Amino acid dipepetide frequency for Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.423AlaAla: 4.423 ± 0.577
0.962AlaCys: 0.962 ± 0.319
2.308AlaAsp: 2.308 ± 0.639
4.231AlaGlu: 4.231 ± 0.836
4.038AlaPhe: 4.038 ± 1.089
3.077AlaGly: 3.077 ± 1.372
1.154AlaHis: 1.154 ± 0.347
4.231AlaIle: 4.231 ± 0.631
2.5AlaLys: 2.5 ± 0.698
5.385AlaLeu: 5.385 ± 0.953
0.769AlaMet: 0.769 ± 0.681
2.308AlaAsn: 2.308 ± 0.983
2.115AlaPro: 2.115 ± 0.493
2.308AlaGln: 2.308 ± 0.674
2.5AlaArg: 2.5 ± 0.875
5.192AlaSer: 5.192 ± 0.581
5.769AlaThr: 5.769 ± 0.87
3.846AlaVal: 3.846 ± 0.611
0.769AlaTrp: 0.769 ± 0.288
1.346AlaTyr: 1.346 ± 0.499
0.0AlaXaa: 0.0 ± 0.0
Cys
0.769CysAla: 0.769 ± 0.454
0.385CysCys: 0.385 ± 0.181
0.769CysAsp: 0.769 ± 0.328
1.154CysGlu: 1.154 ± 0.552
0.385CysPhe: 0.385 ± 0.241
0.962CysGly: 0.962 ± 0.334
0.192CysHis: 0.192 ± 0.235
0.769CysIle: 0.769 ± 0.442
1.346CysLys: 1.346 ± 0.415
1.923CysLeu: 1.923 ± 0.31
0.385CysMet: 0.385 ± 0.174
1.154CysAsn: 1.154 ± 0.391
1.154CysPro: 1.154 ± 0.326
0.769CysGln: 0.769 ± 0.255
1.731CysArg: 1.731 ± 0.857
0.962CysSer: 0.962 ± 0.36
0.577CysThr: 0.577 ± 0.285
0.192CysVal: 0.192 ± 0.12
0.192CysTrp: 0.192 ± 0.12
0.769CysTyr: 0.769 ± 0.266
0.0CysXaa: 0.0 ± 0.0
Asp
3.077AspAla: 3.077 ± 0.938
0.192AspCys: 0.192 ± 0.235
4.231AspAsp: 4.231 ± 2.546
1.923AspGlu: 1.923 ± 0.386
2.5AspPhe: 2.5 ± 0.447
2.5AspGly: 2.5 ± 0.886
2.692AspHis: 2.692 ± 0.715
2.692AspIle: 2.692 ± 0.867
1.731AspLys: 1.731 ± 0.569
5.962AspLeu: 5.962 ± 0.903
0.577AspMet: 0.577 ± 0.379
3.654AspAsn: 3.654 ± 0.939
3.077AspPro: 3.077 ± 0.719
3.269AspGln: 3.269 ± 0.619
2.885AspArg: 2.885 ± 0.473
4.808AspSer: 4.808 ± 1.183
2.115AspThr: 2.115 ± 0.617
1.923AspVal: 1.923 ± 0.638
0.577AspTrp: 0.577 ± 0.252
3.077AspTyr: 3.077 ± 1.349
0.0AspXaa: 0.0 ± 0.0
Glu
3.846GluAla: 3.846 ± 1.648
1.154GluCys: 1.154 ± 0.392
3.077GluAsp: 3.077 ± 0.898
2.692GluGlu: 2.692 ± 1.319
1.731GluPhe: 1.731 ± 0.689
4.038GluGly: 4.038 ± 1.012
0.962GluHis: 0.962 ± 0.432
3.269GluIle: 3.269 ± 0.448
3.077GluLys: 3.077 ± 0.766
3.269GluLeu: 3.269 ± 0.466
1.346GluMet: 1.346 ± 0.589
2.692GluAsn: 2.692 ± 0.665
3.846GluPro: 3.846 ± 1.139
2.692GluGln: 2.692 ± 0.771
2.692GluArg: 2.692 ± 0.884
2.692GluSer: 2.692 ± 0.401
4.231GluThr: 4.231 ± 0.913
2.308GluVal: 2.308 ± 0.501
0.962GluTrp: 0.962 ± 0.626
1.346GluTyr: 1.346 ± 0.515
0.0GluXaa: 0.0 ± 0.0
Phe
1.346PheAla: 1.346 ± 0.415
0.577PheCys: 0.577 ± 0.276
1.538PheAsp: 1.538 ± 0.556
1.731PheGlu: 1.731 ± 0.825
1.346PhePhe: 1.346 ± 0.271
2.308PheGly: 2.308 ± 0.514
1.923PheHis: 1.923 ± 0.317
2.308PheIle: 2.308 ± 0.596
2.5PheLys: 2.5 ± 0.414
7.308PheLeu: 7.308 ± 0.717
0.385PheMet: 0.385 ± 0.231
0.962PheAsn: 0.962 ± 0.558
1.923PhePro: 1.923 ± 0.456
2.5PheGln: 2.5 ± 0.864
1.346PheArg: 1.346 ± 0.559
4.231PheSer: 4.231 ± 1.346
1.346PheThr: 1.346 ± 0.395
1.154PheVal: 1.154 ± 0.567
1.346PheTrp: 1.346 ± 0.559
1.154PheTyr: 1.154 ± 0.53
0.0PheXaa: 0.0 ± 0.0
Gly
2.115GlyAla: 2.115 ± 0.492
0.0GlyCys: 0.0 ± 0.0
3.462GlyAsp: 3.462 ± 0.615
2.885GlyGlu: 2.885 ± 1.123
2.692GlyPhe: 2.692 ± 0.521
1.923GlyGly: 1.923 ± 0.545
1.731GlyHis: 1.731 ± 0.544
3.654GlyIle: 3.654 ± 0.913
3.462GlyLys: 3.462 ± 1.363
6.731GlyLeu: 6.731 ± 0.62
0.577GlyMet: 0.577 ± 0.583
2.5GlyAsn: 2.5 ± 0.486
3.269GlyPro: 3.269 ± 0.832
2.308GlyGln: 2.308 ± 0.506
2.308GlyArg: 2.308 ± 0.526
3.077GlySer: 3.077 ± 0.679
3.846GlyThr: 3.846 ± 0.606
4.423GlyVal: 4.423 ± 1.168
0.962GlyTrp: 0.962 ± 0.46
1.538GlyTyr: 1.538 ± 0.353
0.0GlyXaa: 0.0 ± 0.0
His
1.923HisAla: 1.923 ± 0.535
0.577HisCys: 0.577 ± 0.361
1.346HisAsp: 1.346 ± 0.402
1.538HisGlu: 1.538 ± 0.597
1.538HisPhe: 1.538 ± 0.402
1.154HisGly: 1.154 ± 0.737
0.962HisHis: 0.962 ± 0.499
1.346HisIle: 1.346 ± 0.511
2.115HisLys: 2.115 ± 0.478
2.692HisLeu: 2.692 ± 0.802
0.769HisMet: 0.769 ± 0.635
1.538HisAsn: 1.538 ± 0.63
1.731HisPro: 1.731 ± 0.691
1.731HisGln: 1.731 ± 0.491
1.346HisArg: 1.346 ± 0.505
2.308HisSer: 2.308 ± 0.681
2.308HisThr: 2.308 ± 0.583
0.385HisVal: 0.385 ± 0.263
0.385HisTrp: 0.385 ± 0.209
1.154HisTyr: 1.154 ± 0.532
0.0HisXaa: 0.0 ± 0.0
Ile
3.077IleAla: 3.077 ± 0.798
1.346IleCys: 1.346 ± 0.523
4.423IleAsp: 4.423 ± 0.782
3.846IleGlu: 3.846 ± 0.518
2.308IlePhe: 2.308 ± 0.689
2.5IleGly: 2.5 ± 0.609
0.769IleHis: 0.769 ± 0.565
3.462IleIle: 3.462 ± 0.4
2.885IleLys: 2.885 ± 0.955
7.5IleLeu: 7.5 ± 1.367
1.731IleMet: 1.731 ± 0.775
2.692IleAsn: 2.692 ± 0.696
2.885IlePro: 2.885 ± 0.836
2.115IleGln: 2.115 ± 0.576
2.115IleArg: 2.115 ± 0.481
5.385IleSer: 5.385 ± 0.612
4.615IleThr: 4.615 ± 0.889
3.269IleVal: 3.269 ± 0.667
0.577IleTrp: 0.577 ± 0.452
2.115IleTyr: 2.115 ± 0.348
0.0IleXaa: 0.0 ± 0.0
Lys
2.692LysAla: 2.692 ± 0.603
0.385LysCys: 0.385 ± 0.231
3.077LysAsp: 3.077 ± 0.76
2.5LysGlu: 2.5 ± 0.63
2.885LysPhe: 2.885 ± 0.607
2.308LysGly: 2.308 ± 0.75
1.731LysHis: 1.731 ± 0.377
5.192LysIle: 5.192 ± 1.185
3.462LysLys: 3.462 ± 0.875
5.0LysLeu: 5.0 ± 0.763
0.192LysMet: 0.192 ± 0.215
2.308LysAsn: 2.308 ± 0.648
2.692LysPro: 2.692 ± 0.822
1.731LysGln: 1.731 ± 0.446
1.923LysArg: 1.923 ± 0.303
3.077LysSer: 3.077 ± 0.486
2.885LysThr: 2.885 ± 0.103
4.615LysVal: 4.615 ± 0.892
0.769LysTrp: 0.769 ± 0.482
1.731LysTyr: 1.731 ± 0.569
0.0LysXaa: 0.0 ± 0.0
Leu
7.885LeuAla: 7.885 ± 0.575
2.308LeuCys: 2.308 ± 0.553
5.577LeuAsp: 5.577 ± 0.621
5.962LeuGlu: 5.962 ± 1.239
4.231LeuPhe: 4.231 ± 0.423
6.346LeuGly: 6.346 ± 0.731
3.462LeuHis: 3.462 ± 0.685
6.731LeuIle: 6.731 ± 1.198
6.154LeuLys: 6.154 ± 1.717
9.615LeuLeu: 9.615 ± 1.39
1.923LeuMet: 1.923 ± 0.427
5.577LeuAsn: 5.577 ± 1.334
6.154LeuPro: 6.154 ± 1.389
5.769LeuGln: 5.769 ± 0.701
6.538LeuArg: 6.538 ± 0.829
9.038LeuSer: 9.038 ± 1.18
7.885LeuThr: 7.885 ± 0.692
5.0LeuVal: 5.0 ± 1.091
1.538LeuTrp: 1.538 ± 0.63
2.308LeuTyr: 2.308 ± 0.495
0.0LeuXaa: 0.0 ± 0.0
Met
0.962MetAla: 0.962 ± 0.558
0.385MetCys: 0.385 ± 0.166
0.769MetAsp: 0.769 ± 0.256
1.346MetGlu: 1.346 ± 0.603
0.192MetPhe: 0.192 ± 0.201
0.962MetGly: 0.962 ± 0.42
1.154MetHis: 1.154 ± 0.341
0.385MetIle: 0.385 ± 0.241
0.577MetLys: 0.577 ± 0.257
1.154MetLeu: 1.154 ± 0.391
0.577MetMet: 0.577 ± 0.341
0.769MetAsn: 0.769 ± 0.468
0.385MetPro: 0.385 ± 0.349
0.769MetGln: 0.769 ± 0.342
1.346MetArg: 1.346 ± 0.6
1.731MetSer: 1.731 ± 0.277
1.538MetThr: 1.538 ± 0.738
1.731MetVal: 1.731 ± 0.495
0.0MetTrp: 0.0 ± 0.0
0.385MetTyr: 0.385 ± 0.43
0.0MetXaa: 0.0 ± 0.0
Asn
2.308AsnAla: 2.308 ± 0.847
0.962AsnCys: 0.962 ± 0.477
2.5AsnAsp: 2.5 ± 0.776
3.077AsnGlu: 3.077 ± 1.12
2.5AsnPhe: 2.5 ± 0.485
2.115AsnGly: 2.115 ± 0.803
1.731AsnHis: 1.731 ± 0.672
2.308AsnIle: 2.308 ± 0.533
1.731AsnLys: 1.731 ± 0.519
6.154AsnLeu: 6.154 ± 0.745
0.962AsnMet: 0.962 ± 0.374
4.423AsnAsn: 4.423 ± 1.045
3.077AsnPro: 3.077 ± 0.711
2.692AsnGln: 2.692 ± 0.501
4.038AsnArg: 4.038 ± 0.619
5.577AsnSer: 5.577 ± 1.236
3.269AsnThr: 3.269 ± 1.036
2.5AsnVal: 2.5 ± 0.668
0.385AsnTrp: 0.385 ± 0.231
1.346AsnTyr: 1.346 ± 0.405
0.0AsnXaa: 0.0 ± 0.0
Pro
3.846ProAla: 3.846 ± 1.454
1.538ProCys: 1.538 ± 0.455
3.269ProAsp: 3.269 ± 1.203
2.692ProGlu: 2.692 ± 0.813
1.346ProPhe: 1.346 ± 0.53
3.269ProGly: 3.269 ± 1.272
2.115ProHis: 2.115 ± 0.383
3.462ProIle: 3.462 ± 1.17
3.654ProLys: 3.654 ± 1.244
5.769ProLeu: 5.769 ± 0.911
0.577ProMet: 0.577 ± 0.251
2.692ProAsn: 2.692 ± 0.552
5.962ProPro: 5.962 ± 1.67
3.846ProGln: 3.846 ± 0.334
2.308ProArg: 2.308 ± 0.861
4.231ProSer: 4.231 ± 0.853
3.846ProThr: 3.846 ± 1.376
3.462ProVal: 3.462 ± 0.668
0.192ProTrp: 0.192 ± 0.194
1.154ProTyr: 1.154 ± 0.34
0.0ProXaa: 0.0 ± 0.0
Gln
2.115GlnAla: 2.115 ± 0.334
1.154GlnCys: 1.154 ± 0.435
3.269GlnAsp: 3.269 ± 0.79
2.5GlnGlu: 2.5 ± 0.444
2.115GlnPhe: 2.115 ± 0.382
3.846GlnGly: 3.846 ± 1.542
0.385GlnHis: 0.385 ± 0.166
3.654GlnIle: 3.654 ± 0.824
3.269GlnLys: 3.269 ± 0.672
7.5GlnLeu: 7.5 ± 1.622
0.962GlnMet: 0.962 ± 0.299
1.923GlnAsn: 1.923 ± 0.293
2.308GlnPro: 2.308 ± 0.784
2.5GlnGln: 2.5 ± 1.168
2.885GlnArg: 2.885 ± 0.837
2.885GlnSer: 2.885 ± 0.876
2.5GlnThr: 2.5 ± 0.293
1.538GlnVal: 1.538 ± 0.342
0.577GlnTrp: 0.577 ± 0.415
2.885GlnTyr: 2.885 ± 0.966
0.0GlnXaa: 0.0 ± 0.0
Arg
2.692ArgAla: 2.692 ± 0.527
0.577ArgCys: 0.577 ± 0.286
2.5ArgAsp: 2.5 ± 0.47
2.692ArgGlu: 2.692 ± 0.508
2.115ArgPhe: 2.115 ± 0.673
4.038ArgGly: 4.038 ± 0.474
1.154ArgHis: 1.154 ± 0.421
1.538ArgIle: 1.538 ± 0.294
3.077ArgLys: 3.077 ± 0.67
7.5ArgLeu: 7.5 ± 0.735
0.769ArgMet: 0.769 ± 0.385
2.5ArgAsn: 2.5 ± 0.733
2.692ArgPro: 2.692 ± 0.909
2.885ArgGln: 2.885 ± 0.921
2.5ArgArg: 2.5 ± 0.624
4.423ArgSer: 4.423 ± 0.876
3.462ArgThr: 3.462 ± 0.689
1.923ArgVal: 1.923 ± 0.666
0.769ArgTrp: 0.769 ± 0.442
1.731ArgTyr: 1.731 ± 0.318
0.0ArgXaa: 0.0 ± 0.0
Ser
5.192SerAla: 5.192 ± 0.363
1.154SerCys: 1.154 ± 0.308
4.423SerAsp: 4.423 ± 0.837
3.269SerGlu: 3.269 ± 0.827
2.885SerPhe: 2.885 ± 0.843
5.0SerGly: 5.0 ± 0.471
0.962SerHis: 0.962 ± 0.487
3.462SerIle: 3.462 ± 1.379
3.462SerLys: 3.462 ± 0.759
6.923SerLeu: 6.923 ± 1.298
1.154SerMet: 1.154 ± 0.253
6.154SerAsn: 6.154 ± 1.03
5.0SerPro: 5.0 ± 1.33
3.846SerGln: 3.846 ± 0.787
4.423SerArg: 4.423 ± 1.241
7.5SerSer: 7.5 ± 1.147
6.731SerThr: 6.731 ± 1.808
4.423SerVal: 4.423 ± 0.485
0.769SerTrp: 0.769 ± 0.482
2.5SerTyr: 2.5 ± 1.006
0.0SerXaa: 0.0 ± 0.0
Thr
5.769ThrAla: 5.769 ± 1.271
1.346ThrCys: 1.346 ± 0.415
3.462ThrAsp: 3.462 ± 0.611
3.846ThrGlu: 3.846 ± 0.588
1.346ThrPhe: 1.346 ± 0.438
3.654ThrGly: 3.654 ± 0.9
1.731ThrHis: 1.731 ± 0.57
3.269ThrIle: 3.269 ± 0.599
3.077ThrLys: 3.077 ± 0.97
8.846ThrLeu: 8.846 ± 1.343
1.538ThrMet: 1.538 ± 0.386
2.885ThrAsn: 2.885 ± 0.621
3.654ThrPro: 3.654 ± 1.121
2.5ThrGln: 2.5 ± 0.386
4.038ThrArg: 4.038 ± 1.26
5.962ThrSer: 5.962 ± 0.865
4.615ThrThr: 4.615 ± 1.515
2.692ThrVal: 2.692 ± 0.439
1.346ThrTrp: 1.346 ± 0.318
2.115ThrTyr: 2.115 ± 0.276
0.0ThrXaa: 0.0 ± 0.0
Val
2.885ValAla: 2.885 ± 0.694
0.962ValCys: 0.962 ± 0.31
1.923ValAsp: 1.923 ± 0.536
1.346ValGlu: 1.346 ± 0.613
1.154ValPhe: 1.154 ± 0.722
2.115ValGly: 2.115 ± 1.223
1.538ValHis: 1.538 ± 0.353
5.0ValIle: 5.0 ± 0.83
1.346ValLys: 1.346 ± 0.57
5.192ValLeu: 5.192 ± 1.647
1.154ValMet: 1.154 ± 0.257
3.077ValAsn: 3.077 ± 0.965
4.615ValPro: 4.615 ± 1.168
4.615ValGln: 4.615 ± 1.012
2.5ValArg: 2.5 ± 0.337
3.846ValSer: 3.846 ± 0.685
2.692ValThr: 2.692 ± 0.656
2.885ValVal: 2.885 ± 0.509
0.385ValTrp: 0.385 ± 0.349
1.923ValTyr: 1.923 ± 0.528
0.0ValXaa: 0.0 ± 0.0
Trp
1.731TrpAla: 1.731 ± 1.161
0.0TrpCys: 0.0 ± 0.0
0.385TrpAsp: 0.385 ± 0.209
0.769TrpGlu: 0.769 ± 0.266
0.769TrpPhe: 0.769 ± 0.461
0.769TrpGly: 0.769 ± 0.442
0.385TrpHis: 0.385 ± 0.241
1.154TrpIle: 1.154 ± 0.392
0.962TrpLys: 0.962 ± 0.42
1.346TrpLeu: 1.346 ± 0.432
0.192TrpMet: 0.192 ± 0.12
0.385TrpAsn: 0.385 ± 0.241
0.385TrpPro: 0.385 ± 0.166
0.385TrpGln: 0.385 ± 0.269
0.385TrpArg: 0.385 ± 0.181
0.192TrpSer: 0.192 ± 0.12
1.731TrpThr: 1.731 ± 0.711
0.769TrpVal: 0.769 ± 0.321
0.0TrpTrp: 0.0 ± 0.0
0.769TrpTyr: 0.769 ± 0.482
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.577TyrAla: 0.577 ± 0.341
0.577TyrCys: 0.577 ± 0.361
1.154TyrAsp: 1.154 ± 0.462
1.923TyrGlu: 1.923 ± 0.534
1.154TyrPhe: 1.154 ± 0.387
0.577TyrGly: 0.577 ± 0.361
2.115TyrHis: 2.115 ± 0.599
1.731TyrIle: 1.731 ± 0.38
0.769TyrLys: 0.769 ± 0.255
4.231TyrLeu: 4.231 ± 2.039
0.385TyrMet: 0.385 ± 0.231
3.462TyrAsn: 3.462 ± 0.686
2.308TyrPro: 2.308 ± 0.667
1.731TyrGln: 1.731 ± 0.556
1.731TyrArg: 1.731 ± 0.453
2.115TyrSer: 2.115 ± 0.935
1.731TyrThr: 1.731 ± 0.565
2.115TyrVal: 2.115 ± 0.575
0.962TyrTrp: 0.962 ± 0.284
1.346TyrTyr: 1.346 ± 0.271
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (5201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski