Amino acid dipepetide frequency for Cyprinid herpesvirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.715AlaAla: 10.715 ± 0.947
1.997AlaCys: 1.997 ± 0.155
3.567AlaAsp: 3.567 ± 0.248
4.984AlaGlu: 4.984 ± 0.322
2.896AlaPhe: 2.896 ± 0.216
3.978AlaGly: 3.978 ± 0.243
1.875AlaHis: 1.875 ± 0.176
2.926AlaIle: 2.926 ± 0.224
3.475AlaLys: 3.475 ± 0.269
7.27AlaLeu: 7.27 ± 0.368
1.92AlaMet: 1.92 ± 0.168
2.622AlaAsn: 2.622 ± 0.265
4.786AlaPro: 4.786 ± 0.449
3.246AlaGln: 3.246 ± 0.206
4.664AlaArg: 4.664 ± 0.297
6.417AlaSer: 6.417 ± 0.498
5.472AlaThr: 5.472 ± 1.202
6.036AlaVal: 6.036 ± 0.313
1.235AlaTrp: 1.235 ± 0.165
2.332AlaTyr: 2.332 ± 0.166
0.0AlaXaa: 0.0 ± 0.0
Cys
1.875CysAla: 1.875 ± 0.17
1.006CysCys: 1.006 ± 0.128
1.311CysAsp: 1.311 ± 0.235
1.463CysGlu: 1.463 ± 0.172
0.93CysPhe: 0.93 ± 0.113
1.616CysGly: 1.616 ± 0.18
0.518CysHis: 0.518 ± 0.099
0.838CysIle: 0.838 ± 0.108
1.067CysLys: 1.067 ± 0.139
2.317CysLeu: 2.317 ± 0.178
0.64CysMet: 0.64 ± 0.083
0.93CysAsn: 0.93 ± 0.115
1.646CysPro: 1.646 ± 0.176
0.671CysGln: 0.671 ± 0.114
1.357CysArg: 1.357 ± 0.19
2.195CysSer: 2.195 ± 0.216
1.875CysThr: 1.875 ± 0.209
2.21CysVal: 2.21 ± 0.162
0.335CysTrp: 0.335 ± 0.078
0.701CysTyr: 0.701 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
4.161AspAla: 4.161 ± 0.282
1.082AspCys: 1.082 ± 0.133
3.826AspAsp: 3.826 ± 0.37
3.887AspGlu: 3.887 ± 0.288
1.905AspPhe: 1.905 ± 0.191
3.384AspGly: 3.384 ± 0.227
1.189AspHis: 1.189 ± 0.117
2.606AspIle: 2.606 ± 0.219
2.119AspLys: 2.119 ± 0.162
5.335AspLeu: 5.335 ± 0.278
1.722AspMet: 1.722 ± 0.147
1.631AspAsn: 1.631 ± 0.186
3.277AspPro: 3.277 ± 0.24
1.753AspGln: 1.753 ± 0.156
2.667AspArg: 2.667 ± 0.214
4.191AspSer: 4.191 ± 0.309
3.033AspThr: 3.033 ± 0.28
3.567AspVal: 3.567 ± 0.239
0.823AspTrp: 0.823 ± 0.115
1.783AspTyr: 1.783 ± 0.121
0.0AspXaa: 0.0 ± 0.0
Glu
5.365GluAla: 5.365 ± 0.323
1.539GluCys: 1.539 ± 0.178
4.694GluAsp: 4.694 ± 0.348
5.761GluGlu: 5.761 ± 0.437
1.981GluPhe: 1.981 ± 0.195
2.82GluGly: 2.82 ± 0.219
1.509GluHis: 1.509 ± 0.139
2.18GluIle: 2.18 ± 0.186
2.637GluLys: 2.637 ± 0.267
6.432GluLeu: 6.432 ± 0.326
1.677GluMet: 1.677 ± 0.165
1.722GluAsn: 1.722 ± 0.141
3.079GluPro: 3.079 ± 0.346
2.241GluGln: 2.241 ± 0.212
3.887GluArg: 3.887 ± 0.303
4.512GluSer: 4.512 ± 0.256
4.237GluThr: 4.237 ± 0.278
3.612GluVal: 3.612 ± 0.289
0.991GluTrp: 0.991 ± 0.14
1.555GluTyr: 1.555 ± 0.168
0.0GluXaa: 0.0 ± 0.0
Phe
2.484PheAla: 2.484 ± 0.206
1.052PheCys: 1.052 ± 0.136
2.134PheAsp: 2.134 ± 0.177
2.225PheGlu: 2.225 ± 0.213
1.6PhePhe: 1.6 ± 0.159
2.073PheGly: 2.073 ± 0.209
0.762PheHis: 0.762 ± 0.09
1.265PheIle: 1.265 ± 0.129
1.814PheLys: 1.814 ± 0.171
3.231PheLeu: 3.231 ± 0.233
0.914PheMet: 0.914 ± 0.139
1.616PheAsn: 1.616 ± 0.184
1.341PhePro: 1.341 ± 0.114
1.006PheGln: 1.006 ± 0.133
1.738PheArg: 1.738 ± 0.175
3.109PheSer: 3.109 ± 0.232
2.241PheThr: 2.241 ± 0.186
2.439PheVal: 2.439 ± 0.217
0.472PheTrp: 0.472 ± 0.093
1.585PheTyr: 1.585 ± 0.174
0.0PheXaa: 0.0 ± 0.0
Gly
4.268GlyAla: 4.268 ± 0.241
1.296GlyCys: 1.296 ± 0.137
2.942GlyAsp: 2.942 ± 0.171
3.018GlyGlu: 3.018 ± 0.179
2.058GlyPhe: 2.058 ± 0.17
3.948GlyGly: 3.948 ± 0.337
1.372GlyHis: 1.372 ± 0.161
2.362GlyIle: 2.362 ± 0.202
2.591GlyLys: 2.591 ± 0.232
5.319GlyLeu: 5.319 ± 0.275
1.524GlyMet: 1.524 ± 0.124
1.951GlyAsn: 1.951 ± 0.217
3.048GlyPro: 3.048 ± 0.254
1.738GlyGln: 1.738 ± 0.163
3.246GlyArg: 3.246 ± 0.206
4.603GlySer: 4.603 ± 0.284
3.445GlyThr: 3.445 ± 0.229
4.207GlyVal: 4.207 ± 0.241
1.113GlyTrp: 1.113 ± 0.151
1.829GlyTyr: 1.829 ± 0.187
0.0GlyXaa: 0.0 ± 0.0
His
1.677HisAla: 1.677 ± 0.15
0.655HisCys: 0.655 ± 0.095
0.914HisAsp: 0.914 ± 0.111
1.097HisGlu: 1.097 ± 0.129
0.823HisPhe: 0.823 ± 0.108
1.357HisGly: 1.357 ± 0.133
0.747HisHis: 0.747 ± 0.136
1.052HisIle: 1.052 ± 0.146
1.478HisLys: 1.478 ± 0.158
2.271HisLeu: 2.271 ± 0.17
0.93HisMet: 0.93 ± 0.122
0.854HisAsn: 0.854 ± 0.112
1.265HisPro: 1.265 ± 0.136
0.96HisGln: 0.96 ± 0.136
1.448HisArg: 1.448 ± 0.168
1.829HisSer: 1.829 ± 0.175
1.661HisThr: 1.661 ± 0.152
1.509HisVal: 1.509 ± 0.203
0.335HisTrp: 0.335 ± 0.088
1.143HisTyr: 1.143 ± 0.118
0.0HisXaa: 0.0 ± 0.0
Ile
2.789IleAla: 2.789 ± 0.174
1.174IleCys: 1.174 ± 0.161
1.707IleAsp: 1.707 ± 0.156
2.18IleGlu: 2.18 ± 0.242
1.463IlePhe: 1.463 ± 0.148
1.859IleGly: 1.859 ± 0.193
0.914IleHis: 0.914 ± 0.133
1.768IleIle: 1.768 ± 0.205
2.515IleLys: 2.515 ± 0.208
3.079IleLeu: 3.079 ± 0.242
1.219IleMet: 1.219 ± 0.133
2.225IleAsn: 2.225 ± 0.178
2.5IlePro: 2.5 ± 0.19
1.25IleGln: 1.25 ± 0.135
2.164IleArg: 2.164 ± 0.197
3.048IleSer: 3.048 ± 0.216
2.728IleThr: 2.728 ± 0.246
2.027IleVal: 2.027 ± 0.172
0.442IleTrp: 0.442 ± 0.083
1.189IleTyr: 1.189 ± 0.14
0.0IleXaa: 0.0 ± 0.0
Lys
4.283LysAla: 4.283 ± 0.312
1.25LysCys: 1.25 ± 0.15
2.545LysAsp: 2.545 ± 0.181
3.079LysGlu: 3.079 ± 0.253
1.28LysPhe: 1.28 ± 0.138
2.225LysGly: 2.225 ± 0.183
1.25LysHis: 1.25 ± 0.124
1.814LysIle: 1.814 ± 0.147
3.475LysLys: 3.475 ± 0.337
4.572LysLeu: 4.572 ± 0.308
1.143LysMet: 1.143 ± 0.135
2.347LysAsn: 2.347 ± 0.198
2.881LysPro: 2.881 ± 0.23
1.738LysGln: 1.738 ± 0.186
3.749LysArg: 3.749 ± 0.311
3.688LysSer: 3.688 ± 0.26
3.231LysThr: 3.231 ± 0.248
2.896LysVal: 2.896 ± 0.212
0.64LysTrp: 0.64 ± 0.084
1.189LysTyr: 1.189 ± 0.11
0.0LysXaa: 0.0 ± 0.0
Leu
6.63LeuAla: 6.63 ± 0.356
2.423LeuCys: 2.423 ± 0.216
5.274LeuAsp: 5.274 ± 0.341
5.426LeuGlu: 5.426 ± 0.328
3.384LeuPhe: 3.384 ± 0.219
5.365LeuGly: 5.365 ± 0.265
1.981LeuHis: 1.981 ± 0.159
3.368LeuIle: 3.368 ± 0.232
4.771LeuLys: 4.771 ± 0.293
8.947LeuLeu: 8.947 ± 0.363
2.957LeuMet: 2.957 ± 0.252
3.612LeuAsn: 3.612 ± 0.283
4.71LeuPro: 4.71 ± 0.285
3.262LeuGln: 3.262 ± 0.25
6.02LeuArg: 6.02 ± 0.354
7.667LeuSer: 7.667 ± 0.372
5.624LeuThr: 5.624 ± 0.241
5.533LeuVal: 5.533 ± 0.312
1.524LeuTrp: 1.524 ± 0.166
2.804LeuTyr: 2.804 ± 0.23
0.0LeuXaa: 0.0 ± 0.0
Met
2.347MetAla: 2.347 ± 0.151
0.823MetCys: 0.823 ± 0.104
1.433MetAsp: 1.433 ± 0.165
1.555MetGlu: 1.555 ± 0.135
1.052MetPhe: 1.052 ± 0.13
1.92MetGly: 1.92 ± 0.182
0.488MetHis: 0.488 ± 0.071
0.975MetIle: 0.975 ± 0.136
1.021MetLys: 1.021 ± 0.126
2.835MetLeu: 2.835 ± 0.241
1.204MetMet: 1.204 ± 0.155
0.747MetAsn: 0.747 ± 0.11
1.387MetPro: 1.387 ± 0.14
0.869MetGln: 0.869 ± 0.118
1.951MetArg: 1.951 ± 0.158
1.997MetSer: 1.997 ± 0.207
1.387MetThr: 1.387 ± 0.152
1.951MetVal: 1.951 ± 0.161
0.351MetTrp: 0.351 ± 0.062
0.869MetTyr: 0.869 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
3.292AsnAla: 3.292 ± 0.494
0.625AsnCys: 0.625 ± 0.11
1.357AsnAsp: 1.357 ± 0.119
1.433AsnGlu: 1.433 ± 0.121
1.189AsnPhe: 1.189 ± 0.149
1.829AsnGly: 1.829 ± 0.161
0.884AsnHis: 0.884 ± 0.131
1.707AsnIle: 1.707 ± 0.206
2.21AsnLys: 2.21 ± 0.229
3.582AsnLeu: 3.582 ± 0.268
1.402AsnMet: 1.402 ± 0.169
1.524AsnAsn: 1.524 ± 0.17
2.515AsnPro: 2.515 ± 0.231
1.311AsnGln: 1.311 ± 0.137
2.332AsnArg: 2.332 ± 0.215
2.865AsnSer: 2.865 ± 0.248
2.5AsnThr: 2.5 ± 0.187
2.317AsnVal: 2.317 ± 0.194
0.442AsnTrp: 0.442 ± 0.078
1.082AsnTyr: 1.082 ± 0.167
0.0AsnXaa: 0.0 ± 0.0
Pro
4.908ProAla: 4.908 ± 0.329
1.448ProCys: 1.448 ± 0.184
3.018ProAsp: 3.018 ± 0.235
4.496ProGlu: 4.496 ± 0.323
1.951ProPhe: 1.951 ± 0.153
3.033ProGly: 3.033 ± 0.214
1.158ProHis: 1.158 ± 0.114
2.256ProIle: 2.256 ± 0.198
2.85ProLys: 2.85 ± 0.253
4.405ProLeu: 4.405 ± 0.331
1.143ProMet: 1.143 ± 0.113
1.89ProAsn: 1.89 ± 0.193
5.197ProPro: 5.197 ± 0.466
2.256ProGln: 2.256 ± 0.259
2.835ProArg: 2.835 ± 0.198
5.243ProSer: 5.243 ± 0.337
4.146ProThr: 4.146 ± 0.284
4.542ProVal: 4.542 ± 0.365
0.457ProTrp: 0.457 ± 0.085
1.6ProTyr: 1.6 ± 0.134
0.0ProXaa: 0.0 ± 0.0
Gln
2.561GlnAla: 2.561 ± 0.217
0.762GlnCys: 0.762 ± 0.127
1.844GlnAsp: 1.844 ± 0.161
2.241GlnGlu: 2.241 ± 0.202
0.991GlnPhe: 0.991 ± 0.128
1.768GlnGly: 1.768 ± 0.156
0.93GlnHis: 0.93 ± 0.104
1.387GlnIle: 1.387 ± 0.124
1.768GlnLys: 1.768 ± 0.217
3.627GlnLeu: 3.627 ± 0.271
0.991GlnMet: 0.991 ± 0.116
1.296GlnAsn: 1.296 ± 0.142
2.027GlnPro: 2.027 ± 0.253
2.5GlnGln: 2.5 ± 0.41
2.393GlnArg: 2.393 ± 0.221
2.286GlnSer: 2.286 ± 0.225
2.18GlnThr: 2.18 ± 0.223
2.408GlnVal: 2.408 ± 0.178
0.716GlnTrp: 0.716 ± 0.103
1.296GlnTyr: 1.296 ± 0.139
0.0GlnXaa: 0.0 ± 0.0
Arg
4.862ArgAla: 4.862 ± 0.284
1.707ArgCys: 1.707 ± 0.223
3.658ArgAsp: 3.658 ± 0.278
3.673ArgGlu: 3.673 ± 0.327
2.256ArgPhe: 2.256 ± 0.227
3.125ArgGly: 3.125 ± 0.252
1.646ArgHis: 1.646 ± 0.175
1.981ArgIle: 1.981 ± 0.175
2.759ArgLys: 2.759 ± 0.24
5.213ArgLeu: 5.213 ± 0.352
1.509ArgMet: 1.509 ± 0.127
1.692ArgAsn: 1.692 ± 0.165
3.17ArgPro: 3.17 ± 0.251
2.53ArgGln: 2.53 ± 0.236
4.877ArgArg: 4.877 ± 0.434
4.359ArgSer: 4.359 ± 0.26
3.551ArgThr: 3.551 ± 0.202
4.664ArgVal: 4.664 ± 0.309
0.945ArgTrp: 0.945 ± 0.125
1.738ArgTyr: 1.738 ± 0.173
0.0ArgXaa: 0.0 ± 0.0
Ser
6.264SerAla: 6.264 ± 0.375
1.722SerCys: 1.722 ± 0.191
4.359SerAsp: 4.359 ± 0.274
5.274SerGlu: 5.274 ± 0.354
2.667SerPhe: 2.667 ± 0.256
5.411SerGly: 5.411 ± 0.411
2.058SerHis: 2.058 ± 0.176
3.079SerIle: 3.079 ± 0.192
3.627SerLys: 3.627 ± 0.267
6.295SerLeu: 6.295 ± 0.296
1.768SerMet: 1.768 ± 0.166
2.683SerAsn: 2.683 ± 0.282
4.801SerPro: 4.801 ± 0.424
2.606SerGln: 2.606 ± 0.225
4.268SerArg: 4.268 ± 0.25
8.383SerSer: 8.383 ± 0.629
5.853SerThr: 5.853 ± 0.415
6.417SerVal: 6.417 ± 0.272
1.158SerTrp: 1.158 ± 0.146
2.225SerTyr: 2.225 ± 0.198
0.0SerXaa: 0.0 ± 0.0
Thr
5.898ThrAla: 5.898 ± 0.535
1.616ThrCys: 1.616 ± 0.212
3.262ThrAsp: 3.262 ± 0.225
3.917ThrGlu: 3.917 ± 0.247
2.347ThrPhe: 2.347 ± 0.173
3.627ThrGly: 3.627 ± 0.257
1.509ThrHis: 1.509 ± 0.16
2.439ThrIle: 2.439 ± 0.182
3.14ThrLys: 3.14 ± 0.286
6.173ThrLeu: 6.173 ± 0.332
1.661ThrMet: 1.661 ± 0.185
2.393ThrAsn: 2.393 ± 0.363
4.618ThrPro: 4.618 ± 0.423
2.012ThrGln: 2.012 ± 0.176
3.323ThrArg: 3.323 ± 0.215
5.35ThrSer: 5.35 ± 0.409
6.554ThrThr: 6.554 ± 1.274
5.03ThrVal: 5.03 ± 0.317
0.914ThrTrp: 0.914 ± 0.149
1.981ThrTyr: 1.981 ± 0.144
0.0ThrXaa: 0.0 ± 0.0
Val
4.725ValAla: 4.725 ± 0.314
1.981ValCys: 1.981 ± 0.204
3.856ValAsp: 3.856 ± 0.207
4.024ValGlu: 4.024 ± 0.298
2.515ValPhe: 2.515 ± 0.23
3.688ValGly: 3.688 ± 0.247
1.997ValHis: 1.997 ± 0.167
2.256ValIle: 2.256 ± 0.221
3.414ValLys: 3.414 ± 0.206
6.219ValLeu: 6.219 ± 0.298
1.6ValMet: 1.6 ± 0.161
2.606ValAsn: 2.606 ± 0.221
4.451ValPro: 4.451 ± 0.298
2.545ValGln: 2.545 ± 0.221
4.374ValArg: 4.374 ± 0.256
5.838ValSer: 5.838 ± 0.349
4.496ValThr: 4.496 ± 0.356
4.816ValVal: 4.816 ± 0.274
1.067ValTrp: 1.067 ± 0.136
2.606ValTyr: 2.606 ± 0.223
0.0ValXaa: 0.0 ± 0.0
Trp
1.036TrpAla: 1.036 ± 0.121
0.61TrpCys: 0.61 ± 0.096
0.732TrpAsp: 0.732 ± 0.092
0.747TrpGlu: 0.747 ± 0.108
0.549TrpPhe: 0.549 ± 0.108
0.884TrpGly: 0.884 ± 0.116
0.427TrpHis: 0.427 ± 0.087
0.686TrpIle: 0.686 ± 0.094
0.686TrpLys: 0.686 ± 0.096
1.478TrpLeu: 1.478 ± 0.166
0.472TrpMet: 0.472 ± 0.08
0.457TrpAsn: 0.457 ± 0.083
0.716TrpPro: 0.716 ± 0.103
0.351TrpGln: 0.351 ± 0.073
0.838TrpArg: 0.838 ± 0.125
1.265TrpSer: 1.265 ± 0.131
1.097TrpThr: 1.097 ± 0.128
0.869TrpVal: 0.869 ± 0.128
0.274TrpTrp: 0.274 ± 0.084
0.503TrpTyr: 0.503 ± 0.096
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.271TyrAla: 2.271 ± 0.177
0.732TyrCys: 0.732 ± 0.097
1.509TyrAsp: 1.509 ± 0.158
1.951TyrGlu: 1.951 ± 0.155
1.265TyrPhe: 1.265 ± 0.182
1.966TyrGly: 1.966 ± 0.167
0.793TyrHis: 0.793 ± 0.093
1.296TyrIle: 1.296 ± 0.15
1.859TyrLys: 1.859 ± 0.204
2.683TyrLeu: 2.683 ± 0.218
0.747TyrMet: 0.747 ± 0.099
1.6TyrAsn: 1.6 ± 0.169
1.417TyrPro: 1.417 ± 0.167
1.128TyrGln: 1.128 ± 0.111
1.783TyrArg: 1.783 ± 0.196
2.073TyrSer: 2.073 ± 0.17
2.454TyrThr: 2.454 ± 0.221
2.042TyrVal: 2.042 ± 0.182
0.442TyrTrp: 0.442 ± 0.071
1.219TyrTyr: 1.219 ± 0.151
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 137 proteins (65611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski