Amino acid dipepetide frequency for [Clostridium] cellulosi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.674AlaAla: 8.674 ± 0.166	1.139AlaCys: 1.139 ± 0.045	4.288AlaAsp: 4.288 ± 0.085	5.271AlaGlu: 5.271 ± 0.103	3.309AlaPhe: 3.309 ± 0.069	6.103AlaGly: 6.103 ± 0.105	1.225AlaHis: 1.225 ± 0.04	5.714AlaIle: 5.714 ± 0.099	5.338AlaLys: 5.338 ± 0.083	7.638AlaLeu: 7.638 ± 0.124	1.979AlaMet: 1.979 ± 0.067	2.941AlaAsn: 2.941 ± 0.065	2.231AlaPro: 2.231 ± 0.058	2.521AlaGln: 2.521 ± 0.075	3.267AlaArg: 3.267 ± 0.085	4.392AlaSer: 4.392 ± 0.079	3.081AlaThr: 3.081 ± 0.075	6.735AlaVal: 6.735 ± 0.117	0.521AlaTrp: 0.521 ± 0.029	2.544AlaTyr: 2.544 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	1.259CysAla: 1.259 ± 0.047	0.299CysCys: 0.299 ± 0.026	0.893CysAsp: 0.893 ± 0.045	1.067CysGlu: 1.067 ± 0.046	0.595CysPhe: 0.595 ± 0.027	1.613CysGly: 1.613 ± 0.062	0.277CysHis: 0.277 ± 0.019	1.119CysIle: 1.119 ± 0.042	0.818CysLys: 0.818 ± 0.037	1.086CysLeu: 1.086 ± 0.039	0.332CysMet: 0.332 ± 0.021	0.626CysAsn: 0.626 ± 0.034	0.64CysPro: 0.64 ± 0.038	0.305CysGln: 0.305 ± 0.021	0.795CysArg: 0.795 ± 0.031	0.998CysSer: 0.998 ± 0.042	0.674CysThr: 0.674 ± 0.033	0.979CysVal: 0.979 ± 0.048	0.125CysTrp: 0.125 ± 0.012	0.476CysTyr: 0.476 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.029AspAla: 4.029 ± 0.085	0.867AspCys: 0.867 ± 0.041	2.963AspAsp: 2.963 ± 0.078	4.218AspGlu: 4.218 ± 0.081	2.751AspPhe: 2.751 ± 0.066	4.263AspGly: 4.263 ± 0.082	0.665AspHis: 0.665 ± 0.034	5.086AspIle: 5.086 ± 0.085	4.154AspLys: 4.154 ± 0.089	4.232AspLeu: 4.232 ± 0.078	1.602AspMet: 1.602 ± 0.05	2.525AspAsn: 2.525 ± 0.069	1.978AspPro: 1.978 ± 0.059	0.94AspGln: 0.94 ± 0.038	2.204AspArg: 2.204 ± 0.061	3.347AspSer: 3.347 ± 0.077	3.029AspThr: 3.029 ± 0.073	3.563AspVal: 3.563 ± 0.084	0.534AspTrp: 0.534 ± 0.036	2.405AspTyr: 2.405 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	5.035GluAla: 5.035 ± 0.117	0.749GluCys: 0.749 ± 0.033	3.067GluAsp: 3.067 ± 0.069	4.578GluGlu: 4.578 ± 0.109	2.499GluPhe: 2.499 ± 0.064	3.649GluGly: 3.649 ± 0.073	1.059GluHis: 1.059 ± 0.046	5.562GluIle: 5.562 ± 0.106	6.15GluLys: 6.15 ± 0.115	6.113GluLeu: 6.113 ± 0.106	1.802GluMet: 1.802 ± 0.052	3.841GluAsn: 3.841 ± 0.081	1.89GluPro: 1.89 ± 0.061	2.109GluGln: 2.109 ± 0.069	3.273GluArg: 3.273 ± 0.086	3.406GluSer: 3.406 ± 0.078	3.32GluThr: 3.32 ± 0.065	3.775GluVal: 3.775 ± 0.086	0.504GluTrp: 0.504 ± 0.03	2.5GluTyr: 2.5 ± 0.073	0.0GluXaa: 0.0 ± 0.0
Phe	3.348PheAla: 3.348 ± 0.07	0.731PheCys: 0.731 ± 0.035	2.893PheAsp: 2.893 ± 0.074	2.952PheGlu: 2.952 ± 0.079	1.964PhePhe: 1.964 ± 0.059	3.37PheGly: 3.37 ± 0.078	0.643PheHis: 0.643 ± 0.028	3.588PheIle: 3.588 ± 0.087	2.854PheLys: 2.854 ± 0.067	3.725PheLeu: 3.725 ± 0.081	1.061PheMet: 1.061 ± 0.038	2.106PheAsn: 2.106 ± 0.059	1.385PhePro: 1.385 ± 0.048	0.892PheGln: 0.892 ± 0.041	1.663PheArg: 1.663 ± 0.051	3.212PheSer: 3.212 ± 0.084	2.253PheThr: 2.253 ± 0.055	2.704PheVal: 2.704 ± 0.072	0.355PheTrp: 0.355 ± 0.024	1.694PheTyr: 1.694 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	5.244GlyAla: 5.244 ± 0.11	1.32GlyCys: 1.32 ± 0.042	3.597GlyAsp: 3.597 ± 0.085	4.198GlyGlu: 4.198 ± 0.097	3.333GlyPhe: 3.333 ± 0.079	5.384GlyGly: 5.384 ± 0.103	1.225GlyHis: 1.225 ± 0.043	6.631GlyIle: 6.631 ± 0.11	5.413GlyLys: 5.413 ± 0.102	6.177GlyLeu: 6.177 ± 0.111	2.01GlyMet: 2.01 ± 0.055	3.062GlyAsn: 3.062 ± 0.078	1.613GlyPro: 1.613 ± 0.048	1.831GlyGln: 1.831 ± 0.055	3.414GlyArg: 3.414 ± 0.084	4.207GlySer: 4.207 ± 0.089	4.074GlyThr: 4.074 ± 0.093	5.187GlyVal: 5.187 ± 0.09	0.544GlyTrp: 0.544 ± 0.033	2.941GlyTyr: 2.941 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.144HisAla: 1.144 ± 0.038	0.3HisCys: 0.3 ± 0.02	0.837HisAsp: 0.837 ± 0.035	0.912HisGlu: 0.912 ± 0.037	0.746HisPhe: 0.746 ± 0.035	1.244HisGly: 1.244 ± 0.045	0.329HisHis: 0.329 ± 0.022	1.346HisIle: 1.346 ± 0.045	0.958HisLys: 0.958 ± 0.037	1.291HisLeu: 1.291 ± 0.04	0.426HisMet: 0.426 ± 0.022	0.803HisAsn: 0.803 ± 0.035	0.825HisPro: 0.825 ± 0.037	0.377HisGln: 0.377 ± 0.021	0.729HisArg: 0.729 ± 0.038	0.948HisSer: 0.948 ± 0.037	0.831HisThr: 0.831 ± 0.031	0.95HisVal: 0.95 ± 0.043	0.141HisTrp: 0.141 ± 0.015	0.668HisTyr: 0.668 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.671IleAla: 6.671 ± 0.108	1.274IleCys: 1.274 ± 0.05	4.9IleAsp: 4.9 ± 0.086	5.393IleGlu: 5.393 ± 0.102	3.459IlePhe: 3.459 ± 0.072	5.366IleGly: 5.366 ± 0.104	1.108IleHis: 1.108 ± 0.042	6.764IleIle: 6.764 ± 0.118	5.916IleLys: 5.916 ± 0.098	6.97IleLeu: 6.97 ± 0.13	2.023IleMet: 2.023 ± 0.06	3.999IleAsn: 3.999 ± 0.092	3.464IlePro: 3.464 ± 0.073	1.737IleGln: 1.737 ± 0.051	3.25IleArg: 3.25 ± 0.078	5.82IleSer: 5.82 ± 0.111	4.542IleThr: 4.542 ± 0.089	5.432IleVal: 5.432 ± 0.098	0.607IleTrp: 0.607 ± 0.031	2.688IleTyr: 2.688 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	5.726LysAla: 5.726 ± 0.115	0.901LysCys: 0.901 ± 0.042	4.022LysAsp: 4.022 ± 0.084	5.054LysGlu: 5.054 ± 0.09	2.438LysPhe: 2.438 ± 0.066	4.456LysGly: 4.456 ± 0.09	1.112LysHis: 1.112 ± 0.042	5.69LysIle: 5.69 ± 0.102	6.108LysLys: 6.108 ± 0.115	6.484LysLeu: 6.484 ± 0.103	1.987LysMet: 1.987 ± 0.058	4.185LysAsn: 4.185 ± 0.088	2.574LysPro: 2.574 ± 0.069	2.078LysGln: 2.078 ± 0.063	3.512LysArg: 3.512 ± 0.088	4.39LysSer: 4.39 ± 0.084	4.174LysThr: 4.174 ± 0.073	4.644LysVal: 4.644 ± 0.094	0.582LysTrp: 0.582 ± 0.032	2.938LysTyr: 2.938 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	6.872LeuAla: 6.872 ± 0.118	1.563LeuCys: 1.563 ± 0.05	4.866LeuAsp: 4.866 ± 0.085	5.33LeuGlu: 5.33 ± 0.111	3.976LeuPhe: 3.976 ± 0.102	5.798LeuGly: 5.798 ± 0.101	1.475LeuHis: 1.475 ± 0.046	6.964LeuIle: 6.964 ± 0.119	7.139LeuLys: 7.139 ± 0.105	8.259LeuLeu: 8.259 ± 0.144	2.24LeuMet: 2.24 ± 0.055	4.389LeuAsn: 4.389 ± 0.086	3.861LeuPro: 3.861 ± 0.086	2.178LeuGln: 2.178 ± 0.062	4.052LeuArg: 4.052 ± 0.096	7.116LeuSer: 7.116 ± 0.118	4.825LeuThr: 4.825 ± 0.078	5.09LeuVal: 5.09 ± 0.094	0.696LeuTrp: 0.696 ± 0.037	3.189LeuTyr: 3.189 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	2.082MetAla: 2.082 ± 0.055	0.31MetCys: 0.31 ± 0.021	1.306MetAsp: 1.306 ± 0.045	1.54MetGlu: 1.54 ± 0.053	1.037MetPhe: 1.037 ± 0.04	1.763MetGly: 1.763 ± 0.059	0.368MetHis: 0.368 ± 0.026	1.718MetIle: 1.718 ± 0.055	2.039MetLys: 2.039 ± 0.052	2.705MetLeu: 2.705 ± 0.055	0.668MetMet: 0.668 ± 0.034	1.247MetAsn: 1.247 ± 0.04	1.317MetPro: 1.317 ± 0.038	0.865MetGln: 0.865 ± 0.036	1.261MetArg: 1.261 ± 0.046	1.907MetSer: 1.907 ± 0.06	1.483MetThr: 1.483 ± 0.049	1.552MetVal: 1.552 ± 0.047	0.16MetTrp: 0.16 ± 0.016	0.71MetTyr: 0.71 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.691AsnAla: 3.691 ± 0.078	0.677AsnCys: 0.677 ± 0.035	2.436AsnAsp: 2.436 ± 0.069	2.807AsnGlu: 2.807 ± 0.074	1.943AsnPhe: 1.943 ± 0.055	3.888AsnGly: 3.888 ± 0.08	0.662AsnHis: 0.662 ± 0.033	4.393AsnIle: 4.393 ± 0.096	3.135AsnLys: 3.135 ± 0.065	4.054AsnLeu: 4.054 ± 0.083	1.311AsnMet: 1.311 ± 0.039	2.262AsnAsn: 2.262 ± 0.062	2.339AsnPro: 2.339 ± 0.07	1.155AsnGln: 1.155 ± 0.038	1.912AsnArg: 1.912 ± 0.066	3.106AsnSer: 3.106 ± 0.071	2.641AsnThr: 2.641 ± 0.074	3.137AsnVal: 3.137 ± 0.084	0.41AsnTrp: 0.41 ± 0.028	1.834AsnTyr: 1.834 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.744ProAla: 2.744 ± 0.081	0.501ProCys: 0.501 ± 0.03	2.63ProAsp: 2.63 ± 0.062	3.101ProGlu: 3.101 ± 0.073	1.707ProPhe: 1.707 ± 0.053	2.472ProGly: 2.472 ± 0.063	0.654ProHis: 0.654 ± 0.031	2.55ProIle: 2.55 ± 0.066	2.294ProLys: 2.294 ± 0.061	3.048ProLeu: 3.048 ± 0.072	0.825ProMet: 0.825 ± 0.033	1.543ProAsn: 1.543 ± 0.049	1.069ProPro: 1.069 ± 0.045	1.3ProGln: 1.3 ± 0.044	1.358ProArg: 1.358 ± 0.044	2.187ProSer: 2.187 ± 0.062	1.698ProThr: 1.698 ± 0.048	3.117ProVal: 3.117 ± 0.071	0.343ProTrp: 0.343 ± 0.025	1.507ProTyr: 1.507 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.034GlnAla: 2.034 ± 0.058	0.322GlnCys: 0.322 ± 0.02	1.205GlnAsp: 1.205 ± 0.044	1.472GlnGlu: 1.472 ± 0.054	1.031GlnPhe: 1.031 ± 0.043	1.547GlnGly: 1.547 ± 0.049	0.462GlnHis: 0.462 ± 0.028	2.289GlnIle: 2.289 ± 0.055	2.356GlnLys: 2.356 ± 0.057	2.395GlnLeu: 2.395 ± 0.078	0.821GlnMet: 0.821 ± 0.033	1.644GlnAsn: 1.644 ± 0.053	0.9GlnPro: 0.9 ± 0.038	1.006GlnGln: 1.006 ± 0.044	1.331GlnArg: 1.331 ± 0.046	1.641GlnSer: 1.641 ± 0.055	1.344GlnThr: 1.344 ± 0.048	1.48GlnVal: 1.48 ± 0.047	0.208GlnTrp: 0.208 ± 0.018	1.156GlnTyr: 1.156 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.04ArgAla: 3.04 ± 0.085	0.62ArgCys: 0.62 ± 0.034	2.262ArgAsp: 2.262 ± 0.066	3.339ArgGlu: 3.339 ± 0.079	2.012ArgPhe: 2.012 ± 0.056	2.786ArgGly: 2.786 ± 0.083	0.878ArgHis: 0.878 ± 0.035	3.871ArgIle: 3.871 ± 0.086	3.004ArgLys: 3.004 ± 0.078	4.348ArgLeu: 4.348 ± 0.087	1.249ArgMet: 1.249 ± 0.041	2.073ArgAsn: 2.073 ± 0.056	1.596ArgPro: 1.596 ± 0.051	1.371ArgGln: 1.371 ± 0.044	2.549ArgArg: 2.549 ± 0.07	2.402ArgSer: 2.402 ± 0.066	2.086ArgThr: 2.086 ± 0.055	2.782ArgVal: 2.782 ± 0.068	0.327ArgTrp: 0.327 ± 0.023	1.716ArgTyr: 1.716 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	4.975SerAla: 4.975 ± 0.094	0.871SerCys: 0.871 ± 0.038	3.874SerAsp: 3.874 ± 0.073	3.961SerGlu: 3.961 ± 0.074	2.99SerPhe: 2.99 ± 0.076	5.607SerGly: 5.607 ± 0.105	0.992SerHis: 0.992 ± 0.044	4.67SerIle: 4.67 ± 0.089	4.234SerLys: 4.234 ± 0.077	5.833SerLeu: 5.833 ± 0.109	1.701SerMet: 1.701 ± 0.042	2.882SerAsn: 2.882 ± 0.066	2.253SerPro: 2.253 ± 0.065	1.838SerGln: 1.838 ± 0.063	2.912SerArg: 2.912 ± 0.07	4.542SerSer: 4.542 ± 0.132	2.999SerThr: 2.999 ± 0.07	4.661SerVal: 4.661 ± 0.075	0.46SerTrp: 0.46 ± 0.024	2.189SerTyr: 2.189 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.725ThrAla: 4.725 ± 0.099	0.66ThrCys: 0.66 ± 0.035	2.901ThrAsp: 2.901 ± 0.066	3.015ThrGlu: 3.015 ± 0.068	2.189ThrPhe: 2.189 ± 0.063	4.495ThrGly: 4.495 ± 0.099	0.875ThrHis: 0.875 ± 0.039	4.043ThrIle: 4.043 ± 0.079	2.921ThrLys: 2.921 ± 0.066	5.111ThrLeu: 5.111 ± 0.078	1.139ThrMet: 1.139 ± 0.047	2.046ThrAsn: 2.046 ± 0.062	2.375ThrPro: 2.375 ± 0.069	1.31ThrGln: 1.31 ± 0.051	1.97ThrArg: 1.97 ± 0.056	3.042ThrSer: 3.042 ± 0.082	2.68ThrThr: 2.68 ± 0.078	4.445ThrVal: 4.445 ± 0.08	0.333ThrTrp: 0.333 ± 0.024	1.846ThrTyr: 1.846 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.584ValAla: 4.584 ± 0.088	1.086ValCys: 1.086 ± 0.041	3.63ValAsp: 3.63 ± 0.072	4.066ValGlu: 4.066 ± 0.086	3.206ValPhe: 3.206 ± 0.081	4.242ValGly: 4.242 ± 0.09	1.003ValHis: 1.003 ± 0.04	5.761ValIle: 5.761 ± 0.107	5.161ValLys: 5.161 ± 0.103	6.369ValLeu: 6.369 ± 0.108	1.834ValMet: 1.834 ± 0.059	3.112ValAsn: 3.112 ± 0.072	2.614ValPro: 2.614 ± 0.06	1.627ValGln: 1.627 ± 0.057	2.868ValArg: 2.868 ± 0.082	4.972ValSer: 4.972 ± 0.116	3.961ValThr: 3.961 ± 0.075	4.772ValVal: 4.772 ± 0.105	0.548ValTrp: 0.548 ± 0.03	2.361ValTyr: 2.361 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.532TrpAla: 0.532 ± 0.029	0.146TrpCys: 0.146 ± 0.016	0.488TrpAsp: 0.488 ± 0.034	0.437TrpGlu: 0.437 ± 0.026	0.382TrpPhe: 0.382 ± 0.026	0.549TrpGly: 0.549 ± 0.03	0.16TrpHis: 0.16 ± 0.016	0.529TrpIle: 0.529 ± 0.03	0.49TrpLys: 0.49 ± 0.031	0.77TrpLeu: 0.77 ± 0.039	0.2TrpMet: 0.2 ± 0.018	0.483TrpAsn: 0.483 ± 0.027	0.252TrpPro: 0.252 ± 0.021	0.33TrpGln: 0.33 ± 0.024	0.327TrpArg: 0.327 ± 0.022	0.494TrpSer: 0.494 ± 0.026	0.371TrpThr: 0.371 ± 0.024	0.482TrpVal: 0.482 ± 0.025	0.117TrpTrp: 0.117 ± 0.015	0.313TrpTyr: 0.313 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.502TyrAla: 2.502 ± 0.058	0.64TyrCys: 0.64 ± 0.029	2.295TyrAsp: 2.295 ± 0.07	2.172TyrGlu: 2.172 ± 0.062	1.827TyrPhe: 1.827 ± 0.059	2.808TyrGly: 2.808 ± 0.066	0.632TyrHis: 0.632 ± 0.036	3.096TyrIle: 3.096 ± 0.066	2.574TyrLys: 2.574 ± 0.07	3.27TyrLeu: 3.27 ± 0.075	0.828TyrMet: 0.828 ± 0.04	2.023TyrAsn: 2.023 ± 0.067	1.471TyrPro: 1.471 ± 0.053	0.878TyrGln: 0.878 ± 0.037	1.662TyrArg: 1.662 ± 0.052	2.316TyrSer: 2.316 ± 0.062	2.054TyrThr: 2.054 ± 0.062	2.292TyrVal: 2.292 ± 0.057	0.336TyrTrp: 0.336 ± 0.023	1.663TyrTyr: 1.663 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2007 proteins (639157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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