Amino acid dipepetide frequency for [Clostridium] ultunense Esp

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.711AlaAla: 3.711 ± 0.087	0.547AlaCys: 0.547 ± 0.026	2.438AlaAsp: 2.438 ± 0.051	3.499AlaGlu: 3.499 ± 0.079	2.378AlaPhe: 2.378 ± 0.059	3.766AlaGly: 3.766 ± 0.072	0.839AlaHis: 0.839 ± 0.033	5.885AlaIle: 5.885 ± 0.1	4.415AlaLys: 4.415 ± 0.077	5.687AlaLeu: 5.687 ± 0.091	1.61AlaMet: 1.61 ± 0.046	2.64AlaAsn: 2.64 ± 0.054	1.433AlaPro: 1.433 ± 0.043	1.31AlaGln: 1.31 ± 0.043	2.037AlaArg: 2.037 ± 0.054	2.946AlaSer: 2.946 ± 0.065	2.765AlaThr: 2.765 ± 0.064	3.523AlaVal: 3.523 ± 0.075	0.332AlaTrp: 0.332 ± 0.02	2.139AlaTyr: 2.139 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.405CysAla: 0.405 ± 0.021	0.082CysCys: 0.082 ± 0.01	0.465CysAsp: 0.465 ± 0.024	0.495CysGlu: 0.495 ± 0.025	0.324CysPhe: 0.324 ± 0.017	0.83CysGly: 0.83 ± 0.036	0.216CysHis: 0.216 ± 0.016	0.883CysIle: 0.883 ± 0.03	0.668CysLys: 0.668 ± 0.027	0.578CysLeu: 0.578 ± 0.024	0.197CysMet: 0.197 ± 0.018	0.571CysAsn: 0.571 ± 0.025	0.491CysPro: 0.491 ± 0.027	0.226CysGln: 0.226 ± 0.016	0.339CysArg: 0.339 ± 0.018	0.547CysSer: 0.547 ± 0.027	0.424CysThr: 0.424 ± 0.023	0.449CysVal: 0.449 ± 0.025	0.057CysTrp: 0.057 ± 0.007	0.32CysTyr: 0.32 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.299AspAla: 2.299 ± 0.058	0.474AspCys: 0.474 ± 0.024	2.656AspAsp: 2.656 ± 0.058	5.05AspGlu: 5.05 ± 0.082	2.7AspPhe: 2.7 ± 0.057	3.696AspGly: 3.696 ± 0.077	0.769AspHis: 0.769 ± 0.028	6.796AspIle: 6.796 ± 0.095	5.139AspLys: 5.139 ± 0.079	5.374AspLeu: 5.374 ± 0.087	1.681AspMet: 1.681 ± 0.043	3.171AspAsn: 3.171 ± 0.072	1.631AspPro: 1.631 ± 0.049	1.007AspGln: 1.007 ± 0.037	2.537AspArg: 2.537 ± 0.055	2.831AspSer: 2.831 ± 0.058	2.429AspThr: 2.429 ± 0.05	3.15AspVal: 3.15 ± 0.066	0.385AspTrp: 0.385 ± 0.021	2.806AspTyr: 2.806 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.096GluAla: 4.096 ± 0.091	0.416GluCys: 0.416 ± 0.021	5.143GluAsp: 5.143 ± 0.084	8.604GluGlu: 8.604 ± 0.154	2.847GluPhe: 2.847 ± 0.06	5.158GluGly: 5.158 ± 0.099	0.956GluHis: 0.956 ± 0.034	8.016GluIle: 8.016 ± 0.111	8.099GluLys: 8.099 ± 0.102	7.191GluLeu: 7.191 ± 0.106	2.129GluMet: 2.129 ± 0.055	4.786GluAsn: 4.786 ± 0.078	1.762GluPro: 1.762 ± 0.052	1.744GluGln: 1.744 ± 0.046	3.234GluArg: 3.234 ± 0.064	3.289GluSer: 3.289 ± 0.058	3.21GluThr: 3.21 ± 0.058	4.663GluVal: 4.663 ± 0.085	0.51GluTrp: 0.51 ± 0.029	3.386GluTyr: 3.386 