Amino acid dipepetide frequency for Streptomyces armeniacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.127AlaAla: 23.127 ± 0.179	1.115AlaCys: 1.115 ± 0.024	8.918AlaAsp: 8.918 ± 0.078	9.62AlaGlu: 9.62 ± 0.081	3.396AlaPhe: 3.396 ± 0.046	14.101AlaGly: 14.101 ± 0.097	2.937AlaHis: 2.937 ± 0.043	2.902AlaIle: 2.902 ± 0.04	2.541AlaLys: 2.541 ± 0.048	14.689AlaLeu: 14.689 ± 0.111	2.446AlaMet: 2.446 ± 0.035	1.831AlaAsn: 1.831 ± 0.031	7.639AlaPro: 7.639 ± 0.08	3.642AlaGln: 3.642 ± 0.048	11.226AlaArg: 11.226 ± 0.092	5.614AlaSer: 5.614 ± 0.055	6.482AlaThr: 6.482 ± 0.059	12.443AlaVal: 12.443 ± 0.09	1.747AlaTrp: 1.747 ± 0.025	2.923AlaTyr: 2.923 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.167CysAla: 1.167 ± 0.023	0.103CysCys: 0.103 ± 0.008	0.488CysAsp: 0.488 ± 0.014	0.422CysGlu: 0.422 ± 0.014	0.216CysPhe: 0.216 ± 0.01	1.007CysGly: 1.007 ± 0.023	0.196CysHis: 0.196 ± 0.01	0.152CysIle: 0.152 ± 0.009	0.103CysLys: 0.103 ± 0.007	0.724CysLeu: 0.724 ± 0.02	0.128CysMet: 0.128 ± 0.007	0.122CysAsn: 0.122 ± 0.007	0.481CysPro: 0.481 ± 0.015	0.153CysGln: 0.153 ± 0.009	0.671CysArg: 0.671 ± 0.017	0.434CysSer: 0.434 ± 0.013	0.499CysThr: 0.499 ± 0.015	0.679CysVal: 0.679 ± 0.018	0.129CysTrp: 0.129 ± 0.007	0.158CysTyr: 0.158 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.422AspAla: 8.422 ± 0.081	0.444AspCys: 0.444 ± 0.014	3.718AspAsp: 3.718 ± 0.051	4.123AspGlu: 4.123 ± 0.048	1.659AspPhe: 1.659 ± 0.031	7.314AspGly: 7.314 ± 0.061	1.356AspHis: 1.356 ± 0.025	1.769AspIle: 1.769 ± 0.028	1.123AspLys: 1.123 ± 0.028	5.666AspLeu: 5.666 ± 0.046	0.852AspMet: 0.852 ± 0.02	0.865AspAsn: 0.865 ± 0.021	4.492AspPro: 4.492 ± 0.045	1.414AspGln: 1.414 ± 0.028	5.004AspArg: 5.004 ± 0.049	2.703AspSer: 2.703 ± 0.038	3.338AspThr: 3.338 ± 0.038	4.662AspVal: 4.662 ± 0.044	1.012AspTrp: 1.012 ± 0.022	1.112AspTyr: 1.112 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.652GluAla: 7.652 ± 0.079	0.387GluCys: 0.387 ± 0.015	3.1GluAsp: 3.1 ± 0.044	3.681GluGlu: 3.681 ± 0.054	1.518GluPhe: 1.518 ± 0.024	4.68GluGly: 4.68 ± 0.049	1.692GluHis: 1.692 ± 0.028	2.086GluIle: 2.086 ± 0.032	1.404GluLys: 1.404 ± 0.029	7.401GluLeu: 7.401 ± 0.064	0.922GluMet: 0.922 ± 0.022	1.02GluAsn: 1.02 ± 0.024	4.023GluPro: 4.023 ± 0.052	2.375GluGln: 2.375 ± 0.041	6.154GluArg: 6.154 ± 0.063	2.802GluSer: 2.802 ± 0.041	3.038GluThr: 3.038 ± 0.038	4.388GluVal: 4.388 ± 0.052	0.834GluTrp: 0.834 ± 0.02	1.092GluTyr: 1.092 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.652PheAla: 3.652 ± 0.046	0.272PheCys: 0.272 ± 0.011	1.931PheAsp: 1.931 ± 0.032	1.381PheGlu: 1.381 ± 0.023	0.868PhePhe: 0.868 ± 0.022	2.933PheGly: 2.933 ± 0.039	0.62PheHis: 0.62 ± 0.016	0.656PheIle: 0.656 ± 0.019	0.447PheLys: 0.447 ± 0.017	2.525PheLeu: 2.525 ± 0.037	0.395PheMet: 0.395 ± 0.014	0.515PheAsn: 0.515 ± 0.014	1.329PhePro: 1.329 ± 0.024	0.608PheGln: 0.608 ± 0.015	1.905PheArg: 1.905 ± 0.034	1.387PheSer: 1.387 ± 0.027	1.935PheThr: 1.935 ± 0.031	2.078PheVal: 2.078 ± 0.035	0.391PheTrp: 0.391 ± 0.013	0.516PheTyr: 0.516 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	12.38GlyAla: 12.38 ± 0.102	0.875GlyCys: 0.875 ± 0.02	5.624GlyAsp: 5.624 ± 0.054	5.743GlyGlu: 5.743 ± 0.057	2.758GlyPhe: 2.758 ± 0.039	10.28GlyGly: 10.28 ± 0.101	2.438GlyHis: 2.438 ± 0.039	3.223GlyIle: 3.223 ± 0.042	2.362GlyLys: 2.362 ± 0.044	9.521GlyLeu: 9.521 ± 0.079	2.105GlyMet: 2.105 ± 0.029	1.683GlyAsn: 1.683 ± 0.03	5.746GlyPro: 5.746 ± 0.066	2.783GlyGln: 2.783 ± 0.049	7.911GlyArg: 7.911 ± 0.07	5.565GlySer: 5.565 ± 0.06	6.788GlyThr: 6.788 ± 0.066	7.433GlyVal: 7.433 ± 0.065	1.756GlyTrp: 1.756 ± 0.03	2.185GlyTyr: 2.185 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.858HisAla: 2.858 ± 0.041	0.225HisCys: 0.225 ± 0.01	1.333HisAsp: 1.333 ± 0.026	1.267HisGlu: 1.267 ± 0.022	0.63HisPhe: 0.63 ± 0.016	2.635HisGly: 2.635 ± 0.034	0.658HisHis: 0.658 ± 0.018	0.631HisIle: 0.631 ± 0.018	0.336HisLys: 0.336 ± 0.012	2.334HisLeu: 2.334 ± 0.034	0.344HisMet: 0.344 ± 0.011	0.35HisAsn: 0.35 ± 0.012	1.812HisPro: 1.812 ± 0.031	0.654HisGln: 0.654 ± 0.016	2.199HisArg: 2.199 ± 0.033	1.065HisSer: 1.065 ± 0.023	1.407HisThr: 1.407 ± 0.025	1.721HisVal: 1.721 ± 0.03	0.384HisTrp: 0.384 ± 0.014	0.463HisTyr: 0.463 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.29IleAla: 4.29 ± 0.06	0.264IleCys: 0.264 ± 0.01	1.931IleAsp: 1.931 ± 0.03	1.8IleGlu: 1.8 ± 0.03	0.667IlePhe: 0.667 ± 0.021	3.166IleGly: 3.166 ± 0.045	0.527IleHis: 0.527 ± 0.017	0.729IleIle: 0.729 ± 0.02	0.597IleLys: 0.597 ± 0.017	2.08IleLeu: 2.08 ± 0.035	0.394IleMet: 0.394 ± 0.014	0.588IleAsn: 0.588 ± 0.017	1.567IlePro: 1.567 ± 0.031	0.619IleGln: 0.619 ± 0.017	2.077IleArg: 2.077 ± 0.029	1.526IleSer: 1.526 ± 0.025	1.888IleThr: 1.888 ± 0.028	2.349IleVal: 2.349 ± 0.044	0.326IleTrp: 0.326 ± 0.012	0.476IleTyr: 0.476 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.579LysAla: 2.579 ± 0.046	0.114LysCys: 0.114 ± 0.007	1.197LysAsp: 1.197 ± 0.028	1.099LysGlu: 1.099 ± 0.026	0.414LysPhe: 0.414 ± 0.016	1.688LysGly: 1.688 ± 0.04	0.423LysHis: 0.423 ± 0.017	0.718LysIle: 0.718 ± 0.021	0.798LysLys: 0.798 ± 0.03	1.879LysLeu: 1.879 ± 0.035	0.352LysMet: 0.352 ± 0.015	0.436LysAsn: 0.436 ± 0.015	1.28LysPro: 1.28 ± 0.028	0.641LysGln: 0.641 ± 0.02	1.437LysArg: 1.437 ± 0.03	1.088LysSer: 1.088 ± 0.026	1.176LysThr: 1.176 ± 0.027	1.584LysVal: 1.584 ± 0.032	0.237LysTrp: 0.237 ± 0.011	0.388LysTyr: 0.388 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.48LeuAla: 15.48 ± 0.102	0.853LeuCys: 0.853 ± 0.02	6.721LeuAsp: 6.721 ± 0.062	5.027LeuGlu: 5.027 ± 0.058	2.589LeuPhe: 2.589 ± 0.037	9.212LeuGly: 9.212 ± 0.083	2.361LeuHis: 2.361 ± 0.036	2.911LeuIle: 2.911 ± 0.043	1.727LeuLys: 1.727 ± 0.037	11.422LeuLeu: 11.422 ± 0.105	1.554LeuMet: 1.554 ± 0.03	1.646LeuAsn: 1.646 ± 0.026	6.494LeuPro: 6.494 ± 0.061	2.003LeuGln: 2.003 ± 0.034	9.191LeuArg: 9.191 ± 0.076	5.296LeuSer: 5.296 ± 0.058	6.609LeuThr: 6.609 ± 0.055	8.337LeuVal: 8.337 ± 0.072	1.258LeuTrp: 1.258 ± 0.024	1.811LeuTyr: 1.811 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.223MetAla: 2.223 ± 0.032	0.129MetCys: 0.129 ± 0.007	0.886MetAsp: 0.886 ± 0.022	0.77MetGlu: 0.77 ± 0.019	0.414MetPhe: 0.414 ± 0.013	1.279MetGly: 1.279 ± 0.025	0.357MetHis: 0.357 ± 0.011	0.583MetIle: 0.583 ± 0.018	0.387MetLys: 0.387 ± 0.014	1.717MetLeu: 1.717 ± 0.029	0.295MetMet: 0.295 ± 0.012	0.394MetAsn: 0.394 ± 0.013	1.138MetPro: 1.138 ± 0.025	0.435MetGln: 0.435 ± 0.017	1.45MetArg: 1.45 ± 0.025	1.277MetSer: 1.277 ± 0.026	1.435MetThr: 1.435 ± 0.025	1.279MetVal: 1.279 ± 0.027	0.221MetTrp: 0.221 ± 0.009	0.33MetTyr: 0.33 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.088AsnAla: 2.088 ± 0.027	0.168AsnCys: 0.168 ± 0.007	0.925AsnAsp: 0.925 ± 0.018	0.836AsnGlu: 0.836 ± 0.019	0.45AsnPhe: 0.45 ± 0.017	1.915AsnGly: 1.915 ± 0.035	0.344AsnHis: 0.344 ± 0.015	0.57AsnIle: 0.57 ± 0.018	0.355AsnLys: 0.355 ± 0.013	1.453AsnLeu: 1.453 ± 0.028	0.271AsnMet: 0.271 ± 0.011	0.366AsnAsn: 0.366 ± 0.012	1.251AsnPro: 1.251 ± 0.022	0.429AsnGln: 0.429 ± 0.014	1.176AsnArg: 1.176 ± 0.025	0.873AsnSer: 0.873 ± 0.023	1.009AsnThr: 1.009 ± 0.022	1.278AsnVal: 1.278 ± 0.024	0.254AsnTrp: 0.254 ± 0.01	0.379AsnTyr: 0.379 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.774ProAla: 8.774 ± 0.086	0.36ProCys: 0.36 ± 0.013	4.91ProAsp: 4.91 ± 0.056	5.06ProGlu: 5.06 ± 0.053	1.501ProPhe: 1.501 ± 0.021	7.302ProGly: 7.302 ± 0.074	1.454ProHis: 1.454 ± 0.027	1.024ProIle: 1.024 ± 0.024	1.041ProLys: 1.041 ± 0.022	5.374ProLeu: 5.374 ± 0.061	1.0ProMet: 1.0 ± 0.023	0.845ProAsn: 0.845 ± 0.018	4.087ProPro: 4.087 ± 0.069	1.744ProGln: 1.744 ± 0.035	4.272ProArg: 4.272 ± 0.051	3.184ProSer: 3.184 ± 0.038	2.772ProThr: 2.772 ± 0.035	5.485ProVal: 5.485 ± 0.046	0.879ProTrp: 0.879 ± 0.021	1.592ProTyr: 1.592 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.533GlnAla: 3.533 ± 0.048	0.17GlnCys: 0.17 ± 0.009	1.389GlnAsp: 1.389 ± 0.029	1.417GlnGlu: 1.417 ± 0.024	0.647GlnPhe: 0.647 ± 0.017	2.215GlnGly: 2.215 ± 0.033	0.712GlnHis: 0.712 ± 0.016	0.922GlnIle: 0.922 ± 0.022	0.523GlnLys: 0.523 ± 0.02	3.12GlnLeu: 3.12 ± 0.042	0.428GlnMet: 0.428 ± 0.015	0.44GlnAsn: 0.44 ± 0.014	1.899GlnPro: 1.899 ± 0.048	1.297GlnGln: 1.297 ± 0.035	2.549GlnArg: 2.549 ± 0.038	1.199GlnSer: 1.199 ± 0.025	1.293GlnThr: 1.293 ± 0.023	2.092GlnVal: 2.092 ± 0.036	0.42GlnTrp: 0.42 ± 0.014	0.522GlnTyr: 0.522 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.545ArgAla: 10.545 ± 0.095	0.643ArgCys: 0.643 ± 0.018	4.649ArgAsp: 4.649 ± 0.044	5.328ArgGlu: 5.328 ± 0.056	2.329ArgPhe: 2.329 ± 0.033	6.33ArgGly: 6.33 ± 0.061	2.292ArgHis: 2.292 ± 0.041	2.972ArgIle: 2.972 ± 0.039	1.696ArgLys: 1.696 ± 0.036	9.001ArgLeu: 9.001 ± 0.085	1.754ArgMet: 1.754 ± 0.032	1.369ArgAsn: 1.369 ± 0.024	5.054ArgPro: 5.054 ± 0.056	2.444ArgGln: 2.444 ± 0.033	8.026ArgArg: 8.026 ± 0.078	3.968ArgSer: 3.968 ± 0.046	6.145ArgThr: 6.145 ± 0.058	6.029ArgVal: 6.029 ± 0.054	1.385ArgTrp: 1.385 ± 0.025	1.77ArgTyr: 1.77 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.863SerAla: 6.863 ± 0.059	0.422SerCys: 0.422 ± 0.016	2.701SerAsp: 2.701 ± 0.038	2.543SerGlu: 2.543 ± 0.032	1.404SerPhe: 1.404 ± 0.025	6.32SerGly: 6.32 ± 0.055	1.013SerHis: 1.013 ± 0.021	1.153SerIle: 1.153 ± 0.022	0.917SerLys: 0.917 ± 0.024	4.63SerLeu: 4.63 ± 0.046	1.014SerMet: 1.014 ± 0.023	0.799SerAsn: 0.799 ± 0.02	3.157SerPro: 3.157 ± 0.042	1.175SerGln: 1.175 ± 0.026	3.687SerArg: 3.687 ± 0.045	2.686SerSer: 2.686 ± 0.043	2.87SerThr: 2.87 ± 0.041	4.26SerVal: 4.26 ± 0.046	0.853SerTrp: 0.853 ± 0.02	1.192SerTyr: 1.192 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.994ThrAla: 8.994 ± 0.074	0.382ThrCys: 0.382 ± 0.013	3.685ThrAsp: 3.685 ± 0.038	3.471ThrGlu: 3.471 ± 0.042	1.471ThrPhe: 1.471 ± 0.027	7.093ThrGly: 7.093 ± 0.059	1.172ThrHis: 1.172 ± 0.023	1.365ThrIle: 1.365 ± 0.029	1.029ThrLys: 1.029 ± 0.024	5.521ThrLeu: 5.521 ± 0.051	0.916ThrMet: 0.916 ± 0.022	0.878ThrAsn: 0.878 ± 0.02	3.984ThrPro: 3.984 ± 0.043	1.225ThrGln: 1.225 ± 0.022	3.852ThrArg: 3.852 ± 0.042	2.99ThrSer: 2.99 ± 0.04	3.301ThrThr: 3.301 ± 0.045	6.007ThrVal: 6.007 ± 0.051	0.758ThrTrp: 0.758 ± 0.02	1.27ThrTyr: 1.27 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	10.18ValAla: 10.18 ± 0.076	0.781ValCys: 0.781 ± 0.019	4.655ValAsp: 4.655 ± 0.051	4.501ValGlu: 4.501 ± 0.046	2.341ValPhe: 2.341 ± 0.035	6.107ValGly: 6.107 ± 0.058	1.957ValHis: 1.957 ± 0.03	2.616ValIle: 2.616 ± 0.039	1.509ValLys: 1.509 ± 0.032	9.677ValLeu: 9.677 ± 0.074	1.317ValMet: 1.317 ± 0.023	1.545ValAsn: 1.545 ± 0.03	5.367ValPro: 5.367 ± 0.054	1.989ValGln: 1.989 ± 0.029	7.878ValArg: 7.878 ± 0.066	4.233ValSer: 4.233 ± 0.044	5.363ValThr: 5.363 ± 0.049	7.294ValVal: 7.294 ± 0.066	1.138ValTrp: 1.138 ± 0.027	1.522ValTyr: 1.522 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.594TrpAla: 1.594 ± 0.028	0.165TrpCys: 0.165 ± 0.008	0.824TrpAsp: 0.824 ± 0.02	0.739TrpGlu: 0.739 ± 0.019	0.495TrpPhe: 0.495 ± 0.016	1.036TrpGly: 1.036 ± 0.028	0.411TrpHis: 0.411 ± 0.014	0.465TrpIle: 0.465 ± 0.015	0.32TrpLys: 0.32 ± 0.014	1.78TrpLeu: 1.78 ± 0.026	0.284TrpMet: 0.284 ± 0.012	0.358TrpAsn: 0.358 ± 0.014	0.807TrpPro: 0.807 ± 0.021	0.619TrpGln: 0.619 ± 0.016	1.347TrpArg: 1.347 ± 0.023	0.899TrpSer: 0.899 ± 0.02	0.944TrpThr: 0.944 ± 0.022	0.886TrpVal: 0.886 ± 0.018	0.328TrpTrp: 0.328 ± 0.015	0.339TrpTyr: 0.339 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.936TyrAla: 2.936 ± 0.037	0.162TyrCys: 0.162 ± 0.008	1.462TyrAsp: 1.462 ± 0.027	1.422TyrGlu: 1.422 ± 0.024	0.576TyrPhe: 0.576 ± 0.017	2.542TyrGly: 2.542 ± 0.042	0.385TyrHis: 0.385 ± 0.014	0.415TyrIle: 0.415 ± 0.014	0.311TyrLys: 0.311 ± 0.013	1.991TyrLeu: 1.991 ± 0.03	0.229TyrMet: 0.229 ± 0.011	0.34TyrAsn: 0.34 ± 0.013	1.056TyrPro: 1.056 ± 0.021	0.537TyrGln: 0.537 ± 0.014	1.714TyrArg: 1.714 ± 0.026	0.871TyrSer: 0.871 ± 0.022	1.073TyrThr: 1.073 ± 0.023	1.688TyrVal: 1.688 ± 0.028	0.331TyrTrp: 0.331 ± 0.013	0.395TyrTyr: 0.395 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6639 proteins (2263626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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