Amino acid dipepetide frequency for Hyphomicrobium facile

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.153AlaAla: 16.153 ± 0.161	1.027AlaCys: 1.027 ± 0.027	6.518AlaAsp: 6.518 ± 0.075	7.139AlaGlu: 7.139 ± 0.094	4.37AlaPhe: 4.37 ± 0.065	9.709AlaGly: 9.709 ± 0.096	2.174AlaHis: 2.174 ± 0.04	6.682AlaIle: 6.682 ± 0.095	5.196AlaLys: 5.196 ± 0.068	12.398AlaLeu: 12.398 ± 0.123	3.102AlaMet: 3.102 ± 0.052	3.389AlaAsn: 3.389 ± 0.053	5.525AlaPro: 5.525 ± 0.094	3.611AlaGln: 3.611 ± 0.058	7.712AlaArg: 7.712 ± 0.095	7.175AlaSer: 7.175 ± 0.08	6.084AlaThr: 6.084 ± 0.068	8.225AlaVal: 8.225 ± 0.09	1.43AlaTrp: 1.43 ± 0.035	2.479AlaTyr: 2.479 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.965CysAla: 0.965 ± 0.029	0.12CysCys: 0.12 ± 0.011	0.476CysAsp: 0.476 ± 0.022	0.448CysGlu: 0.448 ± 0.018	0.352CysPhe: 0.352 ± 0.017	0.865CysGly: 0.865 ± 0.028	0.248CysHis: 0.248 ± 0.017	0.421CysIle: 0.421 ± 0.019	0.277CysLys: 0.277 ± 0.016	0.817CysLeu: 0.817 ± 0.025	0.19CysMet: 0.19 ± 0.013	0.252CysAsn: 0.252 ± 0.015	0.453CysPro: 0.453 ± 0.018	0.241CysGln: 0.241 ± 0.014	0.61CysArg: 0.61 ± 0.022	0.533CysSer: 0.533 ± 0.022	0.416CysThr: 0.416 ± 0.02	0.603CysVal: 0.603 ± 0.021	0.119CysTrp: 0.119 ± 0.01	0.234CysTyr: 0.234 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.633AspAla: 6.633 ± 0.079	0.512AspCys: 0.512 ± 0.018	3.327AspAsp: 3.327 ± 0.058	3.432AspGlu: 3.432 ± 0.049	2.126AspPhe: 2.126 ± 0.039	4.791AspGly: 4.791 ± 0.068	1.115AspHis: 1.115 ± 0.033	3.168AspIle: 3.168 ± 0.048	2.02AspLys: 2.02 ± 0.044	5.49AspLeu: 5.49 ± 0.074	1.113AspMet: 1.113 ± 0.03	1.416AspAsn: 1.416 ± 0.037	3.179AspPro: 3.179 ± 0.052	1.801AspGln: 1.801 ± 0.042	3.986AspArg: 3.986 ± 0.053	2.251AspSer: 2.251 ± 0.046	2.595AspThr: 2.595 ± 0.051	4.453AspVal: 4.453 ± 0.062	0.884AspTrp: 0.884 ± 0.027	1.462AspTyr: 1.462 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.083GluAla: 7.083 ± 0.094	0.406GluCys: 0.406 ± 0.015	2.644GluAsp: 2.644 ± 0.048	2.957GluGlu: 2.957 ± 0.061	1.966GluPhe: 1.966 ± 0.041	3.955GluGly: 3.955 ± 0.053	1.215GluHis: 1.215 ± 0.029	3.745GluIle: 3.745 ± 0.058	2.739GluLys: 2.739 ± 0.052	5.384GluLeu: 5.384 ± 0.073	1.414GluMet: 1.414 ± 0.033	1.691GluAsn: 1.691 ± 0.038	2.796GluPro: 2.796 ± 0.05	2.022GluGln: 2.022 ± 0.043	4.778GluArg: 4.778 ± 0.073	2.474GluSer: 2.474 ± 0.052	3.512GluThr: 3.512 ± 0.057	3.615GluVal: 3.615 ± 0.053	0.681GluTrp: 0.681 ± 0.021	1.042GluTyr: 1.042 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.771PheAla: 4.771 ± 0.069	0.401PheCys: 0.401 ± 0.018	2.558PheAsp: 2.558 ± 0.046	2.312PheGlu: 2.312 ± 0.05	1.475PhePhe: 1.475 ± 0.039	3.565PheGly: 3.565 ± 0.059	0.72PheHis: 0.72 ± 0.021	1.868PheIle: 1.868 ± 0.042	1.352PheLys: 1.352 ± 0.038	3.402PheLeu: 3.402 ± 0.052	0.777PheMet: 0.777 ± 0.023	1.169PheAsn: 1.169 ± 0.029	1.655PhePro: 1.655 ± 0.04	1.071PheGln: 1.071 ± 0.03	2.182PheArg: 2.182 ± 0.045	2.478PheSer: 2.478 ± 0.046	1.94PheThr: 1.94 ± 0.044	2.933PheVal: 2.933 ± 0.053	0.589PheTrp: 0.589 ± 0.023	0.918PheTyr: 0.918 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.505GlyAla: 8.505 ± 0.089	0.82GlyCys: 0.82 ± 0.026	4.26GlyAsp: 4.26 ± 0.069	4.31GlyGlu: 4.31 ± 0.055	3.446GlyPhe: 3.446 ± 0.052	6.971GlyGly: 6.971 ± 0.11	1.825GlyHis: 1.825 ± 0.042	4.689GlyIle: 4.689 ± 0.074	3.624GlyLys: 3.624 ± 0.062	8.207GlyLeu: 8.207 ± 0.086	1.961GlyMet: 1.961 ± 0.043	2.315GlyAsn: 2.315 ± 0.05	3.534GlyPro: 3.534 ± 0.052	2.68GlyGln: 2.68 ± 0.046	5.468GlyArg: 5.468 ± 0.061	5.005GlySer: 5.005 ± 0.062	4.428GlyThr: 4.428 ± 0.063	5.89GlyVal: 5.89 ± 0.069	1.285GlyTrp: 1.285 ± 0.034	2.341GlyTyr: 2.341 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.121HisAla: 2.121 ± 0.045	0.226HisCys: 0.226 ± 0.014	1.172HisAsp: 1.172 ± 0.03	1.027HisGlu: 1.027 ± 0.032	0.919HisPhe: 0.919 ± 0.028	1.739HisGly: 1.739 ± 0.042	0.566HisHis: 0.566 ± 0.024	1.026HisIle: 1.026 ± 0.033	0.609HisLys: 0.609 ± 0.022	1.886HisLeu: 1.886 ± 0.043	0.507HisMet: 0.507 ± 0.02	0.504HisAsn: 0.504 ± 0.022	1.249HisPro: 1.249 ± 0.03	0.579HisGln: 0.579 ± 0.022	1.387HisArg: 1.387 ± 0.037	1.067HisSer: 1.067 ± 0.028	0.868HisThr: 0.868 ± 0.027	1.514HisVal: 1.514 ± 0.034	0.305HisTrp: 0.305 ± 0.017	0.579HisTyr: 0.579 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.878IleAla: 7.878 ± 0.09	0.578IleCys: 0.578 ± 0.022	3.7IleAsp: 3.7 ± 0.054	3.787IleGlu: 3.787 ± 0.064	1.928IlePhe: 1.928 ± 0.038	4.908IleGly: 4.908 ± 0.067	0.891IleHis: 0.891 ± 0.03	2.648IleIle: 2.648 ± 0.05	1.987IleLys: 1.987 ± 0.042	4.633IleLeu: 4.633 ± 0.076	0.966IleMet: 0.966 ± 0.026	1.587IleAsn: 1.587 ± 0.039	2.492IlePro: 2.492 ± 0.045	1.271IleGln: 1.271 ± 0.033	3.171IleArg: 3.171 ± 0.042	3.553IleSer: 3.553 ± 0.062	2.825IleThr: 2.825 ± 0.05	4.666IleVal: 4.666 ± 0.067	0.641IleTrp: 0.641 ± 0.024	1.24IleTyr: 1.24 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.817LysAla: 4.817 ± 0.074	0.24LysCys: 0.24 ± 0.014	2.138LysAsp: 2.138 ± 0.048	1.985LysGlu: 1.985 ± 0.046	1.327LysPhe: 1.327 ± 0.033	2.99LysGly: 2.99 ± 0.043	0.769LysHis: 0.769 ± 0.024	2.396LysIle: 2.396 ± 0.049	1.968LysLys: 1.968 ± 0.046	4.001LysLeu: 4.001 ± 0.065	0.919LysMet: 0.919 ± 0.024	1.224LysAsn: 1.224 ± 0.033	2.672LysPro: 2.672 ± 0.046	1.24LysGln: 1.24 ± 0.038	2.882LysArg: 2.882 ± 0.047	2.839LysSer: 2.839 ± 0.049	2.496LysThr: 2.496 ± 0.043	2.745LysVal: 2.745 ± 0.05	0.446LysTrp: 0.446 ± 0.02	0.872LysTyr: 0.872 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.532LeuAla: 12.532 ± 0.13	0.825LeuCys: 0.825 ± 0.027	5.577LeuAsp: 5.577 ± 0.074	5.229LeuGlu: 5.229 ± 0.067	3.558LeuPhe: 3.558 ± 0.056	7.829LeuGly: 7.829 ± 0.072	1.708LeuHis: 1.708 ± 0.037	5.281LeuIle: 5.281 ± 0.06	4.547LeuLys: 4.547 ± 0.059	9.121LeuLeu: 9.121 ± 0.116	2.117LeuMet: 2.117 ± 0.042	2.699LeuAsn: 2.699 ± 0.047	5.267LeuPro: 5.267 ± 0.075	2.732LeuGln: 2.732 ± 0.049	6.173LeuArg: 6.173 ± 0.08	6.55LeuSer: 6.55 ± 0.09	5.466LeuThr: 5.466 ± 0.063	7.079LeuVal: 7.079 ± 0.077	1.098LeuTrp: 1.098 ± 0.029	2.07LeuTyr: 2.07 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.713MetAla: 2.713 ± 0.045	0.158MetCys: 0.158 ± 0.01	0.944MetAsp: 0.944 ± 0.027	0.907MetGlu: 0.907 ± 0.027	0.721MetPhe: 0.721 ± 0.024	1.523MetGly: 1.523 ± 0.035	0.472MetHis: 0.472 ± 0.017	1.28MetIle: 1.28 ± 0.03	1.108MetLys: 1.108 ± 0.026	2.288MetLeu: 2.288 ± 0.049	0.623MetMet: 0.623 ± 0.024	0.754MetAsn: 0.754 ± 0.026	1.378MetPro: 1.378 ± 0.034	0.8MetGln: 0.8 ± 0.027	1.742MetArg: 1.742 ± 0.033	1.709MetSer: 1.709 ± 0.034	1.804MetThr: 1.804 ± 0.037	1.402MetVal: 1.402 ± 0.033	0.217MetTrp: 0.217 ± 0.013	0.328MetTyr: 0.328 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.462AsnAla: 3.462 ± 0.054	0.286AsnCys: 0.286 ± 0.014	1.581AsnAsp: 1.581 ± 0.036	1.392AsnGlu: 1.392 ± 0.034	1.15AsnPhe: 1.15 ± 0.034	2.583AsnGly: 2.583 ± 0.054	0.511AsnHis: 0.511 ± 0.019	1.569AsnIle: 1.569 ± 0.04	0.926AsnLys: 0.926 ± 0.029	2.791AsnLeu: 2.791 ± 0.045	0.574AsnMet: 0.574 ± 0.02	0.817AsnAsn: 0.817 ± 0.032	1.883AsnPro: 1.883 ± 0.04	0.839AsnGln: 0.839 ± 0.027	1.854AsnArg: 1.854 ± 0.039	1.681AsnSer: 1.681 ± 0.046	1.409AsnThr: 1.409 ± 0.037	2.363AsnVal: 2.363 ± 0.047	0.5AsnTrp: 0.5 ± 0.022	0.737AsnTyr: 0.737 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.049ProAla: 6.049 ± 0.089	0.297ProCys: 0.297 ± 0.017	3.383ProAsp: 3.383 ± 0.055	3.688ProGlu: 3.688 ± 0.061	2.009ProPhe: 2.009 ± 0.039	4.384ProGly: 4.384 ± 0.071	1.089ProHis: 1.089 ± 0.031	2.554ProIle: 2.554 ± 0.04	2.207ProLys: 2.207 ± 0.043	4.59ProLeu: 4.59 ± 0.056	1.164ProMet: 1.164 ± 0.029	1.589ProAsn: 1.589 ± 0.034	2.938ProPro: 2.938 ± 0.067	1.662ProGln: 1.662 ± 0.043	2.966ProArg: 2.966 ± 0.056	3.464ProSer: 3.464 ± 0.052	2.517ProThr: 2.517 ± 0.043	3.87ProVal: 3.87 ± 0.059	0.694ProTrp: 0.694 ± 0.026	1.247ProTyr: 1.247 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.404GlnAla: 3.404 ± 0.054	0.217GlnCys: 0.217 ± 0.012	1.352GlnAsp: 1.352 ± 0.034	1.37GlnGlu: 1.37 ± 0.03	1.126GlnPhe: 1.126 ± 0.031	2.099GlnGly: 2.099 ± 0.046	0.642GlnHis: 0.642 ± 0.026	1.846GlnIle: 1.846 ± 0.042	1.414GlnLys: 1.414 ± 0.034	2.896GlnLeu: 2.896 ± 0.045	0.825GlnMet: 0.825 ± 0.029	0.966GlnAsn: 0.966 ± 0.028	1.712GlnPro: 1.712 ± 0.039	1.233GlnGln: 1.233 ± 0.046	2.347GlnArg: 2.347 ± 0.042	2.225GlnSer: 2.225 ± 0.05	1.755GlnThr: 1.755 ± 0.039	1.997GlnVal: 1.997 ± 0.046	0.395GlnTrp: 0.395 ± 0.019	0.673GlnTyr: 0.673 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.177ArgAla: 7.177 ± 0.094	0.537ArgCys: 0.537 ± 0.021	3.896ArgAsp: 3.896 ± 0.059	3.993ArgGlu: 3.993 ± 0.062	2.697ArgPhe: 2.697 ± 0.047	4.565ArgGly: 4.565 ± 0.064	1.558ArgHis: 1.558 ± 0.04	3.922ArgIle: 3.922 ± 0.056	2.601ArgLys: 2.601 ± 0.05	7.122ArgLeu: 7.122 ± 0.097	1.668ArgMet: 1.668 ± 0.037	2.036ArgAsn: 2.036 ± 0.038	3.409ArgPro: 3.409 ± 0.056	2.2ArgGln: 2.2 ± 0.041	5.209ArgArg: 5.209 ± 0.083	4.082ArgSer: 4.082 ± 0.05	3.307ArgThr: 3.307 ± 0.052	4.672ArgVal: 4.672 ± 0.067	0.935ArgTrp: 0.935 ± 0.027	1.747ArgTyr: 1.747 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.03SerAla: 7.03 ± 0.091	0.471SerCys: 0.471 ± 0.018	3.442SerAsp: 3.442 ± 0.049	3.509SerGlu: 3.509 ± 0.056	2.409SerPhe: 2.409 ± 0.043	5.857SerGly: 5.857 ± 0.076	1.168SerHis: 1.168 ± 0.028	3.197SerIle: 3.197 ± 0.057	2.368SerLys: 2.368 ± 0.052	5.704SerLeu: 5.704 ± 0.082	1.395SerMet: 1.395 ± 0.032	1.861SerAsn: 1.861 ± 0.043	3.305SerPro: 3.305 ± 0.052	1.842SerGln: 1.842 ± 0.037	4.004SerArg: 4.004 ± 0.062	3.84SerSer: 3.84 ± 0.059	3.068SerThr: 3.068 ± 0.052	4.356SerVal: 4.356 ± 0.061	0.808SerTrp: 0.808 ± 0.025	1.424SerTyr: 1.424 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.207ThrAla: 6.207 ± 0.065	0.46ThrCys: 0.46 ± 0.017	2.745ThrAsp: 2.745 ± 0.049	2.658ThrGlu: 2.658 ± 0.043	2.218ThrPhe: 2.218 ± 0.044	4.852ThrGly: 4.852 ± 0.062	0.996ThrHis: 0.996 ± 0.027	3.161ThrIle: 3.161 ± 0.053	1.921ThrLys: 1.921 ± 0.039	5.583ThrLeu: 5.583 ± 0.069	1.073ThrMet: 1.073 ± 0.034	1.482ThrAsn: 1.482 ± 0.036	3.326ThrPro: 3.326 ± 0.056	1.399ThrGln: 1.399 ± 0.035	3.171ThrArg: 3.171 ± 0.055	3.31ThrSer: 3.31 ± 0.06	2.932ThrThr: 2.932 ± 0.055	4.178ThrVal: 4.178 ± 0.057	0.691ThrTrp: 0.691 ± 0.024	1.269ThrTyr: 1.269 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.971ValAla: 8.971 ± 0.093	0.667ValCys: 0.667 ± 0.023	3.99ValAsp: 3.99 ± 0.054	4.168ValGlu: 4.168 ± 0.052	2.785ValPhe: 2.785 ± 0.05	5.344ValGly: 5.344 ± 0.069	1.362ValHis: 1.362 ± 0.034	4.138ValIle: 4.138 ± 0.063	2.764ValLys: 2.764 ± 0.046	7.301ValLeu: 7.301 ± 0.09	1.7ValMet: 1.7 ± 0.039	2.009ValAsn: 2.009 ± 0.047	3.725ValPro: 3.725 ± 0.051	2.01ValGln: 2.01 ± 0.043	4.806ValArg: 4.806 ± 0.062	4.646ValSer: 4.646 ± 0.058	4.338ValThr: 4.338 ± 0.059	5.875ValVal: 5.875 ± 0.086	0.919ValTrp: 0.919 ± 0.027	1.525ValTyr: 1.525 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.18TrpAla: 1.18 ± 0.033	0.126TrpCys: 0.126 ± 0.01	0.623TrpAsp: 0.623 ± 0.024	0.561TrpGlu: 0.561 ± 0.022	0.538TrpPhe: 0.538 ± 0.023	0.904TrpGly: 0.904 ± 0.032	0.33TrpHis: 0.33 ± 0.018	0.724TrpIle: 0.724 ± 0.023	0.566TrpLys: 0.566 ± 0.02	1.538TrpLeu: 1.538 ± 0.037	0.353TrpMet: 0.353 ± 0.016	0.467TrpAsn: 0.467 ± 0.02	0.716TrpPro: 0.716 ± 0.023	0.523TrpGln: 0.523 ± 0.019	1.114TrpArg: 1.114 ± 0.033	0.872TrpSer: 0.872 ± 0.028	0.786TrpThr: 0.786 ± 0.028	0.797TrpVal: 0.797 ± 0.026	0.218TrpTrp: 0.218 ± 0.015	0.305TrpTyr: 0.305 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.446TyrAla: 2.446 ± 0.049	0.265TyrCys: 0.265 ± 0.014	1.43TyrAsp: 1.43 ± 0.034	1.247TyrGlu: 1.247 ± 0.037	1.016TyrPhe: 1.016 ± 0.031	2.13TyrGly: 2.13 ± 0.045	0.493TyrHis: 0.493 ± 0.023	1.032TyrIle: 1.032 ± 0.03	0.771TyrLys: 0.771 ± 0.025	2.31TyrLeu: 2.31 ± 0.047	0.433TyrMet: 0.433 ± 0.018	0.678TyrAsn: 0.678 ± 0.024	1.143TyrPro: 1.143 ± 0.034	0.737TyrGln: 0.737 ± 0.027	1.772TyrArg: 1.772 ± 0.037	1.305TyrSer: 1.305 ± 0.035	1.084TyrThr: 1.084 ± 0.033	1.812TyrVal: 1.812 ± 0.039	0.388TyrTrp: 0.388 ± 0.018	0.64TyrTyr: 0.64 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4102 proteins (1277010 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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