Amino acid dipepetide frequency for Aeromonas phage ZPAH7B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.337AlaAla: 12.337 ± 1.609
0.809AlaCys: 0.809 ± 0.291
7.281AlaAsp: 7.281 ± 0.712
7.685AlaGlu: 7.685 ± 1.299
3.843AlaPhe: 3.843 ± 0.552
7.989AlaGly: 7.989 ± 0.949
2.326AlaHis: 2.326 ± 0.382
4.146AlaIle: 4.146 ± 0.691
6.775AlaLys: 6.775 ± 0.64
8.191AlaLeu: 8.191 ± 1.012
3.438AlaMet: 3.438 ± 0.781
3.539AlaAsn: 3.539 ± 0.751
3.034AlaPro: 3.034 ± 0.528
4.753AlaGln: 4.753 ± 0.962
5.966AlaArg: 5.966 ± 0.638
5.056AlaSer: 5.056 ± 0.756
4.247AlaThr: 4.247 ± 0.615
7.382AlaVal: 7.382 ± 0.695
1.011AlaTrp: 1.011 ± 0.248
4.146AlaTyr: 4.146 ± 0.639
0.0AlaXaa: 0.0 ± 0.0
Cys
0.404CysAla: 0.404 ± 0.167
0.404CysCys: 0.404 ± 0.23
0.708CysAsp: 0.708 ± 0.272
0.708CysGlu: 0.708 ± 0.279
0.404CysPhe: 0.404 ± 0.189
0.506CysGly: 0.506 ± 0.225
0.404CysHis: 0.404 ± 0.173
0.91CysIle: 0.91 ± 0.263
0.202CysLys: 0.202 ± 0.148
1.011CysLeu: 1.011 ± 0.306
0.101CysMet: 0.101 ± 0.103
0.202CysAsn: 0.202 ± 0.146
0.708CysPro: 0.708 ± 0.217
0.303CysGln: 0.303 ± 0.164
0.404CysArg: 0.404 ± 0.179
0.506CysSer: 0.506 ± 0.215
0.708CysThr: 0.708 ± 0.274
0.506CysVal: 0.506 ± 0.196
0.202CysTrp: 0.202 ± 0.15
0.404CysTyr: 0.404 ± 0.184
0.0CysXaa: 0.0 ± 0.0
Asp
7.079AspAla: 7.079 ± 0.962
0.607AspCys: 0.607 ± 0.235
3.438AspAsp: 3.438 ± 0.482
4.753AspGlu: 4.753 ± 0.694
2.124AspPhe: 2.124 ± 0.486
5.258AspGly: 5.258 ± 0.76
1.112AspHis: 1.112 ± 0.344
3.034AspIle: 3.034 ± 0.475
3.64AspLys: 3.64 ± 0.515
4.753AspLeu: 4.753 ± 0.923
2.022AspMet: 2.022 ± 0.494
2.225AspAsn: 2.225 ± 0.476
2.427AspPro: 2.427 ± 0.487
1.82AspGln: 1.82 ± 0.449
2.73AspArg: 2.73 ± 0.689
4.449AspSer: 4.449 ± 0.895
4.146AspThr: 4.146 ± 0.767
4.449AspVal: 4.449 ± 0.886
1.011AspTrp: 1.011 ± 0.274
1.921AspTyr: 1.921 ± 0.543
0.0AspXaa: 0.0 ± 0.0
Glu
6.27GluAla: 6.27 ± 0.797
0.506GluCys: 0.506 ± 0.216
4.247GluAsp: 4.247 ± 0.643
4.449GluGlu: 4.449 ± 0.768
2.73GluPhe: 2.73 ± 0.406
3.438GluGly: 3.438 ± 0.471
2.022GluHis: 2.022 ± 0.518
2.124GluIle: 2.124 ± 0.502
3.438GluLys: 3.438 ± 0.616
5.966GluLeu: 5.966 ± 0.527
2.528GluMet: 2.528 ± 0.588
1.719GluAsn: 1.719 ± 0.237
1.921GluPro: 1.921 ± 0.51
5.562GluGln: 5.562 ± 0.74
3.64GluArg: 3.64 ± 0.698
3.438GluSer: 3.438 ± 0.657
2.831GluThr: 2.831 ± 0.385
4.551GluVal: 4.551 ± 0.853
1.213GluTrp: 1.213 ± 0.336
1.82GluTyr: 1.82 ± 0.37
0.0GluXaa: 0.0 ± 0.0
Phe
2.933PheAla: 2.933 ± 0.454
0.303PheCys: 0.303 ± 0.158
2.528PheAsp: 2.528 ± 0.422
1.921PheGlu: 1.921 ± 0.467
1.112PhePhe: 1.112 ± 0.384
3.742PheGly: 3.742 ± 0.617
0.607PheHis: 0.607 ± 0.232
2.124PheIle: 2.124 ± 0.43
2.73PheLys: 2.73 ± 0.525
2.629PheLeu: 2.629 ± 0.477
1.112PheMet: 1.112 ± 0.308
2.326PheAsn: 2.326 ± 0.511
1.416PhePro: 1.416 ± 0.321
1.618PheGln: 1.618 ± 0.323
2.124PheArg: 2.124 ± 0.465
1.82PheSer: 1.82 ± 0.42
1.921PheThr: 1.921 ± 0.51
2.528PheVal: 2.528 ± 0.455
0.404PheTrp: 0.404 ± 0.194
0.809PheTyr: 0.809 ± 0.272
0.0PheXaa: 0.0 ± 0.0
Gly
7.888GlyAla: 7.888 ± 0.879
1.112GlyCys: 1.112 ± 0.447
5.966GlyAsp: 5.966 ± 0.715
3.742GlyGlu: 3.742 ± 0.614
2.933GlyPhe: 2.933 ± 0.363
7.382GlyGly: 7.382 ± 1.05
1.416GlyHis: 1.416 ± 0.292
3.843GlyIle: 3.843 ± 0.476
5.157GlyLys: 5.157 ± 0.78
5.359GlyLeu: 5.359 ± 0.819
2.427GlyMet: 2.427 ± 0.522
3.337GlyAsn: 3.337 ± 0.433
2.022GlyPro: 2.022 ± 0.48
2.629GlyGln: 2.629 ± 0.621
5.461GlyArg: 5.461 ± 0.686
5.764GlySer: 5.764 ± 0.806
3.843GlyThr: 3.843 ± 0.638
5.056GlyVal: 5.056 ± 0.819
0.809GlyTrp: 0.809 ± 0.223
2.326GlyTyr: 2.326 ± 0.717
0.0GlyXaa: 0.0 ± 0.0
His
1.213HisAla: 1.213 ± 0.403
0.303HisCys: 0.303 ± 0.182
1.719HisAsp: 1.719 ± 0.401
0.91HisGlu: 0.91 ± 0.297
0.708HisPhe: 0.708 ± 0.243
1.618HisGly: 1.618 ± 0.468
0.506HisHis: 0.506 ± 0.264
1.315HisIle: 1.315 ± 0.393
0.708HisLys: 0.708 ± 0.218
1.618HisLeu: 1.618 ± 0.461
1.011HisMet: 1.011 ± 0.349
0.506HisAsn: 0.506 ± 0.192
0.91HisPro: 0.91 ± 0.327
0.708HisGln: 0.708 ± 0.204
1.011HisArg: 1.011 ± 0.323
1.416HisSer: 1.416 ± 0.27
1.011HisThr: 1.011 ± 0.274
2.022HisVal: 2.022 ± 0.562
0.404HisTrp: 0.404 ± 0.154
1.315HisTyr: 1.315 ± 0.399
0.0HisXaa: 0.0 ± 0.0
Ile
5.157IleAla: 5.157 ± 0.811
0.303IleCys: 0.303 ± 0.169
1.82IleAsp: 1.82 ± 0.389
3.539IleGlu: 3.539 ± 0.425
1.213IlePhe: 1.213 ± 0.608
3.337IleGly: 3.337 ± 0.592
1.112IleHis: 1.112 ± 0.38
2.124IleIle: 2.124 ± 0.652
2.427IleLys: 2.427 ± 0.339
3.539IleLeu: 3.539 ± 0.508
1.921IleMet: 1.921 ± 0.413
1.921IleAsn: 1.921 ± 0.339
1.921IlePro: 1.921 ± 0.332
2.022IleGln: 2.022 ± 0.491
4.146IleArg: 4.146 ± 0.601
2.427IleSer: 2.427 ± 0.791
2.629IleThr: 2.629 ± 0.435
1.82IleVal: 1.82 ± 0.542
0.506IleTrp: 0.506 ± 0.263
1.517IleTyr: 1.517 ± 0.335
0.0IleXaa: 0.0 ± 0.0
Lys
7.483LysAla: 7.483 ± 1.105
0.303LysCys: 0.303 ± 0.148
3.337LysAsp: 3.337 ± 0.569
4.247LysGlu: 4.247 ± 0.607
2.124LysPhe: 2.124 ± 0.388
4.449LysGly: 4.449 ± 0.674
1.416LysHis: 1.416 ± 0.414
1.921LysIle: 1.921 ± 0.623
3.539LysLys: 3.539 ± 0.629
5.865LysLeu: 5.865 ± 0.753
1.719LysMet: 1.719 ± 0.481
1.517LysAsn: 1.517 ± 0.446
2.831LysPro: 2.831 ± 0.698
3.236LysGln: 3.236 ± 0.562
2.124LysArg: 2.124 ± 0.447
3.135LysSer: 3.135 ± 0.505
3.034LysThr: 3.034 ± 0.428
3.438LysVal: 3.438 ± 0.563
1.213LysTrp: 1.213 ± 0.35
2.124LysTyr: 2.124 ± 0.336
0.0LysXaa: 0.0 ± 0.0
Leu
8.798LeuAla: 8.798 ± 1.185
0.708LeuCys: 0.708 ± 0.31
6.168LeuAsp: 6.168 ± 0.739
4.449LeuGlu: 4.449 ± 0.566
2.629LeuPhe: 2.629 ± 0.497
5.966LeuGly: 5.966 ± 0.573
1.921LeuHis: 1.921 ± 0.4
3.64LeuIle: 3.64 ± 0.581
4.652LeuLys: 4.652 ± 0.596
5.865LeuLeu: 5.865 ± 0.682
2.629LeuMet: 2.629 ± 0.577
3.539LeuAsn: 3.539 ± 0.551
3.944LeuPro: 3.944 ± 0.734
4.045LeuGln: 4.045 ± 0.825
4.247LeuArg: 4.247 ± 0.672
5.663LeuSer: 5.663 ± 0.723
5.157LeuThr: 5.157 ± 0.751
4.652LeuVal: 4.652 ± 0.585
0.91LeuTrp: 0.91 ± 0.293
1.719LeuTyr: 1.719 ± 0.319
0.0LeuXaa: 0.0 ± 0.0
Met
4.753MetAla: 4.753 ± 0.907
0.101MetCys: 0.101 ± 0.107
2.124MetAsp: 2.124 ± 0.53
1.921MetGlu: 1.921 ± 0.562
1.315MetPhe: 1.315 ± 0.439
1.921MetGly: 1.921 ± 0.549
0.607MetHis: 0.607 ± 0.23
0.91MetIle: 0.91 ± 0.267
1.416MetLys: 1.416 ± 0.396
2.73MetLeu: 2.73 ± 0.497
0.809MetMet: 0.809 ± 0.337
1.011MetAsn: 1.011 ± 0.357
1.517MetPro: 1.517 ± 0.333
1.213MetGln: 1.213 ± 0.443
2.427MetArg: 2.427 ± 0.535
3.034MetSer: 3.034 ± 0.313
1.82MetThr: 1.82 ± 0.316
2.326MetVal: 2.326 ± 0.513
0.607MetTrp: 0.607 ± 0.25
0.506MetTyr: 0.506 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
4.146AsnAla: 4.146 ± 0.617
0.506AsnCys: 0.506 ± 0.256
1.315AsnAsp: 1.315 ± 0.379
1.213AsnGlu: 1.213 ± 0.22
1.315AsnPhe: 1.315 ± 0.258
3.135AsnGly: 3.135 ± 0.402
1.213AsnHis: 1.213 ± 0.323
2.326AsnIle: 2.326 ± 0.424
2.831AsnLys: 2.831 ± 0.479
3.034AsnLeu: 3.034 ± 0.534
1.315AsnMet: 1.315 ± 0.464
0.809AsnAsn: 0.809 ± 0.284
2.326AsnPro: 2.326 ± 0.426
1.618AsnGln: 1.618 ± 0.424
2.225AsnArg: 2.225 ± 0.466
2.528AsnSer: 2.528 ± 0.605
1.719AsnThr: 1.719 ± 0.32
2.225AsnVal: 2.225 ± 0.349
0.506AsnTrp: 0.506 ± 0.212
1.315AsnTyr: 1.315 ± 0.445
0.0AsnXaa: 0.0 ± 0.0
Pro
3.236ProAla: 3.236 ± 0.599
0.303ProCys: 0.303 ± 0.152
2.225ProAsp: 2.225 ± 0.474
3.438ProGlu: 3.438 ± 0.85
1.719ProPhe: 1.719 ± 0.411
2.831ProGly: 2.831 ± 0.499
0.809ProHis: 0.809 ± 0.227
1.82ProIle: 1.82 ± 0.396
2.124ProLys: 2.124 ± 0.385
3.539ProLeu: 3.539 ± 0.537
1.315ProMet: 1.315 ± 0.391
1.618ProAsn: 1.618 ± 0.418
1.315ProPro: 1.315 ± 0.351
1.719ProGln: 1.719 ± 0.358
1.416ProArg: 1.416 ± 0.351
3.438ProSer: 3.438 ± 0.508
1.719ProThr: 1.719 ± 0.484
3.944ProVal: 3.944 ± 0.844
0.404ProTrp: 0.404 ± 0.165
1.011ProTyr: 1.011 ± 0.343
0.0ProXaa: 0.0 ± 0.0
Gln
5.258GlnAla: 5.258 ± 0.731
0.202GlnCys: 0.202 ± 0.143
3.135GlnAsp: 3.135 ± 0.733
3.337GlnGlu: 3.337 ± 0.755
1.82GlnPhe: 1.82 ± 0.365
3.438GlnGly: 3.438 ± 0.53
1.416GlnHis: 1.416 ± 0.3
2.326GlnIle: 2.326 ± 0.347
2.831GlnLys: 2.831 ± 0.513
4.247GlnLeu: 4.247 ± 0.607
2.427GlnMet: 2.427 ± 0.59
1.82GlnAsn: 1.82 ± 0.397
0.708GlnPro: 0.708 ± 0.203
2.225GlnGln: 2.225 ± 0.726
2.022GlnArg: 2.022 ± 0.564
1.921GlnSer: 1.921 ± 0.354
2.124GlnThr: 2.124 ± 0.562
2.629GlnVal: 2.629 ± 0.446
0.91GlnTrp: 0.91 ± 0.23
1.82GlnTyr: 1.82 ± 0.321
0.0GlnXaa: 0.0 ± 0.0
Arg
5.258ArgAla: 5.258 ± 0.67
0.404ArgCys: 0.404 ± 0.199
3.742ArgAsp: 3.742 ± 0.575
3.539ArgGlu: 3.539 ± 0.445
2.629ArgPhe: 2.629 ± 0.478
4.247ArgGly: 4.247 ± 0.492
1.112ArgHis: 1.112 ± 0.284
3.236ArgIle: 3.236 ± 0.545
2.528ArgLys: 2.528 ± 0.419
5.258ArgLeu: 5.258 ± 0.648
2.124ArgMet: 2.124 ± 0.453
2.427ArgAsn: 2.427 ± 0.403
2.022ArgPro: 2.022 ± 0.51
2.528ArgGln: 2.528 ± 0.48
3.034ArgArg: 3.034 ± 0.577
2.124ArgSer: 2.124 ± 0.311
2.022ArgThr: 2.022 ± 0.411
3.742ArgVal: 3.742 ± 0.501
1.011ArgTrp: 1.011 ± 0.401
2.225ArgTyr: 2.225 ± 0.474
0.0ArgXaa: 0.0 ± 0.0
Ser
4.854SerAla: 4.854 ± 0.851
0.607SerCys: 0.607 ± 0.299
4.551SerAsp: 4.551 ± 0.968
3.944SerGlu: 3.944 ± 0.789
1.921SerPhe: 1.921 ± 0.457
5.157SerGly: 5.157 ± 0.853
0.809SerHis: 0.809 ± 0.228
2.629SerIle: 2.629 ± 0.485
4.045SerLys: 4.045 ± 0.84
4.045SerLeu: 4.045 ± 0.738
1.921SerMet: 1.921 ± 0.485
2.427SerAsn: 2.427 ± 0.678
3.337SerPro: 3.337 ± 0.574
3.539SerGln: 3.539 ± 0.599
4.247SerArg: 4.247 ± 0.787
3.944SerSer: 3.944 ± 0.813
3.337SerThr: 3.337 ± 0.55
4.652SerVal: 4.652 ± 0.584
1.213SerTrp: 1.213 ± 0.339
1.315SerTyr: 1.315 ± 0.482
0.0SerXaa: 0.0 ± 0.0
Thr
5.865ThrAla: 5.865 ± 0.703
0.809ThrCys: 0.809 ± 0.341
2.022ThrAsp: 2.022 ± 0.518
3.337ThrGlu: 3.337 ± 0.661
1.112ThrPhe: 1.112 ± 0.273
5.056ThrGly: 5.056 ± 0.524
0.607ThrHis: 0.607 ± 0.231
1.82ThrIle: 1.82 ± 0.446
3.539ThrLys: 3.539 ± 0.593
3.843ThrLeu: 3.843 ± 0.556
0.91ThrMet: 0.91 ± 0.239
1.618ThrAsn: 1.618 ± 0.375
3.236ThrPro: 3.236 ± 0.623
1.921ThrGln: 1.921 ± 0.372
1.82ThrArg: 1.82 ± 0.394
4.449ThrSer: 4.449 ± 0.846
1.82ThrThr: 1.82 ± 0.373
3.135ThrVal: 3.135 ± 0.736
0.809ThrTrp: 0.809 ± 0.23
1.719ThrTyr: 1.719 ± 0.447
0.0ThrXaa: 0.0 ± 0.0
Val
7.079ValAla: 7.079 ± 0.846
1.011ValCys: 1.011 ± 0.378
3.337ValAsp: 3.337 ± 0.562
4.551ValGlu: 4.551 ± 0.58
2.933ValPhe: 2.933 ± 0.699
6.168ValGly: 6.168 ± 0.9
1.011ValHis: 1.011 ± 0.281
3.236ValIle: 3.236 ± 0.73
3.438ValLys: 3.438 ± 0.551
4.854ValLeu: 4.854 ± 0.564
2.022ValMet: 2.022 ± 0.387
2.73ValAsn: 2.73 ± 0.439
2.933ValPro: 2.933 ± 0.746
3.64ValGln: 3.64 ± 0.575
4.146ValArg: 4.146 ± 0.715
3.742ValSer: 3.742 ± 0.35
3.236ValThr: 3.236 ± 0.732
4.753ValVal: 4.753 ± 0.915
0.506ValTrp: 0.506 ± 0.233
1.719ValTyr: 1.719 ± 0.547
0.0ValXaa: 0.0 ± 0.0
Trp
1.517TrpAla: 1.517 ± 0.368
0.0TrpCys: 0.0 ± 0.0
1.618TrpAsp: 1.618 ± 0.574
1.213TrpGlu: 1.213 ± 0.28
0.809TrpPhe: 0.809 ± 0.218
0.607TrpGly: 0.607 ± 0.284
0.202TrpHis: 0.202 ± 0.125
0.303TrpIle: 0.303 ± 0.148
1.011TrpLys: 1.011 ± 0.291
2.022TrpLeu: 2.022 ± 0.591
0.303TrpMet: 0.303 ± 0.172
0.404TrpAsn: 0.404 ± 0.213
0.202TrpPro: 0.202 ± 0.136
0.404TrpGln: 0.404 ± 0.264
0.404TrpArg: 0.404 ± 0.199
1.011TrpSer: 1.011 ± 0.277
0.708TrpThr: 0.708 ± 0.253
1.011TrpVal: 1.011 ± 0.314
0.607TrpTrp: 0.607 ± 0.209
0.404TrpTyr: 0.404 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.427TyrAla: 2.427 ± 0.614
0.404TyrCys: 0.404 ± 0.17
1.719TyrAsp: 1.719 ± 0.47
1.517TyrGlu: 1.517 ± 0.448
1.315TyrPhe: 1.315 ± 0.291
2.225TyrGly: 2.225 ± 0.529
0.303TyrHis: 0.303 ± 0.188
1.618TyrIle: 1.618 ± 0.39
2.022TyrLys: 2.022 ± 0.541
3.034TyrLeu: 3.034 ± 0.491
0.91TyrMet: 0.91 ± 0.441
1.921TyrAsn: 1.921 ± 0.516
1.213TyrPro: 1.213 ± 0.466
1.112TyrGln: 1.112 ± 0.353
1.618TyrArg: 1.618 ± 0.367
2.629TyrSer: 2.629 ± 0.557
1.416TyrThr: 1.416 ± 0.384
2.225TyrVal: 2.225 ± 0.43
0.506TyrTrp: 0.506 ± 0.191
0.708TyrTyr: 0.708 ± 0.331
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 29 proteins (9890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski