Amino acid dipepetide frequency for Roseimicrobium gellanilyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.952AlaAla: 11.952 ± 0.112	1.083AlaCys: 1.083 ± 0.025	5.114AlaAsp: 5.114 ± 0.057	6.365AlaGlu: 6.365 ± 0.091	3.694AlaPhe: 3.694 ± 0.045	8.295AlaGly: 8.295 ± 0.132	2.067AlaHis: 2.067 ± 0.04	4.444AlaIle: 4.444 ± 0.047	4.987AlaLys: 4.987 ± 0.073	10.395AlaLeu: 10.395 ± 0.091	2.76AlaMet: 2.76 ± 0.043	2.993AlaAsn: 2.993 ± 0.069	5.404AlaPro: 5.404 ± 0.079	3.65AlaGln: 3.65 ± 0.049	5.972AlaArg: 5.972 ± 0.066	6.445AlaSer: 6.445 ± 0.059	5.935AlaThr: 5.935 ± 0.09	6.98AlaVal: 6.98 ± 0.064	1.665AlaTrp: 1.665 ± 0.029	2.185AlaTyr: 2.185 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.025	0.165CysCys: 0.165 ± 0.01	0.494CysAsp: 0.494 ± 0.017	0.533CysGlu: 0.533 ± 0.015	0.433CysPhe: 0.433 ± 0.014	0.911CysGly: 0.911 ± 0.021	0.362CysHis: 0.362 ± 0.014	0.471CysIle: 0.471 ± 0.015	0.308CysLys: 0.308 ± 0.013	1.074CysLeu: 1.074 ± 0.027	0.207CysMet: 0.207 ± 0.01	0.243CysAsn: 0.243 ± 0.01	0.497CysPro: 0.497 ± 0.016	0.307CysGln: 0.307 ± 0.012	0.613CysArg: 0.613 ± 0.019	0.576CysSer: 0.576 ± 0.016	0.529CysThr: 0.529 ± 0.018	0.753CysVal: 0.753 ± 0.023	0.191CysTrp: 0.191 ± 0.009	0.292CysTyr: 0.292 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.89AspAla: 5.89 ± 0.063	0.451AspCys: 0.451 ± 0.017	2.693AspAsp: 2.693 ± 0.047	3.392AspGlu: 3.392 ± 0.045	2.242AspPhe: 2.242 ± 0.036	5.087AspGly: 5.087 ± 0.082	1.211AspHis: 1.211 ± 0.023	2.414AspIle: 2.414 ± 0.035	2.291AspLys: 2.291 ± 0.043	5.128AspLeu: 5.128 ± 0.051	1.073AspMet: 1.073 ± 0.021	1.408AspAsn: 1.408 ± 0.039	3.013AspPro: 3.013 ± 0.043	1.45AspGln: 1.45 ± 0.03	2.918AspArg: 2.918 ± 0.045	2.782AspSer: 2.782 ± 0.048	2.707AspThr: 2.707 ± 0.049	3.783AspVal: 3.783 ± 0.054	1.058AspTrp: 1.058 ± 0.022	1.519AspTyr: 1.519 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.504GluAla: 6.504 ± 0.094	0.501GluCys: 0.501 ± 0.015	3.021GluAsp: 3.021 ± 0.044	4.19GluGlu: 4.19 ± 0.069	2.286GluPhe: 2.286 ± 0.033	4.57GluGly: 4.57 ± 0.047	1.535GluHis: 1.535 ± 0.027	2.877GluIle: 2.877 ± 0.039	3.752GluLys: 3.752 ± 0.067	5.96GluLeu: 5.96 ± 0.07	1.661GluMet: 1.661 ± 0.035	2.008GluAsn: 2.008 ± 0.03	2.865GluPro: 2.865 ± 0.043	2.422GluGln: 2.422 ± 0.044	4.09GluArg: 4.09 ± 0.056	3.393GluSer: 3.393 ± 0.04	3.145GluThr: 3.145 ± 0.043	4.649GluVal: 4.649 ± 0.059	1.019GluTrp: 1.019 ± 0.022	1.387GluTyr: 1.387 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.668PheAla: 3.668 ± 0.042	0.46PheCys: 0.46 ± 0.014	2.258PheAsp: 2.258 ± 0.028	2.195PheGlu: 2.195 ± 0.034	1.598PhePhe: 1.598 ± 0.032	3.226PheGly: 3.226 ± 0.043	0.921PheHis: 0.921 ± 0.022	1.789PheIle: 1.789 ± 0.033	1.359PheLys: 1.359 ± 0.027	3.726PheLeu: 3.726 ± 0.047	0.781PheMet: 0.781 ± 0.02	1.252PheAsn: 1.252 ± 0.031	1.833PhePro: 1.833 ± 0.035	1.251PheGln: 1.251 ± 0.024	2.295PheArg: 2.295 ± 0.038	2.449PheSer: 2.449 ± 0.037	2.498PheThr: 2.498 ± 0.038	2.66PheVal: 2.66 ± 0.028	0.616PheTrp: 0.616 ± 0.019	1.026PheTyr: 1.026 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	7.431GlyAla: 7.431 ± 0.138	0.861GlyCys: 0.861 ± 0.021	4.289GlyAsp: 4.289 ± 0.08	4.579GlyGlu: 4.579 ± 0.055	3.254GlyPhe: 3.254 ± 0.04	7.422GlyGly: 7.422 ± 0.2	1.822GlyHis: 1.822 ± 0.027	4.069GlyIle: 4.069 ± 0.056	4.532GlyLys: 4.532 ± 0.06	7.091GlyLeu: 7.091 ± 0.067	2.253GlyMet: 2.253 ± 0.037	2.964GlyAsn: 2.964 ± 0.092	2.978GlyPro: 2.978 ± 0.04	2.666GlyGln: 2.666 ± 0.042	4.661GlyArg: 4.661 ± 0.052	5.186GlySer: 5.186 ± 0.113	5.538GlyThr: 5.538 ± 0.196	5.841GlyVal: 5.841 ± 0.067	1.514GlyTrp: 1.514 ± 0.025	2.291GlyTyr: 2.291 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.455HisAla: 2.455 ± 0.042	0.289HisCys: 0.289 ± 0.012	1.249HisAsp: 1.249 ± 0.027	1.457HisGlu: 1.457 ± 0.029	1.038HisPhe: 1.038 ± 0.022	2.132HisGly: 2.132 ± 0.034	0.81HisHis: 0.81 ± 0.022	0.943HisIle: 0.943 ± 0.018	0.678HisLys: 0.678 ± 0.019	2.517HisLeu: 2.517 ± 0.034	0.439HisMet: 0.439 ± 0.014	0.604HisAsn: 0.604 ± 0.015	1.622HisPro: 1.622 ± 0.032	0.786HisGln: 0.786 ± 0.017	1.516HisArg: 1.516 ± 0.029	1.263HisSer: 1.263 ± 0.024	1.205HisThr: 1.205 ± 0.019	1.614HisVal: 1.614 ± 0.029	0.479HisTrp: 0.479 ± 0.015	0.677HisTyr: 0.677 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.989IleAla: 4.989 ± 0.05	0.51IleCys: 0.51 ± 0.014	2.248IleAsp: 2.248 ± 0.037	2.829IleGlu: 2.829 ± 0.043	1.713IlePhe: 1.713 ± 0.028	3.574IleGly: 3.574 ± 0.063	1.146IleHis: 1.146 ± 0.021	2.102IleIle: 2.102 ± 0.04	1.726IleLys: 1.726 ± 0.033	4.19IleLeu: 4.19 ± 0.049	0.844IleMet: 0.844 ± 0.02	1.419IleAsn: 1.419 ± 0.045	2.527IlePro: 2.527 ± 0.036	1.474IleGln: 1.474 ± 0.026	2.674IleArg: 2.674 ± 0.035	2.924IleSer: 2.924 ± 0.045	3.107IleThr: 3.107 ± 0.068	3.183IleVal: 3.183 ± 0.041	0.619IleTrp: 0.619 ± 0.018	1.188IleTyr: 1.188 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.806LysAla: 4.806 ± 0.069	0.311LysCys: 0.311 ± 0.013	2.856LysAsp: 2.856 ± 0.045	3.235LysGlu: 3.235 ± 0.056	1.461LysPhe: 1.461 ± 0.027	3.438LysGly: 3.438 ± 0.055	1.113LysHis: 1.113 ± 0.026	1.879LysIle: 1.879 ± 0.034	2.682LysLys: 2.682 ± 0.057	4.711LysLeu: 4.711 ± 0.061	1.203LysMet: 1.203 ± 0.026	1.535LysAsn: 1.535 ± 0.03	3.075LysPro: 3.075 ± 0.046	1.699LysGln: 1.699 ± 0.035	2.715LysArg: 2.715 ± 0.048	2.59LysSer: 2.59 ± 0.04	2.563LysThr: 2.563 ± 0.039	3.352LysVal: 3.352 ± 0.052	0.701LysTrp: 0.701 ± 0.017	0.965LysTyr: 0.965 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	10.758LeuAla: 10.758 ± 0.099	1.163LeuCys: 1.163 ± 0.028	5.215LeuAsp: 5.215 ± 0.049	5.914LeuGlu: 5.914 ± 0.072	3.364LeuPhe: 3.364 ± 0.048	7.485LeuGly: 7.485 ± 0.083	2.377LeuHis: 2.377 ± 0.041	4.031LeuIle: 4.031 ± 0.046	4.723LeuLys: 4.723 ± 0.058	10.235LeuLeu: 10.235 ± 0.103	2.256LeuMet: 2.256 ± 0.037	3.063LeuAsn: 3.063 ± 0.061	5.805LeuPro: 5.805 ± 0.062	3.578LeuGln: 3.578 ± 0.051	6.587LeuArg: 6.587 ± 0.077	6.103LeuSer: 6.103 ± 0.055	5.93LeuThr: 5.93 ± 0.081	6.9LeuVal: 6.9 ± 0.056	1.446LeuTrp: 1.446 ± 0.031	2.151LeuTyr: 2.151 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.345MetAla: 2.345 ± 0.037	0.194MetCys: 0.194 ± 0.009	1.21MetAsp: 1.21 ± 0.026	1.488MetGlu: 1.488 ± 0.027	0.687MetPhe: 0.687 ± 0.018	1.725MetGly: 1.725 ± 0.028	0.615MetHis: 0.615 ± 0.017	0.953MetIle: 0.953 ± 0.021	1.483MetLys: 1.483 ± 0.029	2.449MetLeu: 2.449 ± 0.037	0.619MetMet: 0.619 ± 0.018	0.952MetAsn: 0.952 ± 0.016	1.502MetPro: 1.502 ± 0.029	0.95MetGln: 0.95 ± 0.023	1.656MetArg: 1.656 ± 0.033	1.59MetSer: 1.59 ± 0.029	1.451MetThr: 1.451 ± 0.026	1.694MetVal: 1.694 ± 0.03	0.288MetTrp: 0.288 ± 0.012	0.385MetTyr: 0.385 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.312AsnAla: 3.312 ± 0.06	0.295AsnCys: 0.295 ± 0.012	1.594AsnAsp: 1.594 ± 0.04	1.663AsnGlu: 1.663 ± 0.029	1.231AsnPhe: 1.231 ± 0.027	3.027AsnGly: 3.027 ± 0.103	0.744AsnHis: 0.744 ± 0.018	1.496AsnIle: 1.496 ± 0.038	1.107AsnLys: 1.107 ± 0.027	3.005AsnLeu: 3.005 ± 0.043	0.599AsnMet: 0.599 ± 0.016	1.086AsnAsn: 1.086 ± 0.056	2.16AsnPro: 2.16 ± 0.029	1.015AsnGln: 1.015 ± 0.021	1.808AsnArg: 1.808 ± 0.029	1.795AsnSer: 1.795 ± 0.052	1.923AsnThr: 1.923 ± 0.073	2.158AsnVal: 2.158 ± 0.042	0.544AsnTrp: 0.544 ± 0.018	0.86AsnTyr: 0.86 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.168ProAla: 6.168 ± 0.079	0.392ProCys: 0.392 ± 0.015	3.408ProAsp: 3.408 ± 0.048	4.19ProGlu: 4.19 ± 0.054	1.93ProPhe: 1.93 ± 0.031	4.363ProGly: 4.363 ± 0.048	1.185ProHis: 1.185 ± 0.03	2.089ProIle: 2.089 ± 0.034	2.606ProLys: 2.606 ± 0.043	4.817ProLeu: 4.817 ± 0.056	1.342ProMet: 1.342 ± 0.022	1.652ProAsn: 1.652 ± 0.029	3.575ProPro: 3.575 ± 0.074	1.982ProGln: 1.982 ± 0.032	2.654ProArg: 2.654 ± 0.041	3.443ProSer: 3.443 ± 0.045	2.979ProThr: 2.979 ± 0.042	4.329ProVal: 4.329 ± 0.055	0.892ProTrp: 0.892 ± 0.021	1.209ProTyr: 1.209 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.627GlnAla: 3.627 ± 0.052	0.324GlnCys: 0.324 ± 0.014	1.628GlnAsp: 1.628 ± 0.026	2.107GlnGlu: 2.107 ± 0.037	1.248GlnPhe: 1.248 ± 0.022	2.7GlnGly: 2.7 ± 0.04	0.909GlnHis: 0.909 ± 0.022	1.609GlnIle: 1.609 ± 0.027	1.751GlnLys: 1.751 ± 0.035	3.15GlnLeu: 3.15 ± 0.042	0.938GlnMet: 0.938 ± 0.024	1.072GlnAsn: 1.072 ± 0.025	2.088GlnPro: 2.088 ± 0.039	1.619GlnGln: 1.619 ± 0.044	2.537GlnArg: 2.537 ± 0.039	2.067GlnSer: 2.067 ± 0.032	1.918GlnThr: 1.918 ± 0.032	2.536GlnVal: 2.536 ± 0.036	0.656GlnTrp: 0.656 ± 0.016	0.782GlnTyr: 0.782 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	5.45ArgAla: 5.45 ± 0.058	0.559ArgCys: 0.559 ± 0.018	3.325ArgAsp: 3.325 ± 0.043	4.452ArgGlu: 4.452 ± 0.065	2.561ArgPhe: 2.561 ± 0.032	4.085ArgGly: 4.085 ± 0.045	1.553ArgHis: 1.553 ± 0.03	3.195ArgIle: 3.195 ± 0.037	2.748ArgLys: 2.748 ± 0.041	6.486ArgLeu: 6.486 ± 0.067	1.767ArgMet: 1.767 ± 0.033	1.836ArgAsn: 1.836 ± 0.028	2.844ArgPro: 2.844 ± 0.042	2.263ArgGln: 2.263 ± 0.04	4.236ArgArg: 4.236 ± 0.055	3.349ArgSer: 3.349 ± 0.044	3.243ArgThr: 3.243 ± 0.041	4.424ArgVal: 4.424 ± 0.047	1.144ArgTrp: 1.144 ± 0.029	1.722ArgTyr: 1.722 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	5.848SerAla: 5.848 ± 0.06	0.582SerCys: 0.582 ± 0.019	3.008SerAsp: 3.008 ± 0.05	3.221SerGlu: 3.221 ± 0.043	2.35SerPhe: 2.35 ± 0.038	5.815SerGly: 5.815 ± 0.124	1.407SerHis: 1.407 ± 0.026	2.753SerIle: 2.753 ± 0.048	2.511SerLys: 2.511 ± 0.037	6.034SerLeu: 6.034 ± 0.048	1.499SerMet: 1.499 ± 0.028	1.795SerAsn: 1.795 ± 0.039	3.582SerPro: 3.582 ± 0.044	2.101SerGln: 2.101 ± 0.03	3.646SerArg: 3.646 ± 0.047	4.179SerSer: 4.179 ± 0.056	3.669SerThr: 3.669 ± 0.069	4.128SerVal: 4.128 ± 0.046	0.962SerTrp: 0.962 ± 0.023	1.512SerTyr: 1.512 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.812ThrAla: 5.812 ± 0.08	0.514ThrCys: 0.514 ± 0.015	2.833ThrAsp: 2.833 ± 0.051	3.033ThrGlu: 3.033 ± 0.047	2.332ThrPhe: 2.332 ± 0.045	5.355ThrGly: 5.355 ± 0.138	1.28ThrHis: 1.28 ± 0.025	2.765ThrIle: 2.765 ± 0.081	2.372ThrLys: 2.372 ± 0.035	6.51ThrLeu: 6.51 ± 0.116	1.197ThrMet: 1.197 ± 0.023	1.824ThrAsn: 1.824 ± 0.067	3.914ThrPro: 3.914 ± 0.046	1.838ThrGln: 1.838 ± 0.025	3.195ThrArg: 3.195 ± 0.041	3.636ThrSer: 3.636 ± 0.064	3.664ThrThr: 3.664 ± 0.104	4.358ThrVal: 4.358 ± 0.082	0.961ThrTrp: 0.961 ± 0.027	1.462ThrTyr: 1.462 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.922ValAla: 6.922 ± 0.062	0.809ValCys: 0.809 ± 0.019	3.662ValAsp: 3.662 ± 0.047	4.534ValGlu: 4.534 ± 0.055	2.715ValPhe: 2.715 ± 0.038	4.936ValGly: 4.936 ± 0.071	1.536ValHis: 1.536 ± 0.028	3.429ValIle: 3.429 ± 0.052	3.401ValLys: 3.401 ± 0.047	7.293ValLeu: 7.293 ± 0.06	1.776ValMet: 1.776 ± 0.03	2.312ValAsn: 2.312 ± 0.046	3.982ValPro: 3.982 ± 0.049	2.525ValGln: 2.525 ± 0.034	4.564ValArg: 4.564 ± 0.045	4.415ValSer: 4.415 ± 0.048	4.509ValThr: 4.509 ± 0.08	5.441ValVal: 5.441 ± 0.059	1.109ValTrp: 1.109 ± 0.025	1.68ValTyr: 1.68 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.172TrpAla: 1.172 ± 0.025	0.186TrpCys: 0.186 ± 0.009	0.865TrpAsp: 0.865 ± 0.02	0.907TrpGlu: 0.907 ± 0.02	0.669TrpPhe: 0.669 ± 0.019	1.04TrpGly: 1.04 ± 0.024	0.485TrpHis: 0.485 ± 0.016	0.747TrpIle: 0.747 ± 0.018	0.993TrpLys: 0.993 ± 0.022	1.928TrpLeu: 1.928 ± 0.037	0.568TrpMet: 0.568 ± 0.015	0.642TrpAsn: 0.642 ± 0.016	0.717TrpPro: 0.717 ± 0.018	0.737TrpGln: 0.737 ± 0.02	1.185TrpArg: 1.185 ± 0.028	1.052TrpSer: 1.052 ± 0.021	0.937TrpThr: 0.937 ± 0.021	1.071TrpVal: 1.071 ± 0.025	0.379TrpTrp: 0.379 ± 0.015	0.385TrpTyr: 0.385 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.028	0.279TyrCys: 0.279 ± 0.01	1.54TyrAsp: 1.54 ± 0.034	1.55TyrGlu: 1.55 ± 0.029	1.053TyrPhe: 1.053 ± 0.023	2.055TyrGly: 2.055 ± 0.03	0.697TyrHis: 0.697 ± 0.018	0.929TyrIle: 0.929 ± 0.024	0.881TyrLys: 0.881 ± 0.021	2.387TyrLeu: 2.387 ± 0.035	0.451TyrMet: 0.451 ± 0.015	0.762TyrAsn: 0.762 ± 0.022	1.225TyrPro: 1.225 ± 0.025	0.953TyrGln: 0.953 ± 0.019	1.722TyrArg: 1.722 ± 0.028	1.366TyrSer: 1.366 ± 0.03	1.407TyrThr: 1.407 ± 0.032	1.693TyrVal: 1.693 ± 0.026	0.421TyrTrp: 0.421 ± 0.013	0.787TyrTyr: 0.787 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6509 proteins (2350827 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---