.018ThrMet: 2.018 ± 1.045
0.336ThrAsn: 0.336 ± 0.23
4.709ThrPro: 4.709 ± 0.557
2.691ThrGln: 2.691 ± 1.126
3.027ThrArg: 3.027 ± 1.695
4.373ThrSer: 4.373 ± 0.688
3.7ThrThr: 3.7 ± 1.009
4.373ThrVal: 4.373 ± 0.65
2.355ThrTrp: 2.355 ± 1.221
1.345ThrTyr: 1.345 ± 0.669
0.0ThrXaa: 0.0 ± 0.0
Val
8.409ValAla: 8.409 ± 0.831
1.345ValCys: 1.345 ± 1.797
2.691ValAsp: 2.691 ± 0.543
2.355ValGlu: 2.355 ± 0.434
2.355ValPhe: 2.355 ± 1.246
5.045ValGly: 5.045 ± 0.323
0.673ValHis: 0.673 ± 0.619
3.027ValIle: 3.027 ± 0.65
0.673ValLys: 0.673 ± 0.344
6.391ValLeu: 6.391 ± 1.056
1.345ValMet: 1.345 ± 0.588
1.345ValAsn: 1.345 ± 0.515
6.727ValPro: 6.727 ± 1.837
2.355ValGln: 2.355 ± 0.864
5.718ValArg: 5.718 ± 0.532
8.409ValSer: 8.409 ± 1.841
5.718ValThr: 5.718 ± 1.433
5.718ValVal: 5.718 ± 1.559
2.355ValTrp: 2.355 ± 0.728
0.336ValTyr: 0.336 ± 0.23
0.0ValXaa: 0.0 ± 0.0
Trp
3.364TrpAla: 3.364 ± 1.671
0.0TrpCys: 0.0 ± 0.0
2.018TrpAsp: 2.018 ± 0.445
1.009TrpGlu: 1.009 ± 0.68
1.345TrpPhe: 1.345 ± 0.742
2.018TrpGly: 2.018 ± 0.655
0.336TrpHis: 0.336 ± 0.23
1.009TrpIle: 1.009 ± 0.286
1.009TrpLys: 1.009 ± 0.55
2.018TrpLeu: 2.018 ± 1.031
0.336TrpMet: 0.336 ± 0.23
0.336TrpAsn: 0.336 ± 0.23
1.682TrpPro: 1.682 ± 0.736
0.336TrpGln: 0.336 ± 0.23
2.691TrpArg: 2.691 ± 0.887
0.673TrpSer: 0.673 ± 0.582
1.345TrpThr: 1.345 ± 0.564
2.691TrpVal: 2.691 ± 0.887
0.0TrpTrp: 0.0 ± 0.0
2.355TrpTyr: 2.355 ± 0.639
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.682TyrAla: 1.682 ± 0.825
0.0TyrCys: 0.0 ± 0.0
1.682TyrAsp: 1.682 ± 1.021
1.345TyrGlu: 1.345 ± 0.581
1.009TyrPhe: 1.009 ± 0.534
1.345TyrGly: 1.345 ± 0.876
1.009TyrHis: 1.009 ± 0.489
1.345TyrIle: 1.345 ± 0.521
0.0TyrLys: 0.0 ± 0.0
3.7TyrLeu: 3.7 ± 1.121
0.336TyrMet: 0.336 ± 0.291
0.0TyrAsn: 0.0 ± 0.0
3.364TyrPro: 3.364 ± 1.095
2.018TyrGln: 2.018 ± 0.966
3.027TyrArg: 3.027 ± 0.886
2.018TyrSer: 2.018 ± 1.133
2.691TyrThr: 2.691 ± 0.556
2.691TyrVal: 2.691 ± 0.525
0.336TyrTrp: 0.336 ± 0.23
2.355TyrTyr: 2.355 ± 0.654
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski