Amino acid dipepetide frequency for Treponema porcinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.989AlaAla: 7.989 ± 0.155
1.105AlaCys: 1.105 ± 0.042
5.127AlaAsp: 5.127 ± 0.109
6.554AlaGlu: 6.554 ± 0.115
3.57AlaPhe: 3.57 ± 0.085
6.411AlaGly: 6.411 ± 0.103
1.094AlaHis: 1.094 ± 0.042
4.141AlaIle: 4.141 ± 0.085
4.87AlaLys: 4.87 ± 0.088
7.126AlaLeu: 7.126 ± 0.12
1.766AlaMet: 1.766 ± 0.048
2.595AlaAsn: 2.595 ± 0.069
2.226AlaPro: 2.226 ± 0.063
2.611AlaGln: 2.611 ± 0.068
3.2AlaArg: 3.2 ± 0.08
4.874AlaSer: 4.874 ± 0.088
2.988AlaThr: 2.988 ± 0.081
7.205AlaVal: 7.205 ± 0.115
0.604AlaTrp: 0.604 ± 0.035
2.519AlaTyr: 2.519 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
1.521CysAla: 1.521 ± 0.052
0.284CysCys: 0.284 ± 0.021
0.796CysAsp: 0.796 ± 0.033
0.747CysGlu: 0.747 ± 0.033
0.756CysPhe: 0.756 ± 0.037
1.528CysGly: 1.528 ± 0.053
0.238CysHis: 0.238 ± 0.018
1.151CysIle: 1.151 ± 0.044
0.689CysLys: 0.689 ± 0.032
1.11CysLeu: 1.11 ± 0.038
0.34CysMet: 0.34 ± 0.024
0.556CysAsn: 0.556 ± 0.027
0.64CysPro: 0.64 ± 0.037
0.314CysGln: 0.314 ± 0.019
0.873CysArg: 0.873 ± 0.034
1.131CysSer: 1.131 ± 0.041
0.902CysThr: 0.902 ± 0.035
0.983CysVal: 0.983 ± 0.037
0.134CysTrp: 0.134 ± 0.013
0.526CysTyr: 0.526 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.457AspAla: 4.457 ± 0.084
0.829AspCys: 0.829 ± 0.03
3.36AspAsp: 3.36 ± 0.092
4.62AspGlu: 4.62 ± 0.084
3.658AspPhe: 3.658 ± 0.068
4.723AspGly: 4.723 ± 0.109
0.56AspHis: 0.56 ± 0.029
4.3AspIle: 4.3 ± 0.079
3.343AspLys: 3.343 ± 0.081
4.088AspLeu: 4.088 ± 0.085
1.359AspMet: 1.359 ± 0.044
2.199AspAsn: 2.199 ± 0.069
1.549AspPro: 1.549 ± 0.044
0.825AspGln: 0.825 ± 0.039
2.097AspArg: 2.097 ± 0.051
4.205AspSer: 4.205 ± 0.092
2.842AspThr: 2.842 ± 0.072
3.809AspVal: 3.809 ± 0.072
0.669AspTrp: 0.669 ± 0.034
2.452AspTyr: 2.452 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
4.743GluAla: 4.743 ± 0.089
0.931GluCys: 0.931 ± 0.04
3.4GluAsp: 3.4 ± 0.077
5.544GluGlu: 5.544 ± 0.135
2.806GluPhe: 2.806 ± 0.065
3.353GluGly: 3.353 ± 0.069
1.08GluHis: 1.08 ± 0.045
5.48GluIle: 5.48 ± 0.088
7.496GluLys: 7.496 ± 0.13
6.097GluLeu: 6.097 ± 0.104
1.855GluMet: 1.855 ± 0.051
4.94GluAsn: 4.94 ± 0.091
2.084GluPro: 2.084 ± 0.076
2.681GluGln: 2.681 ± 0.079
3.181GluArg: 3.181 ± 0.083
3.977GluSer: 3.977 ± 0.083
3.849GluThr: 3.849 ± 0.083
3.585GluVal: 3.585 ± 0.074
0.7GluTrp: 0.7 ± 0.033
2.701GluTyr: 2.701 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
3.737PheAla: 3.737 ± 0.086
1.016PheCys: 1.016 ± 0.04
2.94PheAsp: 2.94 ± 0.072
3.009PheGlu: 3.009 ± 0.07
2.786PhePhe: 2.786 ± 0.08
3.254PheGly: 3.254 ± 0.073
0.706PheHis: 0.706 ± 0.031
3.553PheIle: 3.553 ± 0.07
2.591PheLys: 2.591 ± 0.068
4.364PheLeu: 4.364 ± 0.098
1.141PheMet: 1.141 ± 0.039
2.138PheAsn: 2.138 ± 0.065
1.865PhePro: 1.865 ± 0.05
1.162PheGln: 1.162 ± 0.04
2.031PheArg: 2.031 ± 0.048
4.605PheSer: 4.605 ± 0.101
3.058PheThr: 3.058 ± 0.065
3.144PheVal: 3.144 ± 0.073
0.445PheTrp: 0.445 ± 0.027
1.936PheTyr: 1.936 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.036GlyAla: 5.036 ± 0.111
1.098GlyCys: 1.098 ± 0.034
3.147GlyAsp: 3.147 ± 0.076
3.908GlyGlu: 3.908 ± 0.072
3.377GlyPhe: 3.377 ± 0.074
4.624GlyGly: 4.624 ± 0.136
0.954GlyHis: 0.954 ± 0.037
5.854GlyIle: 5.854 ± 0.093
5.605GlyLys: 5.605 ± 0.087
5.238GlyLeu: 5.238 ± 0.101
1.807GlyMet: 1.807 ± 0.06
3.304GlyAsn: 3.304 ± 0.085
1.157GlyPro: 1.157 ± 0.048
1.594GlyGln: 1.594 ± 0.051
2.731GlyArg: 2.731 ± 0.067
4.349GlySer: 4.349 ± 0.094
4.732GlyThr: 4.732 ± 0.131
4.118GlyVal: 4.118 ± 0.087
0.735GlyTrp: 0.735 ± 0.033
2.586GlyTyr: 2.586 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
0.865HisAla: 0.865 ± 0.033
0.265HisCys: 0.265 ± 0.017
0.751HisAsp: 0.751 ± 0.036
0.823HisGlu: 0.823 ± 0.037
0.894HisPhe: 0.894 ± 0.033
0.986HisGly: 0.986 ± 0.045
0.307HisHis: 0.307 ± 0.022
1.297HisIle: 1.297 ± 0.039
0.918HisLys: 0.918 ± 0.032
1.428HisLeu: 1.428 ± 0.045
0.241HisMet: 0.241 ± 0.015
0.729HisAsn: 0.729 ± 0.029
0.809HisPro: 0.809 ± 0.03
0.411HisGln: 0.411 ± 0.021
0.615HisArg: 0.615 ± 0.028
1.096HisSer: 1.096 ± 0.036
0.889HisThr: 0.889 ± 0.033
0.784HisVal: 0.784 ± 0.034
0.168HisTrp: 0.168 ± 0.015
0.601HisTyr: 0.601 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.727IleAla: 5.727 ± 0.09
1.143IleCys: 1.143 ± 0.046
4.134IleAsp: 4.134 ± 0.081
4.728IleGlu: 4.728 ± 0.087
3.203IlePhe: 3.203 ± 0.074
3.985IleGly: 3.985 ± 0.069
1.117IleHis: 1.117 ± 0.034
5.113IleIle: 5.113 ± 0.111
4.604IleLys: 4.604 ± 0.084
6.314IleLeu: 6.314 ± 0.105
1.53IleMet: 1.53 ± 0.044
3.062IleAsn: 3.062 ± 0.072
3.442IlePro: 3.442 ± 0.063
2.434IleGln: 2.434 ± 0.057
3.226IleArg: 3.226 ± 0.071
5.605IleSer: 5.605 ± 0.091
4.502IleThr: 4.502 ± 0.107
4.454IleVal: 4.454 ± 0.098
0.484IleTrp: 0.484 ± 0.026
2.297IleTyr: 2.297 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.249LysAla: 5.249 ± 0.105
0.775LysCys: 0.775 ± 0.031
4.169LysAsp: 4.169 ± 0.084
5.446LysGlu: 5.446 ± 0.109
2.397LysPhe: 2.397 ± 0.062
3.878LysGly: 3.878 ± 0.069
0.921LysHis: 0.921 ± 0.037
5.8LysIle: 5.8 ± 0.099
6.815LysLys: 6.815 ± 0.102
5.375LysLeu: 5.375 ± 0.085
2.047LysMet: 2.047 ± 0.045
4.972LysAsn: 4.972 ± 0.091
2.239LysPro: 2.239 ± 0.058
2.284LysGln: 2.284 ± 0.055
2.793LysArg: 2.793 ± 0.06
4.553LysSer: 4.553 ± 0.085
4.735LysThr: 4.735 ± 0.085
3.633LysVal: 3.633 ± 0.078
0.623LysTrp: 0.623 ± 0.028
2.691LysTyr: 2.691 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
6.267LeuAla: 6.267 ± 0.123
1.596LeuCys: 1.596 ± 0.046
4.727LeuAsp: 4.727 ± 0.088
5.837LeuGlu: 5.837 ± 0.114
4.776LeuPhe: 4.776 ± 0.1
5.143LeuGly: 5.143 ± 0.085
1.547LeuHis: 1.547 ± 0.046
5.302LeuIle: 5.302 ± 0.1
6.074LeuLys: 6.074 ± 0.109
7.964LeuLeu: 7.964 ± 0.127
2.02LeuMet: 2.02 ± 0.053
4.116LeuAsn: 4.116 ± 0.091
3.69LeuPro: 3.69 ± 0.072
2.541LeuGln: 2.541 ± 0.061
3.573LeuArg: 3.573 ± 0.08
7.509LeuSer: 7.509 ± 0.108
4.539LeuThr: 4.539 ± 0.083
5.291LeuVal: 5.291 ± 0.093
0.731LeuTrp: 0.731 ± 0.032
3.392LeuTyr: 3.392 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
1.795MetAla: 1.795 ± 0.052
0.293MetCys: 0.293 ± 0.021
1.158MetAsp: 1.158 ± 0.04
1.702MetGlu: 1.702 ± 0.042
0.893MetPhe: 0.893 ± 0.032
1.361MetGly: 1.361 ± 0.047
0.417MetHis: 0.417 ± 0.025
1.736MetIle: 1.736 ± 0.045
2.291MetLys: 2.291 ± 0.056
2.108MetLeu: 2.108 ± 0.06
0.654MetMet: 0.654 ± 0.03
1.496MetAsn: 1.496 ± 0.043
0.95MetPro: 0.95 ± 0.043
0.959MetGln: 0.959 ± 0.035
0.994MetArg: 0.994 ± 0.037
1.55MetSer: 1.55 ± 0.049
1.493MetThr: 1.493 ± 0.052
1.174MetVal: 1.174 ± 0.048
0.134MetTrp: 0.134 ± 0.012
0.751MetTyr: 0.751 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.164AsnAla: 4.164 ± 0.083
0.729AsnCys: 0.729 ± 0.032
2.595AsnAsp: 2.595 ± 0.062
3.17AsnGlu: 3.17 ± 0.092
1.993AsnPhe: 1.993 ± 0.054
3.961AsnGly: 3.961 ± 0.094
0.727AsnHis: 0.727 ± 0.035
3.513AsnIle: 3.513 ± 0.076
2.954AsnLys: 2.954 ± 0.07
3.922AsnLeu: 3.922 ± 0.065
1.178AsnMet: 1.178 ± 0.042
2.061AsnAsn: 2.061 ± 0.082
2.479AsnPro: 2.479 ± 0.067
1.391AsnGln: 1.391 ± 0.045
2.114AsnArg: 2.114 ± 0.053
3.274AsnSer: 3.274 ± 0.082
2.601AsnThr: 2.601 ± 0.055
3.117AsnVal: 3.117 ± 0.08
0.501AsnTrp: 0.501 ± 0.027
1.763AsnTyr: 1.763 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
3.051ProAla: 3.051 ± 0.072
0.503ProCys: 0.503 ± 0.028
2.512ProAsp: 2.512 ± 0.059
3.769ProGlu: 3.769 ± 0.074
1.986ProPhe: 1.986 ± 0.05
2.296ProGly: 2.296 ± 0.064
0.541ProHis: 0.541 ± 0.027
1.497ProIle: 1.497 ± 0.043
1.941ProLys: 1.941 ± 0.057
3.215ProLeu: 3.215 ± 0.068
0.62ProMet: 0.62 ± 0.035
1.273ProAsn: 1.273 ± 0.041
1.023ProPro: 1.023 ± 0.042
1.215ProGln: 1.215 ± 0.04
1.104ProArg: 1.104 ± 0.039
2.435ProSer: 2.435 ± 0.072
1.263ProThr: 1.263 ± 0.039
3.619ProVal: 3.619 ± 0.086
0.318ProTrp: 0.318 ± 0.023
1.431ProTyr: 1.431 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
2.224GlnAla: 2.224 ± 0.055
0.354GlnCys: 0.354 ± 0.02
1.347GlnAsp: 1.347 ± 0.042
2.125GlnGlu: 2.125 ± 0.062
1.493GlnPhe: 1.493 ± 0.047
1.577GlnGly: 1.577 ± 0.043
0.452GlnHis: 0.452 ± 0.023
2.432GlnIle: 2.432 ± 0.057
3.099GlnLys: 3.099 ± 0.076
2.651GlnLeu: 2.651 ± 0.063
0.896GlnMet: 0.896 ± 0.035
2.121GlnAsn: 2.121 ± 0.053
0.943GlnPro: 0.943 ± 0.041
1.114GlnGln: 1.114 ± 0.043
1.18GlnArg: 1.18 ± 0.047
1.804GlnSer: 1.804 ± 0.052
1.781GlnThr: 1.781 ± 0.052
1.537GlnVal: 1.537 ± 0.045
0.24GlnTrp: 0.24 ± 0.02
1.082GlnTyr: 1.082 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.896ArgAla: 2.896 ± 0.067
0.552ArgCys: 0.552 ± 0.031
2.004ArgAsp: 2.004 ± 0.057
2.691ArgGlu: 2.691 ± 0.065
2.122ArgPhe: 2.122 ± 0.049
2.186ArgGly: 2.186 ± 0.058
0.673ArgHis: 0.673 ± 0.033
3.593ArgIle: 3.593 ± 0.074
3.152ArgLys: 3.152 ± 0.072
4.004ArgLeu: 4.004 ± 0.094
1.223ArgMet: 1.223 ± 0.047
2.393ArgAsn: 2.393 ± 0.062
1.354ArgPro: 1.354 ± 0.046
1.512ArgGln: 1.512 ± 0.055
2.273ArgArg: 2.273 ± 0.061
2.309ArgSer: 2.309 ± 0.055
2.719ArgThr: 2.719 ± 0.063
2.193ArgVal: 2.193 ± 0.066
0.397ArgTrp: 0.397 ± 0.024
1.533ArgTyr: 1.533 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.217SerAla: 6.217 ± 0.097
1.113SerCys: 1.113 ± 0.037
4.315SerAsp: 4.315 ± 0.086
4.864SerGlu: 4.864 ± 0.102
4.104SerPhe: 4.104 ± 0.08
5.857SerGly: 5.857 ± 0.122
0.898SerHis: 0.898 ± 0.039
4.436SerIle: 4.436 ± 0.08
3.914SerLys: 3.914 ± 0.082
6.367SerLeu: 6.367 ± 0.108
1.432SerMet: 1.432 ± 0.039
2.574SerAsn: 2.574 ± 0.072
2.264SerPro: 2.264 ± 0.051
2.007SerGln: 2.007 ± 0.059
2.891SerArg: 2.891 ± 0.069
5.544SerSer: 5.544 ± 0.127
3.217SerThr: 3.217 ± 0.084
5.825SerVal: 5.825 ± 0.102
0.753SerTrp: 0.753 ± 0.034
2.81SerTyr: 2.81 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
5.081ThrAla: 5.081 ± 0.092
0.627ThrCys: 0.627 ± 0.028
3.46ThrAsp: 3.46 ± 0.082
4.024ThrGlu: 4.024 ± 0.083
2.646ThrPhe: 2.646 ± 0.071
4.73ThrGly: 4.73 ± 0.109
0.837ThrHis: 0.837 ± 0.031
3.706ThrIle: 3.706 ± 0.094
3.296ThrLys: 3.296 ± 0.075
4.775ThrLeu: 4.775 ± 0.097
1.155ThrMet: 1.155 ± 0.038
2.093ThrAsn: 2.093 ± 0.071
2.273ThrPro: 2.273 ± 0.057
1.64ThrGln: 1.64 ± 0.05
1.77ThrArg: 1.77 ± 0.051
3.369ThrSer: 3.369 ± 0.079
2.728ThrThr: 2.728 ± 0.102
5.232ThrVal: 5.232 ± 0.112
0.436ThrTrp: 0.436 ± 0.026
1.86ThrTyr: 1.86 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.094ValAla: 4.094 ± 0.086
1.3ValCys: 1.3 ± 0.046
3.258ValAsp: 3.258 ± 0.075
3.923ValGlu: 3.923 ± 0.087
3.589ValPhe: 3.589 ± 0.082
3.068ValGly: 3.068 ± 0.079
1.069ValHis: 1.069 ± 0.042
4.946ValIle: 4.946 ± 0.084
4.457ValLys: 4.457 ± 0.079
6.628ValLeu: 6.628 ± 0.104
1.563ValMet: 1.563 ± 0.045
2.92ValAsn: 2.92 ± 0.068
3.052ValPro: 3.052 ± 0.081
2.411ValGln: 2.411 ± 0.058
3.079ValArg: 3.079 ± 0.074
5.733ValSer: 5.733 ± 0.101
4.014ValThr: 4.014 ± 0.12
4.312ValVal: 4.312 ± 0.092
0.629ValTrp: 0.629 ± 0.031
2.541ValTyr: 2.541 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.59TrpAla: 0.59 ± 0.03
0.162TrpCys: 0.162 ± 0.016
0.462TrpAsp: 0.462 ± 0.025
0.586TrpGlu: 0.586 ± 0.032
0.461TrpPhe: 0.461 ± 0.027
0.514TrpGly: 0.514 ± 0.028
0.178TrpHis: 0.178 ± 0.017
0.635TrpIle: 0.635 ± 0.029
0.791TrpLys: 0.791 ± 0.039
0.791TrpLeu: 0.791 ± 0.039
0.212TrpMet: 0.212 ± 0.018
0.715TrpAsn: 0.715 ± 0.034
0.204TrpPro: 0.204 ± 0.018
0.374TrpGln: 0.374 ± 0.025
0.37TrpArg: 0.37 ± 0.023
0.592TrpSer: 0.592 ± 0.03
0.588TrpThr: 0.588 ± 0.036
0.411TrpVal: 0.411 ± 0.023
0.135TrpTrp: 0.135 ± 0.014
0.444TrpTyr: 0.444 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.872TyrAla: 2.872 ± 0.079
0.546TyrCys: 0.546 ± 0.025
2.284TyrAsp: 2.284 ± 0.06
2.413TyrGlu: 2.413 ± 0.057
1.97TyrPhe: 1.97 ± 0.06
2.521TyrGly: 2.521 ± 0.064
0.56TyrHis: 0.56 ± 0.029
2.619TyrIle: 2.619 ± 0.063
2.495TyrLys: 2.495 ± 0.063
3.071TyrLeu: 3.071 ± 0.058
0.866TyrMet: 0.866 ± 0.033
1.949TyrAsn: 1.949 ± 0.052
1.369TyrPro: 1.369 ± 0.042
0.972TyrGln: 0.972 ± 0.045
1.685TyrArg: 1.685 ± 0.048
2.886TyrSer: 2.886 ± 0.066
2.3TyrThr: 2.3 ± 0.058
2.161TyrVal: 2.161 ± 0.052
0.378TyrTrp: 0.378 ± 0.023
1.508TyrTyr: 1.508 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2189 proteins (754806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski