Amino acid dipepetide frequency for Vibrio sp. qd031

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.575AlaAla: 7.575 ± 0.102
0.88AlaCys: 0.88 ± 0.03
4.551AlaAsp: 4.551 ± 0.076
5.188AlaGlu: 5.188 ± 0.086
3.407AlaPhe: 3.407 ± 0.054
5.719AlaGly: 5.719 ± 0.097
1.775AlaHis: 1.775 ± 0.04
6.151AlaIle: 6.151 ± 0.078
4.954AlaLys: 4.954 ± 0.072
9.868AlaLeu: 9.868 ± 0.122
2.684AlaMet: 2.684 ± 0.05
3.501AlaAsn: 3.501 ± 0.059
2.873AlaPro: 2.873 ± 0.056
4.038AlaGln: 4.038 ± 0.079
3.589AlaArg: 3.589 ± 0.056
5.276AlaSer: 5.276 ± 0.061
4.798AlaThr: 4.798 ± 0.067
5.824AlaVal: 5.824 ± 0.074
0.978AlaTrp: 0.978 ± 0.028
2.33AlaTyr: 2.33 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.83CysAla: 0.83 ± 0.03
0.162CysCys: 0.162 ± 0.012
0.628CysAsp: 0.628 ± 0.028
0.646CysGlu: 0.646 ± 0.025
0.435CysPhe: 0.435 ± 0.021
0.918CysGly: 0.918 ± 0.031
0.371CysHis: 0.371 ± 0.018
0.572CysIle: 0.572 ± 0.021
0.404CysLys: 0.404 ± 0.021
0.893CysLeu: 0.893 ± 0.029
0.233CysMet: 0.233 ± 0.015
0.386CysAsn: 0.386 ± 0.018
0.448CysPro: 0.448 ± 0.022
0.394CysGln: 0.394 ± 0.019
0.456CysArg: 0.456 ± 0.019
0.722CysSer: 0.722 ± 0.024
0.504CysThr: 0.504 ± 0.022
0.712CysVal: 0.712 ± 0.026
0.128CysTrp: 0.128 ± 0.011
0.316CysTyr: 0.316 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.919AspAla: 4.919 ± 0.078
0.555AspCys: 0.555 ± 0.023
3.336AspAsp: 3.336 ± 0.063
3.865AspGlu: 3.865 ± 0.065
2.487AspPhe: 2.487 ± 0.049
3.805AspGly: 3.805 ± 0.079
1.238AspHis: 1.238 ± 0.038
4.0AspIle: 4.0 ± 0.067
3.121AspLys: 3.121 ± 0.057
5.398AspLeu: 5.398 ± 0.076
1.416AspMet: 1.416 ± 0.037
2.509AspAsn: 2.509 ± 0.053
2.199AspPro: 2.199 ± 0.044
2.073AspGln: 2.073 ± 0.044
2.34AspArg: 2.34 ± 0.045
3.565AspSer: 3.565 ± 0.069
2.907AspThr: 2.907 ± 0.059
4.183AspVal: 4.183 ± 0.062
0.822AspTrp: 0.822 ± 0.029
2.142AspTyr: 2.142 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.139GluAla: 5.139 ± 0.071
0.573GluCys: 0.573 ± 0.023
2.646GluAsp: 2.646 ± 0.053
3.634GluGlu: 3.634 ± 0.081
2.683GluPhe: 2.683 ± 0.047
3.641GluGly: 3.641 ± 0.068
1.722GluHis: 1.722 ± 0.039
3.661GluIle: 3.661 ± 0.066
3.397GluLys: 3.397 ± 0.057
7.305GluLeu: 7.305 ± 0.087
1.725GluMet: 1.725 ± 0.039
2.432GluAsn: 2.432 ± 0.049
2.15GluPro: 2.15 ± 0.05
4.205GluGln: 4.205 ± 0.08
3.379GluArg: 3.379 ± 0.06
3.976GluSer: 3.976 ± 0.06
2.929GluThr: 2.929 ± 0.06
4.396GluVal: 4.396 ± 0.072
0.831GluTrp: 0.831 ± 0.027
1.804GluTyr: 1.804 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.635PheAla: 3.635 ± 0.062
0.481PheCys: 0.481 ± 0.02
3.012PheAsp: 3.012 ± 0.057
2.794PheGlu: 2.794 ± 0.054
1.62PhePhe: 1.62 ± 0.044
3.355PheGly: 3.355 ± 0.06
0.797PheHis: 0.797 ± 0.025
2.701PheIle: 2.701 ± 0.059
1.841PheLys: 1.841 ± 0.044
3.284PheLeu: 3.284 ± 0.064
1.031PheMet: 1.031 ± 0.031
1.916PheAsn: 1.916 ± 0.043
1.407PhePro: 1.407 ± 0.034
1.225PheGln: 1.225 ± 0.031
1.489PheArg: 1.489 ± 0.034
3.183PheSer: 3.183 ± 0.057
2.508PheThr: 2.508 ± 0.062
3.025PheVal: 3.025 ± 0.058
0.531PheTrp: 0.531 ± 0.024
1.288PheTyr: 1.288 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.337GlyAla: 5.337 ± 0.082
0.837GlyCys: 0.837 ± 0.03
3.778GlyAsp: 3.778 ± 0.07
4.562GlyGlu: 4.562 ± 0.069
3.255GlyPhe: 3.255 ± 0.051
4.8GlyGly: 4.8 ± 0.083
1.611GlyHis: 1.611 ± 0.039
4.661GlyIle: 4.661 ± 0.073
3.807GlyLys: 3.807 ± 0.068
6.931GlyLeu: 6.931 ± 0.083
2.031GlyMet: 2.031 ± 0.045
2.505GlyAsn: 2.505 ± 0.049
1.651GlyPro: 1.651 ± 0.037
2.787GlyGln: 2.787 ± 0.052
3.134GlyArg: 3.134 ± 0.054
4.132GlySer: 4.132 ± 0.073
3.526GlyThr: 3.526 ± 0.078
5.403GlyVal: 5.403 ± 0.075
0.965GlyTrp: 0.965 ± 0.03
2.63GlyTyr: 2.63 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.77HisAla: 1.77 ± 0.041
0.381HisCys: 0.381 ± 0.02
1.204HisAsp: 1.204 ± 0.039
1.078HisGlu: 1.078 ± 0.034
1.148HisPhe: 1.148 ± 0.029
1.576HisGly: 1.576 ± 0.038
0.76HisHis: 0.76 ± 0.026
1.465HisIle: 1.465 ± 0.04
1.08HisLys: 1.08 ± 0.032
2.356HisLeu: 2.356 ± 0.05
0.513HisMet: 0.513 ± 0.022
0.988HisAsn: 0.988 ± 0.031
1.238HisPro: 1.238 ± 0.036
1.369HisGln: 1.369 ± 0.035
1.118HisArg: 1.118 ± 0.032
1.698HisSer: 1.698 ± 0.037
1.176HisThr: 1.176 ± 0.029
1.384HisVal: 1.384 ± 0.038
0.402HisTrp: 0.402 ± 0.018
0.942HisTyr: 0.942 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.541IleAla: 6.541 ± 0.087
0.633IleCys: 0.633 ± 0.021
4.53IleAsp: 4.53 ± 0.066
5.139IleGlu: 5.139 ± 0.069
2.043IlePhe: 2.043 ± 0.05
4.799IleGly: 4.799 ± 0.073
1.324IleHis: 1.324 ± 0.037
3.39IleIle: 3.39 ± 0.064
3.141IleLys: 3.141 ± 0.054
4.897IleLeu: 4.897 ± 0.081
1.356IleMet: 1.356 ± 0.038
2.782IleAsn: 2.782 ± 0.051
2.642IlePro: 2.642 ± 0.049
2.233IleGln: 2.233 ± 0.044
2.678IleArg: 2.678 ± 0.049
4.404IleSer: 4.404 ± 0.073
3.633IleThr: 3.633 ± 0.07
4.533IleVal: 4.533 ± 0.073
0.649IleTrp: 0.649 ± 0.029
1.625IleTyr: 1.625 ± 0.034
0.001IleXaa: 0.001 ± 0.001
Lys
4.61LysAla: 4.61 ± 0.073
0.313LysCys: 0.313 ± 0.018
2.528LysAsp: 2.528 ± 0.051
3.132LysGlu: 3.132 ± 0.061
1.531LysPhe: 1.531 ± 0.04
3.317LysGly: 3.317 ± 0.056
1.369LysHis: 1.369 ± 0.035
2.731LysIle: 2.731 ± 0.052
2.743LysLys: 2.743 ± 0.057
5.151LysLeu: 5.151 ± 0.072
1.397LysMet: 1.397 ± 0.035
1.935LysAsn: 1.935 ± 0.046
2.225LysPro: 2.225 ± 0.047
3.193LysGln: 3.193 ± 0.055
2.738LysArg: 2.738 ± 0.053
3.089LysSer: 3.089 ± 0.063
2.803LysThr: 2.803 ± 0.051
3.834LysVal: 3.834 ± 0.061
0.598LysTrp: 0.598 ± 0.021
1.342LysTyr: 1.342 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
9.387LeuAla: 9.387 ± 0.102
1.089LeuCys: 1.089 ± 0.035
6.139LeuAsp: 6.139 ± 0.088
6.289LeuGlu: 6.289 ± 0.075
4.312LeuPhe: 4.312 ± 0.08
7.089LeuGly: 7.089 ± 0.082
2.113LeuHis: 2.113 ± 0.05
6.097LeuIle: 6.097 ± 0.09
5.12LeuLys: 5.12 ± 0.072
10.323LeuLeu: 10.323 ± 0.143
2.623LeuMet: 2.623 ± 0.047
4.585LeuAsn: 4.585 ± 0.072
4.621LeuPro: 4.621 ± 0.064
3.594LeuGln: 3.594 ± 0.069
4.262LeuArg: 4.262 ± 0.068
8.045LeuSer: 8.045 ± 0.097
6.05LeuThr: 6.05 ± 0.078
7.095LeuVal: 7.095 ± 0.091
1.083LeuTrp: 1.083 ± 0.031
2.715LeuTyr: 2.715 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.447MetAla: 2.447 ± 0.044
0.224MetCys: 0.224 ± 0.014
1.438MetAsp: 1.438 ± 0.037
1.304MetGlu: 1.304 ± 0.035
0.92MetPhe: 0.92 ± 0.028
1.908MetGly: 1.908 ± 0.044
0.544MetHis: 0.544 ± 0.022
1.564MetIle: 1.564 ± 0.043
1.421MetLys: 1.421 ± 0.035
2.751MetLeu: 2.751 ± 0.06
0.78MetMet: 0.78 ± 0.027
1.066MetAsn: 1.066 ± 0.032
1.224MetPro: 1.224 ± 0.03
1.155MetGln: 1.155 ± 0.031
1.233MetArg: 1.233 ± 0.032
2.09MetSer: 2.09 ± 0.042
1.604MetThr: 1.604 ± 0.039
1.967MetVal: 1.967 ± 0.04
0.273MetTrp: 0.273 ± 0.014
0.582MetTyr: 0.582 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.384AsnAla: 3.384 ± 0.057
0.404AsnCys: 0.404 ± 0.019
2.475AsnAsp: 2.475 ± 0.044
2.311AsnGlu: 2.311 ± 0.046
1.549AsnPhe: 1.549 ± 0.04
2.912AsnGly: 2.912 ± 0.064
1.045AsnHis: 1.045 ± 0.031
2.561AsnIle: 2.561 ± 0.044
1.991AsnLys: 1.991 ± 0.042
3.888AsnLeu: 3.888 ± 0.056
0.939AsnMet: 0.939 ± 0.028
1.821AsnAsn: 1.821 ± 0.042
2.143AsnPro: 2.143 ± 0.046
2.225AsnGln: 2.225 ± 0.049
1.905AsnArg: 1.905 ± 0.04
2.494AsnSer: 2.494 ± 0.051
2.247AsnThr: 2.247 ± 0.043
2.774AsnVal: 2.774 ± 0.051
0.605AsnTrp: 0.605 ± 0.025
1.388AsnTyr: 1.388 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.875ProAla: 2.875 ± 0.056
0.338ProCys: 0.338 ± 0.019
2.211ProAsp: 2.211 ± 0.041
2.916ProGlu: 2.916 ± 0.051
1.715ProPhe: 1.715 ± 0.038
2.143ProGly: 2.143 ± 0.044
0.954ProHis: 0.954 ± 0.03
2.565ProIle: 2.565 ± 0.044
2.044ProLys: 2.044 ± 0.045
4.092ProLeu: 4.092 ± 0.067
1.101ProMet: 1.101 ± 0.031
1.852ProAsn: 1.852 ± 0.043
1.059ProPro: 1.059 ± 0.033
1.765ProGln: 1.765 ± 0.039
1.301ProArg: 1.301 ± 0.038
2.68ProSer: 2.68 ± 0.053
2.382ProThr: 2.382 ± 0.045
3.04ProVal: 3.04 ± 0.057
0.524ProTrp: 0.524 ± 0.023
1.277ProTyr: 1.277 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.185GlnAla: 4.185 ± 0.071
0.433GlnCys: 0.433 ± 0.019
2.087GlnAsp: 2.087 ± 0.04
2.29GlnGlu: 2.29 ± 0.052
1.935GlnPhe: 1.935 ± 0.042
3.001GlnGly: 3.001 ± 0.045
1.314GlnHis: 1.314 ± 0.039
2.556GlnIle: 2.556 ± 0.045
2.099GlnLys: 2.099 ± 0.047
5.394GlnLeu: 5.394 ± 0.086
1.218GlnMet: 1.218 ± 0.036
1.555GlnAsn: 1.555 ± 0.036
1.721GlnPro: 1.721 ± 0.044
3.34GlnGln: 3.34 ± 0.083
2.479GlnArg: 2.479 ± 0.051
3.166GlnSer: 3.166 ± 0.061
2.305GlnThr: 2.305 ± 0.05
3.372GlnVal: 3.372 ± 0.051
0.793GlnTrp: 0.793 ± 0.028
1.442GlnTyr: 1.442 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.401ArgAla: 3.401 ± 0.05
0.506ArgCys: 0.506 ± 0.022
2.605ArgAsp: 2.605 ± 0.052
2.883ArgGlu: 2.883 ± 0.047
2.261ArgPhe: 2.261 ± 0.047
2.574ArgGly: 2.574 ± 0.051
1.168ArgHis: 1.168 ± 0.032
2.939ArgIle: 2.939 ± 0.046
2.253ArgLys: 2.253 ± 0.051
4.723ArgLeu: 4.723 ± 0.084
1.17ArgMet: 1.17 ± 0.032
1.815ArgAsn: 1.815 ± 0.038
1.555ArgPro: 1.555 ± 0.035
2.149ArgGln: 2.149 ± 0.043
2.289ArgArg: 2.289 ± 0.047
2.799ArgSer: 2.799 ± 0.053
2.133ArgThr: 2.133 ± 0.046
3.164ArgVal: 3.164 ± 0.061
0.654ArgTrp: 0.654 ± 0.025
1.774ArgTyr: 1.774 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.473SerAla: 5.473 ± 0.069
0.586SerCys: 0.586 ± 0.024
3.926SerAsp: 3.926 ± 0.083
4.029SerGlu: 4.029 ± 0.063
2.843SerPhe: 2.843 ± 0.052
4.975SerGly: 4.975 ± 0.073
1.61SerHis: 1.61 ± 0.039
4.49SerIle: 4.49 ± 0.071
3.273SerLys: 3.273 ± 0.054
7.111SerLeu: 7.111 ± 0.096
1.895SerMet: 1.895 ± 0.043
2.792SerAsn: 2.792 ± 0.058
2.456SerPro: 2.456 ± 0.046
3.148SerGln: 3.148 ± 0.067
2.954SerArg: 2.954 ± 0.057
4.595SerSer: 4.595 ± 0.081
3.675SerThr: 3.675 ± 0.06
4.7SerVal: 4.7 ± 0.068
0.889SerTrp: 0.889 ± 0.029
2.05SerTyr: 2.05 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.524ThrAla: 4.524 ± 0.056
0.439ThrCys: 0.439 ± 0.021
2.976ThrAsp: 2.976 ± 0.074
3.15ThrGlu: 3.15 ± 0.054
2.148ThrPhe: 2.148 ± 0.048
3.977ThrGly: 3.977 ± 0.068
1.402ThrHis: 1.402 ± 0.036
3.577ThrIle: 3.577 ± 0.07
2.413ThrLys: 2.413 ± 0.045
6.489ThrLeu: 6.489 ± 0.09
1.269ThrMet: 1.269 ± 0.036
2.018ThrAsn: 2.018 ± 0.042
2.807ThrPro: 2.807 ± 0.055
2.66ThrGln: 2.66 ± 0.056
2.181ThrArg: 2.181 ± 0.042
3.502ThrSer: 3.502 ± 0.056
3.076ThrThr: 3.076 ± 0.053
4.148ThrVal: 4.148 ± 0.076
0.568ThrTrp: 0.568 ± 0.024
1.462ThrTyr: 1.462 ± 0.036
0.001ThrXaa: 0.001 ± 0.001
Val
6.756ValAla: 6.756 ± 0.075
0.768ValCys: 0.768 ± 0.026
4.477ValAsp: 4.477 ± 0.067
4.953ValGlu: 4.953 ± 0.077
2.838ValPhe: 2.838 ± 0.055
4.938ValGly: 4.938 ± 0.072
1.364ValHis: 1.364 ± 0.035
4.906ValIle: 4.906 ± 0.086
3.605ValLys: 3.605 ± 0.058
6.748ValLeu: 6.748 ± 0.081
2.051ValMet: 2.051 ± 0.046
2.94ValAsn: 2.94 ± 0.049
2.595ValPro: 2.595 ± 0.049
2.369ValGln: 2.369 ± 0.042
2.943ValArg: 2.943 ± 0.049
5.159ValSer: 5.159 ± 0.078
4.35ValThr: 4.35 ± 0.082
5.688ValVal: 5.688 ± 0.08
0.763ValTrp: 0.763 ± 0.029
1.931ValTyr: 1.931 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.866TrpAla: 0.866 ± 0.027
0.153TrpCys: 0.153 ± 0.012
0.645TrpAsp: 0.645 ± 0.025
0.592TrpGlu: 0.592 ± 0.023
0.571TrpPhe: 0.571 ± 0.023
0.797TrpGly: 0.797 ± 0.028
0.353TrpHis: 0.353 ± 0.016
0.747TrpIle: 0.747 ± 0.027
0.543TrpLys: 0.543 ± 0.021
1.715TrpLeu: 1.715 ± 0.046
0.411TrpMet: 0.411 ± 0.018
0.521TrpAsn: 0.521 ± 0.022
0.446TrpPro: 0.446 ± 0.022
0.838TrpGln: 0.838 ± 0.029
0.62TrpArg: 0.62 ± 0.028
0.817TrpSer: 0.817 ± 0.028
0.604TrpThr: 0.604 ± 0.025
0.928TrpVal: 0.928 ± 0.029
0.188TrpTrp: 0.188 ± 0.014
0.355TrpTyr: 0.355 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.302TyrAla: 2.302 ± 0.046
0.405TyrCys: 0.405 ± 0.019
1.684TyrAsp: 1.684 ± 0.04
1.474TyrGlu: 1.474 ± 0.033
1.425TyrPhe: 1.425 ± 0.036
2.097TyrGly: 2.097 ± 0.052
0.811TyrHis: 0.811 ± 0.032
1.639TyrIle: 1.639 ± 0.043
1.331TyrLys: 1.331 ± 0.03
3.315TyrLeu: 3.315 ± 0.06
0.651TyrMet: 0.651 ± 0.023
1.143TyrAsn: 1.143 ± 0.037
1.376TyrPro: 1.376 ± 0.034
1.924TyrGln: 1.924 ± 0.046
1.726TyrArg: 1.726 ± 0.036
2.078TyrSer: 2.078 ± 0.046
1.575TyrThr: 1.575 ± 0.04
1.973TyrVal: 1.973 ± 0.042
0.467TyrTrp: 0.467 ± 0.022
1.072TyrTyr: 1.072 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.004
Statistics based on 3553 proteins (1144937 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski