Amino acid dipepetide frequency for Leptothrix mobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.734AlaAla: 19.734 ± 0.221	1.446AlaCys: 1.446 ± 0.037	7.686AlaAsp: 7.686 ± 0.099	6.918AlaGlu: 6.918 ± 0.085	3.587AlaPhe: 3.587 ± 0.07	11.621AlaGly: 11.621 ± 0.094	2.947AlaHis: 2.947 ± 0.051	5.019AlaIle: 5.019 ± 0.072	2.921AlaLys: 2.921 ± 0.064	16.389AlaLeu: 16.389 ± 0.208	3.469AlaMet: 3.469 ± 0.053	2.574AlaAsn: 2.574 ± 0.073	6.829AlaPro: 6.829 ± 0.109	5.831AlaGln: 5.831 ± 0.094	10.33AlaArg: 10.33 ± 0.117	7.354AlaSer: 7.354 ± 0.084	6.747AlaThr: 6.747 ± 0.097	9.591AlaVal: 9.591 ± 0.094	2.296AlaTrp: 2.296 ± 0.047	2.266AlaTyr: 2.266 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.152CysAla: 1.152 ± 0.031	0.101CysCys: 0.101 ± 0.008	0.578CysAsp: 0.578 ± 0.024	0.513CysGlu: 0.513 ± 0.019	0.266CysPhe: 0.266 ± 0.015	1.012CysGly: 1.012 ± 0.032	0.369CysHis: 0.369 ± 0.031	0.348CysIle: 0.348 ± 0.017	0.17CysLys: 0.17 ± 0.012	0.796CysLeu: 0.796 ± 0.025	0.151CysMet: 0.151 ± 0.01	0.208CysAsn: 0.208 ± 0.012	0.499CysPro: 0.499 ± 0.02	0.261CysGln: 0.261 ± 0.015	0.579CysArg: 0.579 ± 0.021	0.477CysSer: 0.477 ± 0.02	0.452CysThr: 0.452 ± 0.019	0.663CysVal: 0.663 ± 0.021	0.112CysTrp: 0.112 ± 0.009	0.17CysTyr: 0.17 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.438AspAla: 8.438 ± 0.099	0.45AspCys: 0.45 ± 0.022	3.256AspAsp: 3.256 ± 0.061	3.38AspGlu: 3.38 ± 0.052	1.83AspPhe: 1.83 ± 0.036	5.594AspGly: 5.594 ± 0.098	1.411AspHis: 1.411 ± 0.036	2.28AspIle: 2.28 ± 0.043	1.356AspLys: 1.356 ± 0.04	6.279AspLeu: 6.279 ± 0.08	1.017AspMet: 1.017 ± 0.027	1.134AspAsn: 1.134 ± 0.031	3.531AspPro: 3.531 ± 0.06	1.87AspGln: 1.87 ± 0.05	4.076AspArg: 4.076 ± 0.056	2.094AspSer: 2.094 ± 0.046	2.768AspThr: 2.768 ± 0.059	4.276AspVal: 4.276 ± 0.061	1.093AspTrp: 1.093 ± 0.032	1.154AspTyr: 1.154 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.063GluAla: 7.063 ± 0.081	0.28GluCys: 0.28 ± 0.015	2.17GluAsp: 2.17 ± 0.041	1.898GluGlu: 1.898 ± 0.042	1.482GluPhe: 1.482 ± 0.029	3.572GluGly: 3.572 ± 0.062	1.345GluHis: 1.345 ± 0.037	2.331GluIle: 2.331 ± 0.041	1.201GluLys: 1.201 ± 0.035	5.787GluLeu: 5.787 ± 0.075	1.061GluMet: 1.061 ± 0.029	1.002GluAsn: 1.002 ± 0.03	2.788GluPro: 2.788 ± 0.051	2.437GluGln: 2.437 ± 0.048	4.884GluArg: 4.884 ± 0.073	2.257GluSer: 2.257 ± 0.046	2.487GluThr: 2.487 ± 0.045	4.006GluVal: 4.006 ± 0.064	0.603GluTrp: 0.603 ± 0.021	0.711GluTyr: 0.711 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.298PheAla: 3.298 ± 0.054	0.326PheCys: 0.326 ± 0.017	2.348PheAsp: 2.348 ± 0.044	1.924PheGlu: 1.924 ± 0.037	1.107PhePhe: 1.107 ± 0.035	2.964PheGly: 2.964 ± 0.059	0.694PheHis: 0.694 ± 0.023	1.277PheIle: 1.277 ± 0.032	0.96PheLys: 0.96 ± 0.028	2.555PheLeu: 2.555 ± 0.047	0.668PheMet: 0.668 ± 0.023	0.891PheAsn: 0.891 ± 0.027	1.235PhePro: 1.235 ± 0.031	1.01PheGln: 1.01 ± 0.026	1.712PheArg: 1.712 ± 0.033	1.671PheSer: 1.671 ± 0.039	1.507PheThr: 1.507 ± 0.032	2.408PheVal: 2.408 ± 0.051	0.447PheTrp: 0.447 ± 0.017	0.682PheTyr: 0.682 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.688GlyAla: 9.688 ± 0.102	0.955GlyCys: 0.955 ± 0.029	4.348GlyAsp: 4.348 ± 0.071	4.382GlyGlu: 4.382 ± 0.059	2.614GlyPhe: 2.614 ± 0.052	7.139GlyGly: 7.139 ± 0.107	2.396GlyHis: 2.396 ± 0.049	3.636GlyIle: 3.636 ± 0.053	2.656GlyLys: 2.656 ± 0.06	10.173GlyLeu: 10.173 ± 0.092	2.078GlyMet: 2.078 ± 0.042	2.023GlyAsn: 2.023 ± 0.06	3.595GlyPro: 3.595 ± 0.057	3.609GlyGln: 3.609 ± 0.05	6.412GlyArg: 6.412 ± 0.076	4.661GlySer: 4.661 ± 0.077	4.47GlyThr: 4.47 ± 0.087	6.677GlyVal: 6.677 ± 0.079	1.723GlyTrp: 1.723 ± 0.041	2.1GlyTyr: 2.1 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	3.461HisAla: 3.461 ± 0.051	0.247HisCys: 0.247 ± 0.013	1.524HisAsp: 1.524 ± 0.034	1.259HisGlu: 1.259 ± 0.032	0.776HisPhe: 0.776 ± 0.026	2.521HisGly: 2.521 ± 0.046	0.713HisHis: 0.713 ± 0.026	0.886HisIle: 0.886 ± 0.027	0.474HisLys: 0.474 ± 0.021	2.537HisLeu: 2.537 ± 0.05	0.408HisMet: 0.408 ± 0.017	0.473HisAsn: 0.473 ± 0.022	1.643HisPro: 1.643 ± 0.037	0.771HisGln: 0.771 ± 0.024	1.873HisArg: 1.873 ± 0.046	0.899HisSer: 0.899 ± 0.026	1.076HisThr: 1.076 ± 0.033	1.838HisVal: 1.838 ± 0.035	0.446HisTrp: 0.446 ± 0.018	0.539HisTyr: 0.539 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.85IleAla: 5.85 ± 0.076	0.354IleCys: 0.354 ± 0.018	3.337IleAsp: 3.337 ± 0.051	3.131IleGlu: 3.131 ± 0.057	0.978IlePhe: 0.978 ± 0.033	4.509IleGly: 4.509 ± 0.068	0.818IleHis: 0.818 ± 0.025	0.994IleIle: 0.994 ± 0.035	1.144IleLys: 1.144 ± 0.032	2.752IleLeu: 2.752 ± 0.05	0.557IleMet: 0.557 ± 0.023	1.135IleAsn: 1.135 ± 0.034	1.698IlePro: 1.698 ± 0.037	1.202IleGln: 1.202 ± 0.033	2.485IleArg: 2.485 ± 0.043	2.018IleSer: 2.018 ± 0.062	2.165IleThr: 2.165 ± 0.045	3.387IleVal: 3.387 ± 0.052	0.451IleTrp: 0.451 ± 0.018	0.776IleTyr: 0.776 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.466LysAla: 3.466 ± 0.069	0.12LysCys: 0.12 ± 0.009	1.319LysAsp: 1.319 ± 0.039	0.939LysGlu: 0.939 ± 0.031	0.711LysPhe: 0.711 ± 0.025	2.028LysGly: 2.028 ± 0.043	0.477LysHis: 0.477 ± 0.021	1.06LysIle: 1.06 ± 0.036	0.947LysLys: 0.947 ± 0.035	2.758LysLeu: 2.758 ± 0.048	0.562LysMet: 0.562 ± 0.021	0.661LysAsn: 0.661 ± 0.023	1.612LysPro: 1.612 ± 0.037	0.853LysGln: 0.853 ± 0.023	1.753LysArg: 1.753 ± 0.04	1.337LysSer: 1.337 ± 0.037	1.499LysThr: 1.499 ± 0.047	2.297LysVal: 2.297 ± 0.052	0.229LysTrp: 0.229 ± 0.014	0.461LysTyr: 0.461 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	16.874LeuAla: 16.874 ± 0.148	0.939LeuCys: 0.939 ± 0.025	6.831LeuAsp: 6.831 ± 0.081	4.507LeuGlu: 4.507 ± 0.071	2.951LeuPhe: 2.951 ± 0.054	9.14LeuGly: 9.14 ± 0.092	2.596LeuHis: 2.596 ± 0.048	4.371LeuIle: 4.371 ± 0.07	2.998LeuLys: 2.998 ± 0.048	12.026LeuLeu: 12.026 ± 0.145	2.516LeuMet: 2.516 ± 0.04	2.486LeuAsn: 2.486 ± 0.049	6.796LeuPro: 6.796 ± 0.083	4.475LeuGln: 4.475 ± 0.072	8.916LeuArg: 8.916 ± 0.104	6.479LeuSer: 6.479 ± 0.081	5.674LeuThr: 5.674 ± 0.098	8.195LeuVal: 8.195 ± 0.084	1.398LeuTrp: 1.398 ± 0.04	1.794LeuTyr: 1.794 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.946MetAla: 2.946 ± 0.046	0.153MetCys: 0.153 ± 0.01	1.106MetAsp: 1.106 ± 0.026	0.694MetGlu: 0.694 ± 0.022	0.57MetPhe: 0.57 ± 0.022	1.691MetGly: 1.691 ± 0.041	0.497MetHis: 0.497 ± 0.018	0.743MetIle: 0.743 ± 0.024	0.785MetLys: 0.785 ± 0.021	2.474MetLeu: 2.474 ± 0.046	0.437MetMet: 0.437 ± 0.02	0.817MetAsn: 0.817 ± 0.025	1.511MetPro: 1.511 ± 0.035	0.884MetGln: 0.884 ± 0.023	1.623MetArg: 1.623 ± 0.035	1.643MetSer: 1.643 ± 0.034	1.564MetThr: 1.564 ± 0.036	1.562MetVal: 1.562 ± 0.034	0.179MetTrp: 0.179 ± 0.012	0.304MetTyr: 0.304 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.822AsnAla: 2.822 ± 0.055	0.217AsnCys: 0.217 ± 0.014	1.301AsnAsp: 1.301 ± 0.061	1.061AsnGlu: 1.061 ± 0.026	0.764AsnPhe: 0.764 ± 0.025	2.016AsnGly: 2.016 ± 0.046	0.501AsnHis: 0.501 ± 0.018	0.907AsnIle: 0.907 ± 0.028	0.613AsnLys: 0.613 ± 0.024	2.491AsnLeu: 2.491 ± 0.063	0.443AsnMet: 0.443 ± 0.02	0.62AsnAsn: 0.62 ± 0.038	1.671AsnPro: 1.671 ± 0.037	0.781AsnGln: 0.781 ± 0.024	1.548AsnArg: 1.548 ± 0.034	0.976AsnSer: 0.976 ± 0.035	1.277AsnThr: 1.277 ± 0.032	1.728AsnVal: 1.728 ± 0.046	0.377AsnTrp: 0.377 ± 0.017	0.504AsnTyr: 0.504 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.486ProAla: 8.486 ± 0.119	0.402ProCys: 0.402 ± 0.017	3.635ProAsp: 3.635 ± 0.06	3.106ProGlu: 3.106 ± 0.049	1.579ProPhe: 1.579 ± 0.035	4.996ProGly: 4.996 ± 0.067	1.205ProHis: 1.205 ± 0.029	1.977ProIle: 1.977 ± 0.041	1.249ProLys: 1.249 ± 0.033	5.536ProLeu: 5.536 ± 0.076	1.383ProMet: 1.383 ± 0.03	1.159ProAsn: 1.159 ± 0.029	2.983ProPro: 2.983 ± 0.064	2.112ProGln: 2.112 ± 0.041	3.338ProArg: 3.338 ± 0.063	2.986ProSer: 2.986 ± 0.047	3.005ProThr: 3.005 ± 0.059	4.756ProVal: 4.756 ± 0.064	0.894ProTrp: 0.894 ± 0.024	1.036ProTyr: 1.036 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	6.369GlnAla: 6.369 ± 0.102	0.261GlnCys: 0.261 ± 0.014	1.656GlnAsp: 1.656 ± 0.036	1.325GlnGlu: 1.325 ± 0.038	1.041GlnPhe: 1.041 ± 0.025	3.133GlnGly: 3.133 ± 0.048	0.954GlnHis: 0.954 ± 0.025	1.718GlnIle: 1.718 ± 0.058	0.848GlnLys: 0.848 ± 0.026	4.17GlnLeu: 4.17 ± 0.06	0.909GlnMet: 0.909 ± 0.026	0.675GlnAsn: 0.675 ± 0.025	2.427GlnPro: 2.427 ± 0.044	1.812GlnGln: 1.812 ± 0.043	3.83GlnArg: 3.83 ± 0.061	1.692GlnSer: 1.692 ± 0.04	1.968GlnThr: 1.968 ± 0.042	3.541GlnVal: 3.541 ± 0.079	0.562GlnTrp: 0.562 ± 0.028	0.576GlnTyr: 0.576 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.756ArgAla: 8.756 ± 0.09	0.689ArgCys: 0.689 ± 0.027	4.017ArgAsp: 4.017 ± 0.067	4.351ArgGlu: 4.351 ± 0.063	2.379ArgPhe: 2.379 ± 0.039	4.945ArgGly: 4.945 ± 0.067	2.478ArgHis: 2.478 ± 0.041	3.54ArgIle: 3.54 ± 0.051	1.768ArgLys: 1.768 ± 0.041	9.373ArgLeu: 9.373 ± 0.114	1.857ArgMet: 1.857 ± 0.036	1.585ArgAsn: 1.585 ± 0.032	4.172ArgPro: 4.172 ± 0.061	3.301ArgGln: 3.301 ± 0.051	6.403ArgArg: 6.403 ± 0.102	4.081ArgSer: 4.081 ± 0.062	3.34ArgThr: 3.34 ± 0.054	5.526ArgVal: 5.526 ± 0.071	1.573ArgTrp: 1.573 ± 0.041	1.751ArgTyr: 1.751 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.024SerAla: 7.024 ± 0.085	0.409SerCys: 0.409 ± 0.019	2.791SerAsp: 2.791 ± 0.048	2.218SerGlu: 2.218 ± 0.04	1.696SerPhe: 1.696 ± 0.034	5.255SerGly: 5.255 ± 0.083	1.229SerHis: 1.229 ± 0.027	2.016SerIle: 2.016 ± 0.043	1.196SerLys: 1.196 ± 0.041	5.582SerLeu: 5.582 ± 0.07	1.106SerMet: 1.106 ± 0.03	1.267SerAsn: 1.267 ± 0.036	3.052SerPro: 3.052 ± 0.054	1.787SerGln: 1.787 ± 0.042	3.662SerArg: 3.662 ± 0.055	2.81SerSer: 2.81 ± 0.057	3.185SerThr: 3.185 ± 0.063	3.89SerVal: 3.89 ± 0.062	0.797SerTrp: 0.797 ± 0.023	1.13SerTyr: 1.13 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	6.175ThrAla: 6.175 ± 0.099	0.449ThrCys: 0.449 ± 0.023	2.658ThrAsp: 2.658 ± 0.073	2.292ThrGlu: 2.292 ± 0.047	1.645ThrPhe: 1.645 ± 0.038	4.8ThrGly: 4.8 ± 0.081	1.147ThrHis: 1.147 ± 0.028	1.871ThrIle: 1.871 ± 0.064	0.921ThrLys: 0.921 ± 0.03	7.142ThrLeu: 7.142 ± 0.076	1.028ThrMet: 1.028 ± 0.026	1.056ThrAsn: 1.056 ± 0.034	3.864ThrPro: 3.864 ± 0.066	1.946ThrGln: 1.946 ± 0.051	3.611ThrArg: 3.611 ± 0.053	2.767ThrSer: 2.767 ± 0.069	2.977ThrThr: 2.977 ± 0.085	4.268ThrVal: 4.268 ± 0.077	0.81ThrTrp: 0.81 ± 0.026	0.954ThrTyr: 0.954 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.023ValAla: 10.023 ± 0.088	0.707ValCys: 0.707 ± 0.023	4.941ValAsp: 4.941 ± 0.062	4.039ValGlu: 4.039 ± 0.056	2.495ValPhe: 2.495 ± 0.041	5.668ValGly: 5.668 ± 0.07	1.751ValHis: 1.751 ± 0.041	3.48ValIle: 3.48 ± 0.058	2.012ValLys: 2.012 ± 0.039	8.658ValLeu: 8.658 ± 0.095	1.847ValMet: 1.847 ± 0.042	1.97ValAsn: 1.97 ± 0.044	4.052ValPro: 4.052 ± 0.057	2.899ValGln: 2.899 ± 0.047	5.738ValArg: 5.738 ± 0.061	4.116ValSer: 4.116 ± 0.066	4.123ValThr: 4.123 ± 0.086	6.433ValVal: 6.433 ± 0.078	1.096ValTrp: 1.096 ± 0.033	1.481ValTyr: 1.481 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.457TrpAla: 1.457 ± 0.038	0.189TrpCys: 0.189 ± 0.01	0.699TrpAsp: 0.699 ± 0.025	0.449TrpGlu: 0.449 ± 0.02	0.537TrpPhe: 0.537 ± 0.021	0.966TrpGly: 0.966 ± 0.029	0.408TrpHis: 0.408 ± 0.018	0.639TrpIle: 0.639 ± 0.023	0.372TrpLys: 0.372 ± 0.02	2.42TrpLeu: 2.42 ± 0.055	0.375TrpMet: 0.375 ± 0.017	0.377TrpAsn: 0.377 ± 0.016	0.909TrpPro: 0.909 ± 0.029	0.892TrpGln: 0.892 ± 0.03	1.568TrpArg: 1.568 ± 0.039	0.855TrpSer: 0.855 ± 0.027	0.904TrpThr: 0.904 ± 0.031	1.089TrpVal: 1.089 ± 0.027	0.288TrpTrp: 0.288 ± 0.015	0.27TrpTyr: 0.27 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.469TyrAla: 2.469 ± 0.045	0.182TyrCys: 0.182 ± 0.011	1.089TyrAsp: 1.089 ± 0.032	0.983TyrGlu: 0.983 ± 0.03	0.677TyrPhe: 0.677 ± 0.023	1.765TyrGly: 1.765 ± 0.041	0.428TyrHis: 0.428 ± 0.017	0.646TyrIle: 0.646 ± 0.023	0.499TyrLys: 0.499 ± 0.023	2.064TyrLeu: 2.064 ± 0.041	0.312TyrMet: 0.312 ± 0.015	0.505TyrAsn: 0.505 ± 0.018	0.954TyrPro: 0.954 ± 0.029	0.734TyrGln: 0.734 ± 0.031	1.544TyrArg: 1.544 ± 0.035	0.928TyrSer: 0.928 ± 0.027	1.193TyrThr: 1.193 ± 0.052	1.396TyrVal: 1.396 ± 0.036	0.288TyrTrp: 0.288 ± 0.014	0.434TyrTyr: 0.434 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4025 proteins (1415505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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