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.218PheAla: 2.218 ± 0.058	0.407PheCys: 0.407 ± 0.021	2.4PheAsp: 2.4 ± 0.048	2.592PheGlu: 2.592 ± 0.059	1.895PhePhe: 1.895 ± 0.058	2.971PheGly: 2.971 ± 0.065	0.695PheHis: 0.695 ± 0.03	4.613PheIle: 4.613 ± 0.085	3.425PheLys: 3.425 ± 0.061	3.994PheLeu: 3.994 ± 0.075	1.08PheMet: 1.08 ± 0.042	2.696PheAsn: 2.696 ± 0.058	1.364PhePro: 1.364 ± 0.045	1.118PheGln: 1.118 ± 0.038	1.388PheArg: 1.388 ± 0.035	2.769PheSer: 2.769 ± 0.064	2.33PheThr: 2.33 ± 0.053	2.412PheVal: 2.412 ± 0.063	0.29PheTrp: 0.29 ± 0.02	1.726PheTyr: 1.726 ± 0.046	0.001PheXaa: 0.001 ± 0.001
Gly	3.987GlyAla: 3.987 ± 0.085	0.731GlyCys: 0.731 ± 0.032	3.419GlyAsp: 3.419 ± 0.068	4.85GlyGlu: 4.85 ± 0.078	3.235GlyPhe: 3.235 ± 0.071	4.615GlyGly: 4.615 ± 0.098	1.11GlyHis: 1.11 ± 0.04	7.701GlyIle: 7.701 ± 0.114	5.872GlyLys: 5.872 ± 0.091	6.525GlyLeu: 6.525 ± 0.103	1.927GlyMet: 1.927 ± 0.057	3.384GlyAsn: 3.384 ± 0.07	1.585GlyPro: 1.585 ± 0.044	1.664GlyGln: 1.664 ± 0.045	2.743GlyArg: 2.743 ± 0.058	3.66GlySer: 3.66 ± 0.058	3.599GlyThr: 3.599 ± 0.066	4.692GlyVal: 4.692 ± 0.07	0.492GlyTrp: 0.492 ± 0.025	3.251GlyTyr: 3.251 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.747HisAla: 0.747 ± 0.032	0.183HisCys: 0.183 ± 0.014	0.678HisAsp: 0.678 ± 0.03	0.876HisGlu: 0.876 ± 0.027	0.642HisPhe: 0.642 ± 0.029	1.167HisGly: 1.167 ± 0.045	0.326HisHis: 0.326 ± 0.02	1.677HisIle: 1.677 ± 0.044	1.001HisLys: 1.001 ± 0.032	1.3HisLeu: 1.3 ± 0.039	0.406HisMet: 0.406 ± 0.019	0.808HisAsn: 0.808 ± 0.032	0.707HisPro: 0.707 ± 0.029	0.415HisGln: 0.415 ± 0.023	0.683HisArg: 0.683 ± 0.03	0.926HisSer: 0.926 ± 0.032	0.757HisThr: 0.757 ± 0.028	0.83HisVal: 0.83 ± 0.033	0.105HisTrp: 0.105 ± 0.011	0.618HisTyr: 0.618 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.773IleAla: 5.773 ± 0.089	0.934IleCys: 0.934 ± 0.036	6.835IleAsp: 6.835 ± 0.115	8.275IleGlu: 8.275 ± 0.106	4.38IlePhe: 4.38 ± 0.095	7.167IleGly: 7.167 ± 0.093	1.523IleHis: 1.523 ± 0.04	10.451IleIle: 10.451 ± 0.143	8.376IleLys: 8.376 ± 0.099	10.005IleLeu: 10.005 ± 0.155	2.627IleMet: 2.627 ± 0.062	5.717IleAsn: 5.717 ± 0.095	3.88IlePro: 3.88 ± 0.073	2.292IleGln: 2.292 ± 0.057	3.814IleArg: 3.814 ± 0.066	6.604IleSer: 6.604 ± 0.104	4.834IleThr: 4.834 ± 0.071	6.52IleVal: 6.52 ± 0.089	0.607IleTrp: 0.607 ± 0.028	3.787IleTyr: 3.787 ± 0.07	0.003IleXaa: 0.003 ± 0.002
Lys	4.627LysAla: 4.627 ± 0.077	0.54LysCys: 0.54 ± 0.026	6.131LysAsp: 6.131 ± 0.094	9.045LysGlu: 9.045 ± 0.116	2.689LysPhe: 2.689 ± 0.059	5.856LysGly: 5.856 ± 0.095	1.105LysHis: 1.105 ± 0.038	7.913LysIle: 7.913 ± 0.094	7.202LysLys: 7.202 ± 0.115	6.928LysLeu: 6.928 ± 0.086	2.172LysMet: 2.172 ± 0.052	5.024LysAsn: 5.024 ± 0.073	2.258LysPro: 2.258 ± 0.051	1.652LysGln: 1.652 ± 0.043	3.493LysArg: 3.493 ± 0.071	4.189LysSer: 4.189 ± 0.074	3.973LysThr: 3.973 ± 0.063	5.597LysVal: 5.597 ± 0.078	0.609LysTrp: 0.609 ± 0.023	3.841LysTyr: 3.841 ± 0.086	0.002LysXaa: 0.002 ± 0.002
Leu	5.404LeuAla: 5.404 ± 0.097	0.747LeuCys: 0.747 ± 0.028	5.663LeuAsp: 5.663 ± 0.075	7.329LeuGlu: 7.329 ± 0.107	3.927LeuPhe: 3.927 ± 0.079	6.789LeuGly: 6.789 ± 0.09	1.13LeuHis: 1.13 ± 0.037	9.057LeuIle: 9.057 ± 0.126	8.156LeuLys: 8.156 ± 0.111	8.459LeuLeu: 8.459 ± 0.142	2.517LeuMet: 2.517 ± 0.055	5.687LeuAsn: 5.687 ± 0.092	3.201LeuPro: 3.201 ± 0.06	1.861LeuGln: 1.861 ± 0.047	3.458LeuArg: 3.458 ± 0.064	6.514LeuSer: 6.514 ± 0.107	4.404LeuThr: 4.404 ± 0.084	5.588LeuVal: 5.588 ± 0.088	0.594LeuTrp: 0.594 ± 0.031	3.24LeuTyr: 3.24 ± 0.062	0.001LeuXaa: 0.001 ± 0.001
Met	2.044MetAla: 2.044 ± 0.057	0.177MetCys: 0.177 ± 0.015	2.041MetAsp: 2.041 ± 0.049	2.61MetGlu: 2.61 ± 0.058	0.887MetPhe: 0.887 ± 0.034	1.971MetGly: 1.971 ± 0.052	0.308MetHis: 0.308 ± 0.021	2.173MetIle: 2.173 ± 0.044	2.358MetLys: 2.358 ± 0.054	2.178MetLeu: 2.178 ± 0.054	0.699MetMet: 0.699 ± 0.029	1.409MetAsn: 1.409 ± 0.042	0.945MetPro: 0.945 ± 0.032	0.497MetGln: 0.497 ± 0.027	0.984MetArg: 0.984 ± 0.035	1.39MetSer: 1.39 ± 0.039	1.295MetThr: 1.295 ± 0.04	2.067MetVal: 2.067 ± 0.049	0.144MetTrp: 0.144 ± 0.011	0.794MetTyr: 0.794 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.403AsnAla: 2.403 ± 0.056	0.553AsnCys: 0.553 ± 0.03	2.114AsnAsp: 2.114 ± 0.049	3.494AsnGlu: 3.494 ± 0.067	2.362AsnPhe: 2.362 ± 0.044	3.342AsnGly: 3.342 ± 0.063	0.848AsnHis: 0.848 ± 0.034	7.113AsnIle: 7.113 ± 0.102	4.992AsnLys: 4.992 ± 0.087	5.43AsnLeu: 5.43 ± 0.09	1.794AsnMet: 1.794 ± 0.044	3.425AsnAsn: 3.425 ± 0.075	2.368AsnPro: 2.368 ± 0.056	1.507AsnGln: 1.507 ± 0.04	2.784AsnArg: 2.784 ± 0.055	3.355AsnSer: 3.355 ± 0.068	2.596AsnThr: 2.596 ± 0.055	3.02AsnVal: 3.02 ± 0.062	0.523AsnTrp: 0.523 ± 0.028	2.427AsnTyr: 2.427 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.529ProAla: 1.529 ± 0.042	0.292ProCys: 0.292 ± 0.019	1.603ProAsp: 1.603 ± 0.049	2.491ProGlu: 2.491 ± 0.061	1.526ProPhe: 1.526 ± 0.04	2.087ProGly: 2.087 ± 0.051	0.628ProHis: 0.628 ± 0.026	3.356ProIle: 3.356 ± 0.067	2.487ProLys: 2.487 ± 0.051	2.879ProLeu: 2.879 ± 0.067	0.831ProMet: 0.831 ± 0.033	1.776ProAsn: 1.776 ± 0.049	0.765ProPro: 0.765 ± 0.033	0.753ProGln: 0.753 ± 0.03	1.11ProArg: 1.11 ± 0.035	1.875ProSer: 1.875 ± 0.046	1.677ProThr: 1.677 ± 0.044	2.204ProVal: 2.204 ± 0.058	0.251ProTrp: 0.251 ± 0.016	1.47ProTyr: 1.47 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.267GlnAla: 1.267 ± 0.043	0.18GlnCys: 0.18 ± 0.015	1.118GlnAsp: 1.118 ± 0.039	1.733GlnGlu: 1.733 ± 0.045	0.967GlnPhe: 0.967 ± 0.033	1.569GlnGly: 1.569 ± 0.048	0.311GlnHis: 0.311 ± 0.019	2.375GlnIle: 2.375 ± 0.048	1.773GlnLys: 1.773 ± 0.041	2.378GlnLeu: 2.378 ± 0.054	0.685GlnMet: 0.685 ± 0.027	1.207GlnAsn: 1.207 ± 0.037	0.646GlnPro: 0.646 ± 0.027	0.617GlnGln: 0.617 ± 0.034	1.008GlnArg: 1.008 ± 0.034	1.273GlnSer: 1.273 ± 0.04	0.933GlnThr: 0.933 ± 0.034	1.63GlnVal: 1.63 ± 0.046	0.225GlnTrp: 0.225 ± 0.016	0.954GlnTyr: 0.954 ± 0.029	0.001GlnXaa: 0.001 ± 0.001
Arg	2.031ArgAla: 2.031 ± 0.049	0.383ArgCys: 0.383 ± 0.02	2.287ArgAsp: 2.287 ± 0.057	3.419ArgGlu: 3.419 ± 0.071	1.786ArgPhe: 1.786 ± 0.049	2.496ArgGly: 2.496 ± 0.053	0.544ArgHis: 0.544 ± 0.023	4.032ArgIle: 4.032 ± 0.068	3.614ArgLys: 3.614 ± 0.073	3.696ArgLeu: 3.696 ± 0.075	1.153ArgMet: 1.153 ± 0.039	2.196ArgAsn: 2.196 ± 0.056	1.159ArgPro: 1.159 ± 0.036	1.083ArgGln: 1.083 ± 0.038	1.906ArgArg: 1.906 ± 0.054	1.675ArgSer: 1.675 ± 0.044	1.788ArgThr: 1.788 ± 0.045	2.56ArgVal: 2.56 ± 0.059	0.331ArgTrp: 0.331 ± 0.021	1.734ArgTyr: 1.734 ± 0.044	0.002ArgXaa: 0.002 ± 0.002
Ser	2.633SerAla: 2.633 ± 0.067	0.49SerCys: 0.49 ± 0.023	2.386SerAsp: 2.386 ± 0.049	3.156SerGlu: 3.156 ± 0.063	2.822SerPhe: 2.822 ± 0.064	3.917SerGly: 3.917 ± 0.074	1.046SerHis: 1.046 ± 0.036	6.625SerIle: 6.625 ± 0.105	4.957SerLys: 4.957 ± 0.08	5.808SerLeu: 5.808 ± 0.09	1.619SerMet: 1.619 ± 0.045	3.289SerAsn: 3.289 ± 0.06	1.795SerPro: 1.795 ± 0.043	1.624SerGln: 1.624 ± 0.044	2.298SerArg: 2.298 ± 0.054	3.607SerSer: 3.607 ± 0.081	2.947SerThr: 2.947 ± 0.063	2.981SerVal: 2.981 ± 0.059	0.409SerTrp: 0.409 ± 0.024	2.424SerTyr: 2.424 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.768ThrAla: 2.768 ± 0.054	0.4ThrCys: 0.4 ± 0.021	2.332ThrAsp: 2.332 ± 0.047	3.018ThrGlu: 3.018 ± 0.063	2.034ThrPhe: 2.034 ± 0.048	3.792ThrGly: 3.792 ± 0.08	0.761ThrHis: 0.761 ± 0.031	5.297ThrIle: 5.297 ± 0.068	3.566ThrLys: 3.566 ± 0.063	4.695ThrLeu: 4.695 ± 0.081	1.123ThrMet: 1.123 ± 0.034	2.439ThrAsn: 2.439 ± 0.05	1.847ThrPro: 1.847 ± 0.05	1.042ThrGln: 1.042 ± 0.034	1.742ThrArg: 1.742 ± 0.051	2.765ThrSer: 2.765 ± 0.059	2.61ThrThr: 2.61 ± 0.056	3.33ThrVal: 3.33 ± 0.06	0.279ThrTrp: 0.279 ± 0.019	1.824ThrTyr: 1.824 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	3.799ValAla: 3.799 ± 0.075	0.54ValCys: 0.54 ± 0.023	4.125ValAsp: 4.125 ± 0.084	5.178ValGlu: 5.178 ± 0.088	2.743ValPhe: 2.743 ± 0.061	4.412ValGly: 4.412 ± 0.081	0.909ValHis: 0.909 ± 0.035	5.567ValIle: 5.567 ± 0.082	4.995ValLys: 4.995 ± 0.081	6.048ValLeu: 6.048 ± 0.082	1.531ValMet: 1.531 ± 0.046	3.166ValAsn: 3.166 ± 0.063	2.056ValPro: 2.056 ± 0.051	1.279ValGln: 1.279 ± 0.043	2.129ValArg: 2.129 ± 0.056	3.657ValSer: 3.657 ± 0.064	2.861ValThr: 2.861 ± 0.06	4.249ValVal: 4.249 ± 0.086	0.323ValTrp: 0.323 ± 0.024	2.394ValTyr: 2.394 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.362TrpAla: 0.362 ± 0.024	0.067TrpCys: 0.067 ± 0.009	0.401TrpAsp: 0.401 ± 0.024	0.509TrpGlu: 0.509 ± 0.026	0.301TrpPhe: 0.301 ± 0.02	0.515TrpGly: 0.515 ± 0.031	0.107TrpHis: 0.107 ± 0.012	0.677TrpIle: 0.677 ± 0.033	0.507TrpLys: 0.507 ± 0.024	0.636TrpLeu: 0.636 ± 0.032	0.208TrpMet: 0.208 ± 0.015	0.409TrpAsn: 0.409 ± 0.022	0.187TrpPro: 0.187 ± 0.014	0.2TrpGln: 0.2 ± 0.016	0.276TrpArg: 0.276 ± 0.021	0.377TrpSer: 0.377 ± 0.021	0.322TrpThr: 0.322 ± 0.02	0.444TrpVal: 0.444 ± 0.022	0.088TrpTrp: 0.088 ± 0.009	0.257TrpTyr: 0.257 ± 0.021	0.001TrpXaa: 0.001 ± 0.001
Tyr	1.798TyrAla: 1.798 ± 0.047	0.425TyrCys: 0.425 ± 0.023	2.344TyrAsp: 2.344 ± 0.057	3.016TyrGlu: 3.016 ± 0.057	1.94TyrPhe: 1.94 ± 0.046	2.925TyrGly: 2.925 ± 0.058	0.719TyrHis: 0.719 ± 0.031	4.197TyrIle: 4.197 ± 0.069	3.243TyrLys: 3.243 ± 0.067	3.937TyrLeu: 3.937 ± 0.069	0.979TyrMet: 0.979 ± 0.038	2.648TyrAsn: 2.648 ± 0.058	1.509TyrPro: 1.509 ± 0.045	0.96TyrGln: 0.96 ± 0.031	1.91TyrArg: 1.91 ± 0.044	2.583TyrSer: 2.583 ± 0.053	1.909TyrThr: 1.909 ± 0.045	2.053TyrVal: 2.053 ± 0.045	0.297TyrTrp: 0.297 ± 0.02	1.98TyrTyr: 1.98 ± 0.057	0.003TyrXaa: 0.003 ± 0.002
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.002XaaIle: 0.002 ± 0.002	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.009XaaXaa: 0.009 ± 0.006

Statistics based on 3144 proteins (870061 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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