Amino acid dipepetide frequency for Cynomolgus macaque cytomegalovirus strain Mauritius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.013AlaAla: 7.013 ± 0.577
1.757AlaCys: 1.757 ± 0.17
2.731AlaAsp: 2.731 ± 0.213
3.308AlaGlu: 3.308 ± 0.218
2.772AlaPhe: 2.772 ± 0.187
3.417AlaGly: 3.417 ± 0.277
1.812AlaHis: 1.812 ± 0.155
3.513AlaIle: 3.513 ± 0.225
2.415AlaLys: 2.415 ± 0.291
6.697AlaLeu: 6.697 ± 0.339
1.619AlaMet: 1.619 ± 0.143
2.484AlaAsn: 2.484 ± 0.192
3.925AlaPro: 3.925 ± 0.281
2.47AlaGln: 2.47 ± 0.223
3.815AlaArg: 3.815 ± 0.24
5.641AlaSer: 5.641 ± 0.281
4.488AlaThr: 4.488 ± 0.286
5.16AlaVal: 5.16 ± 0.322
0.947AlaTrp: 0.947 ± 0.118
1.647AlaTyr: 1.647 ± 0.149
0.0AlaXaa: 0.0 ± 0.0
Cys
1.729CysAla: 1.729 ± 0.171
0.974CysCys: 0.974 ± 0.142
1.276CysAsp: 1.276 ± 0.16
1.153CysGlu: 1.153 ± 0.131
1.153CysPhe: 1.153 ± 0.123
1.565CysGly: 1.565 ± 0.164
0.851CysHis: 0.851 ± 0.12
1.331CysIle: 1.331 ± 0.144
0.81CysLys: 0.81 ± 0.106
3.129CysLeu: 3.129 ± 0.228
0.851CysMet: 0.851 ± 0.101
1.194CysAsn: 1.194 ± 0.138
1.523CysPro: 1.523 ± 0.151
1.125CysGln: 1.125 ± 0.159
1.839CysArg: 1.839 ± 0.194
1.674CysSer: 1.674 ± 0.19
1.825CysThr: 1.825 ± 0.163
1.976CysVal: 1.976 ± 0.179
0.384CysTrp: 0.384 ± 0.066
1.07CysTyr: 1.07 ± 0.117
0.0CysXaa: 0.0 ± 0.0
Asp
2.635AspAla: 2.635 ± 0.202
0.755AspCys: 0.755 ± 0.114
3.472AspAsp: 3.472 ± 0.333
3.555AspGlu: 3.555 ± 0.259
1.99AspPhe: 1.99 ± 0.191
2.059AspGly: 2.059 ± 0.206
1.084AspHis: 1.084 ± 0.127
2.58AspIle: 2.58 ± 0.244
1.263AspLys: 1.263 ± 0.148
4.611AspLeu: 4.611 ± 0.338
1.304AspMet: 1.304 ± 0.136
1.551AspAsn: 1.551 ± 0.148
2.662AspPro: 2.662 ± 0.215
1.263AspGln: 1.263 ± 0.127
2.813AspArg: 2.813 ± 0.204
3.239AspSer: 3.239 ± 0.262
2.621AspThr: 2.621 ± 0.188
2.841AspVal: 2.841 ± 0.221
0.59AspTrp: 0.59 ± 0.1
1.619AspTyr: 1.619 ± 0.153
0.0AspXaa: 0.0 ± 0.0
Glu
3.747GluAla: 3.747 ± 0.226
1.194GluCys: 1.194 ± 0.11
2.855GluAsp: 2.855 ± 0.241
3.623GluGlu: 3.623 ± 0.283
1.414GluPhe: 1.414 ± 0.126
1.99GluGly: 1.99 ± 0.19
1.784GluHis: 1.784 ± 0.16
2.237GluIle: 2.237 ± 0.19
1.935GluLys: 1.935 ± 0.218
4.543GluLeu: 4.543 ± 0.284
1.208GluMet: 1.208 ± 0.131
2.278GluAsn: 2.278 ± 0.169
2.443GluPro: 2.443 ± 0.184
1.729GluGln: 1.729 ± 0.181
3.5GluArg: 3.5 ± 0.275
3.417GluSer: 3.417 ± 0.226
3.596GluThr: 3.596 ± 0.287
3.143GluVal: 3.143 ± 0.227
0.508GluTrp: 0.508 ± 0.102
1.427GluTyr: 1.427 ± 0.129
0.0GluXaa: 0.0 ± 0.0
Phe
2.127PheAla: 2.127 ± 0.156
1.565PheCys: 1.565 ± 0.16
1.702PheAsp: 1.702 ± 0.166
1.77PheGlu: 1.77 ± 0.165
1.935PhePhe: 1.935 ± 0.168
2.361PheGly: 2.361 ± 0.175
1.016PheHis: 1.016 ± 0.138
2.443PheIle: 2.443 ± 0.18
1.235PheLys: 1.235 ± 0.144
4.227PheLeu: 4.227 ± 0.232
1.263PheMet: 1.263 ± 0.112
1.729PheAsn: 1.729 ± 0.144
2.141PhePro: 2.141 ± 0.144
1.633PheGln: 1.633 ± 0.152
2.539PheArg: 2.539 ± 0.209
2.964PheSer: 2.964 ± 0.205
2.8PheThr: 2.8 ± 0.195
3.129PheVal: 3.129 ± 0.239
0.851PheTrp: 0.851 ± 0.118
1.716PheTyr: 1.716 ± 0.172
0.0PheXaa: 0.0 ± 0.0
Gly
2.923GlyAla: 2.923 ± 0.235
1.235GlyCys: 1.235 ± 0.133
2.21GlyAsp: 2.21 ± 0.179
2.251GlyGlu: 2.251 ± 0.227
2.155GlyPhe: 2.155 ± 0.186
3.898GlyGly: 3.898 ± 0.493
1.345GlyHis: 1.345 ± 0.15
2.525GlyIle: 2.525 ± 0.203
1.77GlyLys: 1.77 ± 0.152
4.954GlyLeu: 4.954 ± 0.259
1.07GlyMet: 1.07 ± 0.138
2.086GlyAsn: 2.086 ± 0.16
2.196GlyPro: 2.196 ± 0.207
1.825GlyGln: 1.825 ± 0.176
3.404GlyArg: 3.404 ± 0.281
3.582GlySer: 3.582 ± 0.246
3.623GlyThr: 3.623 ± 0.253
3.87GlyVal: 3.87 ± 0.337
0.618GlyTrp: 0.618 ± 0.084
1.619GlyTyr: 1.619 ± 0.139
0.0GlyXaa: 0.0 ± 0.0
His
2.388HisAla: 2.388 ± 0.188
0.672HisCys: 0.672 ± 0.108
1.592HisAsp: 1.592 ± 0.146
1.441HisGlu: 1.441 ± 0.124
1.221HisPhe: 1.221 ± 0.127
1.825HisGly: 1.825 ± 0.165
1.866HisHis: 1.866 ± 0.226
1.565HisIle: 1.565 ± 0.16
1.057HisLys: 1.057 ± 0.119
3.088HisLeu: 3.088 ± 0.228
0.851HisMet: 0.851 ± 0.112
1.455HisAsn: 1.455 ± 0.138
1.647HisPro: 1.647 ± 0.169
1.276HisGln: 1.276 ± 0.152
3.006HisArg: 3.006 ± 0.251
2.21HisSer: 2.21 ± 0.199
2.251HisThr: 2.251 ± 0.186
2.608HisVal: 2.608 ± 0.191
0.316HisTrp: 0.316 ± 0.069
0.851HisTyr: 0.851 ± 0.111
0.0HisXaa: 0.0 ± 0.0
Ile
2.937IleAla: 2.937 ± 0.202
1.578IleCys: 1.578 ± 0.179
1.99IleAsp: 1.99 ± 0.153
1.908IleGlu: 1.908 ± 0.152
2.264IlePhe: 2.264 ± 0.21
2.388IleGly: 2.388 ± 0.214
1.592IleHis: 1.592 ± 0.163
3.253IleIle: 3.253 ± 0.249
1.894IleLys: 1.894 ± 0.179
5.078IleLeu: 5.078 ± 0.315
1.537IleMet: 1.537 ± 0.142
2.223IleAsn: 2.223 ± 0.184
3.129IlePro: 3.129 ± 0.228
2.114IleGln: 2.114 ± 0.185
2.635IleArg: 2.635 ± 0.175
3.637IleSer: 3.637 ± 0.226
3.39IleThr: 3.39 ± 0.283
4.172IleVal: 4.172 ± 0.256
0.974IleTrp: 0.974 ± 0.129
2.264IleTyr: 2.264 ± 0.197
0.0IleXaa: 0.0 ± 0.0
Lys
2.347LysAla: 2.347 ± 0.19
0.988LysCys: 0.988 ± 0.112
1.468LysAsp: 1.468 ± 0.175
1.592LysGlu: 1.592 ± 0.212
1.345LysPhe: 1.345 ± 0.149
1.647LysGly: 1.647 ± 0.161
1.537LysHis: 1.537 ± 0.136
1.812LysIle: 1.812 ± 0.191
2.045LysLys: 2.045 ± 0.216
3.28LysLeu: 3.28 ± 0.209
1.043LysMet: 1.043 ± 0.112
1.88LysAsn: 1.88 ± 0.195
2.196LysPro: 2.196 ± 0.256
1.619LysGln: 1.619 ± 0.151
3.006LysArg: 3.006 ± 0.201
2.553LysSer: 2.553 ± 0.176
2.608LysThr: 2.608 ± 0.202
1.99LysVal: 1.99 ± 0.202
0.357LysTrp: 0.357 ± 0.071
1.318LysTyr: 1.318 ± 0.147
0.0LysXaa: 0.0 ± 0.0
Leu
6.67LeuAla: 6.67 ± 0.306
3.225LeuCys: 3.225 ± 0.234
3.678LeuAsp: 3.678 ± 0.284
4.158LeuGlu: 4.158 ± 0.295
4.762LeuPhe: 4.762 ± 0.279
4.886LeuGly: 4.886 ± 0.264
3.335LeuHis: 3.335 ± 0.244
5.023LeuIle: 5.023 ± 0.329
3.843LeuLys: 3.843 ± 0.237
10.911LeuLeu: 10.911 ± 0.482
3.033LeuMet: 3.033 ± 0.239
3.513LeuAsn: 3.513 ± 0.255
5.517LeuPro: 5.517 ± 0.268
3.637LeuGln: 3.637 ± 0.263
7.123LeuArg: 7.123 ± 0.336
7.576LeuSer: 7.576 ± 0.339
6.601LeuThr: 6.601 ± 0.343
6.423LeuVal: 6.423 ± 0.356
1.427LeuTrp: 1.427 ± 0.154
3.664LeuTyr: 3.664 ± 0.255
0.0LeuXaa: 0.0 ± 0.0
Met
2.127MetAla: 2.127 ± 0.189
0.837MetCys: 0.837 ± 0.109
1.057MetAsp: 1.057 ± 0.128
1.249MetGlu: 1.249 ± 0.154
1.29MetPhe: 1.29 ± 0.139
1.016MetGly: 1.016 ± 0.143
0.741MetHis: 0.741 ± 0.109
1.468MetIle: 1.468 ± 0.131
0.974MetLys: 0.974 ± 0.111
2.759MetLeu: 2.759 ± 0.209
1.043MetMet: 1.043 ± 0.155
1.07MetAsn: 1.07 ± 0.129
1.263MetPro: 1.263 ± 0.123
1.043MetGln: 1.043 ± 0.126
1.702MetArg: 1.702 ± 0.168
2.168MetSer: 2.168 ± 0.182
1.633MetThr: 1.633 ± 0.153
1.674MetVal: 1.674 ± 0.163
0.425MetTrp: 0.425 ± 0.079
1.112MetTyr: 1.112 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
2.676AsnAla: 2.676 ± 0.202
0.878AsnCys: 0.878 ± 0.108
1.757AsnAsp: 1.757 ± 0.174
2.004AsnGlu: 2.004 ± 0.179
1.249AsnPhe: 1.249 ± 0.137
1.853AsnGly: 1.853 ± 0.157
1.318AsnHis: 1.318 ± 0.157
2.182AsnIle: 2.182 ± 0.221
1.606AsnLys: 1.606 ± 0.163
3.925AsnLeu: 3.925 ± 0.302
1.125AsnMet: 1.125 ± 0.124
2.045AsnAsn: 2.045 ± 0.196
1.99AsnPro: 1.99 ± 0.169
1.578AsnGln: 1.578 ± 0.177
2.278AsnArg: 2.278 ± 0.188
3.198AsnSer: 3.198 ± 0.231
3.157AsnThr: 3.157 ± 0.237
3.362AsnVal: 3.362 ± 0.227
0.494AsnTrp: 0.494 ± 0.079
1.29AsnTyr: 1.29 ± 0.147
0.0AsnXaa: 0.0 ± 0.0
Pro
4.474ProAla: 4.474 ± 0.322
1.414ProCys: 1.414 ± 0.153
2.731ProAsp: 2.731 ± 0.204
2.594ProGlu: 2.594 ± 0.188
2.141ProPhe: 2.141 ± 0.178
2.539ProGly: 2.539 ± 0.242
1.908ProHis: 1.908 ± 0.199
2.539ProIle: 2.539 ± 0.206
2.127ProLys: 2.127 ± 0.22
4.639ProLeu: 4.639 ± 0.265
1.345ProMet: 1.345 ± 0.135
1.674ProAsn: 1.674 ± 0.153
5.476ProPro: 5.476 ± 0.508
2.237ProGln: 2.237 ± 0.223
4.405ProArg: 4.405 ± 0.338
4.982ProSer: 4.982 ± 0.298
3.953ProThr: 3.953 ± 0.271
4.007ProVal: 4.007 ± 0.254
0.604ProTrp: 0.604 ± 0.094
1.757ProTyr: 1.757 ± 0.149
0.0ProXaa: 0.0 ± 0.0
Gln
2.429GlnAla: 2.429 ± 0.207
0.947GlnCys: 0.947 ± 0.108
1.565GlnAsp: 1.565 ± 0.156
2.155GlnGlu: 2.155 ± 0.17
1.29GlnPhe: 1.29 ± 0.144
1.551GlnGly: 1.551 ± 0.154
1.523GlnHis: 1.523 ± 0.175
1.921GlnIle: 1.921 ± 0.18
2.127GlnLys: 2.127 ± 0.175
3.733GlnLeu: 3.733 ± 0.301
0.906GlnMet: 0.906 ± 0.103
1.963GlnAsn: 1.963 ± 0.182
2.319GlnPro: 2.319 ± 0.204
2.717GlnGln: 2.717 ± 0.308
3.019GlnArg: 3.019 ± 0.215
2.402GlnSer: 2.402 ± 0.16
2.566GlnThr: 2.566 ± 0.214
2.429GlnVal: 2.429 ± 0.191
0.343GlnTrp: 0.343 ± 0.066
1.496GlnTyr: 1.496 ± 0.171
0.0GlnXaa: 0.0 ± 0.0
Arg
4.282ArgAla: 4.282 ± 0.294
2.031ArgCys: 2.031 ± 0.18
3.129ArgAsp: 3.129 ± 0.249
3.074ArgGlu: 3.074 ± 0.244
2.539ArgPhe: 2.539 ± 0.219
3.445ArgGly: 3.445 ± 0.339
3.225ArgHis: 3.225 ± 0.255
2.91ArgIle: 2.91 ± 0.213
2.402ArgLys: 2.402 ± 0.158
7.219ArgLeu: 7.219 ± 0.362
1.51ArgMet: 1.51 ± 0.145
2.69ArgAsn: 2.69 ± 0.218
3.994ArgPro: 3.994 ± 0.313
3.335ArgGln: 3.335 ± 0.235
6.478ArgArg: 6.478 ± 0.515
5.078ArgSer: 5.078 ± 0.264
3.843ArgThr: 3.843 ± 0.238
4.035ArgVal: 4.035 ± 0.28
1.208ArgTrp: 1.208 ± 0.135
2.608ArgTyr: 2.608 ± 0.194
0.0ArgXaa: 0.0 ± 0.0
Ser
5.064SerAla: 5.064 ± 0.329
1.908SerCys: 1.908 ± 0.17
3.568SerAsp: 3.568 ± 0.257
4.076SerGlu: 4.076 ± 0.258
3.06SerPhe: 3.06 ± 0.19
4.515SerGly: 4.515 ± 0.299
2.429SerHis: 2.429 ± 0.181
3.431SerIle: 3.431 ± 0.265
2.498SerLys: 2.498 ± 0.199
7.411SerLeu: 7.411 ± 0.324
1.921SerMet: 1.921 ± 0.169
2.676SerAsn: 2.676 ± 0.217
4.776SerPro: 4.776 ± 0.307
2.813SerGln: 2.813 ± 0.185
5.339SerArg: 5.339 ± 0.284
9.525SerSer: 9.525 ± 0.603
5.778SerThr: 5.778 ± 0.575
5.339SerVal: 5.339 ± 0.338
1.194SerTrp: 1.194 ± 0.132
2.223SerTyr: 2.223 ± 0.186
0.0SerXaa: 0.0 ± 0.0
Thr
4.694ThrAla: 4.694 ± 0.338
2.1ThrCys: 2.1 ± 0.193
2.457ThrAsp: 2.457 ± 0.179
3.17ThrGlu: 3.17 ± 0.231
2.964ThrPhe: 2.964 ± 0.229
2.896ThrGly: 2.896 ± 0.179
1.825ThrHis: 1.825 ± 0.169
3.472ThrIle: 3.472 ± 0.259
2.608ThrLys: 2.608 ± 0.233
6.203ThrLeu: 6.203 ± 0.319
1.688ThrMet: 1.688 ± 0.155
2.47ThrAsn: 2.47 ± 0.232
4.337ThrPro: 4.337 ± 0.315
2.594ThrGln: 2.594 ± 0.203
3.843ThrArg: 3.843 ± 0.224
6.409ThrSer: 6.409 ± 0.559
6.752ThrThr: 6.752 ± 0.791
6.039ThrVal: 6.039 ± 0.322
1.084ThrTrp: 1.084 ± 0.139
2.251ThrTyr: 2.251 ± 0.194
0.0ThrXaa: 0.0 ± 0.0
Val
4.762ValAla: 4.762 ± 0.269
1.963ValCys: 1.963 ± 0.189
2.841ValAsp: 2.841 ± 0.215
3.006ValGlu: 3.006 ± 0.217
3.527ValPhe: 3.527 ± 0.254
2.855ValGly: 2.855 ± 0.228
2.182ValHis: 2.182 ± 0.189
3.939ValIle: 3.939 ± 0.238
2.347ValLys: 2.347 ± 0.235
7.315ValLeu: 7.315 ± 0.406
1.963ValMet: 1.963 ± 0.163
2.951ValAsn: 2.951 ± 0.246
3.966ValPro: 3.966 ± 0.22
2.525ValGln: 2.525 ± 0.212
4.474ValArg: 4.474 ± 0.314
5.847ValSer: 5.847 ± 0.324
5.394ValThr: 5.394 ± 0.327
5.147ValVal: 5.147 ± 0.373
1.043ValTrp: 1.043 ± 0.137
2.759ValTyr: 2.759 ± 0.224
0.0ValXaa: 0.0 ± 0.0
Trp
0.549TrpAla: 0.549 ± 0.095
0.48TrpCys: 0.48 ± 0.099
0.672TrpAsp: 0.672 ± 0.094
0.645TrpGlu: 0.645 ± 0.103
0.563TrpPhe: 0.563 ± 0.086
0.535TrpGly: 0.535 ± 0.103
0.7TrpHis: 0.7 ± 0.134
0.823TrpIle: 0.823 ± 0.112
0.563TrpLys: 0.563 ± 0.105
1.661TrpLeu: 1.661 ± 0.14
0.508TrpMet: 0.508 ± 0.083
0.535TrpAsn: 0.535 ± 0.077
0.865TrpPro: 0.865 ± 0.117
0.631TrpGln: 0.631 ± 0.088
1.167TrpArg: 1.167 ± 0.17
1.07TrpSer: 1.07 ± 0.1
0.727TrpThr: 0.727 ± 0.113
0.618TrpVal: 0.618 ± 0.087
0.371TrpTrp: 0.371 ± 0.075
0.645TrpTyr: 0.645 ± 0.097
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.059TyrAla: 2.059 ± 0.161
0.933TyrCys: 0.933 ± 0.108
1.757TyrAsp: 1.757 ± 0.165
1.839TyrGlu: 1.839 ± 0.17
1.523TyrPhe: 1.523 ± 0.147
1.921TyrGly: 1.921 ± 0.176
1.112TyrHis: 1.112 ± 0.15
1.99TyrIle: 1.99 ± 0.173
1.112TyrLys: 1.112 ± 0.147
3.623TyrLeu: 3.623 ± 0.237
0.851TyrMet: 0.851 ± 0.113
1.496TyrAsn: 1.496 ± 0.212
1.18TyrPro: 1.18 ± 0.122
1.235TyrGln: 1.235 ± 0.152
2.649TyrArg: 2.649 ± 0.221
2.374TyrSer: 2.374 ± 0.223
2.251TyrThr: 2.251 ± 0.201
2.841TyrVal: 2.841 ± 0.188
0.59TyrTrp: 0.59 ± 0.085
1.304TyrTyr: 1.304 ± 0.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 290 proteins (72865 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski