Amino acid dipepetide frequency for Grapevine leafroll-associated virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.038AlaAla: 6.038 ± 1.143
0.549AlaCys: 0.549 ± 0.216
3.111AlaAsp: 3.111 ± 0.478
4.575AlaGlu: 4.575 ± 0.881
2.745AlaPhe: 2.745 ± 0.657
3.111AlaGly: 3.111 ± 0.5
1.098AlaHis: 1.098 ± 0.487
4.392AlaIle: 4.392 ± 1.194
5.306AlaLys: 5.306 ± 1.135
6.587AlaLeu: 6.587 ± 1.156
2.562AlaMet: 2.562 ± 0.705
2.928AlaAsn: 2.928 ± 0.521
2.379AlaPro: 2.379 ± 0.451
2.745AlaGln: 2.745 ± 0.494
3.843AlaArg: 3.843 ± 0.591
5.306AlaSer: 5.306 ± 1.343
4.209AlaThr: 4.209 ± 0.661
7.319AlaVal: 7.319 ± 1.152
0.549AlaTrp: 0.549 ± 0.233
3.111AlaTyr: 3.111 ± 0.56
0.0AlaXaa: 0.0 ± 0.0
Cys
0.732CysAla: 0.732 ± 0.332
0.549CysCys: 0.549 ± 0.273
0.915CysAsp: 0.915 ± 0.247
0.366CysGlu: 0.366 ± 0.222
1.83CysPhe: 1.83 ± 0.521
0.732CysGly: 0.732 ± 0.431
0.366CysHis: 0.366 ± 0.222
0.915CysIle: 0.915 ± 0.386
0.915CysLys: 0.915 ± 0.555
1.647CysLeu: 1.647 ± 0.538
0.366CysMet: 0.366 ± 0.319
0.732CysAsn: 0.732 ± 0.308
0.183CysPro: 0.183 ± 0.111
0.549CysGln: 0.549 ± 0.284
0.549CysArg: 0.549 ± 0.231
0.549CysSer: 0.549 ± 0.218
0.366CysThr: 0.366 ± 0.307
1.83CysVal: 1.83 ± 0.431
0.183CysTrp: 0.183 ± 0.111
0.732CysTyr: 0.732 ± 0.292
0.0CysXaa: 0.0 ± 0.0
Asp
3.477AspAla: 3.477 ± 0.611
0.549AspCys: 0.549 ± 0.333
4.026AspAsp: 4.026 ± 0.628
4.758AspGlu: 4.758 ± 0.89
3.294AspPhe: 3.294 ± 0.896
3.843AspGly: 3.843 ± 0.574
0.732AspHis: 0.732 ± 0.308
2.928AspIle: 2.928 ± 0.608
4.209AspLys: 4.209 ± 0.581
4.209AspLeu: 4.209 ± 0.857
1.464AspMet: 1.464 ± 0.297
0.915AspAsn: 0.915 ± 0.505
1.098AspPro: 1.098 ± 0.435
0.366AspGln: 0.366 ± 0.178
3.66AspArg: 3.66 ± 0.939
4.392AspSer: 4.392 ± 1.131
3.843AspThr: 3.843 ± 1.068
6.221AspVal: 6.221 ± 1.022
0.549AspTrp: 0.549 ± 0.305
2.196AspTyr: 2.196 ± 0.513
0.0AspXaa: 0.0 ± 0.0
Glu
4.758GluAla: 4.758 ± 0.989
0.732GluCys: 0.732 ± 0.438
4.026GluAsp: 4.026 ± 0.78
3.477GluGlu: 3.477 ± 1.251
1.281GluPhe: 1.281 ± 0.33
4.026GluGly: 4.026 ± 0.983
0.366GluHis: 0.366 ± 0.222
3.843GluIle: 3.843 ± 1.082
4.941GluLys: 4.941 ± 1.179
7.136GluLeu: 7.136 ± 0.628
1.098GluMet: 1.098 ± 0.385
2.379GluAsn: 2.379 ± 0.8
2.013GluPro: 2.013 ± 0.451
1.464GluGln: 1.464 ± 0.452
2.928GluArg: 2.928 ± 0.451
5.489GluSer: 5.489 ± 1.157
2.928GluThr: 2.928 ± 1.48
4.941GluVal: 4.941 ± 0.464
0.0GluTrp: 0.0 ± 0.0
3.111GluTyr: 3.111 ± 0.711
0.0GluXaa: 0.0 ± 0.0
Phe
1.647PheAla: 1.647 ± 0.596
1.464PheCys: 1.464 ± 0.595
2.562PheAsp: 2.562 ± 0.591
2.928PheGlu: 2.928 ± 0.798
1.83PhePhe: 1.83 ± 0.469
2.562PheGly: 2.562 ± 0.621
1.098PheHis: 1.098 ± 0.304
2.013PheIle: 2.013 ± 0.581
2.379PheLys: 2.379 ± 0.318
3.477PheLeu: 3.477 ± 0.964
1.098PheMet: 1.098 ± 0.376
2.013PheAsn: 2.013 ± 0.377
1.647PhePro: 1.647 ± 0.431
0.915PheGln: 0.915 ± 0.352
2.745PheArg: 2.745 ± 0.763
4.575PheSer: 4.575 ± 1.1
2.196PheThr: 2.196 ± 0.643
5.672PheVal: 5.672 ± 0.833
0.183PheTrp: 0.183 ± 0.209
1.098PheTyr: 1.098 ± 0.303
0.0PheXaa: 0.0 ± 0.0
Gly
4.575GlyAla: 4.575 ± 1.012
0.915GlyCys: 0.915 ± 0.251
5.306GlyAsp: 5.306 ± 0.667
3.66GlyGlu: 3.66 ± 0.627
2.013GlyPhe: 2.013 ± 0.289
5.672GlyGly: 5.672 ± 0.961
1.098GlyHis: 1.098 ± 0.489
2.562GlyIle: 2.562 ± 0.723
5.306GlyLys: 5.306 ± 0.902
5.672GlyLeu: 5.672 ± 0.688
1.83GlyMet: 1.83 ± 0.48
2.562GlyAsn: 2.562 ± 0.485
0.915GlyPro: 0.915 ± 0.421
1.098GlyGln: 1.098 ± 0.388
3.843GlyArg: 3.843 ± 0.774
5.489GlySer: 5.489 ± 0.624
4.026GlyThr: 4.026 ± 0.721
6.038GlyVal: 6.038 ± 0.573
0.366GlyTrp: 0.366 ± 0.207
3.111GlyTyr: 3.111 ± 0.265
0.0GlyXaa: 0.0 ± 0.0
His
1.098HisAla: 1.098 ± 0.487
0.732HisCys: 0.732 ± 0.27
0.549HisAsp: 0.549 ± 0.23
0.732HisGlu: 0.732 ± 0.305
0.549HisPhe: 0.549 ± 0.252
1.281HisGly: 1.281 ± 0.279
0.366HisHis: 0.366 ± 0.222
1.464HisIle: 1.464 ± 0.433
0.915HisLys: 0.915 ± 0.555
1.647HisLeu: 1.647 ± 0.547
0.0HisMet: 0.0 ± 0.0
0.183HisAsn: 0.183 ± 0.215
0.549HisPro: 0.549 ± 0.38
0.366HisGln: 0.366 ± 0.188
0.183HisArg: 0.183 ± 0.188
1.464HisSer: 1.464 ± 0.457
0.915HisThr: 0.915 ± 0.294
1.83HisVal: 1.83 ± 0.415
0.183HisTrp: 0.183 ± 0.197
0.183HisTyr: 0.183 ± 0.182
0.0HisXaa: 0.0 ± 0.0
Ile
4.026IleAla: 4.026 ± 0.461
0.366IleCys: 0.366 ± 0.307
3.477IleAsp: 3.477 ± 0.713
4.026IleGlu: 4.026 ± 0.67
2.928IlePhe: 2.928 ± 0.466
3.111IleGly: 3.111 ± 0.806
0.366IleHis: 0.366 ± 0.255
3.111IleIle: 3.111 ± 0.557
2.196IleLys: 2.196 ± 0.482
4.209IleLeu: 4.209 ± 0.595
0.732IleMet: 0.732 ± 0.292
1.83IleAsn: 1.83 ± 0.537
2.562IlePro: 2.562 ± 0.512
2.196IleGln: 2.196 ± 0.432
2.379IleArg: 2.379 ± 0.864
4.941IleSer: 4.941 ± 1.002
3.111IleThr: 3.111 ± 0.548
4.209IleVal: 4.209 ± 0.571
0.366IleTrp: 0.366 ± 0.264
1.098IleTyr: 1.098 ± 0.537
0.0IleXaa: 0.0 ± 0.0
Lys
3.294LysAla: 3.294 ± 0.892
0.915LysCys: 0.915 ± 0.401
3.843LysAsp: 3.843 ± 0.843
4.026LysGlu: 4.026 ± 0.808
1.647LysPhe: 1.647 ± 0.466
5.306LysGly: 5.306 ± 0.935
0.549LysHis: 0.549 ± 0.237
3.294LysIle: 3.294 ± 0.723
4.026LysLys: 4.026 ± 1.074
6.587LysLeu: 6.587 ± 0.935
0.732LysMet: 0.732 ± 0.242
3.294LysAsn: 3.294 ± 0.428
2.196LysPro: 2.196 ± 0.411
0.732LysGln: 0.732 ± 0.226
6.221LysArg: 6.221 ± 0.946
5.124LysSer: 5.124 ± 0.878
4.209LysThr: 4.209 ± 0.809
4.941LysVal: 4.941 ± 0.788
0.366LysTrp: 0.366 ± 0.222
3.66LysTyr: 3.66 ± 0.92
0.0LysXaa: 0.0 ± 0.0
Leu
5.855LeuAla: 5.855 ± 0.77
1.647LeuCys: 1.647 ± 0.582
4.758LeuAsp: 4.758 ± 0.847
4.209LeuGlu: 4.209 ± 0.714
3.66LeuPhe: 3.66 ± 0.797
5.124LeuGly: 5.124 ± 1.008
1.647LeuHis: 1.647 ± 0.281
5.124LeuIle: 5.124 ± 0.645
6.953LeuLys: 6.953 ± 0.968
7.502LeuLeu: 7.502 ± 1.315
2.196LeuMet: 2.196 ± 0.51
3.477LeuAsn: 3.477 ± 0.595
3.111LeuPro: 3.111 ± 0.783
2.562LeuGln: 2.562 ± 0.57
8.051LeuArg: 8.051 ± 0.778
7.868LeuSer: 7.868 ± 1.458
6.404LeuThr: 6.404 ± 0.513
8.6LeuVal: 8.6 ± 0.928
0.732LeuTrp: 0.732 ± 0.308
2.928LeuTyr: 2.928 ± 0.79
0.0LeuXaa: 0.0 ± 0.0
Met
2.013MetAla: 2.013 ± 0.339
0.0MetCys: 0.0 ± 0.0
1.098MetAsp: 1.098 ± 0.377
1.83MetGlu: 1.83 ± 0.575
1.098MetPhe: 1.098 ± 0.328
1.464MetGly: 1.464 ± 0.457
0.183MetHis: 0.183 ± 0.239
0.915MetIle: 0.915 ± 0.224
1.098MetLys: 1.098 ± 0.328
2.196MetLeu: 2.196 ± 0.416
0.366MetMet: 0.366 ± 0.207
0.915MetAsn: 0.915 ± 0.277
0.0MetPro: 0.0 ± 0.0
0.732MetGln: 0.732 ± 0.289
2.013MetArg: 2.013 ± 0.483
1.281MetSer: 1.281 ± 0.461
1.464MetThr: 1.464 ± 0.436
1.464MetVal: 1.464 ± 0.62
0.0MetTrp: 0.0 ± 0.0
1.281MetTyr: 1.281 ± 0.444
0.0MetXaa: 0.0 ± 0.0
Asn
3.477AsnAla: 3.477 ± 0.839
0.366AsnCys: 0.366 ± 0.193
1.647AsnAsp: 1.647 ± 0.666
3.843AsnGlu: 3.843 ± 0.902
2.745AsnPhe: 2.745 ± 1.002
4.575AsnGly: 4.575 ± 0.607
0.183AsnHis: 0.183 ± 0.186
2.379AsnIle: 2.379 ± 0.827
1.647AsnLys: 1.647 ± 0.403
3.843AsnLeu: 3.843 ± 0.757
0.183AsnMet: 0.183 ± 0.111
0.915AsnAsn: 0.915 ± 0.334
2.745AsnPro: 2.745 ± 0.732
0.915AsnGln: 0.915 ± 0.326
1.647AsnArg: 1.647 ± 0.79
3.294AsnSer: 3.294 ± 0.465
1.83AsnThr: 1.83 ± 0.639
3.477AsnVal: 3.477 ± 0.841
0.183AsnTrp: 0.183 ± 0.197
1.464AsnTyr: 1.464 ± 0.816
0.0AsnXaa: 0.0 ± 0.0
Pro
2.562ProAla: 2.562 ± 0.73
0.366ProCys: 0.366 ± 0.193
1.098ProAsp: 1.098 ± 0.562
3.111ProGlu: 3.111 ± 0.762
1.83ProPhe: 1.83 ± 0.744
2.379ProGly: 2.379 ± 0.583
0.549ProHis: 0.549 ± 0.237
2.928ProIle: 2.928 ± 0.593
2.745ProLys: 2.745 ± 0.66
2.379ProLeu: 2.379 ± 0.945
0.366ProMet: 0.366 ± 0.291
2.745ProAsn: 2.745 ± 0.748
0.732ProPro: 0.732 ± 0.277
0.732ProGln: 0.732 ± 0.226
1.281ProArg: 1.281 ± 0.267
3.294ProSer: 3.294 ± 0.645
1.647ProThr: 1.647 ± 0.387
3.111ProVal: 3.111 ± 0.847
0.183ProTrp: 0.183 ± 0.239
1.281ProTyr: 1.281 ± 0.715
0.0ProXaa: 0.0 ± 0.0
Gln
1.83GlnAla: 1.83 ± 0.485
0.549GlnCys: 0.549 ± 0.23
0.366GlnAsp: 0.366 ± 0.238
0.732GlnGlu: 0.732 ± 0.294
1.098GlnPhe: 1.098 ± 0.416
1.83GlnGly: 1.83 ± 0.415
0.549GlnHis: 0.549 ± 0.233
1.098GlnIle: 1.098 ± 0.217
1.647GlnLys: 1.647 ± 0.404
3.294GlnLeu: 3.294 ± 0.895
0.549GlnMet: 0.549 ± 0.257
1.647GlnAsn: 1.647 ± 0.739
0.915GlnPro: 0.915 ± 0.299
1.098GlnGln: 1.098 ± 0.367
1.83GlnArg: 1.83 ± 0.469
2.562GlnSer: 2.562 ± 0.566
0.915GlnThr: 0.915 ± 0.305
1.098GlnVal: 1.098 ± 0.42
0.183GlnTrp: 0.183 ± 0.111
0.915GlnTyr: 0.915 ± 0.581
0.0GlnXaa: 0.0 ± 0.0
Arg
5.672ArgAla: 5.672 ± 0.782
1.098ArgCys: 1.098 ± 0.548
2.196ArgAsp: 2.196 ± 0.7
4.026ArgGlu: 4.026 ± 0.724
3.111ArgPhe: 3.111 ± 0.657
3.294ArgGly: 3.294 ± 0.55
0.732ArgHis: 0.732 ± 0.423
2.013ArgIle: 2.013 ± 0.796
6.221ArgLys: 6.221 ± 0.995
5.855ArgLeu: 5.855 ± 0.692
0.732ArgMet: 0.732 ± 0.263
3.66ArgAsn: 3.66 ± 0.631
3.111ArgPro: 3.111 ± 0.64
2.013ArgGln: 2.013 ± 0.436
3.294ArgArg: 3.294 ± 0.58
5.306ArgSer: 5.306 ± 0.789
2.196ArgThr: 2.196 ± 0.499
4.575ArgVal: 4.575 ± 1.01
0.732ArgTrp: 0.732 ± 0.377
1.647ArgTyr: 1.647 ± 0.361
0.0ArgXaa: 0.0 ± 0.0
Ser
4.575SerAla: 4.575 ± 0.724
0.732SerCys: 0.732 ± 0.294
3.843SerAsp: 3.843 ± 1.073
4.209SerGlu: 4.209 ± 0.73
3.477SerPhe: 3.477 ± 0.658
5.306SerGly: 5.306 ± 0.679
1.647SerHis: 1.647 ± 0.535
3.477SerIle: 3.477 ± 1.047
6.038SerLys: 6.038 ± 0.865
8.6SerLeu: 8.6 ± 1.11
2.013SerMet: 2.013 ± 0.344
3.843SerAsn: 3.843 ± 0.804
2.928SerPro: 2.928 ± 0.692
2.196SerGln: 2.196 ± 0.756
4.575SerArg: 4.575 ± 0.667
7.502SerSer: 7.502 ± 1.558
5.672SerThr: 5.672 ± 0.723
9.149SerVal: 9.149 ± 0.89
0.915SerTrp: 0.915 ± 0.263
2.928SerTyr: 2.928 ± 0.824
0.0SerXaa: 0.0 ± 0.0
Thr
4.941ThrAla: 4.941 ± 0.612
0.732ThrCys: 0.732 ± 0.431
3.477ThrAsp: 3.477 ± 0.445
2.928ThrGlu: 2.928 ± 0.752
3.111ThrPhe: 3.111 ± 0.73
3.477ThrGly: 3.477 ± 0.897
1.647ThrHis: 1.647 ± 0.636
2.379ThrIle: 2.379 ± 0.401
1.83ThrLys: 1.83 ± 0.451
4.941ThrLeu: 4.941 ± 1.163
2.013ThrMet: 2.013 ± 0.622
1.464ThrAsn: 1.464 ± 0.476
3.477ThrPro: 3.477 ± 0.634
1.464ThrGln: 1.464 ± 0.629
3.294ThrArg: 3.294 ± 0.801
4.575ThrSer: 4.575 ± 0.818
1.83ThrThr: 1.83 ± 0.609
4.941ThrVal: 4.941 ± 0.917
0.732ThrTrp: 0.732 ± 0.507
1.83ThrTyr: 1.83 ± 0.336
0.0ThrXaa: 0.0 ± 0.0
Val
8.6ValAla: 8.6 ± 0.968
1.83ValCys: 1.83 ± 0.364
7.685ValAsp: 7.685 ± 1.453
4.575ValGlu: 4.575 ± 1.439
3.843ValPhe: 3.843 ± 0.537
5.855ValGly: 5.855 ± 0.635
1.098ValHis: 1.098 ± 0.515
3.477ValIle: 3.477 ± 0.485
4.392ValLys: 4.392 ± 0.67
7.868ValLeu: 7.868 ± 1.017
2.013ValMet: 2.013 ± 0.66
3.66ValAsn: 3.66 ± 0.739
4.209ValPro: 4.209 ± 0.897
2.013ValGln: 2.013 ± 0.555
6.587ValArg: 6.587 ± 1.176
7.868ValSer: 7.868 ± 1.028
4.575ValThr: 4.575 ± 0.634
8.417ValVal: 8.417 ± 1.124
0.549ValTrp: 0.549 ± 0.429
3.477ValTyr: 3.477 ± 0.611
0.0ValXaa: 0.0 ± 0.0
Trp
0.732TrpAla: 0.732 ± 0.28
0.183TrpCys: 0.183 ± 0.111
0.183TrpAsp: 0.183 ± 0.111
0.183TrpGlu: 0.183 ± 0.209
0.366TrpPhe: 0.366 ± 0.28
0.183TrpGly: 0.183 ± 0.111
0.0TrpHis: 0.0 ± 0.0
0.366TrpIle: 0.366 ± 0.193
0.549TrpLys: 0.549 ± 0.353
1.647TrpLeu: 1.647 ± 0.387
0.0TrpMet: 0.0 ± 0.0
0.366TrpAsn: 0.366 ± 0.222
0.183TrpPro: 0.183 ± 0.197
0.366TrpGln: 0.366 ± 0.275
0.183TrpArg: 0.183 ± 0.111
0.549TrpSer: 0.549 ± 0.214
0.0TrpThr: 0.0 ± 0.0
1.098TrpVal: 1.098 ± 0.251
0.183TrpTrp: 0.183 ± 0.182
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.562TyrAla: 2.562 ± 0.383
0.732TyrCys: 0.732 ± 0.294
2.562TyrAsp: 2.562 ± 0.708
2.745TyrGlu: 2.745 ± 0.587
1.647TyrPhe: 1.647 ± 0.576
2.928TyrGly: 2.928 ± 0.319
0.915TyrHis: 0.915 ± 0.376
2.562TyrIle: 2.562 ± 0.917
1.647TyrLys: 1.647 ± 0.756
3.111TyrLeu: 3.111 ± 0.532
0.915TyrMet: 0.915 ± 0.222
1.83TyrAsn: 1.83 ± 0.691
0.366TyrPro: 0.366 ± 0.188
0.183TyrGln: 0.183 ± 0.182
2.379TyrArg: 2.379 ± 0.476
2.196TyrSer: 2.196 ± 0.642
2.745TyrThr: 2.745 ± 0.482
3.843TyrVal: 3.843 ± 0.453
0.183TyrTrp: 0.183 ± 0.111
2.013TyrTyr: 2.013 ± 0.808
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (5466 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski