Amino acid dipepetide frequency for Acholeplasma oculi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.052AlaAla: 3.052 ± 0.105
0.338AlaCys: 0.338 ± 0.029
2.387AlaAsp: 2.387 ± 0.085
2.367AlaGlu: 2.367 ± 0.078
3.006AlaPhe: 3.006 ± 0.085
3.052AlaGly: 3.052 ± 0.093
1.054AlaHis: 1.054 ± 0.056
5.136AlaIle: 5.136 ± 0.124
4.063AlaLys: 4.063 ± 0.113
6.483AlaLeu: 6.483 ± 0.126
1.277AlaMet: 1.277 ± 0.057
2.666AlaAsn: 2.666 ± 0.092
1.401AlaPro: 1.401 ± 0.06
1.543AlaGln: 1.543 ± 0.063
1.9AlaArg: 1.9 ± 0.077
3.547AlaSer: 3.547 ± 0.088
3.13AlaThr: 3.13 ± 0.1
3.638AlaVal: 3.638 ± 0.108
0.413AlaTrp: 0.413 ± 0.034
2.761AlaTyr: 2.761 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
0.204CysAla: 0.204 ± 0.025
0.035CysCys: 0.035 ± 0.008
0.258CysAsp: 0.258 ± 0.024
0.233CysGlu: 0.233 ± 0.021
0.194CysPhe: 0.194 ± 0.019
0.376CysGly: 0.376 ± 0.029
0.113CysHis: 0.113 ± 0.014
0.363CysIle: 0.363 ± 0.029
0.287CysLys: 0.287 ± 0.021
0.351CysLeu: 0.351 ± 0.023
0.095CysMet: 0.095 ± 0.016
0.175CysAsn: 0.175 ± 0.02
0.138CysPro: 0.138 ± 0.019
0.142CysGln: 0.142 ± 0.018
0.151CysArg: 0.151 ± 0.017
0.281CysSer: 0.281 ± 0.026
0.19CysThr: 0.19 ± 0.018
0.241CysVal: 0.241 ± 0.022
0.039CysTrp: 0.039 ± 0.009
0.21CysTyr: 0.21 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.632AspAla: 3.632 ± 0.079
0.27AspCys: 0.27 ± 0.024
3.153AspAsp: 3.153 ± 0.124
4.467AspGlu: 4.467 ± 0.111
3.153AspPhe: 3.153 ± 0.078
3.419AspGly: 3.419 ± 0.104
1.172AspHis: 1.172 ± 0.054
5.388AspIle: 5.388 ± 0.127
4.026AspLys: 4.026 ± 0.114
6.553AspLeu: 6.553 ± 0.142
1.465AspMet: 1.465 ± 0.056
2.404AspAsn: 2.404 ± 0.088
1.975AspPro: 1.975 ± 0.077
2.35AspGln: 2.35 ± 0.073
1.709AspArg: 1.709 ± 0.06
3.161AspSer: 3.161 ± 0.096
2.843AspThr: 2.843 ± 0.073
3.941AspVal: 3.941 ± 0.1
0.458AspTrp: 0.458 ± 0.033
2.94AspTyr: 2.94 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
3.925GluAla: 3.925 ± 0.105
0.206GluCys: 0.206 ± 0.024
3.524GluAsp: 3.524 ± 0.097
3.935GluGlu: 3.935 ± 0.106
2.885GluPhe: 2.885 ± 0.074
3.491GluGly: 3.491 ± 0.1
1.248GluHis: 1.248 ± 0.06
5.941GluIle: 5.941 ± 0.133
5.557GluLys: 5.557 ± 0.171
6.799GluLeu: 6.799 ± 0.131
1.702GluMet: 1.702 ± 0.065
3.444GluAsn: 3.444 ± 0.092
1.855GluPro: 1.855 ± 0.063
2.173GluGln: 2.173 ± 0.082
2.431GluArg: 2.431 ± 0.082
4.143GluSer: 4.143 ± 0.099
3.916GluThr: 3.916 ± 0.096
4.913GluVal: 4.913 ± 0.12
0.448GluTrp: 0.448 ± 0.03
2.369GluTyr: 2.369 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.429PheAla: 2.429 ± 0.071
0.173PheCys: 0.173 ± 0.019
3.516PheAsp: 3.516 ± 0.081
3.531PheGlu: 3.531 ± 0.082
2.303PhePhe: 2.303 ± 0.089
3.169PheGly: 3.169 ± 0.095
0.832PheHis: 0.832 ± 0.045
5.132PheIle: 5.132 ± 0.13
4.244PheLys: 4.244 ± 0.095
4.259PheLeu: 4.259 ± 0.112
1.463PheMet: 1.463 ± 0.063
3.273PheAsn: 3.273 ± 0.092
1.189PhePro: 1.189 ± 0.052
1.356PheGln: 1.356 ± 0.053
1.527PheArg: 1.527 ± 0.055
3.211PheSer: 3.211 ± 0.093
2.705PheThr: 2.705 ± 0.095
3.378PheVal: 3.378 ± 0.098
0.33PheTrp: 0.33 ± 0.027
2.144PheTyr: 2.144 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
3.289GlyAla: 3.289 ± 0.11
0.314GlyCys: 0.314 ± 0.028
2.918GlyAsp: 2.918 ± 0.09
3.097GlyGlu: 3.097 ± 0.091
3.588GlyPhe: 3.588 ± 0.091
3.7GlyGly: 3.7 ± 0.156
1.304GlyHis: 1.304 ± 0.055
5.695GlyIle: 5.695 ± 0.118
4.108GlyLys: 4.108 ± 0.106
6.151GlyLeu: 6.151 ± 0.139
1.572GlyMet: 1.572 ± 0.066
2.742GlyAsn: 2.742 ± 0.117
1.271GlyPro: 1.271 ± 0.058
1.777GlyGln: 1.777 ± 0.068
1.886GlyArg: 1.886 ± 0.082
3.749GlySer: 3.749 ± 0.106
3.568GlyThr: 3.568 ± 0.146
4.238GlyVal: 4.238 ± 0.117
0.644GlyTrp: 0.644 ± 0.078
3.176GlyTyr: 3.176 ± 0.132
0.0GlyXaa: 0.0 ± 0.0
His
1.158HisAla: 1.158 ± 0.055
0.097HisCys: 0.097 ± 0.015
1.182HisAsp: 1.182 ± 0.051
1.5HisGlu: 1.5 ± 0.068
1.015HisPhe: 1.015 ± 0.046
1.199HisGly: 1.199 ± 0.057
0.751HisHis: 0.751 ± 0.067
1.909HisIle: 1.909 ± 0.078
1.422HisLys: 1.422 ± 0.063
2.15HisLeu: 2.15 ± 0.074
0.555HisMet: 0.555 ± 0.04
0.885HisAsn: 0.885 ± 0.036
0.978HisPro: 0.978 ± 0.045
1.17HisGln: 1.17 ± 0.06
0.64HisArg: 0.64 ± 0.039
0.937HisSer: 0.937 ± 0.045
1.1HisThr: 1.1 ± 0.046
1.399HisVal: 1.399 ± 0.054
0.163HisTrp: 0.163 ± 0.019
0.945HisTyr: 0.945 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
4.913IleAla: 4.913 ± 0.112
0.404IleCys: 0.404 ± 0.033
6.201IleAsp: 6.201 ± 0.128
6.535IleGlu: 6.535 ± 0.13
4.282IlePhe: 4.282 ± 0.114
5.561IleGly: 5.561 ± 0.143
1.991IleHis: 1.991 ± 0.068
7.447IleIle: 7.447 ± 0.159
7.447IleLys: 7.447 ± 0.159
8.935IleLeu: 8.935 ± 0.17
2.059IleMet: 2.059 ± 0.07
4.556IleAsn: 4.556 ± 0.113
3.275IlePro: 3.275 ± 0.075
3.287IleGln: 3.287 ± 0.09
2.957IleArg: 2.957 ± 0.072
5.885IleSer: 5.885 ± 0.128
5.287IleThr: 5.287 ± 0.189
5.429IleVal: 5.429 ± 0.113
0.555IleTrp: 0.555 ± 0.031
4.09IleTyr: 4.09 ± 0.098
0.0IleXaa: 0.0 ± 0.0
Lys
3.793LysAla: 3.793 ± 0.111
0.204LysCys: 0.204 ± 0.023
5.466LysAsp: 5.466 ± 0.137
6.694LysGlu: 6.694 ± 0.163
2.903LysPhe: 2.903 ± 0.078
3.908LysGly: 3.908 ± 0.084
1.892LysHis: 1.892 ± 0.081
6.128LysIle: 6.128 ± 0.134
7.007LysLys: 7.007 ± 0.168
7.214LysLeu: 7.214 ± 0.161
2.177LysMet: 2.177 ± 0.074
4.806LysAsn: 4.806 ± 0.112
2.396LysPro: 2.396 ± 0.08
2.618LysGln: 2.618 ± 0.092
3.091LysArg: 3.091 ± 0.096
4.486LysSer: 4.486 ± 0.099
4.556LysThr: 4.556 ± 0.096
5.022LysVal: 5.022 ± 0.111
0.468LysTrp: 0.468 ± 0.034
3.675LysTyr: 3.675 ± 0.095
0.0LysXaa: 0.0 ± 0.0
Leu
5.15LeuAla: 5.15 ± 0.118
0.363LeuCys: 0.363 ± 0.026
6.091LeuAsp: 6.091 ± 0.114
6.97LeuGlu: 6.97 ± 0.153
5.024LeuPhe: 5.024 ± 0.113
6.163LeuGly: 6.163 ± 0.14
1.607LeuHis: 1.607 ± 0.062
9.193LeuIle: 9.193 ± 0.155
8.825LeuLys: 8.825 ± 0.177
9.636LeuLeu: 9.636 ± 0.215
2.746LeuMet: 2.746 ± 0.075
6.322LeuAsn: 6.322 ± 0.114
3.32LeuPro: 3.32 ± 0.082
2.359LeuGln: 2.359 ± 0.072
3.268LeuArg: 3.268 ± 0.092
7.732LeuSer: 7.732 ± 0.123
5.903LeuThr: 5.903 ± 0.11
6.3LeuVal: 6.3 ± 0.127
0.702LeuTrp: 0.702 ± 0.046
4.255LeuTyr: 4.255 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.286MetAla: 1.286 ± 0.059
0.076MetCys: 0.076 ± 0.013
1.69MetAsp: 1.69 ± 0.065
1.314MetGlu: 1.314 ± 0.052
1.168MetPhe: 1.168 ± 0.052
1.438MetGly: 1.438 ± 0.06
0.528MetHis: 0.528 ± 0.032
2.909MetIle: 2.909 ± 0.087
2.259MetLys: 2.259 ± 0.077
2.276MetLeu: 2.276 ± 0.067
0.887MetMet: 0.887 ± 0.05
1.746MetAsn: 1.746 ± 0.057
0.78MetPro: 0.78 ± 0.044
0.755MetGln: 0.755 ± 0.042
0.875MetArg: 0.875 ± 0.04
1.622MetSer: 1.622 ± 0.058
1.473MetThr: 1.473 ± 0.052
1.671MetVal: 1.671 ± 0.066
0.147MetTrp: 0.147 ± 0.014
0.97MetTyr: 0.97 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
2.746AsnAla: 2.746 ± 0.089
0.186AsnCys: 0.186 ± 0.022
3.281AsnAsp: 3.281 ± 0.083
3.888AsnGlu: 3.888 ± 0.098
2.406AsnPhe: 2.406 ± 0.075
3.138AsnGly: 3.138 ± 0.115
1.593AsnHis: 1.593 ± 0.066
4.649AsnIle: 4.649 ± 0.108
3.764AsnLys: 3.764 ± 0.097
5.524AsnLeu: 5.524 ± 0.152
1.178AsnMet: 1.178 ± 0.046
2.641AsnAsn: 2.641 ± 0.111
2.435AsnPro: 2.435 ± 0.081
3.264AsnGln: 3.264 ± 0.105
1.913AsnArg: 1.913 ± 0.061
2.53AsnSer: 2.53 ± 0.089
2.575AsnThr: 2.575 ± 0.092
3.219AsnVal: 3.219 ± 0.087
0.433AsnTrp: 0.433 ± 0.033
2.689AsnTyr: 2.689 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
1.302ProAla: 1.302 ± 0.071
0.101ProCys: 0.101 ± 0.013
1.628ProAsp: 1.628 ± 0.059
1.902ProGlu: 1.902 ± 0.066
1.791ProPhe: 1.791 ± 0.067
1.81ProGly: 1.81 ± 0.063
0.64ProHis: 0.64 ± 0.036
2.782ProIle: 2.782 ± 0.08
2.437ProLys: 2.437 ± 0.085
3.033ProLeu: 3.033 ± 0.079
0.78ProMet: 0.78 ± 0.041
1.969ProAsn: 1.969 ± 0.072
0.563ProPro: 0.563 ± 0.031
0.817ProGln: 0.817 ± 0.043
0.959ProArg: 0.959 ± 0.049
2.061ProSer: 2.061 ± 0.074
1.981ProThr: 1.981 ± 0.078
2.183ProVal: 2.183 ± 0.065
0.301ProTrp: 0.301 ± 0.026
1.597ProTyr: 1.597 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
2.063GlnAla: 2.063 ± 0.069
0.097GlnCys: 0.097 ± 0.015
1.642GlnAsp: 1.642 ± 0.062
2.111GlnGlu: 2.111 ± 0.073
1.502GlnPhe: 1.502 ± 0.052
1.874GlnGly: 1.874 ± 0.066
0.596GlnHis: 0.596 ± 0.042
3.087GlnIle: 3.087 ± 0.088
2.856GlnLys: 2.856 ± 0.101
3.26GlnLeu: 3.26 ± 0.08
1.127GlnMet: 1.127 ± 0.048
1.867GlnAsn: 1.867 ± 0.072
0.86GlnPro: 0.86 ± 0.047
1.176GlnGln: 1.176 ± 0.056
1.166GlnArg: 1.166 ± 0.05
2.365GlnSer: 2.365 ± 0.07
2.313GlnThr: 2.313 ± 0.08
2.301GlnVal: 2.301 ± 0.079
0.21GlnTrp: 0.21 ± 0.022
1.508GlnTyr: 1.508 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
1.832ArgAla: 1.832 ± 0.075
0.153ArgCys: 0.153 ± 0.019
1.694ArgAsp: 1.694 ± 0.056
1.913ArgGlu: 1.913 ± 0.077
1.938ArgPhe: 1.938 ± 0.072
1.812ArgGly: 1.812 ± 0.064
0.706ArgHis: 0.706 ± 0.038
3.246ArgIle: 3.246 ± 0.087
2.699ArgLys: 2.699 ± 0.081
3.632ArgLeu: 3.632 ± 0.1
0.993ArgMet: 0.993 ± 0.044
1.772ArgAsn: 1.772 ± 0.061
0.976ArgPro: 0.976 ± 0.049
1.092ArgGln: 1.092 ± 0.046
1.385ArgArg: 1.385 ± 0.061
1.946ArgSer: 1.946 ± 0.065
1.706ArgThr: 1.706 ± 0.065
2.255ArgVal: 2.255 ± 0.067
0.231ArgTrp: 0.231 ± 0.023
1.62ArgTyr: 1.62 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
2.819SerAla: 2.819 ± 0.07
0.248SerCys: 0.248 ± 0.023
3.394SerAsp: 3.394 ± 0.093
3.403SerGlu: 3.403 ± 0.088
3.656SerPhe: 3.656 ± 0.101
4.114SerGly: 4.114 ± 0.103
1.24SerHis: 1.24 ± 0.056
6.128SerIle: 6.128 ± 0.119
5.099SerLys: 5.099 ± 0.129
6.712SerLeu: 6.712 ± 0.126
1.686SerMet: 1.686 ± 0.071
3.815SerAsn: 3.815 ± 0.102
1.572SerPro: 1.572 ± 0.071
1.82SerGln: 1.82 ± 0.066
1.971SerArg: 1.971 ± 0.063
3.879SerSer: 3.879 ± 0.124
3.326SerThr: 3.326 ± 0.1
3.879SerVal: 3.879 ± 0.112
0.512SerTrp: 0.512 ± 0.033
3.328SerTyr: 3.328 ± 0.111
0.0SerXaa: 0.0 ± 0.0
Thr
2.837ThrAla: 2.837 ± 0.086
0.254ThrCys: 0.254 ± 0.027
2.973ThrAsp: 2.973 ± 0.084
3.035ThrGlu: 3.035 ± 0.081
3.077ThrPhe: 3.077 ± 0.111
3.597ThrGly: 3.597 ± 0.132
1.368ThrHis: 1.368 ± 0.064
5.386ThrIle: 5.386 ± 0.144
4.073ThrLys: 4.073 ± 0.1
6.232ThrLeu: 6.232 ± 0.154
1.17ThrMet: 1.17 ± 0.046
2.988ThrAsn: 2.988 ± 0.104
2.053ThrPro: 2.053 ± 0.073
1.63ThrGln: 1.63 ± 0.069
1.665ThrArg: 1.665 ± 0.058
3.547ThrSer: 3.547 ± 0.097
3.083ThrThr: 3.083 ± 0.099
3.708ThrVal: 3.708 ± 0.127
0.541ThrTrp: 0.541 ± 0.032
3.244ThrTyr: 3.244 ± 0.161
0.0ThrXaa: 0.0 ± 0.0
Val
3.625ValAla: 3.625 ± 0.11
0.305ValCys: 0.305 ± 0.026
4.03ValAsp: 4.03 ± 0.089
4.325ValGlu: 4.325 ± 0.113
3.436ValPhe: 3.436 ± 0.093
4.034ValGly: 4.034 ± 0.135
1.17ValHis: 1.17 ± 0.053
6.003ValIle: 6.003 ± 0.126
4.649ValLys: 4.649 ± 0.107
6.993ValLeu: 6.993 ± 0.153
1.62ValMet: 1.62 ± 0.071
3.103ValAsn: 3.103 ± 0.081
1.857ValPro: 1.857 ± 0.067
1.651ValGln: 1.651 ± 0.055
2.16ValArg: 2.16 ± 0.074
4.723ValSer: 4.723 ± 0.121
3.978ValThr: 3.978 ± 0.122
4.816ValVal: 4.816 ± 0.132
0.526ValTrp: 0.526 ± 0.036
2.953ValTyr: 2.953 ± 0.087
0.0ValXaa: 0.0 ± 0.0
Trp
0.343TrpAla: 0.343 ± 0.029
0.037TrpCys: 0.037 ± 0.008
0.378TrpAsp: 0.378 ± 0.031
0.388TrpGlu: 0.388 ± 0.029
0.503TrpPhe: 0.503 ± 0.054
0.454TrpGly: 0.454 ± 0.032
0.144TrpHis: 0.144 ± 0.019
0.761TrpIle: 0.761 ± 0.042
0.425TrpLys: 0.425 ± 0.036
0.799TrpLeu: 0.799 ± 0.042
0.231TrpMet: 0.231 ± 0.023
0.58TrpAsn: 0.58 ± 0.041
0.161TrpPro: 0.161 ± 0.019
0.272TrpGln: 0.272 ± 0.025
0.217TrpArg: 0.217 ± 0.021
0.448TrpSer: 0.448 ± 0.031
0.39TrpThr: 0.39 ± 0.034
0.493TrpVal: 0.493 ± 0.034
0.093TrpTrp: 0.093 ± 0.013
0.4TrpTyr: 0.4 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.819TyrAla: 2.819 ± 0.087
0.215TyrCys: 0.215 ± 0.021
3.072TyrAsp: 3.072 ± 0.103
3.299TyrGlu: 3.299 ± 0.096
2.332TyrPhe: 2.332 ± 0.078
2.478TyrGly: 2.478 ± 0.085
1.203TyrHis: 1.203 ± 0.056
3.813TyrIle: 3.813 ± 0.079
3.258TyrLys: 3.258 ± 0.089
4.94TyrLeu: 4.94 ± 0.119
1.085TyrMet: 1.085 ± 0.055
2.297TyrAsn: 2.297 ± 0.134
1.583TyrPro: 1.583 ± 0.056
2.73TyrGln: 2.73 ± 0.096
1.729TyrArg: 1.729 ± 0.064
2.35TyrSer: 2.35 ± 0.074
2.435TyrThr: 2.435 ± 0.103
2.932TyrVal: 2.932 ± 0.082
0.303TyrTrp: 0.303 ± 0.03
2.136TyrTyr: 2.136 ± 0.092
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1468 proteins (484631 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski