Amino acid dipepetide frequency for Burkholderia phage BcepSauron

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.304AlaAla: 12.304 ± 0.557
1.12AlaCys: 1.12 ± 0.12
6.146AlaAsp: 6.146 ± 0.299
6.842AlaGlu: 6.842 ± 0.355
3.67AlaPhe: 3.67 ± 0.263
6.469AlaGly: 6.469 ± 0.389
2.277AlaHis: 2.277 ± 0.175
4.777AlaIle: 4.777 ± 0.234
4.827AlaLys: 4.827 ± 0.381
8.646AlaLeu: 8.646 ± 0.337
2.675AlaMet: 2.675 ± 0.181
3.172AlaAsn: 3.172 ± 0.241
4.466AlaPro: 4.466 ± 0.347
4.964AlaGln: 4.964 ± 0.291
8.024AlaArg: 8.024 ± 0.423
5.349AlaSer: 5.349 ± 0.274
5.611AlaThr: 5.611 ± 0.35
6.656AlaVal: 6.656 ± 0.317
1.431AlaTrp: 1.431 ± 0.125
3.496AlaTyr: 3.496 ± 0.228
0.0AlaXaa: 0.0 ± 0.0
Cys
1.207CysAla: 1.207 ± 0.137
0.162CysCys: 0.162 ± 0.045
0.634CysAsp: 0.634 ± 0.083
0.659CysGlu: 0.659 ± 0.098
0.348CysPhe: 0.348 ± 0.069
0.983CysGly: 0.983 ± 0.121
0.249CysHis: 0.249 ± 0.058
0.361CysIle: 0.361 ± 0.067
0.485CysLys: 0.485 ± 0.074
0.684CysLeu: 0.684 ± 0.098
0.299CysMet: 0.299 ± 0.057
0.448CysAsn: 0.448 ± 0.078
0.585CysPro: 0.585 ± 0.102
0.336CysGln: 0.336 ± 0.06
0.523CysArg: 0.523 ± 0.077
0.759CysSer: 0.759 ± 0.103
0.585CysThr: 0.585 ± 0.096
0.921CysVal: 0.921 ± 0.111
0.1CysTrp: 0.1 ± 0.039
0.386CysTyr: 0.386 ± 0.076
0.0CysXaa: 0.0 ± 0.0
Asp
6.992AspAla: 6.992 ± 0.29
0.547AspCys: 0.547 ± 0.094
4.74AspAsp: 4.74 ± 0.439
4.989AspGlu: 4.989 ± 0.603
2.152AspPhe: 2.152 ± 0.141
4.703AspGly: 4.703 ± 0.219
1.281AspHis: 1.281 ± 0.145
2.724AspIle: 2.724 ± 0.162
2.513AspLys: 2.513 ± 0.187
5.188AspLeu: 5.188 ± 0.303
1.742AspMet: 1.742 ± 0.137
1.779AspAsn: 1.779 ± 0.158
3.508AspPro: 3.508 ± 0.22
2.003AspGln: 2.003 ± 0.188
3.732AspArg: 3.732 ± 0.222
3.235AspSer: 3.235 ± 0.211
3.533AspThr: 3.533 ± 0.229
4.28AspVal: 4.28 ± 0.235
1.095AspTrp: 1.095 ± 0.123
2.115AspTyr: 2.115 ± 0.161
0.0AspXaa: 0.0 ± 0.0
Glu
6.506GluAla: 6.506 ± 0.394
0.759GluCys: 0.759 ± 0.095
4.392GluAsp: 4.392 ± 0.54
3.757GluGlu: 3.757 ± 0.317
2.924GluPhe: 2.924 ± 0.183
3.284GluGly: 3.284 ± 0.176
1.966GluHis: 1.966 ± 0.176
3.57GluIle: 3.57 ± 0.21
2.874GluLys: 2.874 ± 0.227
5.822GluLeu: 5.822 ± 0.317
1.655GluMet: 1.655 ± 0.144
2.165GluAsn: 2.165 ± 0.144
2.302GluPro: 2.302 ± 0.189
2.973GluGln: 2.973 ± 0.207
4.416GluArg: 4.416 ± 0.246
3.185GluSer: 3.185 ± 0.176
3.558GluThr: 3.558 ± 0.212
4.255GluVal: 4.255 ± 0.258
1.082GluTrp: 1.082 ± 0.132
2.289GluTyr: 2.289 ± 0.174
0.0GluXaa: 0.0 ± 0.0
Phe
3.073PheAla: 3.073 ± 0.162
0.498PheCys: 0.498 ± 0.078
2.874PheAsp: 2.874 ± 0.204
2.102PheGlu: 2.102 ± 0.175
1.269PhePhe: 1.269 ± 0.121
2.911PheGly: 2.911 ± 0.205
0.846PheHis: 0.846 ± 0.113
1.356PheIle: 1.356 ± 0.163
1.692PheLys: 1.692 ± 0.149
2.463PheLeu: 2.463 ± 0.155
1.157PheMet: 1.157 ± 0.111
1.53PheAsn: 1.53 ± 0.164
1.592PhePro: 1.592 ± 0.127
1.107PheGln: 1.107 ± 0.126
2.177PheArg: 2.177 ± 0.179
2.214PheSer: 2.214 ± 0.156
2.239PheThr: 2.239 ± 0.177
2.426PheVal: 2.426 ± 0.181
0.523PheTrp: 0.523 ± 0.078
1.356PheTyr: 1.356 ± 0.126
0.0PheXaa: 0.0 ± 0.0
Gly
6.034GlyAla: 6.034 ± 0.32
0.771GlyCys: 0.771 ± 0.112
4.155GlyAsp: 4.155 ± 0.25
3.371GlyGlu: 3.371 ± 0.227
2.973GlyPhe: 2.973 ± 0.204
4.516GlyGly: 4.516 ± 0.311
1.605GlyHis: 1.605 ± 0.134
3.546GlyIle: 3.546 ± 0.239
3.521GlyLys: 3.521 ± 0.247
5.25GlyLeu: 5.25 ± 0.228
1.791GlyMet: 1.791 ± 0.155
3.222GlyAsn: 3.222 ± 0.273
2.737GlyPro: 2.737 ± 0.185
2.177GlyGln: 2.177 ± 0.15
4.23GlyArg: 4.23 ± 0.245
4.13GlySer: 4.13 ± 0.277
5.337GlyThr: 5.337 ± 0.338
5.213GlyVal: 5.213 ± 0.302
1.182GlyTrp: 1.182 ± 0.14
2.948GlyTyr: 2.948 ± 0.223
0.0GlyXaa: 0.0 ± 0.0
His
2.376HisAla: 2.376 ± 0.207
0.199HisCys: 0.199 ± 0.054
1.393HisAsp: 1.393 ± 0.121
1.679HisGlu: 1.679 ± 0.167
0.759HisPhe: 0.759 ± 0.094
1.841HisGly: 1.841 ± 0.165
0.684HisHis: 0.684 ± 0.089
1.095HisIle: 1.095 ± 0.132
0.958HisLys: 0.958 ± 0.103
1.804HisLeu: 1.804 ± 0.138
0.759HisMet: 0.759 ± 0.11
0.697HisAsn: 0.697 ± 0.093
1.356HisPro: 1.356 ± 0.139
0.759HisGln: 0.759 ± 0.105
1.468HisArg: 1.468 ± 0.129
1.194HisSer: 1.194 ± 0.129
1.244HisThr: 1.244 ± 0.137
1.879HisVal: 1.879 ± 0.169
0.286HisTrp: 0.286 ± 0.073
0.622HisTyr: 0.622 ± 0.103
0.0HisXaa: 0.0 ± 0.0
Ile
4.653IleAla: 4.653 ± 0.269
0.498IleCys: 0.498 ± 0.071
3.931IleAsp: 3.931 ± 0.234
3.745IleGlu: 3.745 ± 0.252
0.883IlePhe: 0.883 ± 0.104
3.023IleGly: 3.023 ± 0.184
0.945IleHis: 0.945 ± 0.109
1.916IleIle: 1.916 ± 0.17
2.675IleLys: 2.675 ± 0.239
3.533IleLeu: 3.533 ± 0.224
1.381IleMet: 1.381 ± 0.142
2.575IleAsn: 2.575 ± 0.223
2.376IlePro: 2.376 ± 0.203
1.443IleGln: 1.443 ± 0.146
3.309IleArg: 3.309 ± 0.224
2.55IleSer: 2.55 ± 0.179
3.334IleThr: 3.334 ± 0.223
3.546IleVal: 3.546 ± 0.248
0.46IleTrp: 0.46 ± 0.078
1.169IleTyr: 1.169 ± 0.131
0.0IleXaa: 0.0 ± 0.0
Lys
5.213LysAla: 5.213 ± 0.377
0.411LysCys: 0.411 ± 0.079
2.264LysAsp: 2.264 ± 0.185
2.662LysGlu: 2.662 ± 0.196
2.065LysPhe: 2.065 ± 0.18
3.284LysGly: 3.284 ± 0.243
1.157LysHis: 1.157 ± 0.122
2.476LysIle: 2.476 ± 0.18
3.844LysLys: 3.844 ± 0.392
4.28LysLeu: 4.28 ± 0.262
1.58LysMet: 1.58 ± 0.144
1.791LysAsn: 1.791 ± 0.175
2.488LysPro: 2.488 ± 0.174
2.078LysGln: 2.078 ± 0.182
3.272LysArg: 3.272 ± 0.242
2.389LysSer: 2.389 ± 0.178
2.824LysThr: 2.824 ± 0.21
3.172LysVal: 3.172 ± 0.231
0.722LysTrp: 0.722 ± 0.099
1.816LysTyr: 1.816 ± 0.149
0.0LysXaa: 0.0 ± 0.0
Leu
7.726LeuAla: 7.726 ± 0.316
0.796LeuCys: 0.796 ± 0.106
4.989LeuAsp: 4.989 ± 0.278
5.014LeuGlu: 5.014 ± 0.294
2.861LeuPhe: 2.861 ± 0.186
5.2LeuGly: 5.2 ± 0.26
1.928LeuHis: 1.928 ± 0.177
3.521LeuIle: 3.521 ± 0.188
4.18LeuLys: 4.18 ± 0.256
5.947LeuLeu: 5.947 ± 0.304
2.214LeuMet: 2.214 ± 0.156
4.031LeuAsn: 4.031 ± 0.205
3.794LeuPro: 3.794 ± 0.228
2.588LeuGln: 2.588 ± 0.18
5.884LeuArg: 5.884 ± 0.286
5.262LeuSer: 5.262 ± 0.224
5.138LeuThr: 5.138 ± 0.29
5.611LeuVal: 5.611 ± 0.262
0.921LeuTrp: 0.921 ± 0.101
2.961LeuTyr: 2.961 ± 0.154
0.0LeuXaa: 0.0 ± 0.0
Met
3.011MetAla: 3.011 ± 0.17
0.224MetCys: 0.224 ± 0.06
1.48MetAsp: 1.48 ± 0.13
1.592MetGlu: 1.592 ± 0.15
0.746MetPhe: 0.746 ± 0.109
1.928MetGly: 1.928 ± 0.166
0.634MetHis: 0.634 ± 0.096
1.456MetIle: 1.456 ± 0.139
1.879MetLys: 1.879 ± 0.151
2.202MetLeu: 2.202 ± 0.151
0.622MetMet: 0.622 ± 0.081
1.107MetAsn: 1.107 ± 0.104
1.145MetPro: 1.145 ± 0.129
1.319MetGln: 1.319 ± 0.136
1.555MetArg: 1.555 ± 0.156
1.779MetSer: 1.779 ± 0.138
1.916MetThr: 1.916 ± 0.146
1.754MetVal: 1.754 ± 0.174
0.274MetTrp: 0.274 ± 0.053
0.871MetTyr: 0.871 ± 0.104
0.0MetXaa: 0.0 ± 0.0
Asn
3.844AsnAla: 3.844 ± 0.204
0.336AsnCys: 0.336 ± 0.067
1.953AsnAsp: 1.953 ± 0.146
2.165AsnGlu: 2.165 ± 0.168
1.057AsnPhe: 1.057 ± 0.134
3.707AsnGly: 3.707 ± 0.273
0.958AsnHis: 0.958 ± 0.126
1.717AsnIle: 1.717 ± 0.152
1.754AsnLys: 1.754 ± 0.135
2.874AsnLeu: 2.874 ± 0.23
1.07AsnMet: 1.07 ± 0.12
1.356AsnAsn: 1.356 ± 0.14
2.413AsnPro: 2.413 ± 0.171
1.219AsnGln: 1.219 ± 0.126
2.252AsnArg: 2.252 ± 0.155
2.252AsnSer: 2.252 ± 0.149
2.401AsnThr: 2.401 ± 0.201
3.334AsnVal: 3.334 ± 0.2
0.908AsnTrp: 0.908 ± 0.102
1.344AsnTyr: 1.344 ± 0.135
0.0AsnXaa: 0.0 ± 0.0
Pro
4.454ProAla: 4.454 ± 0.309
0.361ProCys: 0.361 ± 0.068
3.147ProAsp: 3.147 ± 0.214
3.483ProGlu: 3.483 ± 0.23
1.406ProPhe: 1.406 ± 0.129
3.434ProGly: 3.434 ± 0.224
1.033ProHis: 1.033 ± 0.116
1.829ProIle: 1.829 ± 0.181
2.339ProLys: 2.339 ± 0.197
3.085ProLeu: 3.085 ± 0.193
0.983ProMet: 0.983 ± 0.106
1.891ProAsn: 1.891 ± 0.155
1.717ProPro: 1.717 ± 0.162
1.692ProGln: 1.692 ± 0.161
2.152ProArg: 2.152 ± 0.175
2.687ProSer: 2.687 ± 0.204
2.961ProThr: 2.961 ± 0.169
3.894ProVal: 3.894 ± 0.249
0.535ProTrp: 0.535 ± 0.082
1.53ProTyr: 1.53 ± 0.145
0.0ProXaa: 0.0 ± 0.0
Gln
4.354GlnAla: 4.354 ± 0.251
0.411GlnCys: 0.411 ± 0.075
1.617GlnAsp: 1.617 ± 0.149
2.152GlnGlu: 2.152 ± 0.186
1.978GlnPhe: 1.978 ± 0.179
2.264GlnGly: 2.264 ± 0.203
1.07GlnHis: 1.07 ± 0.12
2.127GlnIle: 2.127 ± 0.178
1.543GlnLys: 1.543 ± 0.154
2.675GlnLeu: 2.675 ± 0.189
1.294GlnMet: 1.294 ± 0.12
1.456GlnAsn: 1.456 ± 0.148
1.431GlnPro: 1.431 ± 0.126
1.941GlnGln: 1.941 ± 0.154
2.849GlnArg: 2.849 ± 0.182
2.053GlnSer: 2.053 ± 0.141
1.704GlnThr: 1.704 ± 0.139
2.675GlnVal: 2.675 ± 0.186
0.759GlnTrp: 0.759 ± 0.103
1.431GlnTyr: 1.431 ± 0.133
0.0GlnXaa: 0.0 ± 0.0
Arg
7.887ArgAla: 7.887 ± 0.42
0.659ArgCys: 0.659 ± 0.087
4.491ArgAsp: 4.491 ± 0.233
5.101ArgGlu: 5.101 ± 0.272
2.003ArgPhe: 2.003 ± 0.141
3.969ArgGly: 3.969 ± 0.242
1.157ArgHis: 1.157 ± 0.119
3.595ArgIle: 3.595 ± 0.207
2.774ArgLys: 2.774 ± 0.226
5.536ArgLeu: 5.536 ± 0.278
2.003ArgMet: 2.003 ± 0.157
2.14ArgAsn: 2.14 ± 0.187
2.165ArgPro: 2.165 ± 0.17
2.413ArgGln: 2.413 ± 0.185
4.255ArgArg: 4.255 ± 0.257
3.309ArgSer: 3.309 ± 0.19
3.309ArgThr: 3.309 ± 0.219
5.126ArgVal: 5.126 ± 0.294
0.746ArgTrp: 0.746 ± 0.11
2.314ArgTyr: 2.314 ± 0.168
0.0ArgXaa: 0.0 ± 0.0
Ser
5.374SerAla: 5.374 ± 0.257
0.535SerCys: 0.535 ± 0.093
3.334SerAsp: 3.334 ± 0.228
3.384SerGlu: 3.384 ± 0.197
2.177SerPhe: 2.177 ± 0.164
4.827SerGly: 4.827 ± 0.331
1.232SerHis: 1.232 ± 0.124
2.687SerIle: 2.687 ± 0.194
2.998SerLys: 2.998 ± 0.217
4.852SerLeu: 4.852 ± 0.239
1.692SerMet: 1.692 ± 0.135
2.127SerAsn: 2.127 ± 0.187
2.339SerPro: 2.339 ± 0.157
1.879SerGln: 1.879 ± 0.154
3.147SerArg: 3.147 ± 0.193
3.297SerSer: 3.297 ± 0.29
3.745SerThr: 3.745 ± 0.268
4.155SerVal: 4.155 ± 0.229
0.759SerTrp: 0.759 ± 0.101
1.99SerTyr: 1.99 ± 0.153
0.0SerXaa: 0.0 ± 0.0
Thr
5.847ThrAla: 5.847 ± 0.326
0.697ThrCys: 0.697 ± 0.097
3.471ThrAsp: 3.471 ± 0.207
3.508ThrGlu: 3.508 ± 0.238
2.413ThrPhe: 2.413 ± 0.193
4.678ThrGly: 4.678 ± 0.388
1.294ThrHis: 1.294 ± 0.146
3.235ThrIle: 3.235 ± 0.24
3.06ThrLys: 3.06 ± 0.248
5.822ThrLeu: 5.822 ± 0.249
1.393ThrMet: 1.393 ± 0.135
2.525ThrAsn: 2.525 ± 0.227
2.948ThrPro: 2.948 ± 0.19
2.227ThrGln: 2.227 ± 0.17
3.533ThrArg: 3.533 ± 0.216
3.371ThrSer: 3.371 ± 0.249
4.143ThrThr: 4.143 ± 0.28
4.653ThrVal: 4.653 ± 0.218
0.945ThrTrp: 0.945 ± 0.117
2.102ThrTyr: 2.102 ± 0.189
0.0ThrXaa: 0.0 ± 0.0
Val
7.141ValAla: 7.141 ± 0.307
1.082ValCys: 1.082 ± 0.116
4.665ValAsp: 4.665 ± 0.233
4.528ValGlu: 4.528 ± 0.271
2.065ValPhe: 2.065 ± 0.141
4.404ValGly: 4.404 ± 0.269
1.63ValHis: 1.63 ± 0.157
3.62ValIle: 3.62 ± 0.219
3.521ValLys: 3.521 ± 0.228
5.785ValLeu: 5.785 ± 0.267
1.903ValMet: 1.903 ± 0.16
2.787ValAsn: 2.787 ± 0.19
3.347ValPro: 3.347 ± 0.19
3.023ValGln: 3.023 ± 0.17
5.101ValArg: 5.101 ± 0.249
4.603ValSer: 4.603 ± 0.245
4.703ValThr: 4.703 ± 0.229
5.424ValVal: 5.424 ± 0.32
1.132ValTrp: 1.132 ± 0.144
2.326ValTyr: 2.326 ± 0.169
0.0ValXaa: 0.0 ± 0.0
Trp
1.443TrpAla: 1.443 ± 0.137
0.199TrpCys: 0.199 ± 0.054
0.796TrpAsp: 0.796 ± 0.103
0.746TrpGlu: 0.746 ± 0.083
0.622TrpPhe: 0.622 ± 0.089
0.871TrpGly: 0.871 ± 0.093
0.386TrpHis: 0.386 ± 0.068
0.858TrpIle: 0.858 ± 0.107
0.734TrpLys: 0.734 ± 0.102
1.244TrpLeu: 1.244 ± 0.134
0.448TrpMet: 0.448 ± 0.071
0.759TrpAsn: 0.759 ± 0.106
0.56TrpPro: 0.56 ± 0.085
0.398TrpGln: 0.398 ± 0.071
0.846TrpArg: 0.846 ± 0.106
0.771TrpSer: 0.771 ± 0.109
0.958TrpThr: 0.958 ± 0.133
1.157TrpVal: 1.157 ± 0.128
0.249TrpTrp: 0.249 ± 0.061
0.684TrpTyr: 0.684 ± 0.094
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.483TyrAla: 3.483 ± 0.232
0.448TyrCys: 0.448 ± 0.081
2.376TyrAsp: 2.376 ± 0.165
2.252TyrGlu: 2.252 ± 0.196
1.033TyrPhe: 1.033 ± 0.122
2.413TyrGly: 2.413 ± 0.168
0.722TyrHis: 0.722 ± 0.092
1.48TyrIle: 1.48 ± 0.131
1.63TyrLys: 1.63 ± 0.156
2.874TyrLeu: 2.874 ± 0.178
0.821TyrMet: 0.821 ± 0.09
1.356TyrAsn: 1.356 ± 0.136
1.344TyrPro: 1.344 ± 0.138
1.244TyrGln: 1.244 ± 0.116
2.227TyrArg: 2.227 ± 0.176
2.14TyrSer: 2.14 ± 0.164
2.625TyrThr: 2.625 ± 0.183
2.662TyrVal: 2.662 ± 0.189
0.622TyrTrp: 0.622 ± 0.091
0.896TyrTyr: 0.896 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 446 proteins (80383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski