Amino acid dipepetide frequency for Mucispirillum schaedleri ASF457

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.737AlaAla: 6.737 ± 0.141	0.959AlaCys: 0.959 ± 0.045	4.0AlaAsp: 4.0 ± 0.081	5.154AlaGlu: 5.154 ± 0.104	3.041AlaPhe: 3.041 ± 0.074	5.816AlaGly: 5.816 ± 0.123	0.932AlaHis: 0.932 ± 0.039	4.032AlaIle: 4.032 ± 0.09	5.033AlaLys: 5.033 ± 0.083	6.54AlaLeu: 6.54 ± 0.103	1.637AlaMet: 1.637 ± 0.054	2.928AlaAsn: 2.928 ± 0.068	1.84AlaPro: 1.84 ± 0.058	1.772AlaGln: 1.772 ± 0.057	2.223AlaArg: 2.223 ± 0.064	4.156AlaSer: 4.156 ± 0.08	2.632AlaThr: 2.632 ± 0.084	6.888AlaVal: 6.888 ± 0.123	0.406AlaTrp: 0.406 ± 0.028	2.79AlaTyr: 2.79 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	0.702CysAla: 0.702 ± 0.034	0.168CysCys: 0.168 ± 0.017	0.646CysAsp: 0.646 ± 0.035	0.648CysGlu: 0.648 ± 0.034	0.483CysPhe: 0.483 ± 0.032	0.955CysGly: 0.955 ± 0.044	0.344CysHis: 0.344 ± 0.037	1.022CysIle: 1.022 ± 0.044	0.752CysLys: 0.752 ± 0.037	0.801CysLeu: 0.801 ± 0.036	0.286CysMet: 0.286 ± 0.022	0.534CysAsn: 0.534 ± 0.029	0.526CysPro: 0.526 ± 0.032	0.28CysGln: 0.28 ± 0.021	0.404CysArg: 0.404 ± 0.025	1.046CysSer: 1.046 ± 0.042	0.445CysThr: 0.445 ± 0.026	0.594CysVal: 0.594 ± 0.032	0.059CysTrp: 0.059 ± 0.009	0.424CysTyr: 0.424 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.289AspAla: 3.289 ± 0.085	0.54AspCys: 0.54 ± 0.029	3.251AspAsp: 3.251 ± 0.08	4.159AspGlu: 4.159 ± 0.09	2.93AspPhe: 2.93 ± 0.062	3.2AspGly: 3.2 ± 0.067	0.541AspHis: 0.541 ± 0.03	6.866AspIle: 6.866 ± 0.113	5.65AspLys: 5.65 ± 0.106	4.242AspLeu: 4.242 ± 0.074	1.859AspMet: 1.859 ± 0.053	4.428AspAsn: 4.428 ± 0.088	1.224AspPro: 1.224 ± 0.043	0.628AspGln: 0.628 ± 0.028	1.678AspArg: 1.678 ± 0.059	2.731AspSer: 2.731 ± 0.058	3.154AspThr: 3.154 ± 0.066	3.196AspVal: 3.196 ± 0.075	0.388AspTrp: 0.388 ± 0.022	2.865AspTyr: 2.865 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	3.943GluAla: 3.943 ± 0.093	0.685GluCys: 0.685 ± 0.034	3.265GluAsp: 3.265 ± 0.079	4.636GluGlu: 4.636 ± 0.127	2.614GluPhe: 2.614 ± 0.066	2.649GluGly: 2.649 ± 0.076	1.108GluHis: 1.108 ± 0.043	6.207GluIle: 6.207 ± 0.094	7.042GluLys: 7.042 ± 0.128	5.796GluLeu: 5.796 ± 0.093	1.9GluMet: 1.9 ± 0.058	5.243GluAsn: 5.243 ± 0.101	1.539GluPro: 1.539 ± 0.049	2.121GluGln: 2.121 ± 0.063	2.534GluArg: 2.534 ± 0.07	3.292GluSer: 3.292 ± 0.075	3.241GluThr: 3.241 ± 0.072	3.609GluVal: 3.609 ± 0.082	0.38GluTrp: 0.38 ± 0.024	3.732GluTyr: 3.732 ± 0.078	0.0GluXaa: 0.0 ± 0.0
Phe	3.366PheAla: 3.366 ± 0.081	0.501PheCys: 0.501 ± 0.027	2.599PheAsp: 2.599 ± 0.057	2.545PheGlu: 2.545 ± 0.058	2.503PhePhe: 2.503 ± 0.081	2.963PheGly: 2.963 ± 0.076	0.761PheHis: 0.761 ± 0.034	5.009PheIle: 5.009 ± 0.107	3.49PheLys: 3.49 ± 0.082	4.289PheLeu: 4.289 ± 0.103	1.336PheMet: 1.336 ± 0.05	2.913PheAsn: 2.913 ± 0.077	1.401PhePro: 1.401 ± 0.053	1.136PheGln: 1.136 ± 0.038	1.392PheArg: 1.392 ± 0.052	3.307PheSer: 3.307 ± 0.078	2.674PheThr: 2.674 ± 0.065	2.44PheVal: 2.44 ± 0.058	0.305PheTrp: 0.305 ± 0.025	2.053PheTyr: 2.053 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	4.455GlyAla: 4.455 ± 0.108	0.831GlyCys: 0.831 ± 0.035	2.9GlyAsp: 2.9 ± 0.076	3.393GlyGlu: 3.393 ± 0.075	3.051GlyPhe: 3.051 ± 0.066	4.003GlyGly: 4.003 ± 0.102	0.908GlyHis: 0.908 ± 0.046	6.068GlyIle: 6.068 ± 0.1	4.72GlyLys: 4.72 ± 0.096	5.189GlyLeu: 5.189 ± 0.103	1.778GlyMet: 1.778 ± 0.061	2.743GlyAsn: 2.743 ± 0.074	1.015GlyPro: 1.015 ± 0.038	1.509GlyGln: 1.509 ± 0.054	2.748GlyArg: 2.748 ± 0.069	4.036GlySer: 4.036 ± 0.084	3.146GlyThr: 3.146 ± 0.071	3.971GlyVal: 3.971 ± 0.086	0.442GlyTrp: 0.442 ± 0.026	3.048GlyTyr: 3.048 ± 0.078	0.0GlyXaa: 0.0 ± 0.0
His	0.953HisAla: 0.953 ± 0.034	0.215HisCys: 0.215 ± 0.018	0.804HisAsp: 0.804 ± 0.037	0.8HisGlu: 0.8 ± 0.038	0.822HisPhe: 0.822 ± 0.035	1.054HisGly: 1.054 ± 0.044	0.349HisHis: 0.349 ± 0.024	1.843HisIle: 1.843 ± 0.06	1.207HisLys: 1.207 ± 0.049	1.327HisLeu: 1.327 ± 0.045	0.274HisMet: 0.274 ± 0.02	1.067HisAsn: 1.067 ± 0.042	0.716HisPro: 0.716 ± 0.034	0.385HisGln: 0.385 ± 0.023	0.552HisArg: 0.552 ± 0.03	1.108HisSer: 1.108 ± 0.037	0.929HisThr: 0.929 ± 0.045	0.774HisVal: 0.774 ± 0.032	0.093HisTrp: 0.093 ± 0.013	0.682HisTyr: 0.682 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.014IleAla: 6.014 ± 0.102	1.009IleCys: 1.009 ± 0.041	5.877IleAsp: 5.877 ± 0.085	5.98IleGlu: 5.98 ± 0.116	4.389IlePhe: 4.389 ± 0.118	4.812IleGly: 4.812 ± 0.097	1.436IleHis: 1.436 ± 0.045	8.891IleIle: 8.891 ± 0.155	7.816IleLys: 7.816 ± 0.127	8.034IleLeu: 8.034 ± 0.14	2.399IleMet: 2.399 ± 0.064	6.115IleAsn: 6.115 ± 0.125	3.233IlePro: 3.233 ± 0.067	2.085IleGln: 2.085 ± 0.066	2.776IleArg: 2.776 ± 0.059	6.979IleSer: 6.979 ± 0.131	5.375IleThr: 5.375 ± 0.1	5.264IleVal: 5.264 ± 0.106	0.525IleTrp: 0.525 ± 0.027	4.036IleTyr: 4.036 ± 0.087	0.0IleXaa: 0.0 ± 0.0
Lys	5.469LysAla: 5.469 ± 0.099	0.84LysCys: 0.84 ± 0.037	5.269LysAsp: 5.269 ± 0.102	7.012LysGlu: 7.012 ± 0.138	2.891LysPhe: 2.891 ± 0.066	4.586LysGly: 4.586 ± 0.087	1.351LysHis: 1.351 ± 0.047	7.122LysIle: 7.122 ± 0.131	7.121LysLys: 7.121 ± 0.138	6.591LysLeu: 6.591 ± 0.097	2.405LysMet: 2.405 ± 0.053	6.028LysAsn: 6.028 ± 0.117	2.187LysPro: 2.187 ± 0.055	2.602LysGln: 2.602 ± 0.074	2.718LysArg: 2.718 ± 0.072	5.243LysSer: 5.243 ± 0.085	4.385LysThr: 4.385 ± 0.084	4.544LysVal: 4.544 ± 0.085	0.543LysTrp: 0.543 ± 0.033	4.555LysTyr: 4.555 ± 0.106	0.0LysXaa: 0.0 ± 0.0
Leu	5.572LeuAla: 5.572 ± 0.097	0.9LeuCys: 0.9 ± 0.04	4.714LeuAsp: 4.714 ± 0.085	5.538LeuGlu: 5.538 ± 0.103	4.373LeuPhe: 4.373 ± 0.107	4.879LeuGly: 4.879 ± 0.107	1.496LeuHis: 1.496 ± 0.052	7.504LeuIle: 7.504 ± 0.124	7.653LeuLys: 7.653 ± 0.12	7.877LeuLeu: 7.877 ± 0.124	2.261LeuMet: 2.261 ± 0.061	5.644LeuAsn: 5.644 ± 0.088	2.937LeuPro: 2.937 ± 0.067	2.545LeuGln: 2.545 ± 0.069	2.701LeuArg: 2.701 ± 0.067	6.952LeuSer: 6.952 ± 0.122	4.287LeuThr: 4.287 ± 0.079	4.379LeuVal: 4.379 ± 0.098	0.573LeuTrp: 0.573 ± 0.031	3.884LeuTyr: 3.884 ± 0.091	0.0LeuXaa: 0.0 ± 0.0
Met	2.247MetAla: 2.247 ± 0.061	0.231MetCys: 0.231 ± 0.019	1.446MetAsp: 1.446 ± 0.047	1.732MetGlu: 1.732 ± 0.053	1.078MetPhe: 1.078 ± 0.047	1.649MetGly: 1.649 ± 0.054	0.428MetHis: 0.428 ± 0.026	1.972MetIle: 1.972 ± 0.057	2.27MetLys: 2.27 ± 0.063	2.683MetLeu: 2.683 ± 0.064	0.706MetMet: 0.706 ± 0.036	1.472MetAsn: 1.472 ± 0.053	1.162MetPro: 1.162 ± 0.042	1.282MetGln: 1.282 ± 0.042	1.028MetArg: 1.028 ± 0.041	1.82MetSer: 1.82 ± 0.056	1.284MetThr: 1.284 ± 0.039	1.509MetVal: 1.509 ± 0.052	0.158MetTrp: 0.158 ± 0.017	0.955MetTyr: 0.955 ± 0.038	0.0MetXaa: 0.0 ± 0.0
Asn	3.814AsnAla: 3.814 ± 0.088	0.516AsnCys: 0.516 ± 0.028	3.307AsnAsp: 3.307 ± 0.067	3.537AsnGlu: 3.537 ± 0.079	2.501AsnPhe: 2.501 ± 0.059	3.761AsnGly: 3.761 ± 0.091	0.885AsnHis: 0.885 ± 0.039	7.91AsnIle: 7.91 ± 0.121	5.865AsnLys: 5.865 ± 0.119	4.531AsnLeu: 4.531 ± 0.082	2.01AsnMet: 2.01 ± 0.063	4.795AsnAsn: 4.795 ± 0.119	2.207AsnPro: 2.207 ± 0.064	1.637AsnGln: 1.637 ± 0.061	1.757AsnArg: 1.757 ± 0.049	3.82AsnSer: 3.82 ± 0.091	3.611AsnThr: 3.611 ± 0.087	3.49AsnVal: 3.49 ± 0.081	0.356AsnTrp: 0.356 ± 0.027	2.431AsnTyr: 2.431 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.519ProAla: 2.519 ± 0.065	0.358ProCys: 0.358 ± 0.024	2.035ProAsp: 2.035 ± 0.051	2.416ProGlu: 2.416 ± 0.067	1.643ProPhe: 1.643 ± 0.048	1.287ProGly: 1.287 ± 0.047	0.531ProHis: 0.531 ± 0.029	1.789ProIle: 1.789 ± 0.057	2.122ProLys: 2.122 ± 0.056	2.821ProLeu: 2.821 ± 0.071	0.613ProMet: 0.613 ± 0.028	1.433ProAsn: 1.433 ± 0.04	0.697ProPro: 0.697 ± 0.034	0.773ProGln: 0.773 ± 0.033	0.807ProArg: 0.807 ± 0.039	1.765ProSer: 1.765 ± 0.054	1.178ProThr: 1.178 ± 0.044	3.134ProVal: 3.134 ± 0.073	0.218ProTrp: 0.218 ± 0.017	1.58ProTyr: 1.58 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.047GlnAla: 2.047 ± 0.054	0.26GlnCys: 0.26 ± 0.021	1.672GlnAsp: 1.672 ± 0.057	1.989GlnGlu: 1.989 ± 0.044	1.063GlnPhe: 1.063 ± 0.038	1.617GlnGly: 1.617 ± 0.054	0.496GlnHis: 0.496 ± 0.03	2.34GlnIle: 2.34 ± 0.067	2.184GlnLys: 2.184 ± 0.063	2.264GlnLeu: 2.264 ± 0.064	0.764GlnMet: 0.764 ± 0.035	1.712GlnAsn: 1.712 ± 0.052	0.603GlnPro: 0.603 ± 0.035	0.973GlnGln: 0.973 ± 0.04	0.8GlnArg: 0.8 ± 0.036	1.703GlnSer: 1.703 ± 0.05	1.371GlnThr: 1.371 ± 0.047	1.53GlnVal: 1.53 ± 0.053	0.195GlnTrp: 0.195 ± 0.02	1.215GlnTyr: 1.215 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.065ArgAla: 2.065 ± 0.059	0.38ArgCys: 0.38 ± 0.025	1.726ArgAsp: 1.726 ± 0.056	2.177ArgGlu: 2.177 ± 0.061	1.669ArgPhe: 1.669 ± 0.05	1.765ArgGly: 1.765 ± 0.053	0.631ArgHis: 0.631 ± 0.03	2.895ArgIle: 2.895 ± 0.062	2.758ArgLys: 2.758 ± 0.072	3.26ArgLeu: 3.26 ± 0.085	0.998ArgMet: 0.998 ± 0.037	1.933ArgAsn: 1.933 ± 0.054	1.069ArgPro: 1.069 ± 0.038	1.197ArgGln: 1.197 ± 0.039	1.344ArgArg: 1.344 ± 0.052	1.753ArgSer: 1.753 ± 0.053	1.425ArgThr: 1.425 ± 0.046	2.043ArgVal: 2.043 ± 0.061	0.259ArgTrp: 0.259 ± 0.022	1.676ArgTyr: 1.676 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.615SerAla: 4.615 ± 0.104	0.837SerCys: 0.837 ± 0.041	3.684SerAsp: 3.684 ± 0.073	3.914SerGlu: 3.914 ± 0.089	3.716SerPhe: 3.716 ± 0.086	4.52SerGly: 4.52 ± 0.089	1.087SerHis: 1.087 ± 0.043	6.198SerIle: 6.198 ± 0.103	5.057SerLys: 5.057 ± 0.085	6.107SerLeu: 6.107 ± 0.106	1.732SerMet: 1.732 ± 0.052	3.696SerAsn: 3.696 ± 0.092	1.849SerPro: 1.849 ± 0.052	1.697SerGln: 1.697 ± 0.051	2.255SerArg: 2.255 ± 0.055	5.299SerSer: 5.299 ± 0.12	2.823SerThr: 2.823 ± 0.076	4.007SerVal: 4.007 ± 0.094	0.48SerTrp: 0.48 ± 0.035	3.075SerTyr: 3.075 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	4.499ThrAla: 4.499 ± 0.106	0.528ThrCys: 0.528 ± 0.029	2.984ThrAsp: 2.984 ± 0.064	2.694ThrGlu: 2.694 ± 0.066	2.372ThrPhe: 2.372 ± 0.055	4.361ThrGly: 4.361 ± 0.091	0.953ThrHis: 0.953 ± 0.04	4.412ThrIle: 4.412 ± 0.085	3.381ThrLys: 3.381 ± 0.078	4.442ThrLeu: 4.442 ± 0.074	1.181ThrMet: 1.181 ± 0.044	2.661ThrAsn: 2.661 ± 0.079	1.987ThrPro: 1.987 ± 0.065	1.21ThrGln: 1.21 ± 0.05	1.463ThrArg: 1.463 ± 0.04	3.245ThrSer: 3.245 ± 0.066	2.361ThrThr: 2.361 ± 0.077	3.71ThrVal: 3.71 ± 0.095	0.271ThrTrp: 0.271 ± 0.019	2.151ThrTyr: 2.151 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	3.808ValAla: 3.808 ± 0.096	0.837ValCys: 0.837 ± 0.035	3.354ValAsp: 3.354 ± 0.078	3.995ValGlu: 3.995 ± 0.088	3.157ValPhe: 3.157 ± 0.078	2.855ValGly: 2.855 ± 0.086	0.773ValHis: 0.773 ± 0.039	6.038ValIle: 6.038 ± 0.106	4.914ValLys: 4.914 ± 0.098	5.548ValLeu: 5.548 ± 0.11	1.643ValMet: 1.643 ± 0.057	3.438ValAsn: 3.438 ± 0.074	1.957ValPro: 1.957 ± 0.057	1.473ValGln: 1.473 ± 0.047	2.116ValArg: 2.116 ± 0.064	4.81ValSer: 4.81 ± 0.109	3.663ValThr: 3.663 ± 0.085	3.65ValVal: 3.65 ± 0.083	0.401ValTrp: 0.401 ± 0.027	2.8ValTyr: 2.8 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.436TrpAla: 0.436 ± 0.027	0.084TrpCys: 0.084 ± 0.011	0.4TrpAsp: 0.4 ± 0.035	0.409TrpGlu: 0.409 ± 0.029	0.325TrpPhe: 0.325 ± 0.024	0.397TrpGly: 0.397 ± 0.024	0.2TrpHis: 0.2 ± 0.019	0.469TrpIle: 0.469 ± 0.029	0.454TrpLys: 0.454 ± 0.027	0.582TrpLeu: 0.582 ± 0.034	0.162TrpMet: 0.162 ± 0.017	0.377TrpAsn: 0.377 ± 0.028	0.129TrpPro: 0.129 ± 0.011	0.295TrpGln: 0.295 ± 0.02	0.218TrpArg: 0.218 ± 0.018	0.409TrpSer: 0.409 ± 0.029	0.325TrpThr: 0.325 ± 0.024	0.352TrpVal: 0.352 ± 0.023	0.069TrpTrp: 0.069 ± 0.009	0.301TrpTyr: 0.301 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.966TyrAla: 2.966 ± 0.072	0.437TyrCys: 0.437 ± 0.027	2.888TyrAsp: 2.888 ± 0.075	2.811TyrGlu: 2.811 ± 0.067	2.363TyrPhe: 2.363 ± 0.07	2.829TyrGly: 2.829 ± 0.066	0.744TyrHis: 0.744 ± 0.036	4.46TyrIle: 4.46 ± 0.095	3.973TyrLys: 3.973 ± 0.094	3.743TyrLeu: 3.743 ± 0.088	1.166TyrMet: 1.166 ± 0.038	3.579TyrAsn: 3.579 ± 0.078	1.442TyrPro: 1.442 ± 0.048	1.198TyrGln: 1.198 ± 0.044	1.508TyrArg: 1.508 ± 0.047	3.173TyrSer: 3.173 ± 0.077	2.555TyrThr: 2.555 ± 0.065	2.147TyrVal: 2.147 ± 0.066	0.272TyrTrp: 0.272 ± 0.022	2.169TyrTyr: 2.169 ± 0.075	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2091 proteins (665262 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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