Amino acid dipepetide frequency for Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.688AlaAla: 18.688 ± 0.17	1.115AlaCys: 1.115 ± 0.027	6.947AlaAsp: 6.947 ± 0.072	7.454AlaGlu: 7.454 ± 0.081	4.228AlaPhe: 4.228 ± 0.062	10.453AlaGly: 10.453 ± 0.121	2.162AlaHis: 2.162 ± 0.04	6.65AlaIle: 6.65 ± 0.07	4.899AlaLys: 4.899 ± 0.076	13.346AlaLeu: 13.346 ± 0.119	3.504AlaMet: 3.504 ± 0.05	2.991AlaAsn: 2.991 ± 0.049	6.202AlaPro: 6.202 ± 0.085	4.279AlaGln: 4.279 ± 0.058	8.458AlaArg: 8.458 ± 0.086	6.959AlaSer: 6.959 ± 0.086	6.635AlaThr: 6.635 ± 0.077	9.103AlaVal: 9.103 ± 0.077	1.427AlaTrp: 1.427 ± 0.034	2.566AlaTyr: 2.566 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.02CysAla: 1.02 ± 0.027	0.135CysCys: 0.135 ± 0.011	0.539CysAsp: 0.539 ± 0.019	0.41CysGlu: 0.41 ± 0.015	0.308CysPhe: 0.308 ± 0.014	0.965CysGly: 0.965 ± 0.025	0.216CysHis: 0.216 ± 0.014	0.406CysIle: 0.406 ± 0.016	0.222CysLys: 0.222 ± 0.011	0.74CysLeu: 0.74 ± 0.022	0.144CysMet: 0.144 ± 0.009	0.225CysAsn: 0.225 ± 0.013	0.473CysPro: 0.473 ± 0.018	0.23CysGln: 0.23 ± 0.012	0.637CysArg: 0.637 ± 0.022	0.486CysSer: 0.486 ± 0.019	0.397CysThr: 0.397 ± 0.019	0.637CysVal: 0.637 ± 0.021	0.11CysTrp: 0.11 ± 0.008	0.206CysTyr: 0.206 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.968AspAla: 6.968 ± 0.067	0.497AspCys: 0.497 ± 0.019	3.369AspAsp: 3.369 ± 0.048	3.222AspGlu: 3.222 ± 0.054	2.089AspPhe: 2.089 ± 0.039	4.999AspGly: 4.999 ± 0.058	1.32AspHis: 1.32 ± 0.031	2.848AspIle: 2.848 ± 0.048	1.998AspLys: 1.998 ± 0.043	5.725AspLeu: 5.725 ± 0.058	1.11AspMet: 1.11 ± 0.028	1.328AspAsn: 1.328 ± 0.029	3.431AspPro: 3.431 ± 0.048	1.842AspGln: 1.842 ± 0.042	4.26AspArg: 4.26 ± 0.055	2.319AspSer: 2.319 ± 0.043	2.566AspThr: 2.566 ± 0.042	4.24AspVal: 4.24 ± 0.051	0.844AspTrp: 0.844 ± 0.024	1.527AspTyr: 1.527 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.996GluAla: 6.996 ± 0.081	0.328GluCys: 0.328 ± 0.015	2.307GluAsp: 2.307 ± 0.047	2.352GluGlu: 2.352 ± 0.044	1.812GluPhe: 1.812 ± 0.04	3.511GluGly: 3.511 ± 0.056	1.147GluHis: 1.147 ± 0.025	3.388GluIle: 3.388 ± 0.053	1.949GluLys: 1.949 ± 0.044	5.485GluLeu: 5.485 ± 0.061	1.386GluMet: 1.386 ± 0.031	1.234GluAsn: 1.234 ± 0.03	2.68GluPro: 2.68 ± 0.042	2.289GluGln: 2.289 ± 0.043	4.605GluArg: 4.605 ± 0.068	2.239GluSer: 2.239 ± 0.036	3.166GluThr: 3.166 ± 0.048	3.829GluVal: 3.829 ± 0.057	0.634GluTrp: 0.634 ± 0.02	0.848GluTyr: 0.848 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.811PheAla: 4.811 ± 0.056	0.395PheCys: 0.395 ± 0.017	2.604PheAsp: 2.604 ± 0.051	1.962PheGlu: 1.962 ± 0.035	1.355PhePhe: 1.355 ± 0.034	3.852PheGly: 3.852 ± 0.054	0.662PheHis: 0.662 ± 0.023	1.594PheIle: 1.594 ± 0.037	1.164PheLys: 1.164 ± 0.03	3.12PheLeu: 3.12 ± 0.049	0.739PheMet: 0.739 ± 0.02	1.103PheAsn: 1.103 ± 0.028	1.55PhePro: 1.55 ± 0.035	0.961PheGln: 0.961 ± 0.024	2.2PheArg: 2.2 ± 0.037	2.141PheSer: 2.141 ± 0.035	1.979PheThr: 1.979 ± 0.04	2.9PheVal: 2.9 ± 0.045	0.495PheTrp: 0.495 ± 0.022	0.827PheTyr: 0.827 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.367GlyAla: 9.367 ± 0.104	0.88GlyCys: 0.88 ± 0.023	4.452GlyAsp: 4.452 ± 0.06	4.368GlyGlu: 4.368 ± 0.06	3.664GlyPhe: 3.664 ± 0.045	7.223GlyGly: 7.223 ± 0.107	1.791GlyHis: 1.791 ± 0.04	4.559GlyIle: 4.559 ± 0.058	3.29GlyLys: 3.29 ± 0.051	8.593GlyLeu: 8.593 ± 0.088	2.015GlyMet: 2.015 ± 0.039	2.161GlyAsn: 2.161 ± 0.037	3.553GlyPro: 3.553 ± 0.048	2.65GlyGln: 2.65 ± 0.038	5.967GlyArg: 5.967 ± 0.066	4.759GlySer: 4.759 ± 0.077	4.531GlyThr: 4.531 ± 0.07	6.224GlyVal: 6.224 ± 0.06	1.287GlyTrp: 1.287 ± 0.029	2.325GlyTyr: 2.325 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.275HisAla: 2.275 ± 0.041	0.228HisCys: 0.228 ± 0.012	1.258HisAsp: 1.258 ± 0.03	0.916HisGlu: 0.916 ± 0.027	0.773HisPhe: 0.773 ± 0.023	1.977HisGly: 1.977 ± 0.035	0.614HisHis: 0.614 ± 0.026	0.84HisIle: 0.84 ± 0.023	0.514HisLys: 0.514 ± 0.02	1.986HisLeu: 1.986 ± 0.039	0.401HisMet: 0.401 ± 0.015	0.458HisAsn: 0.458 ± 0.017	1.367HisPro: 1.367 ± 0.031	0.636HisGln: 0.636 ± 0.021	1.53HisArg: 1.53 ± 0.033	0.958HisSer: 0.958 ± 0.025	0.792HisThr: 0.792 ± 0.024	1.374HisVal: 1.374 ± 0.029	0.332HisTrp: 0.332 ± 0.015	0.536HisTyr: 0.536 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.935IleAla: 7.935 ± 0.071	0.489IleCys: 0.489 ± 0.019	3.853IleAsp: 3.853 ± 0.051	3.602IleGlu: 3.602 ± 0.05	1.541IlePhe: 1.541 ± 0.032	5.428IleGly: 5.428 ± 0.07	0.871IleHis: 0.871 ± 0.022	2.193IleIle: 2.193 ± 0.047	1.769IleLys: 1.769 ± 0.038	3.929IleLeu: 3.929 ± 0.054	0.827IleMet: 0.827 ± 0.021	1.508IleAsn: 1.508 ± 0.034	2.312IlePro: 2.312 ± 0.035	1.268IleGln: 1.268 ± 0.03	3.096IleArg: 3.096 ± 0.036	2.915IleSer: 2.915 ± 0.046	2.864IleThr: 2.864 ± 0.051	4.492IleVal: 4.492 ± 0.06	0.551IleTrp: 0.551 ± 0.017	1.186IleTyr: 1.186 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.383LysAla: 4.383 ± 0.068	0.169LysCys: 0.169 ± 0.01	1.769LysAsp: 1.769 ± 0.043	1.472LysGlu: 1.472 ± 0.034	1.092LysPhe: 1.092 ± 0.027	2.514LysGly: 2.514 ± 0.048	0.649LysHis: 0.649 ± 0.02	1.893LysIle: 1.893 ± 0.04	1.448LysLys: 1.448 ± 0.042	3.99LysLeu: 3.99 ± 0.061	0.848LysMet: 0.848 ± 0.024	0.859LysAsn: 0.859 ± 0.024	2.517LysPro: 2.517 ± 0.054	1.326LysGln: 1.326 ± 0.026	2.507LysArg: 2.507 ± 0.041	1.955LysSer: 1.955 ± 0.045	2.089LysThr: 2.089 ± 0.036	2.605LysVal: 2.605 ± 0.046	0.35LysTrp: 0.35 ± 0.016	0.711LysTyr: 0.711 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.496LeuAla: 13.496 ± 0.112	0.858LeuCys: 0.858 ± 0.024	5.872LeuAsp: 5.872 ± 0.068	4.5LeuGlu: 4.5 ± 0.056	3.584LeuPhe: 3.584 ± 0.054	8.279LeuGly: 8.279 ± 0.084	1.867LeuHis: 1.867 ± 0.038	5.476LeuIle: 5.476 ± 0.066	3.728LeuLys: 3.728 ± 0.059	9.764LeuLeu: 9.764 ± 0.114	2.208LeuMet: 2.208 ± 0.035	2.584LeuAsn: 2.584 ± 0.041	5.679LeuPro: 5.679 ± 0.072	3.022LeuGln: 3.022 ± 0.049	6.93LeuArg: 6.93 ± 0.085	6.391LeuSer: 6.391 ± 0.064	5.869LeuThr: 5.869 ± 0.067	7.32LeuVal: 7.32 ± 0.085	1.137LeuTrp: 1.137 ± 0.03	2.032LeuTyr: 2.032 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.814MetAla: 2.814 ± 0.042	0.17MetCys: 0.17 ± 0.01	0.939MetAsp: 0.939 ± 0.026	0.858MetGlu: 0.858 ± 0.024	0.733MetPhe: 0.733 ± 0.021	1.423MetGly: 1.423 ± 0.033	0.426MetHis: 0.426 ± 0.014	1.416MetIle: 1.416 ± 0.031	0.913MetLys: 0.913 ± 0.027	2.542MetLeu: 2.542 ± 0.045	0.667MetMet: 0.667 ± 0.02	0.664MetAsn: 0.664 ± 0.019	1.484MetPro: 1.484 ± 0.034	0.898MetGln: 0.898 ± 0.021	1.721MetArg: 1.721 ± 0.03	1.649MetSer: 1.649 ± 0.033	1.893MetThr: 1.893 ± 0.032	1.648MetVal: 1.648 ± 0.032	0.221MetTrp: 0.221 ± 0.013	0.327MetTyr: 0.327 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.253AsnAla: 3.253 ± 0.05	0.239AsnCys: 0.239 ± 0.013	1.448AsnAsp: 1.448 ± 0.032	1.206AsnGlu: 1.206 ± 0.029	0.963AsnPhe: 0.963 ± 0.028	2.267AsnGly: 2.267 ± 0.048	0.475AsnHis: 0.475 ± 0.018	1.325AsnIle: 1.325 ± 0.03	0.79AsnLys: 0.79 ± 0.025	2.558AsnLeu: 2.558 ± 0.042	0.573AsnMet: 0.573 ± 0.018	0.735AsnAsn: 0.735 ± 0.023	1.692AsnPro: 1.692 ± 0.035	0.821AsnGln: 0.821 ± 0.023	1.71AsnArg: 1.71 ± 0.032	1.263AsnSer: 1.263 ± 0.032	1.283AsnThr: 1.283 ± 0.028	2.079AsnVal: 2.079 ± 0.039	0.42AsnTrp: 0.42 ± 0.016	0.713AsnTyr: 0.713 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.676ProAla: 6.676 ± 0.088	0.336ProCys: 0.336 ± 0.016	3.534ProAsp: 3.534 ± 0.048	3.402ProGlu: 3.402 ± 0.049	1.987ProPhe: 1.987 ± 0.04	4.364ProGly: 4.364 ± 0.058	1.086ProHis: 1.086 ± 0.027	2.542ProIle: 2.542 ± 0.043	1.941ProLys: 1.941 ± 0.042	4.938ProLeu: 4.938 ± 0.062	1.219ProMet: 1.219 ± 0.028	1.527ProAsn: 1.527 ± 0.03	3.233ProPro: 3.233 ± 0.091	1.891ProGln: 1.891 ± 0.036	3.346ProArg: 3.346 ± 0.052	3.115ProSer: 3.115 ± 0.043	2.767ProThr: 2.767 ± 0.045	4.131ProVal: 4.131 ± 0.059	0.718ProTrp: 0.718 ± 0.024	1.182ProTyr: 1.182 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.273GlnAla: 4.273 ± 0.056	0.222GlnCys: 0.222 ± 0.013	1.443GlnAsp: 1.443 ± 0.033	1.317GlnGlu: 1.317 ± 0.027	1.193GlnPhe: 1.193 ± 0.03	2.324GlnGly: 2.324 ± 0.045	0.706GlnHis: 0.706 ± 0.021	1.999GlnIle: 1.999 ± 0.039	1.034GlnLys: 1.034 ± 0.03	3.212GlnLeu: 3.212 ± 0.045	0.848GlnMet: 0.848 ± 0.021	0.848GlnAsn: 0.848 ± 0.026	2.057GlnPro: 2.057 ± 0.044	1.487GlnGln: 1.487 ± 0.036	2.67GlnArg: 2.67 ± 0.044	1.958GlnSer: 1.958 ± 0.035	1.824GlnThr: 1.824 ± 0.036	2.353GlnVal: 2.353 ± 0.047	0.436GlnTrp: 0.436 ± 0.016	0.615GlnTyr: 0.615 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.172ArgAla: 8.172 ± 0.085	0.568ArgCys: 0.568 ± 0.021	4.194ArgAsp: 4.194 ± 0.061	3.932ArgGlu: 3.932 ± 0.055	2.736ArgPhe: 2.736 ± 0.044	5.042ArgGly: 5.042 ± 0.053	1.6ArgHis: 1.6 ± 0.033	3.845ArgIle: 3.845 ± 0.058	2.452ArgLys: 2.452 ± 0.044	7.608ArgLeu: 7.608 ± 0.073	1.75ArgMet: 1.75 ± 0.033	1.809ArgAsn: 1.809 ± 0.033	3.657ArgPro: 3.657 ± 0.047	2.407ArgGln: 2.407 ± 0.044	5.617ArgArg: 5.617 ± 0.08	3.895ArgSer: 3.895 ± 0.053	3.334ArgThr: 3.334 ± 0.047	4.674ArgVal: 4.674 ± 0.052	1.009ArgTrp: 1.009 ± 0.029	1.715ArgTyr: 1.715 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.706SerAla: 6.706 ± 0.078	0.441SerCys: 0.441 ± 0.018	3.147SerAsp: 3.147 ± 0.048	2.757SerGlu: 2.757 ± 0.044	2.335SerPhe: 2.335 ± 0.036	5.476SerGly: 5.476 ± 0.076	1.028SerHis: 1.028 ± 0.027	2.917SerIle: 2.917 ± 0.048	1.717SerLys: 1.717 ± 0.037	5.518SerLeu: 5.518 ± 0.068	1.283SerMet: 1.283 ± 0.033	1.475SerAsn: 1.475 ± 0.034	3.017SerPro: 3.017 ± 0.048	1.675SerGln: 1.675 ± 0.035	3.721SerArg: 3.721 ± 0.048	3.432SerSer: 3.432 ± 0.071	2.934SerThr: 2.934 ± 0.05	4.157SerVal: 4.157 ± 0.056	0.734SerTrp: 0.734 ± 0.022	1.427SerTyr: 1.427 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.759ThrAla: 6.759 ± 0.083	0.438ThrCys: 0.438 ± 0.017	2.814ThrAsp: 2.814 ± 0.045	2.684ThrGlu: 2.684 ± 0.043	1.908ThrPhe: 1.908 ± 0.033	4.911ThrGly: 4.911 ± 0.069	0.971ThrHis: 0.971 ± 0.027	3.081ThrIle: 3.081 ± 0.05	1.751ThrLys: 1.751 ± 0.039	5.938ThrLeu: 5.938 ± 0.072	1.28ThrMet: 1.28 ± 0.028	1.37ThrAsn: 1.37 ± 0.033	3.448ThrPro: 3.448 ± 0.054	1.539ThrGln: 1.539 ± 0.033	3.276ThrArg: 3.276 ± 0.047	3.135ThrSer: 3.135 ± 0.05	3.314ThrThr: 3.314 ± 0.058	4.288ThrVal: 4.288 ± 0.05	0.625ThrTrp: 0.625 ± 0.021	1.124ThrTyr: 1.124 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.705ValAla: 9.705 ± 0.091	0.628ValCys: 0.628 ± 0.02	4.057ValAsp: 4.057 ± 0.058	4.228ValGlu: 4.228 ± 0.063	2.689ValPhe: 2.689 ± 0.043	5.65ValGly: 5.65 ± 0.07	1.381ValHis: 1.381 ± 0.028	4.082ValIle: 4.082 ± 0.054	2.448ValLys: 2.448 ± 0.048	7.646ValLeu: 7.646 ± 0.077	1.856ValMet: 1.856 ± 0.034	1.948ValAsn: 1.948 ± 0.042	3.871ValPro: 3.871 ± 0.047	2.208ValGln: 2.208 ± 0.043	4.874ValArg: 4.874 ± 0.053	4.317ValSer: 4.317 ± 0.052	4.561ValThr: 4.561 ± 0.054	6.437ValVal: 6.437 ± 0.082	0.884ValTrp: 0.884 ± 0.025	1.479ValTyr: 1.479 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.163TrpAla: 1.163 ± 0.03	0.135TrpCys: 0.135 ± 0.009	0.582TrpAsp: 0.582 ± 0.02	0.465TrpGlu: 0.465 ± 0.017	0.51TrpPhe: 0.51 ± 0.018	0.872TrpGly: 0.872 ± 0.023	0.335TrpHis: 0.335 ± 0.015	0.691TrpIle: 0.691 ± 0.02	0.444TrpLys: 0.444 ± 0.015	1.618TrpLeu: 1.618 ± 0.037	0.358TrpMet: 0.358 ± 0.015	0.41TrpAsn: 0.41 ± 0.015	0.657TrpPro: 0.657 ± 0.024	0.562TrpGln: 0.562 ± 0.02	1.158TrpArg: 1.158 ± 0.032	0.845TrpSer: 0.845 ± 0.021	0.77TrpThr: 0.77 ± 0.023	0.767TrpVal: 0.767 ± 0.021	0.208TrpTrp: 0.208 ± 0.012	0.256TrpTyr: 0.256 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.607TyrAla: 2.607 ± 0.043	0.234TyrCys: 0.234 ± 0.012	1.374TyrAsp: 1.374 ± 0.031	1.079TyrGlu: 1.079 ± 0.026	0.911TyrPhe: 0.911 ± 0.024	2.128TyrGly: 2.128 ± 0.042	0.457TyrHis: 0.457 ± 0.017	0.887TyrIle: 0.887 ± 0.026	0.673TyrLys: 0.673 ± 0.023	2.343TyrLeu: 2.343 ± 0.037	0.389TyrMet: 0.389 ± 0.016	0.576TyrAsn: 0.576 ± 0.021	1.053TyrPro: 1.053 ± 0.027	0.825TyrGln: 0.825 ± 0.023	1.734TyrArg: 1.734 ± 0.037	1.165TyrSer: 1.165 ± 0.032	1.087TyrThr: 1.087 ± 0.031	1.693TyrVal: 1.693 ± 0.032	0.384TyrTrp: 0.384 ± 0.014	0.638TyrTyr: 0.638 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4811 proteins (1579866 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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